| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.80559945 |
| The adapter protein Grb 10 associates preferentially with the insulin receptor as compared with the IGF 1 receptor in mouse fibroblasts . 0.80559945^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| The interaction was specific for the insulin receptor and the insulin like growth factor 1 receptor , and it required a catalytically active receptor kinase domain and an intact Grb 10 SH2 domain . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Using the yeast two hybrid system , we have isolated a new substrate of the insulin like growth factor 1 receptor ( IGF IR ) , identified as Grb 10 , a member of the family of SH 2 domain proteins . ^^^ With the help of several mutants of the IGF IR , we have mapped the binding site of Grb 10 between amino acids 1229 and 1245 of the receptor , a sequence that is dispensable for the mitogenic activity of the IGF IR . ^^^ Grb 10 coprecipitates with the IGF IR in cell lysates and is probably involved in the regulation of its activity . . ^^^ Grb 10 : A new substrate of the insulin like growth factor 1 receptor . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Coexpression of LexA IGFIR beta with Ad Grb 10 resulted in strong activation of both LacZ and LEU 2 reporter genes ; this interaction was dependent upon a tyrosine kinase active receptor but did not require tyrosine 950 . . ^^^ Evidence for the direct interaction of the insulin like growth factor 1 receptor with IRS 1 , Shc , and Grb 10 . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Grb 10 interacts differentially with the insulin receptor , insulin like growth factor 1 receptor , and epidermal growth factor receptor via the Grb 10 Src homology 2 ( SH 2 ) domain and a second novel domain located between the pleckstrin homology and SH 2 domains . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| We also identified human Grb 10 , an adaptor protein with SH 2 domain associated with the IGF IR beta subunit . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Grb 10 has been described as a cellular partner of several receptor tyrosine kinases , including the insulin receptor ( IR ) and the insulin like growth factor 1 ( IGF 1 ) receptor ( IGF IR ) . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Human GRB 10 on chromosome 7 , a homologue of the mouse imprinted gene Grb 10 , is a candidate , because GRB 10 has a suppressive effect on growth , through its interaction with either the IGF 1 receptor or the GH receptor , and two patients with RSS were shown to have a maternally derived duplication of 7p11 p 13 , encompassing GRB 10 . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Similar experiments performed with other members of the Grb 7 family , Grb 7 and Grb 10 , and with IGF 1 receptor argue in favor of a specific inhibition of the IR catalytic activity by Grb 14 . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Grb 10 is an interacting partner of the insulin like growth factor 1 receptor ( IGF IR ) and the insulin receptor ( IR ) . ^^^ Here we show that in mouse embryo fibroblasts overexpressing Grb 10 and the IGF IR ( p6 / Grb10 ) , there is a strong ligand dependent increase in ubiquitination of the IGF IR compared with that in parental cells ( p 6 ) . ^^^ Grb 10 coimmunoprecipitates with the IGF IR and endogenous Nedd 4 in p6 / Grb10 cells , suggesting the presence of a Grb10 / Nedd4 / IGF IR complex . ^^^ Likewise , overexpression of a Grb 10 mutant lacking the Src homology 2 ( SH 2 ) domain impaired ubiquitination of the IGF IR in parental p 6 and p6 / Grb10 cells , indicating that Grb 10 binding to Nedd 4 is critical for ubiquitination of the receptor . ^^^ These results suggest a role for the Grb10 / Nedd4 complex in regulating ubiquitination and stability of the IGF IR , and they suggest that Grb 10 serves as an adapter to form a bridge between Nedd 4 and the IGF IR . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Grb 10 proteins are binding partners for several trans membrane tyrosine kinase receptors , including the insulin like growth factor receptor ( IGF IR ) and the insulin receptor ( IR ) . ^^^ Many recent reports have suggested a very important role of Grb 10 in regulating IGF IR signaling . ^^^ In this review , we will focus on the role of Grb 10 in IGF 1 induced mitogenesis and we will discuss the recent findings that show the involvement of Grb 10 in the regulation of ligand induced ubiquitination , internalization , and stability of the IGF IR . . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Regulation of signaling responses from the IGF IR involves the actions of regulatory adapter proteins including RACK 1 and Grb 10 that recruit or sequester cytoplasmic proteins , and the actions of phosphatases including tyrosine PTP 1B , PTEN , and PP2A . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Grb 10 directly interacts with a number of mitogenic receptor tyrosine kinases including the insulin ( IR ) and insulin like growth factor 1 ( IGF IR ) receptor . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Although IGF 1 receptor autophosphorylation normally correlates with receptor signaling , we demonstrate a decrease in IGF 1 stimulated receptor phosphorylation in Grb 10 knockdown cells . ^^^ Pretreatment of cells with the protein tyrosine phosphatase inhibitor pervanadate partially reverses this effect of Grb 10 knockdown on receptor phosphorylation , indicating that endogenous Grb 10 may block phosphatase access to the activated IGF 1 receptor . ^^^ Modulation of the Grb 10 IGF 1 receptor pathway may represent a mechanism that regulates IGF 1 responsive cell and tissue growth . . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| Cloning , chromosome localization , expression , and characterization of an Src homology 2 and pleckstrin homology domain containing insulin receptor binding protein hGrb10gamma . hGrb10alpha ( previously named Grb IR ) is a Src homology 2 domain containing protein that binds with high affinity to the tyrosine phosphorylated insulin receptor and insulin like growth factor 1 receptor . ^^^ |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
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