| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.81605611 |
| It has been shown that SHP 2 , a tyrosine phosphatase , can bind to the activated IGF IR in vitro ; however , its role in IGF IR dephosphorylation in whole cells is unknown . 0.81605611^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Finally , using several insulin and IGF 1 receptor mutants , we found that the kinase regulatory autophosphorylation sites play an important role in the interaction of these receptors with the SHP 2 SH 2 domain . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| We have shown that recruitment of the tyrosine phosphatase Src homology 2 containing phosphotyrosine phosphatase 2 ( SHP 2 ) to the IGF 1 receptor ( IGF IR ) is an important determinant of the duration of IGF IR phosphorylation . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Ligand occupancy of these three proteins influences the recruitment of the phosphatase SHP 2 to the IGF 1 receptor and thereby modulates the duration of IGF 1 receptor tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Subsequently , SHP 2 is transferred to IGF 1 receptor and regulates the duration of IGF 1 receptor phosphorylation . ^^^ This was associated with a lack of SHP 2 transfer to IGF 1 receptor and sustained receptor phosphorylation . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| This delay in SHP 2 transfer seems to account for the increase in the duration of IGF 1 receptor phosphorylation and for enhanced downstream signaling . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| IGF 1 also elicited time dependent recruitment of protein tyrosine phosphatase SHP 2 that coincided with dephosphorylation of the tyrosine phosphorylated IGF 1 receptor tyrosine kinase . ^^^ The alpha ( 5 ) beta ( 3 ) disintegrin echistatin accelerated the rate of SHP 2 recruitment and deactivation of the IGF 1 receptor tyrosine kinase . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of the beta 3 subunit of the alphaVbeta 3 integrin is required for embrane association of the tyrosine phosphatase SHP 2 and its further recruitment to the insulin like growth factor 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Here we report that expression of the beta subunit of platelet derived growth factor receptor ( PDGFR beta ) was specifically downregulated in mutant fibroblasts lacking a functional Shp 2 , while the levels of PDGFR alpha EGFR and IGFIR were not changed . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Evidence is provided that the beta 1 cytodomain plays an important role in mediating beta 1 integrin association with either IRS 1 or Grb 2 associated binder 1 ( Gab 1 ) / SH2 containing protein tyrosine phosphate 2 ( Shp 2 ) , downstream effectors of IGF IR : specifically , beta1A associates with IRS 1 and beta1C with Gab1 / Shp2 . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Shear stress also significantly reduced the amounts of co immunoprecipitated SHP 2 and 1 with IGF IR , suggesting that the synergy between shear stress and IGF 1 in osteoblast proliferation involves integrin dependent recruitment of SHP 2 and 1 away from IGF IR . . ^^^ |
|
| Interacting proteins: P08069 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Functional blocking monoclonal antibody against integrins alpha ( 5 ) beta 3 , but not alpha 2 alpha3 , alpha 4 alpha6 beta 1 , beta 4 or alpha2beta1 , inhibited the IGF 1 stimulated invasion and proliferation in cervical cancer cells . alpha ( 5 ) beta 3 integrin modulated IGF 1R phosphorylation by altering the rate of Src homology 2 containing phosphotyrosine phosphatase ( SHP 2 ) recruitment to the activated IGF 1R . ^^^ |
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