| Interacting proteins: P08069 and P63244 |
Pubmed |
SVM Score :0.73884463 |
| RACK 1 also interacted with the IGF 1R in fibroblasts and MCF 7 cells and with endogenous insulin receptor in COS cells . 0.73884463^^^ |
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| Interacting proteins: P08069 and P63244 |
Pubmed |
SVM Score :1.2836199 |
| In several types of mammalian cells , RACK 1 interacted with IGF IR , protein kinase C , and beta 1 integrin in response to IGF 1 and phorbol 12 myristate 13 acetate stimulation . 1.2836199^^^ We identified RACK 1 , a WD repeat family member and a Gbeta homologue , and demonstrated that RACK 1 interacts with the IGF IR but not with the closely related insulin receptor ( IR ) . 0.65272647^^^ |
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| Interacting proteins: P08069 and P63244 |
Pubmed |
SVM Score :0.56738733 |
| Intracellular association of RACK 1 via its N terminal WD domains 1 to 4 ( WD 1 4 ) with insulin receptor ( IR ) / IGF 1R is augmented upon respective ligand stimulation , whereas association with STAT 3 is constitutive . 0.56738733^^^ |
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| Interacting proteins: P08069 and P63244 |
Pubmed |
SVM Score :0.0 |
| RACK 1 mediated integration of adhesion and insulin like growth factor 1 ( IGF 1 ) signaling and cell migration are defective in cells expressing an IGF 1 receptor mutated at tyrosines 1250 and 1251 . ^^^ The scaffolding protein receptor for activated C kinase ( RACK 1 ) has been proposed to mediate the integration of insulin like growth factor 1 receptor ( IGF IR ) and adhesion signaling . ^^^ |
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| Interacting proteins: P08069 and P63244 |
Pubmed |
SVM Score :0.0 |
| The WD repeat scaffolding protein RACK 1 can mediate integration of the insulin like growth factor 1 receptor ( IGF IR ) and integrin signaling in transformed cells . ^^^ |
|
| Interacting proteins: P08069 and P63244 |
Pubmed |
SVM Score :0.0 |
| Regulation of signaling responses from the IGF IR involves the actions of regulatory adapter proteins including RACK 1 and Grb 10 that recruit or sequester cytoplasmic proteins , and the actions of phosphatases including tyrosine PTP 1B , PTEN , and PP2A . ^^^ |
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