| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :1.2486424 |
| Additional binding experiments in vitro showed that Crk 2 might interact with the phosphorylated IGF 1 receptor through its SH 2 domain . 1.2486424^^^ Interaction in vitro of the product of the c Crk 2 proto oncogene with the insulin like growth factor 1 receptor . 0.75183722^^^ Different domains of the IGF 1 receptor were expressed as ( His ) 6 tagged fusion peptides , phosphorylated with activated wheat germ agglutinin purified IGF 1 receptors and tested for association with GST Crk 2 fusion proteins . 0.66124258^^^ |
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| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| IGF 1 stimulation of Crk 2 phosphorylation , a novel substrate of the IGF IR , was similar in cells expressing mutated and wild type IGF IRs . ^^^ |
|
| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| By binding to Hybrid Rs ( A ) , insulin activated the IGF 1 half receptor beta subunit and the IGF IR specific substrate CrkII . ^^^ |
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| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| These findings indicate that Crk 2 is an endogenous substrate of the IGF 1 receptor tyrosine kinase and provide the first demonstration that a mitogenic growth factor induces tyrosine phosphorylation of endogenous c Crk . . ^^^ |
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| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| Moreover , TGF beta 1 decreased the IGF 1 induced tyrosine phosphorylation of the adaptor protein CrkII and its association with the IGF 1 receptor . ^^^ |
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| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of the interaction between insulin receptor and IGF 1 receptor with c Crk and Crk L in a yeast two hybrid system . ^^^ We have employed a yeast two hybrid approach and mutational analysis to dissect the capabilities of the insulin receptor and the IGF 1 receptor to directly associate with Crk isoforms . ^^^ In contrast , interaction of the IGF 1 receptor with the Crk IISH 2 domain was only detectable when Crk 2 was truncated in its C terminal part , indicating the transient nature of this interaction . ^^^ |
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| Interacting proteins: P08069 and P46108 |
Pubmed |
SVM Score :0.0 |
| This study demonstrates that the activation of the insulin like growth factor 1 receptor induces changes in the tyrosine phosphorylation and protein protein interactions of the Crk proteins in vivo . ^^^ The different responses of CrkL and CrkII to insulin like growth factor 1 receptor activation suggest distinct roles for these two adapter proteins in signal transduction . . ^^^ |
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