| Interacting proteins: P08069 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P23458 |
Pubmed |
SVM Score :0.0 |
| JAK 1 and Tyk 2 activation by the homologous polycythemia vera JAK 2 V617F mutation : cross talk with IGF 1 receptor . ^^^ |
|
| Interacting proteins: P08069 and P23458 |
Pubmed |
SVM Score :0.0 |
| Insulin and insulin like growth factor 1 ( IGF 1 ) treatment of cells overexpressing the insulin receptor or the IGF 1 receptor promotes phosphorylation and activation of Janus kinases JAK 1 and JAK 2 but not of TYK 2 . ^^^ |
|
| Interacting proteins: P08069 and P23458 |
Pubmed |
SVM Score :0.0 |
| Platelet derived growth factor receptor A ( PDGFRA ) , insulin like growth factor 1 receptor ( IGF 1R ) , Janus kinase 1 ( JAK 1 ) , TYK 2 , discoidin domain receptor 2 ( DDR 2 ) , and Lyn were expressed in SF , and the expression of PDGFRA , IGF 1R , and DDR 2 in SF of RA were higher than that of osteoarthritis ( OA , as control ) . ^^^ |
|
| Interacting proteins: P08069 and P23458 |
Pubmed |
SVM Score :0.0 |
| Sixteen cDNAs were identical to the known kinase genes ( PKC beta , JAK 1 , JAK 2 , TYK 2 , HCK , FGR , FYN , BLK , c FES , FER , c ABL , c KIT , FLK 1 , FLK 2 , IGF1R , and ECK ) . ^^^ |
|
| Interacting proteins: P08069 and P23458 |
Pubmed |
SVM Score :0.0 |
| Moreover , tyrosine phosphorylation of STAT 3 , JAK 1 , and JAK 2 was increased upon IGF 1 stimulation of endogenous IGF IR in 293T cells transfected with the respective STAT or JAK expression vector . ^^^ Dominant negative JAK 1 or JAK 2 was able to block the IGF IR mediated tyrosine phosphorylation of STAT 3 in 293T cells . ^^^ |
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