| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| All NHM cells and mesothelioma cell lines expressed IGF 1 , IGF binding protein 3 ( IGFBP 3 ) , and IGF 1 receptor mRNA by either Northern blot or reverse transcription polymerase chain reaction analysis . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Reduction of ventral prostate weight by finasteride is associated with suppression of insulin like growth factor 1 ( IGF 1 ) and IGF 1 receptor genes and with an increase in IGF binding protein 3 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Since insulin like growth factor 1 ( IGF 1 ) is an important hormone regulator of intestinal proliferation , this study examined the effects of dietary protein content and tumor necrosis factor ( TNF ) on mRNA levels of IGF 1 , IGF 1 receptor , IGF binding protein 3 ( IGFBP 3 ) , and IGFBP 4 and on the histology of the colon , jejunum , and ileum in protein malnourished rats . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| To this purpose , the effects of the LHRH agonist Zoladex ( LHRH A ) on 1 ) the mitogenic action of IGF 1 , 2 ) the tyrosine phosphorylation of type 1 IGF 1 receptor ( IGF IR ) , 3 ) the concentration of IGF IR , and 4 ) the secretion of IGF binding protein 3 were studied . ^^^ The results obtained show that in DU 145 cells , LHRH A 1 ) counteracts the mitogenic action of IGF 1 in a dose dependent manner , 2 ) prevents the IGF 1 induced tyrosine phosphorylation of the IGF IR , 3 ) reduces the concentration of IGF IR without affecting its Kd value , and 4 ) does not affect the secretion of IGF binding protein 3 in the conditioned medium from these cells . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor ( IGF ) 1 , IGF 1 receptor , and IGF binding protein 3 messenger ribonucleic acids and protein in corpora lutea from prostaglandin F ( 2alpha ) treated gilts . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to determine the effects of aging and caloric restriction ( CR ) on insulin like growth factor 1 ( IGF 1 ) , IGF 1 receptor ( IGF IR ) , IGF binding protein 3 ( IGFBP 3 ) and IGFBP 4 expression in the stomach and colon of male Fischer 344 rats . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| However , the addition of IGF binding protein 3 , which decreased IGF IR signaling , restored trastuzumab induced growth inhibition . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| However , des ( 1 3 ) IGF 1 , which weakly binds IGF binding protein 3 ( IGFBP 3 ) , induced IGF IR phosphorylation . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| GH increased IGF binding protein 3 ( IGFBP 3 ) , IGF 1 receptor protein and its phosphorylation . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NO production and protein expression of NOS , IGF 1 receptor ( IGF 1R ) and IGF binding protein 3 ( IGFBP 3 ) were measured by Griess assay and Western blot analysis , respectively . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Fibroblast conditioned medium , as well as exogenous IGF 1 , increased protein synthesis in cardiac myocytes , and this increase was inhibited by antibodies against IGF 1 and IGF 1 receptor , IGF binding protein 3 , and IGF 1 receptor antagonist . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| The insulin like growth factor receptor ( IGF IR ) is critical in epidermal development and IGF binding protein 3 ( IGFBP 3 ) , a modulator of cellular activity with or without IGF dependence , co localises with epidermal IGF IRs . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We examined myocardial expression of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 3 ( IGFBP 3 ) , IGF receptor 1 ( IGF 1R ) and IGF 2R in fetal sheep with maternal undernutrition . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We studied expression of the ligands IGF 1 and IGF 2 , the inhibitory IGF binding protein 3 , the type 1 IGF receptor ( IGF IR ) , and the downstream mediator insulin receptor substrate 1 by immunohistochemistry in 56 tissue specimens ( 28 low grade and 28 high grade prostate adenocarcinomas ) . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We examined the effect of recombinant human IGF binding protein 3 ( rhIGFBP 3 ) , an antagonist of IGF IR signaling , in Herceptin resistant breast cells in vitro and in tumors in vivo . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| In addition , incubation of bovine fibroblasts with IGFBP 3 had modifying effects on type 1 IGF receptor mediated signalling because 1 ) the bioeffectiveness of [ Gln 3 , Ala 4 , Tyr 15 , Leu 16 ] IGF 1 and insulin , IGF 1 receptor activators with little or no affinity for IGFBP 3 , was potentiated by preincubation with IGFBP 3 ; and 2 ) fibroblast responsiveness to IGF 1 analogs with different affinities for the type 1 IGF receptor was enhanced in direct relation to the ability of the peptide to bind to the receptor . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| The effect of IGF 1 on IGFBP 2 levels and the synergistic action of IGF 1 and RA on IGFBP 3 levels in CM were blocked by alpha IR 3 , a monoclonal antibody to the human IGF 1 receptor , indicating that these effects required signal transduction through the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| IGF 1 and IGFBP 3 show progressive increases , whereas the erythrocyte IGF 1 receptor binding capacity decreases by 6 months , and GHBP shows little change during the first year of GH treatment . ^^^ Data from this study suggest that changes in IGFBP 3 and , to a lesser extent , IGF 1 are the major correlates of growth rate , and that down regulation of the IGF 1 receptor may have relatively little influence on growth rate compared with changes in IGFBP 3 and IGF I . . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Jejunal mRNA content for IGF 1 , IGF 1 receptor , and IGF binding proteins 3 and 4 ( IGFBP 3 , 4 ) were determined by Northern blotting . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We have asked whether the IGFBP 3 has an effect on cell growth , which is independent of its ability to bind IGF 1 and thus inhibit the activation of the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Pretreatment of MDA MB 468 and MDA MB 231 cells with IGF 1 receptor antibody ( alpha IR 3 ) blocked the IGF 1 effect on IGFBP 3 levels in the media in both cell lines and IGFBP 2 and IGFBP 5 secreted levels in MDA MB 468 cell conditioned media . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We report that while TNF alpha had no consistent effect on the levels of IGF 1 , IGF 2 , or on IGF 1 receptor ( protein and messenger RNA ( mRNA ) ] , it stimulated IGFBP activity and particularly IGFBP 3 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| IGF 1 receptor , and five IGF binding proteins ( IGFBPs ) , IGFBP 1 , IGFBP 2 , IGFBP 3 , IGFBP 4 , and IGFBP 5 in smooth muscle cells ( SMCs ) using colloidal gold immunocytochemistry . ^^^ Quantitative reverse transcription polymerase chain reaction ( QRT PCR ) performed on de novo atherectomy specimens identified mRNA for IGF 1 , IGF 1 receptor , IGFBP 1 , IGFBP 2 , IGFBP 4 , IGFBP 5 levels and detected mRNA for IGFBP 3 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Although TAM can increase IGFBP 3 expression in MCF 7 cells , and this binding protein has been shown to be able to inhibit IGF action , TAM had no effect on IGF 1 stimulated tyrosine phosphorylation of IGF 1 receptor or the downstream signaling molecule , insulin receptor substrate 1 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| While antioestrogens such as tamoxifen and droloxifene reduce the expression of IGF IR in vitro and suppress plasma levels of IGF 1 but elevate IGF binding protein 1 in vivo , megestrol acetate may reduce the delivery of IGFs to the tissues by inhibition of IGFBP 3 protease activity . . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| In contrast , des ( 1 3 ) IGF 1 manifested a remarkably higher potency as compared with IGF 1 in inducing short and middle term cellular responses in IGF IR transfected Ishikawa endometrial cancer cells possessing a high number of both the receptor and the cell membrane bound IGFBP 3 . ^^^ Thus , this difference in the effects of IGF 1 and des ( 1 3 ) IGF 1 can be attributed to the attenuation of IGF 1 mediated IGF IR signaling by membrane bound IGFBP 3 . . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| These results suggest that IGFBP 3 enhances apoptosis by reducing bioavailability of ligands for the IGF 1 receptor and suggest that modulation of IGFBP 3 expression by ICI contributes to apoptosis induced by this compound . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Both human and rat mesangial cells grown on BSA AGE showed increased IGF 1 and total and bioactive TGF beta medium levels and enhanced IGF 1 , IGF 2 , and TGF beta 1 gene expression , compared with cells grown on BSA , whereas total IGFBP and IGFBP 3 medium content , IGF receptor density and affinity , and IGF 1 receptor transcripts were unchanged . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Moreover , the addition of CF CM to PTC increased cell associated IGFBP 3 on PTC surfaces , without changes in IGF 1 receptor numbers or affinity and without changes in PTC mRNA for IGFBP 3 . ^^^ Des ( 1 3 ) IGF 1 , an analog that binds to the IGF 1 receptor but not to IGFBPs , provided a less potent stimulus for PTC growth compared with IGF 1 , indicating that cell associated IGFBP 3 facilitates the action of IGF 1 on PTC . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Leu IGF 1 , which has reduced affinity for the IGF 1 receptor but normal affinity for IGFBPs , failed to increase IGFBP 3 protein and mRNA levels , whereas B chain IGF 1 ( normal affinity for the receptor but reduced affinity for IGFBPs ) elicited the response , thus implying an IGF 1 receptor mediated event . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Treatments greater than 10 UI of hCG resulted in a significant suppression of mammary IGFBP 3 and IGF 1 receptor expression . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We studied the influence of 24 hour hypoxia ( 10 % oxygen ) , 48 hour hyperoxia ( 75 % oxygen ) , and relative hypoxia ( shifting from 48 hours in 75 % oxygen to 24 hours in room air ) on the gene expression of IGF 1 , IGF 1 receptor ( IGF IR ) , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 in retina using a solution hybridization RNase protection assay . ^^^ Hypoxia induced a significant increase in retinal IGF IR ( 178 % ) , IGFBP 2 ( 227 % ) , and IGFBP 3 ( 317 % ) mRNA ; however , retinal IGF 1 mRNA was reduced , as well as serum growth hormone ( GH ) . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Conversely , anti IGF 1R mAb and IGFBP 3 inhibit DNA synthesis . ^^^ IGFBP 3 also modifies the DU 145 cell cycle , decreases p 34 ( cdc 2 ) levels , and IGF 1R autophosphorylation . ^^^ Inhibition of MMP 9 expression is also associated with a decrease in IGFBP 3 proteolysis and with reduced signaling through the IGF 1R . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Testosterone was administered to peripubertal rats and the responses of mRNA of GH receptor , IGF 1 , IGF 1 receptor and IGF binding proteins 1 and 3 ( IGFBP 1 and IGFBP 3 ) as well as circulating IGF 1 were evaluated in two time related models : over 12 h after a single injection ( short term study ) and 10 days after continuous administration ( long term study ) . ^^^ These data suggest that the effect of testosterone on growth ( as assessed by weight gain ) is small and is not mediated by changes in hepatic gene expression of IGF 1 , IGF 1 receptor , IGFBP 1 , IGFBP 3 or circulating IGF 1 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Antagonists of the IGF 1 receptor , IGF 1 Analog or monoclonal antibody 1H7 , elicited concentration dependent inhibition of growth and decrease in IGFBP 3 , IGFBP 4 , and IGFBP 5 production , implying that endogenous IGF 1 stimulated growth and IGFBP production . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| IGFBP 3 was originally defined by the somatomedin hypothesis as the principal carrier of IGF 1 in the circulation and the primary regulator of the amount of free IGF 1 available to interact with the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Large amounts of mRNA were detected for the type 1 receptor ( IGF 1R ) and for IGF binding protein ( IGFBP ) 5 , localised to the PT and PD , and less intense specific hybridisation signals were obtained with mRNAs for IGF 2 , type 2 receptor ( IGF 2R ) and IGFBP 3 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : We have investigated the effect of SA on prostate cancer cell ( DU 145 , LNCaP and PC 3 ) growth and expression of IGFs ( IGF 1 , IGF 2 and IGF 1 receptor ( IGF IR ) ) , IGFBP 3 and vascular endothelial growth factor ( VEGF ) . ^^^ Gene expression studies by RT PCR have demonstrated a decrease in mRNAs of IGF 2 in DU 145 , IGF 1 , and IGF IR in LNCaP , and IGF 2 and VEGF in PC 3 cells and an increase in IGFBP 3 in both DU 145 and PC 3 cells by treatment with SA . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| In addition , 12 pairs of significantly coexpressed IGF system components were detected ( IGF 1 < > IGF 1R , IGF 1 < > IGF 2R , IGF 1 < > IGFBP 3 , IGF 1 < > IGFBP 6 , IGFBP 3 < > IGF 1R , IGFBP 6 < > IGF 1R , IGFBP 1 < > IGF 2R , IGFBP 3 < > IGF 2R , IGFBP 5 < > IGF 2R , IGFBP 3 < > IGFBP 5 , IGFBP 3 < > IGFBP 6 , IGFBP 5 < > IGFBP 6 ) . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| However , the protein levels for IGF 1 receptor and IGFBP 3 and 4 did not correlate with mRNA levels . ^^^ There were no differences in mRNA levels for IGF 1 receptor and IGFBP 3 and 4 between diabetic and non diabetic HREC cultures , suggesting a post transcriptional regulation of IGF 1 receptor and the two IGFBPs . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| IGFBP 3 levels were inversely related to the number of IGF 1 binding sites on erythrocytes and to the K ( d ) of the IGF 1 receptor on PBMCs . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Treatment of confluent C 6 cells with 200 microg / ml Poly ( IC ) for 24 h decreased levels of immunoreactive IGF 1 in conditioned medium ( CM ) to 55 % of the control value , decreased IGF 1 receptor beta subunit levels to 28 % of the control value , and decreased levels of IGFBP 3 , IGFBP 4 , and IGFBP 5 protein in CM to 45 % , 50 % , and 30 % of the control values , respectively . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| The effect of IGFBP 3 and the fragments on IGF 1 receptor ( IGFIR ) signaling pathways was studied by testing IGF 1 induced receptor autophosphorylation in IGFIR overexpressing NIH 3T3 cells . ^^^ IGFBP 3 showed a dose dependent inhibition of autophosphorylation of the beta subunit of IGFIR . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Cross linking experiments using iodinated or unlabeled IGFBP 3 and anti IGF IR antibodies indicated that the inhibitory effects do not involve direct interaction between IGFBP 3 and IGF IR . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Estradiol induced epithelial cell proliferation was associated with inhibition of IGFBP 3 gene expression , stimulation of IGFBP 2 gene expression , and increases in IGF 1R , IRS 1 , IRS 2 , and c Raf 1 levels . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Effect of IGFBP 3 on IGF and IGF analogue induced insulin like growth factor 1 receptor ( IGFIR ) signalling . ^^^ Insulin like growth factor binding protein 3 ( IGFBP 3 ) binds IGF 1 and IGF 2 with high affinity , at least an order of magnitude higher than the affiniy of the IGFs for the IGFIR . ^^^ It has been hypothesized that IGFBP 3 inhibits IGF binding to the IGFIR via a mechanism independent of its ability to sequester IGFs . ^^^ In the present study , we examined the effects of IGFBP 3 and its proteolytic fragments on the initial events of the IGFIR signalling pathway . ^^^ IGFBP 3 inhibited IGF 1 , IGF 2 , Des ( 1 3 ) IGF 1 and Long ( R 3 ) IGF 1 induced IGFIR phosphorylation in a dose dependent manner at similar concentration range but not QAYL induced IGFIR P . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We hypothesize that the enhanced binding of IGF 1 at pH 5 . 8 is facilitated by increased association of IGFBP 3 at this pH and that the resulting cell associated IGF 1 is IGFBP 3 and not IGF IR bound . ^^^ Increased internalization and nuclear association of IGF 1 at pH 5 . 8 in the presence of IGFBP 3 was evident , yet cell proliferation was reduced by IGFBP 3 at both pH 5 . 8 and 7 . 4 indicating that IGFBP 3 cell associated IGF 1 does not signal the cell to proliferate and that the resulting transfer of bound IGF 1 from IGF IR to IGFBP 3 results in diminished proliferation . ^^^ Because IGF 1 receptor binding is affected by IGF binding proteins ( IGFBPs ) , we examined how pH impacted IGFBP 3 regulation of IGF 1 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor ( IGF ) binding protein 3 ( IGFBP 3 ) can stimulate apoptosis and inhibit cell proliferation directly and independently of binding IGFs or indirectly by forming complexes with IGF 1 and IGF 2 that prevent them from activating the IGF 1 receptor to stimulate cell survival and proliferation . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| IGFBP 3 can inhibit the activities of IGFs by interfering with the interaction between IGFs and their receptor IGF IR . ^^^ Epithelial ovarian cancer ( EOC ) tissues express IGFBP 3 , IGFs and IGF IR . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| No differences were observed in the expression of IGF 2 , IGFBP 3 and 6 and IGF IR throughout the lifespan of the corpus luteum . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We recently found that , in addition to its ability to bind IGFs , IGFBP 3 also inhibits IGF IR activation independently of IGF binding and without interacting directly with IGF IR . ^^^ Breast carcinoma derived cells ( MCF 7 ) were stimulated by des ( 1 3 ) IGF 1 or [ Gln ( 3 ) , Ala ( 4 ) , Tyr ( 15 ) , Leu ( 16 ) ] IGF 1 , two IGF analogues with intact affinity for IGF IR , but with weak or virtually no affinity for IGFBPs , then incubated with IGFBP 3 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Our data indicate that loss of autocrine / paracrine IGFBP 3 loops may lead to HCC tumor growth and suggest that modulating production of the IGFs , IGFBP 3 , and IGF IR may represent a novel approach in the treatment of HCC . . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| It is hypothesized that in ISS an alteration of the signal transduction pathway between the GH receptor and IGFBP 3 synthesis results in a local imbalance with high IGFBP 3 levels and lower IGF 1 availability for the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| This finding is consistent with experimental data that indicate that IGFBP 3 can inhibit cellular proliferation and induce apoptosis independent of IGF 1 and the IGF 1 receptor . . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Recombinant IGFBP 3 and IGFBP 4 were found to inhibit the IGF induced proliferation of an NIH3T3 cell line engineered to overexpress the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Histological analysis and immunocytochemical staining confirmed that TNF alpha specifically increases IGFBP 3 and IGFBP 4 immunoreactivity , as well as that of the IGF1R , in radial glial and Purkinje cells . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Addition of recombinant human IGFBP 3 or antibodies against IGF 1 or IGF IR significantly inhibited proliferation of KF . ^^^ The bioavailability of IGF 1 may be related to the levels of IGFBP 3 produced , which in turn influences KF proliferation , suggesting that modulation of IGF 1 , IGF IR , and IGFBP 3 , individually or in combination , may represent novel approaches to the treatment of keloids . . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| In pancreatitis tissue , a significant increase in IGF 1 and IGFBP 3 content was accompanied by a distinct increase in IGF 1 receptor expression , compared to control pancreas tissue . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| With respect to the gene expression of other IGF system components , VA deficiency caused a twofold induction of IGF 1 receptor ( IGF IR ) mRNA in the heart and a twofold reduction in IGFBP 6 mRNA in the lungs , but did not alter the expression of IGF 2 , IGFBP 1 , IGFBP 3 , IGFBP 4 or IGFBP 5 in all tissues examined . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Sixty seven breast surgical specimens from women with and without diabetes who did not have cancer and from women with and without diabetes who did have cancer were studied for insulin like growth factor 1 ( IGF 1 ) , the IGF 1 receptor ( IGF IR ) , insulin like growth factor binding protein 3 ( IGFBP 3 ) , and oestrogen receptor 1 gene expression . ^^^ RESULTS : The expression of IGF 1 and IGF IR was significantly lower in the cancer groups , whereas there was no significant difference for IGFBP 3 between women with and without cancer . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Human fibroblasts , glioblastoma cells , and murine myoblasts were used to determine the kinetics of IGF 2 binding to cell surface IGFBP 3 , IGFBP 5 , and the IGF 1R , respectively . ^^^ Together with the current work , these findings imply that Zn2+ acts in vivo to prevent secreted IGF 2 from binding to IGFBP 3 and IGFBP 5 , thus maintaining IGF 2 in an `` active state , ' ' i . e . , readily available for IGF 1R association . . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| In addition , expression analyses by quantitative RT PCR on RNA from laser microdissected matched normal prostate and prostate tumour samples revealed that IGF IR gene expression was up regulated in nine of 12 prostate cancers , whereas IGFBP 3 gene expression was down regulated in all 12 prostate carcinomas analysed . ^^^ These results indicate an important role for IGF IR and IGFBP 3 in the homeostasis of prostate carcinoma cells and provide a further basis for targeting IGF IR or IGFBP 3 gene expression in order to improve understanding of the IGF IR activated signalling pathways and as a potential treatment for prostate cancer . . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| The results of preclinical studies indicate that a diversity of interventions which antagonize IGF IR signaling or augment IGFBP 3 function inhibit tumor cell growth in models of human cancers . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Addition of IGFBP 3 inhibited IGF 1 mediated IGF type 1 receptor ( IGF IR ) phosphorylation and activation of the downstream molecule Akt in BALB / c 3T3 fibroblasts overexpressing human IGF IR ( 3T3 IGF IR ) and in two human colon cancer cell lines ( COLO 201 and HT 29 ) . ^^^ Coincubation of the IGF I / IGFBP 3 complex with MMP 7 restored IGF 1 mediated IGF IR phosphorylation and activation of Akt in these cell lines . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| In colostrum fed calves , DEXA decreased ( P < 0 . 05 ) mRNA levels of IGF 1 ( esophagus , fundus , duodenum , and ileum ) , IGF 2 ( fundus ) , IGFBP 2 ( fundus ) , IGFBP 3 ( fundus ) , IGF1R ( esophagus , ileum , and colon ) , IGF2R ( fundus ) , GHR ( fundus ) , and InsR ( esophagus , fundus ) , but in formula fed calves DEXA increased mRNA levels of IGF 1 ( esophagus , rumen , jejunum , and colon ) . ^^^ Furthermore , DEXA increased ( P < 0 . 05 ) mRNA levels of IGF 2 ( pylorus ) , IGFBP 3 ( duodenum ) , IGF2R ( pylorus ) , and GHR ( ileum ) , but decreased mRNA levels of IGFBP 2 ( ileum ) , and IGF1R ( fundus ) . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| The direct effects of IGFBP 3 were determined in the presence of an IGF 1 receptor antagonist to eliminate its IGF 1 dependent effects . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| IGF 1 receptor ( IGF IR ) and its downstream signaling pathways Akt and ERK were phosphorylated by IGFBP 3 , whereas inhibition of IGF IR phosphorylation with tyrphostin AG 1024 suppressed the antiapopoptic effect of IGFBP 3 . ^^^ Moreover , the survival effect of IGFBP 3 seems to be mediated by the IGF IR . . ^^^ IGF 1 receptor ( IGF IR ) and its downstream signaling pathways Akt and ERK were phosphorylated by IGFBP 3 , whereas inhibition of IGF IR phosphorylation with tyrphostin AG 1024 suppressed the antiapopoptic effect of IGFBP 3 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Levels of GH , IGF 1 , and IGFBP 3 were above the 95th percentile in the serum of the 3 year old girl with a mono allelic deletion of the IGF1R gene , suggesting IGF 1 resistance . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Both the IGF IR and IGFBP 3 were present in respectively 4 / 4 and 4 / 8 human malignant renal tissues . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| All four hormones increased gene and / or protein expression of PSA , IGF IR , IGF 1 , and IGFBP 2 and decreased that of AR , ERbeta , IGF 2 , and IGFBP 3 . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We studied by real time reverse transcription PCR , whether there are differences in the abundance of mRNA coding for IGF 1 , IGF 2 , IGFBP 2 , IGFBP 3 , IGF 1R , IGF 2R , GHR , and InsR in compartmentalized layers ( fractions ) of jejunum and ileum of 5 d old calves fed colostrum . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The colocalization of insulin like growth factor binding protein 3 ( IGFBP 3 ) and IGF 1 receptor ( IGF IR ) in the basal / germinative layer of the epidermis suggests a key role in modulating epidermal homeostasis . ^^^ METHODS : ( 1 ) Total RNA was isolated from fluorescence activated cell sorted basal human keratinocyte subtypes [ keratinocyte stem cells , transit amplifying keratinocytes ( TA ) , postmitotic differentiating keratinocytes ( PMD ) ] , and real time polymerase chain reaction analysis was used to determine the abundance of IGFBP 3 and IGF IR mRNAs . ( 2 ) An IGFBP 3 transgenic mouse model was then used to assess the effect of excess epidermal IGFBP 3 on keratinocyte proliferation . ^^^ RESULTS : ( 1 ) The highest levels of IGFBP 3 mRNA were detected in TA keratinocytes , in contrast to IGF IR mRNA levels which were highest in PMD keratinocytes . ( 2 ) Elevated human IGFBP 3 mRNA and protein was confirmed in the epidermis of skin derived from transgenic mice . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Cu deficiency depressed serum and heart IGF 1 and heart IGFBP 3 protein levels and increased cardiac IGF 1 receptor protein . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| On PNDs 14 and 56 , IGFBP 3 mRNA was decreased in the uterus of EV treated ewes , but IGF 1R and IGFBP 4 mRNAs were not affected . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that the level of IGF 1 and ALS mRNAs is dramatically decreased in both young and aged dwarf livers , transcripts encoding IGF IR and IGFBP 1 are elevated in young dwarfs , but normalize to control levels in aged dwarf livers while transcripts encoding IGFBP 3 are elevated only in aged controls . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| When SW 837 cells were treated with EGCG for a longer time , i . e . , 96 h , a very low concentration ( 1 . 0 microg / ml ) of EGCG also caused inhibition of activation of IGF 1R , a decrease in the IGF 1 protein , and an increase in the IGFBP 3 protein . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| The effect of IGFBP 3 was independent of the blockade of the IGF 1 receptor . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Secreted IGFBP 3 neutralized IGFs and prevented IGF 1 receptor ( IGF IR ) activation . ^^^ When stably overexpressed , wild type IGFBP 3 but not I56G / L80G / L81G ( GGG ) mutant IGFBP 3 , which has a reduced affinity to IGFs , prevented IGF 1 from activating IGF IR and Akt as well as stimulating cell proliferation . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| IGFBP 3 , IGF 1 , IGF 1 receptor and GH receptor mRNA levels were quantified using real time RT PCR . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| We investigated the actions of DHT , T , DHEA , and estradiol ( E 2 ) on insulin like growth factor ( IGF ) 1 , IGF 2 , IGF 1 receptor ( R ) , IGF binding protein ( IGFBP ) 2 , IGFBP 3 , and IGFBP 5 in primary cultures of human prostatic stromal cells by assessing cell proliferation , mRNA expression , and protein secretion by MTT growth assay , quantitative real time PCR , and ELISA , respectively . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Igf 1R , IGFBP 3 , hRas , Ets 2 , JunB , Egr 1 , Id 1 , MIDA 1 and p 16 gene expressions were measured using quantitative real time PCR in total RNA isolated from punch biopsies from psoriatic involved ( n = 9 ) and uninvolved skin ( n = 9 ) and from cutaneous squamous cell cancer ( SCC ) involved ( n = 8 ) and uninvolved skin ( n = 8 ) . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| IGFBP 3 acts mainly through IGF dependent mechanisms and the protein may therefore represent an alternative strategy to inhibit IGF IR functions . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| IGF 1 enhanced the phosphorylation of IGF 1R , Akt and Erk1 / 2 in KYN 2 cells , and coadministration of IGFBP 3 blocked all types of activation by IGF 1 investigated here . ^^^ Furthermore reduced expression of IGFBP 3 , but not that of IGF 1R , was significantly correlated with tumor size , histological differentiation , capsular invasion and portal venous invasion . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Elucidation of novel pathways downstream of p 53 have established a link between this important tumor suppressor gene and the insulin like growth factor 1 receptor ( IGF 1r ) , either via direct regulation of IGF 1 receptor levels , or modulation of IGFs via transactivation of the insulin like growth factor binding protein 3 ( IGF BP 3 ) gene . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| Almost 90 per cent of haemangiopericytomas expressed IGF 1 receptor ( IGF IR ) mRNA ( 17 out of 19 ) , five ( 26 . 3 per cent ) expressed IGF binding protein 1 ( IGF BP 1 ) , three ( 15 . 8 per cent ) expressed IGF BP 2 , and four ( 21 per cent ) exhibited IGF BP 3 mRNA . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Treatment with IGF BP 3 significantly reduced the levels ( mean intensity per pixel ) of EGF R , IGF 2 , and VEGF in all three cell lines and IGF 1 receptor ( IGF IR ) in representative ME 180 cell line . ^^^ CONCLUSIONS : Levels of EGF R , IGF 2 , IGF IR , and VEGF are significantly reduced following treatment with IGF BP 3 in cervical cancer . ^^^ |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|