| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.58830239 |
| Knock down of Shc with a specific small inhibitory RNA decreased the association of ERalpha with IGF 1R by 87 % , suggesting that Shc is a crucial molecule in the formation of this ternary complex . 0.58830239^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.72054785 |
| We observed that IGF IR negatively correlated with ERalpha in the group of all tumors and in axillary node negative cancer ( p < 0 . 03 , p < 0 . 05 , respectively ) , but not in the subgroup of node positive cancer . 0.72054785^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Estrogen receptor alpha rapidly activates the IGF 1 receptor pathway . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Role of estrogen receptor alpha in modulating IGF 1 receptor signaling and function in breast cancer . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| We have provided evidence that the IGF 1 receptor serves as an anchor for ERalpha in the plasma membrane . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| This study provides evidence that simultaneous targeting of IGF IR and the estrogen receptor may enhance the therapeutic effect . . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| In view of results suggesting that IGF 1 is a more potent mitogen than estradiol for breast cancer cells and data demonstrating a positive correlation between estrogen receptor level and IGF 1 receptor level of breast cancer cells , the IGF 1 lowering effect of tamoxifen may contribute to the cytostatic activity of the drug . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| IGF 1 receptor ( 9 . 4+ / 96 vs . 10 . 5+ / 57 per microg protein ) and estrogen receptor ( 18 . 4+ / 1 . 14 vs . 19 . 6 + 1 . 6 per microg protein ) levels were not significantly different in tumors from exercised animals compared to those from sedentary animals . ^^^ For both sets of tumors , correlation between estrogen receptor content and growth rate is positive , while the correlation between IGF 1 receptor content and growth rate is negative . ^^^ The results of this study suggest that exercise prior to NMU administration does not affect tumor burden but does alter tumor growth rate , which is not due to differences in estrogen receptor or IGF 1 receptor content . . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| To analyse whether this effect is mediated through estrogen receptors and through cross talk between steroid and insulin like growth factor ( IGF ) systems , we have concomitantly administered antagonists of estrogen receptor ( ICI 182 , 780 ) or the IGF 1 receptor ( JB 1 ) with estradiol . ^^^ In conclusion , an interaction of estrogen receptor and IGF 1 receptor signalling may mediate neuroprotection in the adult rat hippocampus . . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The role of estrogen receptors and IGF 1 receptors in the synaptic changes has been studied by assessing the number of axo somatic synapses in ovariectomized rats treated with intracerebroventricular administration of the estrogen receptor antagonist ICI 182 , 780 and the IGF 1 receptor antagonist JBI to ovariectomized rats . ^^^ Both the estrogen receptor antagonist and the IGF 1 receptor antagonist blocked the estrogen induced synaptic decrease . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| To gain insight into the mechanisms involved in the cross talk between IGF 1 receptor ( IGF 1R ) and estrogen receptor signaling pathways , we used MCF 7 derived cells ( SX 13 ) , which exhibit a 50 % reduction in IGF 1R expression . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Protein expressions of IGF 1 receptor ( IGF 1 R ) , estrogen receptor ( ER ) , and cell proliferation associated nuclear antigen ( ki 67 ) were analysed by streptavidin peroxide method in 40 cases . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| In addition to cytomorphological criteria , expression of ER alpha and beta , RAR alpha and beta , and IGF 1 receptor in the nucleus should be examined . . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Systemic estradiol administration resulted in a transient immunocoprecipitation of the IGF 1 receptor with the estrogen receptor alpha and in a transient increase in tyrosine phosphorylation of the IGF 1 receptor in the hypothalamus of adult ovariectomized Wistar rats . ^^^ The interaction with the IGF 1 receptor was specific for the alpha form of the estrogen receptor and was also induced by intracerebroventricular injection of IGF 1 . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Estrogens increase the effect of IGF 1 on breast cancer cells by stimulating the expression of IGF 1 and IGF 1 receptor ; IGFs enhance the action of estrogens by regulating the production of estrogen receptor . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| This study examined the role of crosstalk between estrogen receptor ( ER ) alpha and the IGF 1 receptor as a critical mediator of hormone and growth factor dependent neurite outgrowth in a homogenous cell system . ^^^ We used control PC 12 cells and PC 12 cells stably transfected with ER alpha , both of which express IGF 1 receptor . ^^^ Cells were treated for 1 week with vehicle , 1 nM E ( 2 ) or 100 ng / ml IGF 1 alone or with E ( 2 ) or IGF 1 in the presence of either the IGF 1 receptor antagonist JB 1 or the ER antagonist ICI 182 , 780 . ^^^ The ER and IGF 1 receptor antagonists similarly blocked the E ( 2 ) induced increase in neurite lengths in ER alpha transfected cells . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The protein levels of ERalpha , IGF 1 Receptor ( IGF IR ) and Bcl 2 were severely reduced , when RU 58 ( R ) 1 cells were cultured with RU 58 , 668 and the expression of progesterone receptor ( PR ) was lost . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Postulated mechanisms of action are as follows : ( a ) reduction of levels of circulating IGF 1 , which will decrease activation of the IGF 1 receptor and subsequent signaling pathways ; ( b ) increasing local IGF binding proteins , which may have IGF dependent effects through obstruction of IGF interaction with local IGF 1 receptor as well as IGF independent effects ; and ( c ) interference with estrogens and estrogen receptor action , which may have direct ( and possibly synergistic ) effects on IGF signaling . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| In both BG 1 and MCF 7 cells , epidermal growth factor receptor number is low ( < 20000 / cell ) , while insulin like growth factor 1 receptor level was highest in estrogen receptor positive cell lines . ^^^ For example , insulin like growth factor 1 receptor was higher in BG 1 and MCF 7 cells than in estrogen receptor negative cells ( HeLa > MDA MB 435 > HBL 100 ) . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The MEDLINE database and ongoing studies were examined for clinical , epidemiological and laboratory data on ; ( a ) alcohol related increase in the incidence of breast cancer in relation to menopausal status , oestrogen concentrations and the oestrogen receptor ( ER ) status of the tumour ; ( b ) activation of insulin like growth factor 1 receptor ( IGF1R ) in mammary tissue by alcohol related hyperinsulinaemia ; ( c ) interaction between ER and IGF1R in breast cancer cell systems . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Furthermore , estrogen receptor beta and insulin like growth factor 1 receptor immunoreactivities were colocalized in the Purkinje cells of the cerebellum . ^^^ Colocalization of estrogen receptor beta and insulin like growth factor 1 receptor was also detected in cells with the morphology of astrocytes in all regions assessed . ^^^ Furthermore , the colocalization of immunoreactivity for estrogen receptor beta and insulin like growth factor 1 receptor in glial cells suggests that glia may also play a role in the interactions of insulin like growth factor 1 and estrogen in the rat brain . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Differential insulin like growth factor 1 receptor signaling and function in estrogen receptor ( ER ) positive MCF 7 and ER negative MDA MB 231 breast cancer cells . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The expression of oestrogen receptor ( ER ) and that of the insulin like growth factor 1 receptor ( IGF IR ) are positively correlated in breast cancer specimens . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| While no significant changes in serum levels of mammotrophic hormones were detected , increased immunostaining for insulin like growth factor 1 receptor , estrogen receptor alpha , and progesterone receptor in the genistein + methoxychlor group suggested that local factors involved in regulating mammary growth may have played a role in propagating the endocrine effects of these two compounds . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The ER cross talks with a number of mitogenic signaling pathways and second messengers , like the epidermal growth factor receptor , the insulin like growth factor 1 receptor , mitogen activated protein ( MAP ) kinase , phosphatidylinositol 3 kinase / Akt , dopamine , and cyclic AMP . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The dose dependent effect of a 24 h treatment with estradiol ( E ( 2 ) ) ( 1 , 2 , 5 , 10 nM ) and raloxifene ( Rx ) ( 1 , 5 , 10 , 20 microM ) on ER alpha and ER beta mRNA expression , collagen bio synthesis , prolidase activity , MMP 2 , MMP 9 , insulin like growth factor 1 receptor expression ( IGF 1R ) and beta 1 integrin expressions in cultured fibroblasts obtained from postmenopausal women were examined . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To observe the distribution and change of insulin like growth factor 1 receptor ( IGF 1R ) , estrogen receptor alpha ( ER alpha ) and their co expression in the brains of normal newborn female rats and in the brains of those with hypoxic ischemic brain damage ( HIBD ) . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Unlike classical growth factor receptors , such as insulin like growth factor 1 receptor ( IGF1R ) and epidermal growth factor receptor ( EGFR ) , estrogen receptor has no transmembrane and kinase domains and is known to initiate E 2 rapid signals by forming a protein complex with many signaling molecules . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The IGF IR and the estrogen receptor ( ER ) are usually co expressed and the two signaling systems are engaged in a complex functional cross talk controlling cell proliferation . ^^^ However , in breast cancer , except for the well established correlation with ER status , the associations of the IGF IR with other prognostic parameters are still insufficiently documented . . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The clinical importance of these epigenetic and genetic changes has recently been stressed by the finding that IGF1R signaling alters the apoptotic response of breast cancer cells to genotoxic stress and , in addition , IGF1R activation sensitizes cells to estrogen by inducing phosphorylation of the estrogen receptor . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| In hormone responsive breast cancer cells , IGF IR function is strongly linked with estrogen receptor ( ER ) action . ^^^ The IGF IR and the ER are co expressed in breast tumors . ^^^ In ER negative breast cancer cells , usually displaying a more aggressive phenotype , the levels of the IGF IR and IRS 1 are often low and IGF is not mitogenic , yet the IGF IR is still required for metastatic spread . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Administration of the chemicals to ERalpha knockout mice did not activate IGF IR , indicating that ERalpha is required for activation of uterine IGF IR by these diverse chemicals . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| HeLa cells , which do not contain endogenous estrogen receptors ( ER ) , were transiently transfected with IGF 1R promoter constructs with or without a plasmid encoding human ERalpha or ERbeta and treated with 100 nm 17beta estradiol ( E ( 2 ) ) for 24 h . ^^^ Similarly , E ( 2 ) decreased IGF 1R transcription by 21 % in rat aortic smooth muscle cells ( RASMC ) , which express endogenous ER . ^^^ Repression of IGF 1R promoter activity by a combination of ERalpha and E ( 2 ) did not appear to be mediated via direct binding of ER to the IGF 1R promoter but rather by inhibition of SP 1 binding to the IGF 1R promoter . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Statistical analysis ( ROC analysis for tumor grade ) demonstrated that down regulation of IGF IR and IRS 1 correlated better with tumor progression than reduction of ER expression or increase in cell proliferation , IGF IR showing the best correlation , followed by IRS 1 and , less significant , ER and Ki 67 . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| However , ERalpha positive C 4 12 cells now exhibited estrogen induction of IGF IR and IRS 1 levels and responded mitogenically to both estrogen and IGF 1 . ^^^ |
|
| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The interaction of ERs and IGF IR in the brain may depend on interactions between neural cells expressing ERs with neural cells expressing IGF IR , or on direct interactions of the signaling pathways of alpha and beta ERs and IGF IR in the same cell , since most neurons expressing IGF IR also express at least one of the ER subtypes . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Together these data demonstrate that 1 ) functional signaling proximal to IGF 1R is maintained in the alpha ERKO mouse uterus , 2 ) ER alpha is necessary for IGF 1 induction of uterine nuclear proliferative responses , and 3 ) cross talk between IGF 1R and ER signaling pathways exists in vivo . . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Many genes have been selected as targets for antisense therapy , including HER 2 / neu , PKA , TGF alpha , EGFR , TGF beta , IGFIR , P 12 , MDM 2 , BRCA , Bcl 2 , ER , VEGF , MDR , ferritin , transferrin receptor , IRE , C fos , HSP 27 , C myc , C raf and metallothionein genes . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Both exert their actions through the IGF type 1 receptor ( IGF1R ) , which is able to cooperate with the estrogen receptor in the regulation of growth associated gene expression . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| We therefore examined by immunohistochemistry the expression of IGF IR in primary tumors and breast cancer metastases to lymph nodes , and correlated IGF IR positivity with estrogen receptor ( ER ) status and selected clinicopathological features . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The present study was aimed at evaluating the hypothesis that IGF IR gene transcription in breast cancer cells is under inhibitory control by WT 1 and , furthermore , that the mechanism of action of WT 1 involves functional and physical interactions with estrogen receptor alpha ( ERalpha ) . ^^^ To examine the potential interplay between WT 1 and ERalpha in control of IGF IR gene transcription we employed ER depleted C 4 cells that were generated by clonal selection of ER positive MCF 7 cells that were maintained in estrogen free conditions . ^^^ Triple cotransfection experiments using an ERalpha expression vector in the absence or presence of WT 1 expression vectors , along with an IGF IR promoter reporter plasmid , revealed that ERalpha stimulated IGF IR promoter activity whereas coexpression of WT 1 abrogated the effect of ERalpha . ^^^ Combined , our results suggest that WT 1 suppresses IGF IR gene transcription in breast cancer cells via a mechanism that involves protein protein association with ERalpha . ^^^ As a result of this interaction , the ability of ERalpha to transactivate the IGF IR promoter is abrogated . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Our recent in vitro studies also suggest that EGFR signalling productively cross talks with insulin like growth factor receptor ( IGF 1R ) and , where present , activates ER on key AF 1 serine residues to facilitate acquired tamoxifen resistant growth . ^^^ We also present our clinical immunohistochemical findings that IGF 1R expression , its phosphorylation on tyrosine 1316 , and also phosphorylation on serine 118 of ER are not only prominent in ER+ tamoxifen responsive disease , but are also detectable in ER+ de novo and acquired tamoxifen resistant breast cancer , where there is evidence of EGFR / ER cross talk . ^^^ Our data suggest that agents to deplete effectively ER or IGF 1R signalling may be of value in treating ER+ de novo / acquired tamoxifen resistance in addition to tamoxifen responsive disease in vivo . ^^^ IGF 1R inhibitors may also prove valuable in ER patients , since considerable IGF 1R signalling activity was apparent within approximately 50 % of such tumours . . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| We hypothesize that Rg 1 may exert its actions in MCF 7 cell via the activation of crosstalk between ER and insulin growth factor 1 receptor ( IGF IR ) dependent pathways . ^^^ The stimulation of IGF IR expression by Rg 1 in MCF 7 cells appears to require ER , and its actions might involve ligand independent activation of ER . . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| The present experiments sought to determine the implication of estrogen receptors ( ERalpha and ERbeta ) and their interaction with insulin like growth factor receptor ( IGF IR ) signaling pathways in neuroprotection by estradiol against 1 methyl 4 phenyl 1 , 2 , 3 , 6 tetrahydropyridine ( MPTP ) toxicity . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| Radicicol and monocillin 1 were also evaluated in a solid phase competition assay for their ability to bind Hsp 90 and to deplete cellular levels of two known Hsp 90 client proteins with relevance to breast cancer , estrogen receptor ( ER ) , and the type 1 insulin like growth factor receptor ( IGF 1R ) . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| IGF1R overexpression was detected in 71 cases ( 47 % ) , and was correlated with lower nuclear grade ( P = 0 . 03 ) , positive estrogen receptor ( ER ) and / or progesterone receptor status ( P = 0 . 002 ) . pERK1 / 2 expression , detected in 53 cases ( 35 % ) , was correlated with positive ER ( P < 0 . 0001 ) and lower nuclear grade ( P = 0 . 014 ) . pAKT expression , detected in 88 cases ( 59 % ) , was not correlated with nuclear grade , hormone receptors status or other clinical parameters . ^^^ Of the 71 IGF1R overexpressing tumors , pERK1 / 2 expression was detected in 27 ( 56 % ) of 48 ER positive cases but in only four ( 17 % ) of 23 ER negative cases ( P = 0 . 022 ) . ^^^ |
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| Interacting proteins: P08069 and P03372 |
Pubmed |
SVM Score :0.0 |
| ER alpha , ER beta , IGF 1 , and IGF 1R were expressed ( immunohistochemistry ) in all biopsies ( 18 of 18 ) of intrahepatic cholangiocarcinoma . ^^^ ER alpha was expressed ( Western blot ) only by the HuH 28 cell line ( intrahepatic cholangiocarcinoma ) , whereas ER beta , IGF 1 , and IGF 1R were expressed in the three cell lines examined . ^^^ In serum deprived HuH 28 cells , serum readmission induced stimulation of cell proliferation that was inhibited by ER and IGF 1R antagonists . 17beta Estradiol and IGF 1 stimulated proliferation of HuH 28 cells to a similar extent to that of MCF 7 ( breast cancer ) but greater than that of TFK 1 and Mz ChA 1 , inhibiting apoptosis and exerting additive effects . ^^^ Modulation of ER and IGF 1R could represent a strategy for the management of cholangiocarcinoma . . ^^^ |
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