| Interacting proteins: O14508 and P08069 |
Pubmed |
SVM Score :0.0 |
| Using the interaction trap screen ( active cytoplasmic domain of the IGF IR ) 55PIK and SOCS 2 proteins were also identified . ^^^ |
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| Interacting proteins: O14508 and P08069 |
Pubmed |
SVM Score :0.0 |
| In a yeast two hybrid screen of a human fetal brain library , we have previously identified SOCS 2 as a binding partner of the activated IGF 1 receptor ( IGFIR ) . ^^^ |
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| Interacting proteins: O14508 and P08069 |
Pubmed |
SVM Score :0.0 |
| Biochemical evidence that SOCS 2 binds to the IGF 1 receptor ( IGF IR ) supports the novel possibility that SOCS 2 limits IGF 1 action . ^^^ The current study tested the hypothesis that SOCS 2 normally limits basal or IGF 1 induced intestinal growth and limits IGF IR signaling in intestinal epithelial cells . ^^^ The effects of SOCS 2 on IGF IR signaling were examined in ex vivo cultures of SOCS 2 null and WT intestine and Caco 2 cells . ^^^ IGF 1 stimulated activation of IGF IR and downstream signaling intermediates were enhanced in the intestine of SOCS 2 null mice and were decreased by SOCS 2 overexpression in Caco 2 cells . ^^^ SOCS 2 bound directly to the endogenous IGF IR in Caco 2 cells . ^^^ |
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| Interacting proteins: O14508 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14508 and P08069 |
Pubmed |
SVM Score :0.0 |
| NA |
|