| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| In accordance with the time and order of onset in NRTN responsiveness , Ret protein was first detected in ciliary ganglia at E 6 , subsequently in trigeminal ganglia at E 9 , and in vestibular ganglia at E 12 . ^^^ Exogenous application of retinoic acid induced NRTN responsiveness and Ret protein expression from E 9 vestibular ganglion neurons , suggesting that retinoic acid can regulate Ret protein expression in peripheral sensory neurons in vitro . ^^^ These results demonstrate that NRTN exerts neurotrophic effects on different cranial ganglia at different developmental stages and that the onset and offset of NRTN responsiveness are regulated mainly by the spatiotemporal patterns of Ret , but not of GFRalpha receptors . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NRTN signals via a receptor complex composed of the high affinity binding receptor component GFRalpha 2 and the transmembrane tyrosine kinase Ret . ^^^ NRTN mRNA was expressed in smooth muscle of penile blood vessels and corpus cavernosum in adult rat as well as in several intrapelvic organs , whereas GFRalpha 2 and Ret mRNAs were expressed in virtually all cell bodies of the penile neurons , originating in the major pelvic ganglia . ( 125 ) 1 NRTN injected into the shaft of the penis was retrogradely transported into the major pelvic and dorsal root ganglia . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Seizure activity regulates gene expression for glial cell line derived neurotrophic factor ( GDNF ) and neurturin ( NRTN ) , and their receptor components , the transmembrane c Ret tyrosine kinase and the glycosylphosphatidylinositol anchored GDNF family receptor ( GFR ) alpha 1 and alpha 2 in limbic structures . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| We have used in situ hybridization to study the mRNA expression of NRTN , GDNF , Ret , GFRalpha 1 , and GFRalpha 2 during embryonic development and in the adult mouse . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Neurturin ( NRTN ) , signalling via the GDNF family receptor alpha 2 ( GFRalpha 2 ) and Ret tyrosine kinase , has recently been identified as an essential target derived factor for many parasympathetic neurons . ^^^ NRTN is expressed in salivary and lacrimal glands , while GFRalpha 2 and Ret are expressed in the corresponding submandibular , otic and sphenopalatine ganglia . ^^^ Thus , GDNF signalling via GFRalpha1 / Ret is essential in the early gangliogenesis of some , but not all , cranial parasympathetic neurons , whereas NRTN signalling through GFRalpha2 / Ret is essential for the development and maintenance of parasympathetic target innervation . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| GDNF and NRTN bind to the tyrosine kinase receptor Ret and the receptors GFRalpha 1 and GFRalpha 2 . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Exposure to 30 100 ng / ml GDNF or neurturin ( NRTN ) resulted in activation of ret . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Virtually all neurons in the cardiac parasympathetic ganglia exhibited the cholinergic phenotype , and over 90 % of these cells contained both components of the NRTN receptor , Ret tyrosine kinase and GDNF family receptor alpha 2 ( GFRalpha 2 ) . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| A receptor complex comprised of TrnR 1 ( GDNFR alpha ) and Ret was recently identified and found to be capable of mediating both GDNF and NTN signaling . ^^^ TrnR 2 is attached to the cell surface via a GPI linkage , and can mediate both NTN and GDNF signaling through Ret in vitro . ^^^ Fibroblasts expressing TrnR 2 and Ret are approximately 30 fold more sensitive to NTN than to GDNF treatment , whereas those expressing TrnR 1 and Ret respond equivalently to both factors , suggesting the TrnR 2 Ret complex acts preferentially as a receptor for NTN . ^^^ Comparative analysis of TrnR 1 , TrnR 2 , and Ret expression indicates that multiple receptor complexes , capable of mediating GDNF and NTN signaling , exist in vivo . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that NTN induces Ret phosphorylation in primary cultures of rat superior cervical ganglion ( SCG ) neurons . ^^^ NTN also caused Ret phosphorylation in fibroblasts that were transfected stably with Ret and GDNFRalpha but not in cells expressing Ret alone . ^^^ A glycosylphosphatidylinositol linked protein also was important for NTN and GDNF signaling in SCG neurons ; phosphatidylinositol specific phospholipase C treatment of SCG cultures reduced the ability of NTN to phosphorylate Ret and the ability of NTN or GDNF to activate the mitogen activated protein kinase pathway . ^^^ NTN and GDNF also caused sustained activation of Ret and the mitogen activated protein kinase pathway in SCG neurons . ^^^ These data indicate that NTN is a physiologically relevant ligand for the Ret receptor and suggest that NTN may have a critical role in the development of many neuronal populations . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NTN utilizes a receptor complex system that consists of Ret and another GPI linked receptor , NTNR alpha . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| The receptor tyrosine kinase RET is part of a functional receptor for glial cell derived neurotrophic factor ( GDNF ) and neurturin ( NTN ) which are potent neurotrophic factors for motoneurons . ^^^ The persistence of RET like immunoreactivity in the majority of large motoneurons in ALS could be important in the design of clinical trials of GDNF and NTN . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Finally , we show that NTN , in the presence of NTNR alpha , induces tyrosine phosphorylation of Ret , and that NTN , NTNR alpha and Ret form a physical complex on the cell surface . ^^^ These findings identify Ret and NTNR alpha as signalling and ligand binding components , respectively , of a receptor for NTN and define a novel family of receptors for neurotrophic and differentiation factors composed of a shared transmembrane protein tyrosine kinase and a ligand specific GPI linked protein . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization was then used to map cellular expression of the GDNF related trophic factor neurturin ( NTN ) and GDNFR beta mRNA in developing and adult mice , and comparisons with GDNFR alpha and RET were made . ^^^ NTN colocalized with RET and GDNFR alpha in ureteric buds of the developing kidney . ^^^ Although NTN and GDNFR beta expression patterns are sometimes complementary , this is not always the case , suggesting multiple modi operandi of GDNF and NTN in relation to RET and the two binding proteins , GDNFR alpha and GDNFR beta . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Recent studies demonstrated that GDNF and NTN use a multicomponent receptor system in which glycosyl phosphatidylinositol ( GPI ) linked cell surface proteins and Ret receptor tyrosine kinase function as the ligand binding and signalling components , respectively . ^^^ The results demonstrated that Ca2+ ions might be required for the complex formation of Ret and GDNF or NTN that induces Ret oligomerization and autophosphorylation . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Fibroblasts transfected with Ret and one of the coreceptors GFRalpha 1 or GFRalpha 2 do not respond to persephin , suggesting that persephin utilizes additional , or different , receptor components than GDNF and NTN . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Recently , glial cell line derived neurotrophic factor ( GDNF ) and a second family member , neurturin ( NTN ) , have been found to mediate their signals by binding to a heterotetrameric complex of c Ret tyrosine kinase receptors and glycosylphosphatidylinositol linked proteins , GFR alpha 1 ( GDNFR alpha ) or GFR alpha 2 ( TrnR2 / GDNFR beta / NTNR alpha / RETL2 ) . ^^^ Here , we studied the effect of GDNF and NTN on human neuroblastomas in the short term primary culture system , as well as the expression of c Ret , GFR alpha 1 , GFR alpha 2 , GDNF , and NTN . ^^^ Many primary neuroblastomas expressed c Ret , GFR alpha 1 , and GFR alpha 2 as well as their ligands , GDNF and NTN , suggesting the presence of a paracrine or autocrine signaling system within the tumor tissue . ^^^ These imply that the GDNF ( NTN ) / c Ret / GFR alpha 1 ( GFR alpha 2 ) signaling may have an important role in regulating the growth , differentiation , and cell death of neuroblastomas . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Considering that RET and glial cell line derived neurotrophic factor ( GDNF ) mutations have been reported in the disease , we regarded the other RET ligand , neurturin ( NTN ) , as an attractive candidate gene , especially as it shares large homologies with GDNF . ^^^ Interestingly , it appears that the NTN mutation reported here is not sufficient to cause HSCR , and this multiplex family also segregates a RET mutation . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| We have used in situ hybridization to study the mRNA expression of NTN , GDNF , RET , GFRalpha 1 , and GFRalpha 2 in the central nervous system ( CNS ) of adult mice . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Signaling by GDNF and NTN depends on the tyrosine kinase receptor Ret and on GFRalpha 1 and 2 . ^^^ The absence of Ret expression at E 14 suggests that both GDNF and NTN may employ an additional , unknown receptor . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Both GDNF and NTN signal through a receptor complex consisting of the signal transducing subunit , Ret , and a ligand specific binding subunit , termed GDNF family receptor ( GFR ) alpha 1 and GFRalpha 2 , respectively . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NTN exerts its effects through a multicomponent receptor system which include a receptor ( GFRalpha 2 ) and the proto oncogene c RET . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| The glial cell line derived neurotrophic factor ( GDNF ) ligands ( GDNF , Neurturin [ NTN ] , and Persephin [ PSP ] ) signal through a multicomponent receptor system composed of a high affinity binding component ( GFRalpha 1 GFRalpha4 ) and a common signaling component ( RET ) . ^^^ Artemin can also activate the GFRalpha 1 RET complex and supports the survival of dopaminergic midbrain neurons in culture , indicating that like GDNF ( GFRalpha 1 RET ) and NTN ( GFRalpha 2 RET ) , Artemin has a preferred receptor ( GFRalpha 3 RET ) but that alternative receptor interactions also occur . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Ret is the receptor for glial cell line derived neurotrophic factor ( GDNF ) and neurturin ( NTN ) . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Neurturin ( NTN ) is a neuronal survival factor that activates the Ret tyrosine kinase in the presence of a GPI linked coreceptor ( either GFR alpha 1 or GFR alpha 2 ) . ^^^ The loss of GFR alpha 2 expressing neurons , in conjunction with earlier studies , provides strong support for GFR alpha2 / Ret receptor complexes as the critical mediators of NTN function in vivo . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Glial cell line derived neurotrophic factor ( GDNF ) and a related protein , neurturin ( NTN ) , require a GPI linked coreceptor , either GFR alpha 1 or GFR alpha 2 , for signaling via the transmembrane Ret tyrosine kinase . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Following seizures , GDNF and NTN mRNAs were elevated in dentate granule cells , and c Ret mRNA in hilar neurons and non pyramidal cells in CA 1 and CA 3 regions . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Glial cell line derived neurotrophic factor ( GDNF ) and neurturin ( NTN ) mediate their actions through a unique multicomponent receptor system composed of Ret receptor tyrosine kinase and glycosyl phosphatidylinositol linked cell surface proteins ( designated GFRalpha 1 and GFRalpha 2 ) . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| RET is a member of the receptor tyrosine kinase ( RTK ) superfamily , which can transduce signalling by glial cell line derived neurotrophic factor ( GDNF ) and neurturin ( NTN ) in cultured cells . ^^^ In order to determine whether in addition to being sufficient , RET is also necessary for signalling by these growth factors , we studied the response to GDNF and NTN of primary neuronal cultures ( peripheral sensory and central dopaminergic neurons ) derived from wild type and RET deficient mice . ^^^ Our experiments show that absence of a functional RET receptor abrogates the biological responses of neuronal cells to both GDNF and NTN . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Using in situ hybridization , the expression of glial cell line derived neurotrophic factor ( GDNF ) , neurturin ( NTN ) , persephin ( PSP ) , GFRalpha 1 , GFRalpha 2 , GFRalpha 3 and RET mRNA in human fetal spinal cord was studied . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| GDNF , NTN , PSP , and ART mediate their signals via a common receptor tyrosine kinase , Ret , but their ligand specificity is determined by a novel class of glycosylphosphatidylinositol ( GPI ) anchored proteins called the GDNF family receptor alpha ( GFR alpha ) . ^^^ GDNF binds preferentially to GFR alpha 1 , NTN GFR alpha 2 , ART GRF alpha 3 , and PSP GFR alpha 4 as a co receptor to activate Ret . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Neurturin ( NTN ) and its receptor components ( GFRalpha 2 and Ret ) play an important role in the survival of different populations of neurons in the central and peripheral nervous systems . ^^^ To gain insight into their possible functions throughout normal retinal development and during retinal neuronal apoptosis , the retinal distribution of expression of NTN and GFRalpha 2 mRNAs and Ret protein were compared in control and retinal degeneration ( rd ) mice . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Recent studies have identified a multi component receptor system for the neurotrophic factor , glial cell line derived neurotrophic factor ( GDNF ) and its homolog , neurturin ( NTN ) , comprising the signaling tyrosine kinase , Ret and multiple GPI linked binding proteins , GDNF family receptor alpha 1 and alpha 2 ( GFRalpha 1 and GFRalpha 2 ) . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Here we show that Ret , GFRalpha 1 ( the GDNF receptor ) , and GFRalpha 2 ( the NTN receptor ) are expressed by testicular germ cells , while GDNF and NTN are expressed by Sertoli cells . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| RET transduces a signal following activation by ligands of the glial cell line derived neurotrophic factor ( GDNF ) family of neurotrophins which currently comprises GDNF , neuturin ( NTN ) , artemin ( ART ) and persephin ( PSP ) . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Expression of RET and its ligand complexes , GDNF / GFRalpha 1 and NTN / GFRalpha 2 , in medullary thyroid carcinomas . ^^^ Glial cell line derived neurotropic factor ( GDNF ) and its membrane bound GDNF family receptor alpha ( GFRalpha 1 ) , as well as neurturin ( NTN ) and its membrane bound receptor GFRalpha 2 form a complex with the RET product , a receptor tyrosine kinase , resulting in downstream signaling to the nucleus . ^^^ METHODS : The mRNA expression of RET , GDNF , GFRalpha 1 , NTN and GFRalpha 2 was investigated by mRNA in situ hybridization , and confirmed by reverse transcription PCR analysis . ^^^ All MTCs showed expression of RET , 13 expressed GDNF , 12 expressed GFRalpha 1 and 9 expressed NTN and GFRalpha 2 . ^^^ In 7 of the tumors RET , GDNF and GFRalpha 1 were expressed at high levels , and in five of these seven tumors NTN and GFRalpha 2 genes were also expressed at high levels . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of RET / GDNF / NTN genes in children with total colonic aganglionosis with small bowel involvement . ^^^ Recently , germline mutations of RET , GDNF , and NTN genes have been reported in HSCR . ^^^ DNA sequences of all the RET / GDNF / NTN coding regions were determined by the direct dyedeoxy terminator cycle method . ^^^ These results also urge us to examine if the RET germline mutation may cause critical alteration of the GDNF / NTN Ret signal transduction more severely in homo ( hemi ) zygosity and in male fetuses during organogenesis . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Expression analysis of RET and the GDNF / GFRalpha 1 and NTN / GFRalpha 2 ligand complexes in pheochromocytomas and paragangliomas . ^^^ Glial cell line derived neurotrophic factor ( GDNF ) and neurturin ( NTN ) have been shown to function as independent ligands to RET , binding in a complex with the membrane bound receptors GFRalpha 1 and GFRalpha 2 respectively . ^^^ Here we have investigated the mRNA expression of RET and its ligand complexes , GDNF / GFRalpha 1 and NTN / GFRalpha 2 , in a panel of pheochromocytomas and paragangliomas using mRNA in situ hybridization . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Novel , specific MAbs with varying epitope specificities and blocking activity will be valuable tools for both the in vitro and in vivo characterization of NTN and its relationship to the GFRalpha 2 and Ret receptors . . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Glial cell line derived neurotrophic factor ( GDNF ) and neurturin ( NTN ) bind to GFR alpha 1 and GFR alpha 2 receptors , respectively , and their neurotrophic activity is mediated by the tyrosine kinase receptor , Ret . ^^^ Although GDNF , NTN and Ret mRNA levels were at the limit of detection , RNase protection assays revealed relatively high amounts of GFR alpha 1 and GFR alpha transcripts . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| GDNF and NTN act through a two component receptor system consisting of the ligand specific binding subunits GDNF family receptor ( GFR ) alpha 1 and GFRalpha 2 and the common transducing subunit c Ret . ^^^ To establish an assay system for these studies , several neural cell lines were screened for the presence of GDNF and NTN receptor subunits by RT PCR and immunoblot analysis . c Ret expression was detectable only in Neuro2A cells , which did not express GFRalpha 1 or GFRalpha 2 . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| It is a multigenic malformation and until now , eight genes have been involved in the etiology of this disease : genes encoding proteins of the RET signaling pathway ( RET , GDNF and NTN ) , genes participating in the endothelin ( EDN ) type B receptor pathway ( EDNRB , EDN 3 and ECE 1 ) , the SOX 10 gene and the SIP 1 gene that is mutated in syndromic forms of HSCR . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Glial cell line derived neurotrophic factor ( GDNF ) , neurturin ( NTN ) and their receptors ( GFRalpha 1 , GFRalpha 2 and Ret ) play an important role in the survival of neurons in the central and peripheral nervous system . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| We investigated the immunohistochemical expression of GDNF , NTN , and their receptors ( GFRalpha 1 , 2 , and 3 , and Ret ) in normal human kidney and in 42 nephroblastomas , 20 of which were associated with nephrogenic rests ( group A ) and 22 were not ( group B ) . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| METHODS : Retinal expression of NTN , GDNF , their corresponding receptors GFRalpha 2 and 1 , the transmembrane receptor tyrosine kinase ( Ret ) , and cSrc p 60 , a member of the cytoplasmic protein tyrosine kinases family , were analyzed by Western blot analysis and immunocytochemistry in cyclic light and dark reared rats in the presence and absence of intense light exposure . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Mutations in genes that encode RET ligands ( GDNF and NTN ) ; components of another signaling pathway ( EDNRB , EDN 3 , ECE 1 ) ; and the transcription factor , SOX 10 , have been identified in HSCR patients . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| They exert their biological effects by activating the RET tyrosine kinase in the presence of a GPI linked coreceptor , either GFR alpha 1 ( considered to be the favored coreceptor for GDNF ) or GFR alpha 2 ( the preferred NTN coreceptor ) . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Germline mutations of the RET proto oncogene ( RET ) , its ligand glial cell derived neurotrophic factor ( GDNF ) , and neurturin ( NTN ) gene have been reported in patients with Hirschsprung ' s disease . ^^^ DNA sequences of all the RET / GDNF / NTN coding regions were determined using a direct DyeDeoxy Terminator Cycle method . ^^^ No germline RET / GDNF / NTN mutations were found in his parents . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Neurturin ( NTN ) is an important neurotrophic factor for parasympathetic neurons ; however , no studies to date have investigated the signalling mechanisms downstream of GFRalpha 2 and Ret activation underlying this neurotrophic support . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Although mutations in eight different genes ( EDNRB , EDN 3 , ECE 1 , SOX 10 , RET , GDNF , NTN , SIP 1 ) have been identified in affected individuals , it is now clear that RET and EDNRB are the primary genes implicated in the etiology of HSCR . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NTN and GDNF are thought to bind with different affinities to the GDNF family receptor alpha 2 ( GFRalpha 2 ) , and can activate the same multi component receptor system consisting of GFRalpha 2 , receptor tyrosine kinase Ret ( RET ) and NCAM . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| Moreover , we found that the biological activity of pro NTN differs from mature NTN , as pro NTN did not form a signaling complex with the tyrosine kinase receptor Ret and GFRalpha 2 or GFRalpha 1 . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| GDNF and NTN signaling is mediated by a two component receptor : a signal transducing component , RET , which is shared by both ligands , and a ligand specific binding component , GFR alpha 1 ( higher GDNF affinity ) or GFR alpha 2 ( higher NTN affinity ) . ^^^ |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99748 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
|