| Interacting proteins: Q8WU20 and P07949 |
Pubmed |
SVM Score :0.59342002 |
| These experiments demonstrate that FRS 2 couples both ligand regulated and oncogenic forms of RET , with the MAP kinase signaling cascade as part of the response of RET under normal biological conditions and pathological conditions , such as MEN 2 and papillary thyroid carcinomas . . 0.59342002^^^ We demonstrate that oncogenic RET PTC proteins are associated with FRS 2 constitutively , leading to tyrosine phosphorylation of FRS 2 , MAP kinase stimulation , and cell proliferation . 0.52824228^^^ |
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| Interacting proteins: Q8WU20 and P07949 |
Pubmed |
SVM Score :0.0 |
| Further , we show that in Ret transfected cells the suc 1 associated neurotrophic factor induced tyrosine phosphorylation target , SNT , is chronically phosphorylated in tyrosine residues , and associates with the Sos substrate . ^^^ Moreover , our data indicate SNT as a substrate for both Ret mutants , which might mediate the activation of this cascade . . ^^^ |
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| Interacting proteins: Q8WU20 and P07949 |
Pubmed |
SVM Score :0.0 |
| NA |
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