| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.56106352 |
| However , in intact cells , the interaction of Grb 2 with the two short and long Ret isoforms expressed separately is of similar strength , thus suggesting that Ret short isoform interaction with Grb 2 could be mediated not only by Shc but also by a molecule that binds preferentially to this isoform . 0.56106352^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| Ligand stimulation of neuronal cells induced the assembly of a large protein complex containing c Ret , Grb 2 , and tyrosine phosphorylated forms of Shc , p 85 ( PI3K ) , the adaptor Gab 2 , and the protein tyrosine phosphatase SHP 2 . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| Among the 6 autophosphorylation sites found in the wild type RET receptor , the MEN2B mutant lacked phosphorylation at Tyr 1096 , leading to decreased Grb 2 binding , while simultaneously creating a new phosphorylation site . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb 2 adaptor proteins . ^^^ In addition , in cells containing either Ret or Trk oncoproteins , Shc proteins are constitutively phosphorylated on tyrosine and bound to Grb 2 . ^^^ Only in in vitro experiments were Ret and Trk oncoproteins shown to bind the SH 2 region of Grb 2 . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| RET alternate splicing influences the interaction of activated RET with the SH 2 and PTB domains of Shc , and the SH 2 domain of Grb 2 . ^^^ |
|
| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| Characterization of Ret Shc Grb 2 complex induced by GDNF , MEN 2A , and MEN 2B mutations . ^^^ The results showed that all of them induce a signal transducing complex consisting of Ret , Shc , and Grb 2 proteins . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| In this report , using a constitutively activated Ret TK form , Ret ptc 2 , we demonstrate that the MEN 2B as the activated WT Ret TK binds to several SH 2 signalling proteins such as Shc , Grb 2 , Phospholipase Cgamma , Crk and Nck . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| Because activation of Ras requires recruitment of Grb 2 and SOS to the plasma membrane , the subcellular distribution of Ret / ptc2 was investigated , and it was found to localize to the cell periphery . ^^^ Because Shc interacts with MEN 2 forms of Ret , and because phosphorylation of Shc results in Grb 2 recruitment and subsequent signaling through Ras and Raf , the potential interaction between Ret / ptc2 and Shc was investigated . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| Ret oncogene signal transduction via a IRS 2 / PI 3 kinase / PKB and a SHC / Grb 2 dependent pathway : possible implication for transforming activity in NIH3T3 cells . ^^^ Moreover , Ret 9bp induces phosphorylation of SHC resulting in growth factor receptor binding protein 2 ( Grb 2 ) binding and activation of the mitogen activating protein ( MAP ) kinase pathway . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| In response to GDNF stimulation , SHC bound to GAB 1 and GRB 2 adaptor proteins as well as RET , and SHC and GAB 1 were highly phosphorylated on tyrosine . ^^^ The complex formation consisting of SHC , GAB 1 and GRB 2 was almost abolished by replacement of tyrosine 1062 in RET with phenylalanine . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| RET dimerization and its complex formation with Shc and Grb 2 adaptor proteins were detected in tumor tissues . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| Whereas SHC bound to RET was associated with GRB 2 and GAB 1 proteins , SNT / FRS2 was associated with GRB 2 only , suggesting that SNT / FRS2 is involved mainly in the activation of the RAS / mitogen activated protein kinase ( MAPK ) pathway but not the phosphatidylinositol 3 kinase ( PI 3 K ) / AKT pathway . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| Dominant negative GRB 2 expressed in MDCK cells together with RET 9 or RET 51 significantly reduces branching . ^^^ Therefore , GRB 2 is necessary for RET mediated branching of MDCK cells . . ^^^ |
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| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| The association of Cbl with RET was indirect and was mediated through Grb 2 . ^^^ A constitutive complex of Grb 2 and Cbl could be recruited to both receptor isoforms via docking of Shc to phosphorylated Tyr 1062 in RET . ^^^ |
|
| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|