| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| Only RET protein derived from MEN2A transfectant cells had increased autokinase activity , whereas MEN2B transfectant cells demonstrated selective activation of the mitogen activated protein kinase , Jun kinase 1 ( Jnk 1 ) . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| Amongst these , the PI 3 K / AKT and JNK pathways appeared to be more strongly activated in the cells expressing RET MEN2B than in the cells expressing RET MEN2A , suggesting the possibility that these pathways may be involved in the disease phenotype . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| This suggested that the association of Nck to tyrosine 361 in Dok 1 is necessary for the JNK and c Jun activation by glial cell line derived neurotrophic factor or RET MEN2B . ^^^ Because a high level of the JNK phosphorylation was observed in the cells expressing RET MEN2B , its strong activation via Nck binding to Dok 1 may be responsible for aggressive properties of medullary thyroid carcinoma developed in MEN 2B . . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that oxalate inhibits renal PTC proliferation via oxidative stress , p 38 MAPK / JNK , and cPLA ( 2 ) signaling pathways . . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| In order to identify pathways that are relevant for Ret signalling to the nucleus , we have investigated its ability to induce the c Jun NH 2 terminal protein kinases ( JNK ) . ^^^ Here we show that triggering the endogenous Ret , expressed in PC 12 cells , induces JNK activity ; moreover , Ret is able to activate JNK either when transiently transfected in COS 1 cells or when stably expressed in NIH3T3 fibroblasts or in PC Cl 3 epithelial thyroid cells . ^^^ JNK activation is dependent on the Ret kinase function , as a kinase deficient RET mutant , associated with Hirschsprung ' s disease , fails to activate JNK . ^^^ The pathway leading to the activation of JNK by RET is clearly divergent from that leading to the activation of ERK : substitution of the tyrosine 1062 of Ret , the Shc binding site , for phenylalanine abrogates ERK but not JNK activation . ^^^ Experiments conducted with dominant negative mutants or with negative regulators demonstrate that JNK activation by Ret is mediated by Rho / Rac related small GTPases and , particularly , by Cdc42 . . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| Current evidence indicates that signal transduction by RET activates several second messenger systems including the PLC gamma , Ras , JNK and inositol phosphate pathways . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| RET can activate various signaling pathways such as RAS / extracellular signal regulated kinase ( ERK ) , phosphatidylinositol 3 kinase ( PI3K ) / AKT , p 38 mitogen activated protein kinase ( MAPK ) and c Jun N terminal kinase ( JNK ) pathways . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| Expression of down stream molecules of RET ( p ERK , p p 38 MAPK , p JNK and p AKT ) in papillary thyroid carcinomas . ^^^ To evaluate the roles of 4 putative downstream molecules ( ERK , p 38 MAPK , JNK and AKT ) of the RET signal pathway in the tumorigenesis of papillary carcinomas , the expression patterns of RET and phosphorylated forms of ERK , p 38 MAPK , JNK and AKT were evaluated in 115 cases of papillary thyroid carcinomas by 3 mm core tissue microarray based immunohistochemical staining . ^^^ There was no difference in the p JNK expression between RET protein positive and RET protein negative papillary carcinomas ( p > 0 . 05 ) . ^^^ Our results showing constitutive expression of p JNK in most cases of surgically excised papillary thyroid carcinomas irrespective of RET protein expression status suggest that JNK activation may play a role in the tumorigenesis or survival of sporadic papillary thyroid carcinoma . . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| Furthermore , tyrosine residues in DOK 1 , the p 85 subunit of phosphatidylinositol 3 ' kinase , JNK 1 and 2 , P 38 , and phospholipase gamma were directly phosphorylated by RET . ^^^ CONCLUSIONS : RET directly phosphorylates tyrosine residues on FAK , ERK 1 / 2 , DOK 1 , the p 85 subunit of of phosphatidylinositol 3 ' kinase , JNK 1 and 2 , P 38 , and phospholipase gamma . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| GDNF induced OECs migration was demonstrated depending on GFRalpha 1 and Ret receptor , and activation of JNK and Src signaling cascades . ^^^ |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
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