| Interacting proteins: P07949 and P40763 |
Pubmed |
SVM Score :0.74447362 |
| In this study , we show that RET / PTC associates with signal transducer and activator of transcription 3 ( STAT 3 ) and activates it by the specific phosphorylation of the tyrosine 705 residue . 0.74447362^^^ |
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| Interacting proteins: P07949 and P40763 |
Pubmed |
SVM Score :0.0 |
| Here , we report that MEN2A RET activates Signal Transducer and Activator of Transcription 3 ( STAT 3 ) via two YxxV / Q STAT 3 docking sites , Tyr 752 and Tyr 928 . ^^^ MEN2A RET induced cellular transformation by activation of STAT 3 . ^^^ MEN2A RET induces both Tyr 705 and Ser 727 phosphorylation of STAT 3 , and STAT 3 serine phosphorylation is required for its maximal transcriptional activity . ^^^ |
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| Interacting proteins: P07949 and P40763 |
Pubmed |
SVM Score :0.0 |
| STAT 3 expression was observed in 12 / 12 ( 100 % ) papillary thyroid carcinomas ( PTC ) but in none of the follicular tumors . ^^^ In conclusion , in thyroid nodules STAT 3 is expressed only in PTC and a number of FA . ^^^ |
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| Interacting proteins: P07949 and P40763 |
Pubmed |
SVM Score :0.0 |
| RET / PTC mediated Y 705 phosphorylation of STAT 3 was inhibited by addition of SU 11248 , and the inhibitory effects of SU 11248 on the tyrosine phosphorylation and transcriptional activation of STAT 3 were very closely correlated with decreased autophosphorylation of RET / PTC . ^^^ |
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| Interacting proteins: P07949 and P40763 |
Pubmed |
SVM Score :0.0 |
| Utilizing a novel antibody array , we identified constitutive phosphorylation of STAT 3 in cells expressing the 2B mutation but not wild type RET . ^^^ In multiple endocrine neoplasia 2B ( MEN 2B ) patients expressing RET ( M918T ) , nuclear enrichment of STAT 3 and elevated expression of CXCR 4 was detected in metastatic thyroid C cell carcinoma in the liver . ^^^ |
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| Interacting proteins: P07949 and P40763 |
Pubmed |
SVM Score :0.0 |
| Moreover , we show that the dysfunctional signaling properties of these mutants , when compared with wild type RET , involve constitutive activation of signal transducers and activators of transcription 3 ( STAT 3 ) . ^^^ Furthermore , we show that STAT 3 activation is mediated by a signaling pathway involving Src , JAK 1 , and JAK 2 , differing from STAT 3 activation promoted by RET ( C634R ) which was previously found to be independent of Src and JAKs . ^^^ Finally , immunohistochemical analysis of FMTC tumor samples support the in vitro data , because nuclear localized , Y 705 phosphorylated STAT 3 , as well as a high degree of RET expression at the plasma membrane was observed . . ^^^ |
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| Interacting proteins: P07949 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07949 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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