| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| This residual wave of Erk phosphorylation was independent of the kinase activity of c Ret . ^^^ These results indicate that upon ligand stimulation , at least two distinct protein complexes assemble on phosphorylated Tyr 1062 of c Ret via Shc , one leading to activation of the Ras / Erk pathway through recruitment of Grb2 / Sos and another to the PI3K / Akt pathway through recruitment of Grb2 / Gab2 followed by p 85 ( PI3K ) and SHP 2 . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Furthermore , FGF 2 induced GDNF causes enhanced phosphorylation of c Ret and the signaling components Akt and Erk . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| We also show that treatment of human PTC cells with recombinant exogenous OPN stimulated Matrigel invasion and activated the ERK and 5 AKT murine thymoma viral oncogene homolog 1 / protein kinase B ; signaling pathways . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Ret receptor tyrosine kinase activates extracellular signal regulated kinase 2 in SK N MC cells . ^^^ Previously , using a human epidermal growth factor receptor Ret chimaeric receptor ( HERRet ) stably transfected into fibroblasts , it was shown that Ret activation induces the activation of p21ras , but , surprisingly , activation of extracellular signal regulated kinase 2 ( ERK 2 ) was not observed ( Santoro et al . ( 1994 ) Mol . ^^^ These results suggest that Ret can induce ERK 2 activation in a p21ras dependent manner in cells derived from tissue where Ret is endogenously expressed . . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Cell scattering of SK N MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK 2 activation . ^^^ Analysis of the kinetics of ERK 2 activation and downstream events revealed that Ret and FGF receptor activation led to sustained ERK 2 activation and SRE transactivation , while PDGF treatment led to transient ERK 2 activation and failed to induce SRE transactivation . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| The pathway leading to the activation of JNK by RET is clearly divergent from that leading to the activation of ERK : substitution of the tyrosine 1062 of Ret , the Shc binding site , for phenylalanine abrogates ERK but not JNK activation . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Abrogation of nerve growth factor induced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK . ^^^ Here we took advantage of two rat pheochromocytoma derived cell lines ( PC12 / MEN2A and PC12 / MEN2B ) to investigate whether Ret induced nerve growth factor ( NGF ) unresponsiveness might involve impairment of ERK signaling . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Using the neuroectodermic SK N MC cell line , we found that the Ret tyrosine kinase activity is essential for GDNF to induce phosphatidylinositol 3 kinase ( PI3K ) / Akt and ERK pathways as well as cell rescue . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Suppression of the Ret 9bp tyrosine kinase activity by SHP 1 caused a decrease in activation of Erk 2 ( extracellular signal regulated kinase ) and abolished PKB / Akt ( protein kinase B ) phosphorylation . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| When Erk activation is inhibited , ureteric bud tips show less cell proliferation than controls and they also produce fewer laminin rich processes penetrating the mesenchyme and fail to show the strong concentration of apical actin filaments typical of controls ; apoptosis and expression of Ret and Ros , are , however , normal . ^^^ The activity of the Erk MAP kinase pathway is dependent on at least two known regulators of ureteric bud branching ; the GDNF Ret signalling system and sulphated glycosaminoglycans . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Mitogenic effect of glial cell line derived neurotrophic factor is dependent on the activation of p70S6 kinase , but independent of the activation of ERK and up regulation of Ret in SH SY5Y cells . ^^^ In contrast , the activation of the ERK pathway and the resulting induction of immediate early genes parallel the increases in Ret protein levels . ^^^ These results suggest that GDNF promotes cell proliferation via the activation of p70S6K , independent of the ERK signaling pathway , and that GDNF activates the Akt / p70S6K pathway more efficiently than the ERK pathway in the cells in which Ret expression is low . . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| RET can activate various signaling pathways such as RAS / extracellular signal regulated kinase ( ERK ) , phosphatidylinositol 3 kinase ( PI3K ) / AKT , p 38 mitogen activated protein kinase ( MAPK ) and c Jun N terminal kinase ( JNK ) pathways . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Expression of down stream molecules of RET ( p ERK , p p 38 MAPK , p JNK and p AKT ) in papillary thyroid carcinomas . ^^^ To evaluate the roles of 4 putative downstream molecules ( ERK , p 38 MAPK , JNK and AKT ) of the RET signal pathway in the tumorigenesis of papillary carcinomas , the expression patterns of RET and phosphorylated forms of ERK , p 38 MAPK , JNK and AKT were evaluated in 115 cases of papillary thyroid carcinomas by 3 mm core tissue microarray based immunohistochemical staining . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Expression of Gab 1 PI3K m in SK N MC human primitive neuroectodermal tumor cells expressing wild type RET markedly impaired Akt phosphorylation , Rac 1 activation , and lamellipodia formation that were induced by GDNF whereas expression of Gab 1 SHP2 m partially impaired Erk activation . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Several such drugs are currently being developed to inhibit RET , Ras , Raf , as well as other factors impacted by the ERK pathway . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Moreover , ART failed to induce phosphorylation of extracellular signal related kinase ( ERK ) and Akt in these cells and was > 10 ( 4 ) fold less potent than GDNF in stimulating RET phosphorylation . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Here we show that the 3 proteins function along a linear oncogenic signaling cascade in which RET / PTC induces RAS dependent BRAF activation and RAS and BRAF dependent ERK activation . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that RET signals through focal adhesion kinase ( FAK ) in medullary thyroid cancer cells and that extracellular signal regulated kinase ( ERK ) activity can be blocked by pp 2 , an inhibitor of both Src and RET . ^^^ We hypothesized that RET could directly phosphorylate FAK and ERK . ^^^ METHODS : RET and ERK kinase activity were measured with the use of an in vitro kinase assay . ^^^ The relative contribution of RET in phosphorylation of ERK was tested by treating cells with PD 98059 , an inhibitor of MEK , and the RET inhibitor PP 2 , then measuring ERK activity . ^^^ Inhibition of both MEK ( upstream of ERK ) and RET was more potent than inhibition of either alone in decreasing ERK activity . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| Signaling downstream of Ret is thus modified through a mechanism that involves the adaptor protein Shc as well as ERK , eventually blocking Akt activation . ^^^ |
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| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07949 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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