| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.95345874 |
| As in other cells , Gab 2 was found to associate with several signaling molecules including Src homology 2 containing protein tyrosine phosphatase 2 , Grb 2 , Lyn , and phospholipase C gamma ( PLC gamma ) . 0.95345874^^^ These results suggest that in addition to the positive effects mediated by PI 3 kinase that are apparent in Gab 2 ( / ) mast cells , Gab 2 by interacting with Lyn and PLC gamma may have negative regulatory effects on Fc epsilon RI induced mast cell signaling and functions . . 0.57011977^^^ The association of Gab 2 with Lyn and PLC gamma were enhanced after receptor aggregation . 0.54335704^^^ |
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| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| To characterize the interactions between Gab 2 and its SH 2 containing binding partners , we designed a modified yeast two hybrid system in which the Lyn tyrosine kinase is expressed in a regulated manner in yeast . ^^^ |
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| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| Among these LAT , SLP 76 and Gab 2 are critically important as adapters that facilitate events initiated by IgE receptor dependent activation of Src family protein tyrosine kinases , Lyn and Fyn . ^^^ |
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| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| G CSF induced tyrosine phosphorylation of Gab 2 is Lyn kinase dependent and associated with enhanced Akt and differentiative , not proliferative , responses . ^^^ Phosphorylation of Gab 2 occurred in wild type , but not Lyn deficient , G CSFR transfected DT 40 B cells . ^^^ These data propose that Lyn , not Jak 2 , phosphorylates Gab 2 and that maximal phosphorylation of Gab 2 requires Y 764 , a Grb 2 binding site . ^^^ All together , these data indicate that G CSF treatment leads to Lyn mediated tyrosine phosphorylation of Gab 2 , which may serve as an important intermediate of enhanced Akt activity and myeloid differentiation , not growth / survival response . . ^^^ |
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| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| Fc epsilon RI induced signaling in the presence of constitutively active Lyn exhibited enhanced phosphorylation of the receptor subunits , Syk , LAT , Gab 2 , phospholipase C ( PLC ) gamma 1 and PLC gamma 2 , and production of phosphatidylinositol 3 , 4 , 5 trisphosphate . ^^^ |
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| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| Lyn and Syk were essential , whereas Fyn , Gab 2 , and the phosphoinositide 3 kinase Akt pathway were not critical for survival . ^^^ |
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| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| Conversely , tyrosine phosphorylation of the adaptor protein Gab 2 , which is essential for mast cell degranulation , was inhibited after Ag stimulation of Lyn unique domain transfectants , and Ag induced release of histamine was inhibited up to 48 % . ^^^ |
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| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| We found that Gab 2 tyrosyl phosphorylation requires Lyn and Syk . ^^^ |
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| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| In this study , we report that FcepsilonRI aggregation leads to increased Fer / Fps kinase activities and that Fer phosphorylation downstream of FcepsilonRI is independent of Syk , Fyn , and Gab 2 but requires Lyn . ^^^ |
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| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
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