| Interacting proteins: Q9HCN6 and P07948 |
Pubmed |
SVM Score :0.0 |
| In addition , glycoprotein 4 ( GPIV , CD 36 ) , one of the major platelet membrane glycoproteins , was associated in a complex with the Fyn , Yes , and Lyn proteins in platelet lysates . ^^^ |
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| Interacting proteins: Q9HCN6 and P07948 |
Pubmed |
SVM Score :0.0 |
| Using coprecipitation methods with convulxin coupled beads and antibodies against FcRgamma and the Src family , we showed that Fyn and Lyn , but not Yes , Src , Fgr , Hck , and Lck , were physically associated with the GPVI FcRgamma complex irrespective of stimulation . ^^^ |
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| Interacting proteins: Q9HCN6 and P07948 |
Pubmed |
SVM Score :0.0 |
| In the current study , the role of 2 Src family kinases , Fyn and Lyn , in GPVI signaling has been examined using murine platelets deficient in one or both kinases . ^^^ This study provides the first genetic evidence that Fyn and Lyn mediate FcR immune receptor tyrosine based activation motif phosphorylation and PLC gamma 2 activation after the ligation of GPVI . ^^^ |
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| Interacting proteins: Q9HCN6 and P07948 |
Pubmed |
SVM Score :0.0 |
| The glycoprotein 6 ( GPVI ) Fc receptor ( FcR ) gamma chain complex , a key activatory receptor for collagen on platelet surface membranes , is constitutively associated with the Src family kinases Fyn and Lyn . ^^^ Molecular cloning of GPVI has revealed the presence of a proline rich domain in the sequence of GPVI cytoplasmic tail which has the consensus for interaction with the Src homology 3 ( SH 3 ) domains of Fyn and Lyn . ^^^ Furthermore , depletion of the proline rich domain in GPVI ( Pro ( ) GPVI ) prevented binding of Fyn and Lyn and markedly reduced phosphorylation of FcR gamma chain in transiently transfected COS 7 cells , but did not affect the association of the gamma chain with GPVI . ^^^ These findings demonstrate that the proline rich domain of GPVI mediates the association with Fyn / Lyn via their SH 3 domain and that this interaction initiates activation signals through GPVI . . ^^^ |
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| Interacting proteins: Q9HCN6 and P07948 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Phosphorylation of c Cbl through GpVI is reduced in murine platelets deficient in the Src family kinases Fyn and Lyn , demonstrating that they lie upstream of c Cbl phosphorylation . ^^^ |
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| Interacting proteins: Q9HCN6 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HCN6 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
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