| Interacting proteins: Q99062 and P07948 |
Pubmed |
SVM Score :0.69310982 |
| In this study , we show that the Lyn and Syk kinases are associated with the G CSFR in neutrophils from SCN patients with point mutations in the cytoplasmic domain of the G CSFR mRNA . 0.69310982^^^ |
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| Interacting proteins: Q99062 and P07948 |
Pubmed |
SVM Score :0.0 |
| We also demonstrated that tyrosine phosphorylation of the Src kinases Hck and Lyn occurs following G CSF stimulation of cells expressing WT G CSF R , but that Hck is not phosphorylated in mutant G CSF R transfectants . ^^^ |
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| Interacting proteins: Q99062 and P07948 |
Pubmed |
SVM Score :0.0 |
| Granulocyte colony stimulating factor receptor signaling involves the formation of a three component complex with Lyn and Syk protein tyrosine kinases . ^^^ Lyn and Syk were recovered in anti G CSFR immunoprecipitates ; Lyn was detected in the absence of ligand . ^^^ On the basis of immunoprecipitation and sequence analysis data , we propose that the human G CSFR forms a three component signaling complex with Lyn and Syk . ^^^ |
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| Interacting proteins: Q99062 and P07948 |
Pubmed |
SVM Score :0.0 |
| To determine the role of specific PTK in G CSF signaling we expressed the human G CSFR in cell lines derived from DT 40 B cells , which lack either the Src related Lyn or Syk . ^^^ |
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| Interacting proteins: Q99062 and P07948 |
Pubmed |
SVM Score :0.0 |
| Together , these data establish Lyn and Hck as key negative regulators of granulopoiesis and raise the possibility that loss of Src family kinase activation by the d 715 G CSFR may contribute to its hyperproliferative phenotype . . ^^^ |
|
| Interacting proteins: Q99062 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99062 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|