Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
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Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.74996741
The association of Pyk 2 with Lyn was dependent on stimulation with MCP 1 and on tyrosine phosphorylation of Pyk 2 . 0.74996741^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
In contrast to Lyn , PYK 2 , FAK , MAPK / ERK1 , SAPK / JNK , and Cdk 5 , only Fyn could phosphorylate alpha synuclein . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
RAFTK also mediated the KSHV GPCR induced activation of Lyn , a Src family kinase . ^^^ Kaposi ' s sarcoma associated herpesvirus encoded G protein coupled receptor activation of c jun amino terminal kinase / stress activated protein kinase and lyn kinase is mediated by related adhesion focal tyrosine kinase / proline rich tyrosine kinase 2 . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Short myristoylated peptides were derived from the target regions of the tyrosine kinases c Kit and Lyn and the serine / threonine kinases 3 phosphoinositide dependent kinase 1 ( PDK 1 ) and Akt / protein kinase B ( PKB ) . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
These observations provide the first example of an IL 3 regulable PTK , and strongly suggest that the p53 / 56 LYN kinase participates in early IL 3 initiated signalling events , at least in some human leukemic cell lines . . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Our results show that addition of antibodies to IgD or to IgM can stimulate the PTK activity of the blk , fyn , and lyn gene products . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
The PKC activity increases later than the Lyn activity and pretreatment with the PTK inhibitors genistein or herbimycin A abrogates the EMF induced PKC signal . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
These results suggest that lyn plays an important role in CD 40 mediated PTK activation and identify PLC gamma 2 and PI 3 kinase targets for CD 40 mediated phosphorylation , suggesting a role for these two enzymes in CD 40 signal transduction . . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
The BCR associates with two classes of tyrosine kinase : Src family kinase ( Src protein tyrosine kinase [ PTK ] ; Lyn , Fyn , Blk , or Lck ) and Syk kinase . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
CD 19 is coupled , via protein tyrosine kinases ( PTKs ) , to PLC and phosphatidylinositol 3 ' kinase ( PI 3 ' kinase ) , and it interacts with the Src type nonreceptor PTK lyn . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
The c src gene family has nine known members ( blk , c fgr , fyn , hck , lck , lyn , c src , c yes and yrk ) , each encoding a cytoplasmic protein tyrosine kinase ( PTK ) believed to be involved in signal transduction . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
The Lyn gene encodes a PTK that is believed to participate in the transduction of signals from a variety of cell membrane receptors . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Nanomolar concentrations of hypericin inhibit the protein tyrosine kinase activities ( PTK ) of the epidermal growth factor receptor and the insulin receptor , while being ineffective towards the cytosolic protein tyrosine kinases Lyn , Fgr , TPK IIB and CSK . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
We demonstrate here that LFA 1 is physically associated in the YT human NK like cell line cells with a PTK ( s ) that is distinct from Src family PTKs such as Lck , Fyn , or Lyn . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Baseline Lyn PTK activity is substantially reduced , and slg cross linking fails to activate Lyn , Syk , Pl 3 K , PLC gamma 2 , Vav , Shc , and MAPK . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Two isoforms of lck / yes related novel ( LYN ) protein tyrosine kinase ( PTK ) appear to play a role in B cell IgM and FcERI receptor signaling . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
The association of Fc gamma RII with Src PTK was specific for Fc gamma RII activation of THP 1 cells , since activation of cells via the high affinity Fc gamma receptor , Fc gamma RI ( CD 64 ) , did not result in association of Fc gamma RII with Hck or Lyn . ^^^ Our data demonstrate a functional and physical association of Fc gamma RII with Hck and Lyn consistent with the involvement of Src PTK in Fc gamma RII mediated signal transduction . . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
In these studies , AlFx and Na3VO4 stimulated rapid tyrosine phosphorylation of Ig alpha , Ig beta , and additional cellular proteins , including the protein tyrosine kinase ( PTK ) Lyn . ^^^ Alternatively , Lyn , may be a downstream effector of phosphorylated Ig alpha and Ig beta as suggested by the reported ability of biphosphorylated Ig alpha to activate Fyn PTK in vitro . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
While each PTK phosphorylated FcgammaRIIa / c , FcgammaRIIb 1 was phosphorylated by Lyn and Blk whereas FcgammaRIIb 2 became phosphorylated only by Blk . ^^^ Comparison of the phosphorylation pattern of each PTK observed in vitro with the phosphorylation pattern observed in vivo suggests that Lyn is the most likely candidate for FcgammaRIIa / c and FcgammaRIIb 1 phosphorylation in vivo . . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Activation of rat mast cells through the receptor with high affinity for IgE ( Fc epsilonRI ) requires a complex set of interactions involving transmembrane subunits of the Fc epsilonRI and two classes of nonreceptor protein tyrosine kinase ( PTK ) . the Src family PTK p53 / p56 ( lyn ) ( Lyn ) and the Syk / ZAP family PTK p 72 ( syk ) ( Syk ) . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Co precipitation studies have shown that Src related PTK , such as Lyn , associates with the p 85 regulatory subunit of PI 3 kinase via SH 2 and SH 3 domain binding with their cognate ligands . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
A fraction of the 53 56 kDa bands were identified as the protein tyrosine kinase ( PTK ) , Lyn which also bound to ITIM peptide , pointing to its role in initiating Fc gamma RIIb mediated negative regulation . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
By using co immunoprecipitation techniques and in vitro kinase assays , the uPAR associated proteins were identified as Janus ( Jak ) and Src non receptor protein tyrosine kinases ( PTK ) Jak 1 , Tyk 2 , and p 59 ( fyn ) , p53 / 56 ( lyn ) , p53 / 59 ( hck ) , and p 55 ( fgr ) . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
In this report , we show that the Src family nonreceptor protein tyrosine kinase ( PTK ) Lyn associates with aggregated IgA Fc receptor ( Fc alpha R ) in the monocytic cell line THP 1 . ^^^ However , interaction of Lyn with IgG Fc receptor ( Fc gamma R ) in THP 1 cells was unaffected by short treatment with the PTK inhibitor . ^^^ The Src family PTK involved in Fc alpha R mediated tyrosine phosphorylation appears to be Lyn , which coprecipitated with aggregated Fc alpha R complexes . . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Unlike the Fc epsilonRI mediated activation , where both the membrane associated protein tyrosine kinase ( PTK ) Lyn and the cytoplasmic PTK Syk are responsible for initiating the signaling cascade , only Lyn has been implicated in Thy 1 mediated activation in RBL cells . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Selectivity studies of peptides 23 30 toward p60c src , Lyn , and Lck PTK showed in general high Lyn / Src and moderate Lck / Src selectivity ratios . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Sepharose 4B gel chromatography fractionation followed by density gradient ultracentrifugation revealed both size and density heterogeneity of Thy 1 and Lyn PTK complexes . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
We show here that resting platelets contain highly active pp53 / 56 ( Lyn ) PTK within membrane microdomains ( rafts ) isolated biochemically with or without the use of detergent . ^^^ This fraction is also greatly enriched in the transmembrane glycoprotein CD 36 , known to associate with Lyn PTK , but in transfection studies we could find no evidence to suggest that CD 36 affects the distribution or function of Lyn . ^^^ Upon platelet activation Lyn activity remains constant or diminishes and pp 60 ( c src ) PTK within this fraction becomes highly activated , indicating the dynamic nature of the membrane microdomains . ^^^ It is suggested that the function of active Lyn PTK in the resting platelet is to allow prolonged survival of this anucleate cell . . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Association of Syk protein tyrosine kinase ( PTK ) with LMP2A occurs at the two tyrosines of the LMP2A immunoreceptor tyrosine based activation motif , and it is hypothesized that Lyn PTK associates with the YEEA amino acid motif at LMP2A tyrosine 112 ( Y 112 ) . ^^^ To examine the specific association of Lyn PTK to LMP2A , a panel of LMP2A cDNA expression vectors containing LMP2A mutations were transfected into an EBV negative B cell line and analyzed for Lyn and LMP2A coimmunoprecipitation . ^^^ Together these data indicate the importance of the LMP2A Y 112 residue in the ability of LMP2A to block BCR mediated signal transduction and place the role of this residue and its interaction with Lyn PTK as essential to LMP2A phosphorylation , PTK loading , and down modulation of PTKs involved in BCR mediated signal transduction . . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
From the lysates of BL 41 cells SHP 2 and phosphatidylinositol 3 kinase ( PI 3 K ) , as well as the protein tyrosine kinase ( PTK ) Lyn bind both to the BCR co clustered Fc gamma RIIb and to its P ITIM peptide . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
We utilized the established chicken B cell line , DT 40 cells and their derived mutants , lacking the respective PTK [ DT40 / Syk ( ) , DT40 / Lyn ( ) and DT40 / Btk ( ) ] , to examine a role of these PTK in apoptotic processes induced by anti cancer drugs . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
To determine the role of specific PTK in G CSF signaling we expressed the human G CSFR in cell lines derived from DT 40 B cells , which lack either the Src related Lyn or Syk . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Furthermore , tyrosine phosphorylation of FcepsilonRI , association of FcepsilonRI with Lyn and PTK activity associated with FcepsilonRI , all of which are enhanced upon FcepsilonRI aggregation in RBL CD45H , are impaired in RBL CD45L . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Virulent organisms induced early PTK activation and the tyrosine phosphorylation of several endogenous substrates , including Hck and Lyn , two Src related kinases . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Regulation is achieved by cross talk between Src family PTKs and CD 19 ; Lyn is essential for CD 19 phosphorylation , while CD 19 establishes an Src family PTK activation loop that amplifies kinase activity . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
HIV SUgp 120 ( HIV surface glycoprotein ) , T cell receptor ( TCR ) CD4+ and co receptors promote aggregation of these lipid `` rafts ' ' which concentrate the Src family tyrosine kinases SFKs ( PTK , Lyn , Fyn , Lck ) , GPI ( glycosyl phosphatidylinositol ) anchored proteins , and phosphatidylinositol kinases PI ( 3 ) K and PI ( 4 ) K , inducing cell signalling . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
In both B 1 and B 2 cells BCR cross linking induced a modest increase of CD 19 associated Lyn , a Src family protein tyrosine kinase ( PTK ) thought to be important for CD 19 phosphorylation . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
More recent results established that MAFA ' s inhibitory action involves at least two different enzymes : Following the tyrosyl phosphorylation of MAFA ITIM by the PTK Lyn , two phosphatases SHIP and SHP 2 are recruited to it at the plasma membrane where they propagate the inhibitory signals . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
We evaluated the dependency of neutrophil O production on PTK Lyn and MAPK ERK1 / 2 in rats after thermal injury . ^^^ Activation of PTK Lyn was assessed by immunoprecipitation . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
The HLA DR induced signaling events were accompanied by the induction of cell cell adhesion that could be inhibited by PTK and Lyn but not ERK1 / 2 inhibitors . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
We have reported previously that deoxygenation of sickle cells stimulates KCC and activates Syk ( a Syk family PTK ) , but not Lyn ( an Src family PTK ) . ^^^ Methyl 2 , 5 dihydroxycinnamate ( DHC ) , a PTK inhibitor , was more selective for Syk than Lyn , while staurosporine ( ST ) , a broad specificity protein kinase inhibitor , inhibited Lyn more than Syk . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
Lyn is the only member of the Src family expressed in DT 40 B cells , which provide a unique model to study the singular contribution of this protein tyrosine kinase ( PTK ) family to cell signaling . ^^^ Most of these expression changes have not been previously associated with Lyn PTK signaling . ^^^ Changes in GANP expression were also confirmed in Lyn deficient mice , suggesting that Lyn PTK has a unique function not compensated for by other Src kinases . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
The Dok 1 mutants having tyrosine to phenylalanine ( YF ) substitution ( s ) at Tyr 336 and / or Tyr 340 lost their inhibitory effect on Ras and Erk downstream of Src like PTK , Lyn or Fyn , whereas the rasGAP binding of each mutant remained intact . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
The tyrosine kinases Lyn and Syk are activated by the fibrillar peptides and initiate a signaling cascade resulting in a transient release of intracellular calcium that results in the activation of classical PKC and the recently described calcium sensitive tyrosine kinase PYK 2 . ^^^ We demonstrate that PYK 2 is positioned downstream of Lyn , Syk , and PKC . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
The tyrosine phosphorylation of Pyk 2 was downstream of protein kinases Lyn , Syk and protein kinase C and cytoskeletal organization . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
In 293 cells expressing recombinant BRDG 1 and various PTKs , Tec and Pyk 2 , but not Btk , Bmx , Lyn , Syk , or c Abl , induced marked phosphorylation of BRDG 1 on tyrosine residues . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
METHODS : Triton 10 insoluble ( actin cytoskeleton ) fractions from suspension phase cells and cells adherent to the beta ( 1 ) integrin ligand fibronectin were assessed for the presence of the integrin associated kinase Pyk 2 , the scaffolding protein paxillin , and the downstream Src family kinase Lyn . ^^^ Lysates were subjected to immunoprecipitation with anti phosphotyrosine and probed for Pyk 2 , paxillin , and Lyn . ^^^ Cells adherent to fibronectin for 20 minutes demonstrated marked increases in Pyk 2 , paxillin , and Lyn activation in comparison to fibronectin adherent and suspension phase cells . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
In washed platelets , coincubation with neutrophils resulted in reduced formation of large aggregates when stimulated with collagen or thrombin and repressed agonist induced activation of tyrosine protein kinases ( Syk , Lyn , Src , and Pyk 2 ) , but not thrombin induced ERK and p 38 MAP kinase . ^^^
Interacting proteins: Q14289 and P07948 Pubmed SVM Score :0.0
CCK stimulated an association of Lyn with PKC delta , Shc , p 125 ( FAK ) and PYK 2 as well as with their autophosphorylated forms , but not with Cbl , p 85 , p 130 ( CAS ) or ERK 1 / 2 . ^^^ CCK ' s activation of Lyn is likely an important mediator of its ability to cause tyrosine phosphorylation of numerous important cellular mediators such as p 125 ( FAK ) , PYK 2 , PKC delta and Shc , which play central roles in CCK ' s effects on acinar cell function . . ^^^