| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| Consistent with this observation , pp 55 selectively binds to isolated SH 2 domains of Lck , Lyn , Src , and Fyn but not to the SH 2 domains of ZAP 70 , Syk , Shc , SLP 76 , Grb 2 , phosphatidylinositol 3 kinase , and c abl in vitro . ^^^ |
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| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation studies demonstrate association of SLP 76 with SLAP 130 , Vav , Fyn , Lyn , and the FcR gamma chain in CRP stimulated platelets . ^^^ The physiological significance of this is uncertain , however , since tyrosine phosphorylation of SLP 76 in vivo is not altered in either Fyn or Lyn deficient platelets . ^^^ |
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| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| Evidence that phospholipase C gamma 2 interacts with SLP 76 , Syk , Lyn , LAT and the Fc receptor gamma chain after stimulation of the collagen receptor glycoprotein 6 in human platelets . ^^^ These were found to include PLC gamma 2 , Syk , SH 2 domain containing leucocyte protein of 76 kDa ( SLP 76 ) , Lyn , linker for activation of T cells ( LAT ) and the FcR gamma chain . ^^^ These data indicate that the C terminal SH 2 domain of PLC gamma 2 is important for PLC gamma 2 regulation through possible interactions with SLP 76 , Syk , Lyn , LAT and the FcR gamma chain . . ^^^ |
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| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| In XLA platelets , collagen treatment increased tyrosine phosphorylation of Tec and several other signaling proteins , including Lyn , Fyb , Slp 76 , and the Wiskott Aldrich syndrome protein . ^^^ |
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| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| Lyn , Syk , and SLP 76 , along with tyrosine phosphorylated 28 , 32 , and 130 kDa proteins , bound selectively to a glutathione S transferase protein encoding the SH 2 domains of SHP 1 , suggesting that this is the major site of interaction . ^^^ |
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| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| Immobilized ophioluxin was used to isolate the glycoprotein 6 Fcgamma complex from resting platelets , which also contained Fyn , Lyn , Syk , LAT , and SLP 76 . ^^^ |
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| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| Among these LAT , SLP 76 and Gab 2 are critically important as adapters that facilitate events initiated by IgE receptor dependent activation of Src family protein tyrosine kinases , Lyn and Fyn . ^^^ |
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| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| The phosphatidylinositol 3 kinase ( PI3K ) selective inhibitor wortmannin , and mouse platelets deficient in Lyn , Src , Syk , Src homology 2 ( SH 2 ) domain containing leukocyte protein 76 ( SLP 76 ) , phospholipase Cgamma 2 ( PLCgamma 2 ) , linker for activation of T cells ( LAT ) , or Fc receptor gamma chain ( FcRgamma chain ) were used for these studies . ^^^ The results also clearly demonstrate that bt / VWF mediated agglutination induced TxA 2 production is dependent on signaling apparently initiated by Lyn , enhanced by Src , and propagated through Syk , SLP 76 , PI3K , PLCgamma 2 , and protein kinase C ( PKC ) . . ^^^ |
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| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| The signaling that results in TxA 2 production was shown to be initiated by Lyn , enhanced by Src , and propagated through Syk , SLP 76 , PI3K , PLCgamma 2 , and PKC . ^^^ The results demonstrate that Btk is downstream of Lyn , Syk , SLP 76 , and PI3K ; upstream of ERK1 / 2 , PLCgamma 2 , and PKC ; and greatly enhances Akt phosphorylation . ^^^ |
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| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|