| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :1.2245998 |
| Coimmunoprecipitation assay demonstrated that Lyn , a src family tyrosine kinase , was constitutively associated with PI3K . 1.2245998^^^ |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.81849367 |
| The Src homology 3 domain of Lyn was shown to display differentiation dependent associations with other regulatory proteins , including phosphatidylinositol 3 kinase ( PI 3 K ) . 0.81849367^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| We previously showed by M 13 phage display that the Src , Fyn , Lyn , and phosphatidylinositol 3 kinase ( PI3K ) SH 3 domains preferred the same class 1 type core binding sequence , RPLPP psi P . ^^^ These libraries were screened for binding to the Src , Fyn , Lyn , Yes , and PI3K SH 3 domains . ^^^ The amino acids selected in the flanking sequences were similar for Src , Fyn , and Yes SH 3 domains ; however , Lyn and PI3K SH 3 domains showed distinct binding specificities . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| Identification of Src , Fyn , Lyn , PI3K and Abl SH 3 domain ligands using phage display libraries . ^^^ We have employed a novel modification of phage display involving biased libraries to identify peptide ligands of the Src , Fyn , Lyn , PI3K and Abl SH 3 domains . ^^^ The Src SH 3 domain prefers the sequence XXXRPLPPLPXP , Fyn prefers XXXRPLPP ( I / L ) PXX , Lyn prefers RXXRPLPPLPXP , PI3K prefers RXXRPLPPLPP while the Abl SH 3 domain selects phage containing the sequence PPPYPPPP ( I / V ) PXX . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| This process has been proposed to be mediated by an interaction between the Src family kinase LYN and the p 85 subunit of PI3K and / or through p 85 membrane recruitment mediated by CBL and / or CD 19 . ^^^ However , calcium signaling and other PI3K dependent signals are relatively preserved in a LYN kinase deficient B lymphocyte cell line , suggesting that an alternative pathway for PI3K activation exists . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| PI3K p 85 was also shown to colocalize and , by co immunoprecipitation , to be physically associated with phosphorylated Lyn kinase in lipid bodies induced to form in human polymorphonuclear leukocytes . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that factor VIIa ( the natural ligand for TF ) induces the activation of the Src family members c Src , Lyn , and Yes , and subsequently phosphatidylinositol 3 kinase ( PI3K ) , followed by stimulation of c Akt / protein kinase B as well as the small GTPases Rac and Cdc 42 . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| These events promoted Lyn activation and Igbeta phosphorylation and led to the generation of a raft associated signaling module composed of tyrosine phosphorylated Lyn , Syk , BLNK , PI3K , Btk , VAV , and PLCgamma 2 . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| We show that in DT 40 chicken B cell lines , antibody stimulation leads to PI3K dependent tyrosine phosphorylation of DAPP 1 that is lost in Lyn or Syk deficient cell lines but not Btk deficient cell lines . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of BCAP , mediated by Lyn , provides binding site ( s ) for phosphoinositide 3 kinase ( PI3K ) , thereby participating in Akt activation . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| Under our conditions , hydrogen peroxide induced PI3K and Akt activation was independent of Lyn , Syk , Cbl , BCAP , or Ras when each was eliminated individually either by mutation or by a specific inhibitor . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| The phosphatidylinositol 3 kinase ( PI3K ) selective inhibitor wortmannin , and mouse platelets deficient in Lyn , Src , Syk , Src homology 2 ( SH 2 ) domain containing leukocyte protein 76 ( SLP 76 ) , phospholipase Cgamma 2 ( PLCgamma 2 ) , linker for activation of T cells ( LAT ) , or Fc receptor gamma chain ( FcRgamma chain ) were used for these studies . ^^^ The results also clearly demonstrate that bt / VWF mediated agglutination induced TxA 2 production is dependent on signaling apparently initiated by Lyn , enhanced by Src , and propagated through Syk , SLP 76 , PI3K , PLCgamma 2 , and protein kinase C ( PKC ) . . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| Upon BCR cross linking , LIME was tyrosine phosphorylated by Lyn and associated with Lyn , Grb 2 , PLC gamma 2 , and PI3K . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| The signaling that results in TxA 2 production was shown to be initiated by Lyn , enhanced by Src , and propagated through Syk , SLP 76 , PI3K , PLCgamma 2 , and PKC . ^^^ The results demonstrate that Btk is downstream of Lyn , Syk , SLP 76 , and PI3K ; upstream of ERK1 / 2 , PLCgamma 2 , and PKC ; and greatly enhances Akt phosphorylation . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| Finally , this association triggers SH 3 mediated binding of Lyn and Fyn to PI 3 K , resulting in PI 3 K activation . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| Comparative analysis of binding activities of Blk , Lyn , and Fyn shows that these kinases differ in their abilities to associate with MAPK and PI 3 K , suggesting that they may preferentially bind and subsequently phosphorylate distinct sets of downstream effector molecules in vivo . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| By contrast , CD 19 was markedly tyrosine phosphorylated and was associated with lyn and PI 3 K . ^^^ |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| From the lysates of BL 41 cells SHP 2 and phosphatidylinositol 3 kinase ( PI 3 K ) , as well as the protein tyrosine kinase ( PTK ) Lyn bind both to the BCR co clustered Fc gamma RIIb and to its P ITIM peptide . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation experiments show that NEP associates with tyrosine phosphorylated Lyn kinase , which then binds the p 85 subunit of phosphatidylinositol 3 kinase ( PI 3 K ) resulting in an NEP Lyn PI 3 K protein complex . ^^^ |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| However , the PI 3 K inhibitor Ly 294002 resensitizes Lyn Delta N cells to apoptosis . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| AMPA also activated the src family tyrosine kinase , Lyn , and the downstream target of the phosphatidylinositol 3 kinase ( PI 3 K ) pathway , Akt . ^^^ |
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| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| We have shown that the effects of NEP are mediated by its ability to catalytically inactivate substrates such as bombesin and endothelin 1 , but also through direct protein protein interaction with other protein such as Lyn kinase [ which associates with the p 85 subunit of phosphatidylinositol 3 kinase ( PI 3 K ) resulting in NEP Lyn PI 3 K protein complex ] , ezrin / radixin / moesin ( ERM ) proteins , and the PTEN tumor suppressor protein . ^^^ |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48736 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|