| Interacting proteins: P46109 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P07948 |
Pubmed |
SVM Score :0.0 |
| In addition , Tec and Lyn were shown to phosphorylate Dok 1 , whereas phosphorylated Dok 1 was demonstrated to bind to the SH 2 domains of several signaling molecules activated by SCF , including Abl , CrkL , SHIP , and PLCgamma 1 , but not those of Vav and Shc . ^^^ |
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| Interacting proteins: P46109 and P07948 |
Pubmed |
SVM Score :0.0 |
| CrkL is recruited through its SH 2 domain to the erythropoietin receptor and plays a role in Lyn mediated receptor signaling . ^^^ Overexpression of Lyn induced constitutive phosphorylation of CrkL and activation of Erk , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of Erk . ^^^ Furthermore , Lyn , but not Jak 2 , phosphorylated CrkL on tyrosine in in vitro kinase assays . ^^^ Together , the present study suggests that , upon Epo stimulation , CrkL is recruited to the EpoR through interaction between the CrkL SH 2 domain and phosphorylated Tyr ( 460 ) in the EpoR cytoplasmic domain and undergoes tyrosine phosphorylation by receptor associated Lyn to activate the downstream signaling pathway leading to the activation of Erk and Elk 1 . . ^^^ |
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| Interacting proteins: P46109 and P07948 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that HGF induces strong tyrosine phosphorylation of the proto oncogene product c Cbl in B cells and increases Cbl association with the Src family tyrosine kinases Fyn and Lyn , as well as with phosphatidylinositol 3 kinase and CrkL . ^^^ |
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| Interacting proteins: P46109 and P07948 |
Pubmed |
SVM Score :0.0 |
| In imatinib mesylate resistant K 562 cells displaying increased Bcr / Abl expression , bortezomib / flavopiridol treatment markedly increased apoptosis in association with down regulation of Bcr / Abl and BclxL , and diminished phosphorylation of Lyn , Hck , CrkL , and Akt . ^^^ |
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