| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :1.3139447 |
| Tec was also shown to make a stable complex with Lyn in vivo . 1.3139447^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :1.2386437 |
| The study shows that Tec and Dok 1 form a stable complex with Lyn and 2 unidentified phosphoproteins of 56 and 140 kd . 1.2386437^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| Here we describe for the first time the constitutive expression of 15 tyrosine kinases , tyro 1 , tyro 4 , tyro 6 , hyk , Ptk 3 , Ryk , tie , yes , lyn , tec , Jak 1 , Jak 2 , Jak 3 , c abl , and flk , in renal glomeruli . ^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis of unique clones resulted in the identification of the catalytic domains of several characterized tyrosine kinases , including lyn , hck , c fgr , tec , JAK 2 , itk , and the putative receptor kinase ryk , and expression of these kinases has not previously been described in the intestine . ^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| Tec protein tyrosine kinase is an effector molecule of Lyn protein tyrosine kinase . ^^^ We could previously show that , through the Tec homology domain , Tec is bound to Lyn kinase both in vitro and in vivo . ^^^ Because Tec is coexpressed with Lyn in many hematopoietic cell types , it has been intriguing to investigate the biological role of the Tec Lyn association . ^^^ Here we demonstrate that Lyn can phosphorylate tyrosine residues of the Tec protein , and thereby activate Tec in 3T3 fibroblasts . ^^^ However , coexpression of Tec has little effect on the phospho tyrosine contents of Lyn . ^^^ |
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| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| PLC gamma 2 activation in EMF stimulated cells is mediated by stimulation of the Bruton ' s tyrosine kinase ( BTK ) , a member of the Src related TEC family of protein tyrosine kinases , which acts downstream of LYN kinase and upstream of PLC gamma 2 . ^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the lead dimethoxyquinazoline compound , WHI P 131 , which showed potent JAK 3 inhibitory activity ( IC 50 of 78 microM ) , did not inhibit JAK 1 and JAK 2 , the ZAP / SYK family tyrosine kinase SYK , the TEC family tyrosine kinase BTK , the SRC family tyrosine kinase LYN , or the receptor family tyrosine kinase insulin receptor kinase , even at concentrations as high as 350 microM . ^^^ |
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| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| In 293 cells expressing recombinant BRDG 1 and various PTKs , Tec and Pyk 2 , but not Btk , Bmx , Lyn , Syk , or c Abl , induced marked phosphorylation of BRDG 1 on tyrosine residues . ^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| In XLA platelets , collagen treatment increased tyrosine phosphorylation of Tec and several other signaling proteins , including Lyn , Fyb , Slp 76 , and the Wiskott Aldrich syndrome protein . ^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| Several protein tyrosine kinases are activated rapidly following engagement of the BCR / preBCR complexes , including members of the Src family ( Lyn and Blk ) , the Syk / ZAP70 family ( Syk ) , and the Tec family ( Btk ) . ^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| Both Lyn and Tec were capable of phosphorylating Dok 1 . ^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| Proteomics approaches permitted the identification of tyrosine kinases from three families : Src ( Lyn ) , Csk , and Tec ( Bmx , Btk ) . ^^^ |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|