| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| VEGF stimulation specifically activated c Src kinase activity but not that of other related Src kinases such as Lyn , Fyn , or Hck in KS cells . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Nanomolar concentrations of hypericin inhibit the protein tyrosine kinase activities ( PTK ) of the epidermal growth factor receptor and the insulin receptor , while being ineffective towards the cytosolic protein tyrosine kinases Lyn , Fgr , TPK IIB and CSK . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| We also show that the HS 1 peptide can be used for the specific monitoring of p72syk since neither the two Src related c Fgr and Lyn kinases ( needing a hydrophobic instead of acidic residue at position 1 ) nor CSK appreciably phosphorylate it . . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| In these Csk negative cells , Lyn became constitutively active and highly phosphorylated at the autophosphorylation site , indicating that Csk is necessary to sustain Lyn in an inactive state . ^^^ Since the C terminal tyrosine phosphorylation of Lyn is barely detectable in the unstimulated , wild type B cells , our data suggest that the activities of Csk and a certain protein tyrosine phosphatase ( s ) are balanced to maintain Lyn at a hypophosphorylated and inactive state . ^^^ The degree of activation of both the Lyn and Syk kinases in Csk negative cells was comparable to that observed in wild type cells after BCR stimulation . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| With all protein kinases tested , namely PKA , CK 1 , CK 2 , MAP kinase ( ERK 1 ) , c Fgr , Lyn , CSK and TPK IIB / p38Syk , staurosporine inhibition was competitive with respect to ATP , regardless of its inhibitory power . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| The photodynamic inhibitory effect of hypericin and a number of hypericin derivatives were investigated in vitro using numerous growth factor regulated protein kinases including receptor bound ( Insulin R , EGF R ) and non receptor ( Lyn , c Fgr , CSK , Syk ) protein tyrosine kinases as well as Ser / Thr ( PK C , protein kinase CK 2 , CK 1 ) protein kinases . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Lyn and c Fgr phosphorylated by C terminal Src kinase ( CSK ) at their down regulatory site are resistant to the action of both PTPases while the [ Phe 6 ] Src ( 514 533 ) phosphopeptide , representing the highly similar site affected by CSK in c Src , is readily dephosphorylated by both PTPases , although to a different extent . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| The Src peptide and its derivatives were tested as inhibitors of three non receptor tyrosine kinases ( Lyn , belonging to the Src family , CSK and PTK IIB ) and a non receptor protein tyrosine phosphatase obtained from human T cell ( TC PTP ) . ^^^ The biomimetic analogues , which do not significantly affect the activity of CSK , PTK IIB and TC PTP , act as efficient inhibitors on Lyn , influencing both the exogenous phosphorylation and , especially , its autophosphorylation . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| RPDE 6 exhibited selectivity in binding to the SH 3 domains of c Abl , Crk , Csk , Lck , Lyn , Fyn and 5 Src , with binding to the SH 3 regions of the Src related tyrosyl kinases Lyn and Fyn being the most effective . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| An association between active Cdc 2 and the Src related kinases Lyn and Fyn was also demonstrated , although Cdc 2 was not found associated with the tyrosine kinases , Csk and Syk . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Translocation of the Csk homologous kinase ( Chk / Hyl ) controls activity of CD 36 anchored Lyn tyrosine kinase in thrombin stimulated platelets . ^^^ Chk and Lyn , but not Csk and c Src , co fractionated in the higher density lysate fractions of resting platelets , with Chk being found to localize close to CD 36 ( membrane glycoprotein 4 ) anchored Lyn . ^^^ These results suggest that Chk , but not Csk , may function as a translocation controlled negative regulator of CD 36 anchored Lyn in thrombin induced platelet activation . . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Sequence specificity of C terminal Src kinase ( CSK ) a comparison with Src related kinases c Fgr and Lyn . ^^^ An eicosapeptide encompassing the C terminal tail of c Src ( Tyr 527 ) which is conserved in most Src related protein kinases , is phosphorylated by C terminal Src kinase ( CSK ) and by the two Src related protein kinases c Fgr and Lyn , with similar kinetic constants . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Specific activity of Lyn at the basal state was decreased in Csk expressing cells , and further decreased in mCsk expressing cells . ^^^ The onset of FcepsilonRI mediated Lyn activation was delayed in Csk expressing cells , and further delayed in mCsk expressing cells . ^^^ These findings indicate ( 1 ) Csk negatively regulates rapid FcepsilonRI / Lyn coupling , and ( 2 ) Csk activity is potentially required for its termination . ^^^ The durations of Syk phosphorylation and MAP kinase activation also closely correlated with those of Lyn activation , but [ Ca2+ ] 1 elevation and histamine release followed different temporal patterns : the delayed responses in Csk expressing cells and in mCsk expressing cells led to sustained [ Ca2+ ] 1 oscillation and histamine release , while the prompt responses in parent cells and mCsk ( ) expressing cells rapidly subsided . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| The Csk homologous kinase ( Chk ) , which is co expressed with C terminal Src kinase ( Csk ) in hematopoietic cells , negatively regulates Src family kinases in vitro with selectivity toward Lyn but not c Src in platelets . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Our results reveal that the non receptor tyrosine kinases , Abl , Fyn , Lyn , Btk and Csk , are expressed in all three cell types . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Because the Src family kinase Lyn plays a pivotal role in FcepsilonRI mediated cellular activation , we examined whether Csk is involved in FcepsilonRI signaling events . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| GEM in Neuro2a cells , separated as a low density membrane fraction , contains essentially all glycosphingolipids and sphingomyelin , together with five signal transducer molecules ( c Src , Lyn , Csk , Rho A , Ha Ras ) . ( 3 ) H Labeled Il ( 3 ) NeuAc LacCer ( GM 3 ) , Gb4Cer ( globoside ) , and Il ( 3 ) NeuAc Gg4Cer ( GM 1 ) added exogenously to cells were incorporated and concentrated in the low density GEM fraction . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| We find that c Src , Lyn and Csk are enriched in the sphingolipid enriched fraction prepared from these cells . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Taken together with our previous data on tyrosine kinases Lyn and Syk , the Gq coupled pathway requires tyrosine kinases Csk , Lyn , and Syk , while the Gi coupled pathway requires tyrosine kinases Btk and Syk to feed into the MAPK cascade in these cells . ^^^ The central role of Syk is further strengthened by data showing that Syk can bind to purified Lyn , Csk , or Btk . . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| In Y567F , Lyn activation on SCF stimulation decreased and C terminal Src kinase ( Csk ) suppressed KIT mediated Ca ( 2+ ) influx and cell migration , suggesting that Y 567 mediated Src family kinase ( SFK ) activation leads to Ca ( 2+ ) influx and migration . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| This became apparent from the hyperresponsive degranulation of lyn / bone marrow derived mast cells , which is driven by hyperactivation of Fyn kinase that occurs , in part , through the loss of negative regulation by COOH terminal Src kinase ( Csk ) and the adaptor , Csk binding protein . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| The two SFKs respond to integrin ligation by different mechanisms : Lyn , by increased autophosphorylation of a catalytic tyrosine ; and Fyn , by reduced Csk phosphorylation of the inhibitory COOH terminal tyrosine . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Synthetic peptides containing tyrosine analogues displaying different side chain orientations were analyzed by NMR techniques and tested as potential substrates of the nonreceptor tyrosine kinases Syk , Csk , Lyn , and Fyn . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| Proteomics approaches permitted the identification of tyrosine kinases from three families : Src ( Lyn ) , Csk , and Tec ( Bmx , Btk ) . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| In rat basophilic leukemia ( RBL ) 2H3 cells , the levels of tyrosine phosphorylation of Cbp / PAG and its association with Csk , a negative regulator for Lyn , significantly elevate immediately after aggregation of FcepsilonRI . ^^^ These findings combined with the fact that Cbp / PAG , Lyn , and aggregated FcepsilonRI are localized to lipid rafts , suggest that upon FcepsilonRI aggregation Cbp / PAG down regulates the receptor associated Lyn activity through relocating Csk to rafts , thereby efficiently mediating feedback inhibition of FcepsilonRI signaling . . ^^^ |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|