| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| Among the targets of mIg induced tyrosine phosphorylation are the tyrosine kinases encoded by the lyn , blk , fyn , and syk genes , the mIg associated proteins MB 1 and Ig beta , phospholipase C gamma 1 and gamma 2 , as well as many unidentified proteins . ^^^ |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| The Ig alpha chain cytoplasmic domain bound to the Src family kinases Lyn and Fyn , phosphatidylinositol 3 kinase ( PI 3 kinase ) , and an unidentified 38 kilodalton phosphoprotein ; the cytoplasmic tail of Ig beta bound PI 3 kinase and unidentified 40 and 42 kilodalton phosphoproteins . ^^^ |
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| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| Our results show that the enzyme activities of Lyn and Blk were stimulated within seconds of antigen receptor engagement and correlated with the initial tyrosine phosphorylation of the Ig alpha and Ig beta subunits of the B cell antigen receptor . ^^^ |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| Of the tyrosine kinases transfected ( Lyn , Blk , Hck , Syk , Fyn ) , only Blk was able to phosphorylate and subsequently associate with cotransfected Ig alpha and Ig beta chimeras in vivo . ^^^ |
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| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| In these studies , AlFx and Na3VO4 stimulated rapid tyrosine phosphorylation of Ig alpha , Ig beta , and additional cellular proteins , including the protein tyrosine kinase ( PTK ) Lyn . ^^^ Interestingly , the extent and kinetics of the mIg associated Lyn and Ig alpha / Ig beta phosphorylation was correlated , suggesting that Lyn may mediate receptor phosphorylation . ^^^ Alternatively , Lyn , may be a downstream effector of phosphorylated Ig alpha and Ig beta as suggested by the reported ability of biphosphorylated Ig alpha to activate Fyn PTK in vitro . ^^^ The data are consistent with modulation of phosphorylation of Ig alpha and Ig beta through both PTP inhibition and AlFx treatment , and a common intermediary in or effector of these phosphorylation pathways appears to be the Lyn kinase . . ^^^ |
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| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| The PTKs Blk and Lyn implicated in B cell signalling were found to prefer peptide substrates of the structure I / L Y D / E 10 L which resemble critical features of the ITAM motifs found in , e . g . the intracellular components Ig alpha and Ig beta of the beta cell receptor . ^^^ |
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| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| In these pro B cell lines Ig alpha and Ig beta were found to associate with the lyn tyrosine kinase , suggesting that they may play some functional role at this B cell differentiation stage . ^^^ |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| The cross linking of the B cell Ag receptor ( BCR ) leads to the initiation of a signal transduction cascade in which the earliest events involve the phosphorylation of the immunoreceptor tyrosine based activation motifs of Ig alpha and Ig beta by the Src family kinase Lyn and association of the BCR with the actin cytoskeleton . ^^^ |
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| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| Coligation of the cytoplasmic region of PD 1 with the B cell receptor ( BCR ) in IIA1 . 6 transformants inhibited BCR mediated growth retardation , Ca ( 2+ ) mobilization , and tyrosine phosphorylation of effector molecules , including Ig beta , Syk , phospholipase C gamma 2 ( PLC gamma 2 ) , and ERK1 / 2 , whereas phosphorylation of Lyn and Dok was not affected . ^^^ |
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| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| These transcripts included the B cell receptor components CD76a and b ( Ig alpha and Ig beta ) and accessory c Src family kinases Lyn and Blk . ^^^ |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| Their unanticipated association with the Lyn protein tyrosine kinase nevertheless suggests functional potential for the Igalpha / Igbeta molecules in pro B cells . ^^^ |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| These events promoted Lyn activation and Igbeta phosphorylation and led to the generation of a raft associated signaling module composed of tyrosine phosphorylated Lyn , Syk , BLNK , PI3K , Btk , VAV , and PLCgamma 2 . ^^^ |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| B cell Ag receptor ( BCR ) signaling occurs via tyrosine phosphorylation of CD79a and CD79b ITAMs , leading to recruitment and activation of Lyn and Syk tyrosine kinases and subsequent downstream events . ^^^ |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|