Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P21802 and P07948	Pubmed	SVM Score :0.0
Cbl mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor 2 activation supports osteoblast differentiation . ^^^ Here , we identified a role for the Src family members Lyn and Fyn in osteoblast differentiation promoted by constitutive activation of FGF receptor 2 ( FGFR 2 ) . ^^^ We show that the overactive FGFR 2 S252W mutation induced decreased Src family kinase tyrosine phosphorylation and activity associated with decreased Lyn and Fyn protein expression in human osteoblasts . ^^^ Pharmacological stimulation of Src family kinases or transfection with Lyn or Fyn vectors repressed alkaline phosphatase ( ALP ) up regulation induced by overactive FGFR 2 . ^^^ Inhibition of proteasome activity restored normal Lyn and Fyn expression and ALP activity in FGFR 2 mutant osteoblasts . ^^^
Interacting proteins: P21802 and P07948	Pubmed	SVM Score :0.0
We identified 30 tyrosine kinases expressed in these tissues : they include 10 non receptor tyrosine kinases ( yes , fyn , lyn , brk , abl , arg , jak 1 , jak 3 , tyk 2 and itk ) , 17 receptor tyrosine kinases ( erbB 2 , PDGF Ralpha , PDGF Rbeta , kit , c fms , met , ron , FGF R 1 , FGF R 2 , FGF R 3 , FGF R 4 , cek 5 , tie 1 , tkt , axl , sky and Ins R ) , 2 dual kinases ( mek and sek ) and one possible novel kinase . ^^^