| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :1.2375568 |
| We also demonstrated that Epo phosphorylated Lyn is associated with tyrosine phosphorylated PLC gamma 2 and PI 3 kinase in WT Epo R FDC P 1 stimulated cells . 1.2375568^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Signal transduction via CD 40 involves activation of lyn kinase and phosphatidylinositol 3 kinase , and phosphorylation of phospholipase C gamma 2 . ^^^ These results suggest that lyn plays an important role in CD 40 mediated PTK activation and identify PLC gamma 2 and PI 3 kinase targets for CD 40 mediated phosphorylation , suggesting a role for these two enzymes in CD 40 signal transduction . . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| In contrast , crosslinking of sIg on cells infected with EBV recombinants with null mutations in LMP2A results in transient tyrosine phosphorylation of lyn , syk , phospholipase C gamma 2 and phosphatidylinositol 3 ' kinase , transiently increased intracellular free calcium , and reactivation of lytic EBV infection . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Taken together , these results indicate that EMF induced PLC gamma 2 activation is mediated by LYN regulated stimulation of SYK , which acts downstream of LYN kinase and upstream of PLC gamma2 . . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| PLC gamma 2 activation in EMF stimulated cells is mediated by stimulation of the Bruton ' s tyrosine kinase ( BTK ) , a member of the Src related TEC family of protein tyrosine kinases , which acts downstream of LYN kinase and upstream of PLC gamma 2 . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Evidence that phospholipase C gamma 2 interacts with SLP 76 , Syk , Lyn , LAT and the Fc receptor gamma chain after stimulation of the collagen receptor glycoprotein 6 in human platelets . ^^^ These were found to include PLC gamma 2 , Syk , SH 2 domain containing leucocyte protein of 76 kDa ( SLP 76 ) , Lyn , linker for activation of T cells ( LAT ) and the FcR gamma chain . ^^^ FcR gamma chain and Lyn were found to co immunoprecipitate with PLC gamma 2 as well as with unidentified 110 kDa and 75 kDa phosphoproteins . ^^^ These data indicate that the C terminal SH 2 domain of PLC gamma 2 is important for PLC gamma 2 regulation through possible interactions with SLP 76 , Syk , Lyn , LAT and the FcR gamma chain . . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Coligation of the cytoplasmic region of PD 1 with the B cell receptor ( BCR ) in IIA1 . 6 transformants inhibited BCR mediated growth retardation , Ca ( 2+ ) mobilization , and tyrosine phosphorylation of effector molecules , including Ig beta , Syk , phospholipase C gamma 2 ( PLC gamma 2 ) , and ERK1 / 2 , whereas phosphorylation of Lyn and Dok was not affected . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Significantly , 2 APB induced InsP ( 3 ) R and TRPC 3 activation was prevented in DT 40 knockout cells devoid of the BCR and PLC gamma 2 coupled adaptor / kinases , Syk , Lyn , Btk or BLNK . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Baseline Lyn PTK activity is substantially reduced , and slg cross linking fails to activate Lyn , Syk , Pl 3 K , PLC gamma 2 , Vav , Shc , and MAPK . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Analysis of mutants of the chicken B cell line DT 40 deficient in either Syk , Lyn , Btk , or PLC gamma 2 revealed that BCR induced activation of PKC mu , like activation of PLC gamma 2 , requires Syk and is partially regulated by Btk , but is Lyn independent . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| This study provides the first genetic evidence that Fyn and Lyn mediate FcR immune receptor tyrosine based activation motif phosphorylation and PLC gamma 2 activation after the ligation of GPVI . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Thus , in NCI H 292 epithelial cells , IFN gamma activates PLC gamma 2 via an upstream tyrosine kinase to induce activation of PKC alpha and c Src or Lyn , resulting in activation of STAT1alpha , and GAS in the ICAM 1 promoter , followed by initiation of ICAM 1 expression and monocyte adhesion . . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| In contrast , the tumor cells in all cases of lymphocyte predominance Hodgkin disease were positive for Fyn , Syk , BLNK , and PLC gamma 2 , and Lyn immunostaining was seen in a minority of biopsies . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Fc epsilon RI induced signaling in the presence of constitutively active Lyn exhibited enhanced phosphorylation of the receptor subunits , Syk , LAT , Gab 2 , phospholipase C ( PLC ) gamma 1 and PLC gamma 2 , and production of phosphatidylinositol 3 , 4 , 5 trisphosphate . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| Upon BCR cross linking , LIME was tyrosine phosphorylated by Lyn and associated with Lyn , Grb 2 , PLC gamma 2 , and PI3K . ^^^ |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|