| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.62460736 |
| Recent findings indicate that Ig alpha associates with Src family kinases , including Fyn and Lyn , via an approximately 26 amino acid motif termed ARH 1 . 0.62460736^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| The Ig alpha chain cytoplasmic domain bound to the Src family kinases Lyn and Fyn , phosphatidylinositol 3 kinase ( PI 3 kinase ) , and an unidentified 38 kilodalton phosphoprotein ; the cytoplasmic tail of Ig beta bound PI 3 kinase and unidentified 40 and 42 kilodalton phosphoproteins . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| Our results show that the enzyme activities of Lyn and Blk were stimulated within seconds of antigen receptor engagement and correlated with the initial tyrosine phosphorylation of the Ig alpha and Ig beta subunits of the B cell antigen receptor . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| Of the tyrosine kinases transfected ( Lyn , Blk , Hck , Syk , Fyn ) , only Blk was able to phosphorylate and subsequently associate with cotransfected Ig alpha and Ig beta chimeras in vivo . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| In these studies , AlFx and Na3VO4 stimulated rapid tyrosine phosphorylation of Ig alpha , Ig beta , and additional cellular proteins , including the protein tyrosine kinase ( PTK ) Lyn . ^^^ Interestingly , the extent and kinetics of the mIg associated Lyn and Ig alpha / Ig beta phosphorylation was correlated , suggesting that Lyn may mediate receptor phosphorylation . ^^^ Alternatively , Lyn , may be a downstream effector of phosphorylated Ig alpha and Ig beta as suggested by the reported ability of biphosphorylated Ig alpha to activate Fyn PTK in vitro . ^^^ The data are consistent with modulation of phosphorylation of Ig alpha and Ig beta through both PTP inhibition and AlFx treatment , and a common intermediary in or effector of these phosphorylation pathways appears to be the Lyn kinase . . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| The PTKs Blk and Lyn implicated in B cell signalling were found to prefer peptide substrates of the structure I / L Y D / E 10 L which resemble critical features of the ITAM motifs found in , e . g . the intracellular components Ig alpha and Ig beta of the beta cell receptor . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| Cross linking of the IgM receptor induces rapid translocation of IgM associated Ig alpha , Lyn , and Syk tyrosine kinases to the membrane skeleton . ^^^ Furthermore , two BCR associated kinases that are known to play critical roles in anti IgM induced B cell signaling , the src family kinase Lyn and the non src family kinase Syk , accumulate in the membrane skeleton shortly after BCR cross linking , when most of IgM and Ig alpha accumulate in this fraction . ^^^ The kinetics of recruitment of the bulk of Ig alpha , Lyn , and Syk into the membrane skeleton appeared to precede the accumulation of their hypertyrosine phosphorylated forms , suggesting that activation of the BCR associated signaling molecules occurs in this fraction . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| In these pro B cell lines Ig alpha and Ig beta were found to associate with the lyn tyrosine kinase , suggesting that they may play some functional role at this B cell differentiation stage . ^^^ |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| The biochemical characteristics of the proteins ( isoelectric point and relative molecular mass ) obtained and the subsequent use of antibodies that are specific for different cellular proteins confirmed the participation of HS 1 , Vav , Ig alpha , Lyn and Btk in antigen receptor mediated signal transduction . ^^^ |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a ( Ig alpha ) ITAM by Lyn , a Src family protein tyrosine kinase . ^^^ |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| The cross linking of the B cell Ag receptor ( BCR ) leads to the initiation of a signal transduction cascade in which the earliest events involve the phosphorylation of the immunoreceptor tyrosine based activation motifs of Ig alpha and Ig beta by the Src family kinase Lyn and association of the BCR with the actin cytoskeleton . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| Flow cytometry , combined Western blot immunoprecipitation kinase assays , and confocal microscopy revealed that both the nonpairing and pairing mu HC assembled with the Ig alpha beta dimer ; however , in contrast to a pairing mu HC , the nonpairing mu HC was retained in the ER cis Golgi compartment , and neither colocalized with the src kinase lyn nor induced tyrosine phosphorylation of Ig alpha after pervanadate treatment of cells . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| Furthermore , crosslinking of the chimeras resulted in tyrosine phosphorylation of the Ig alpha and Tg beta tails and their association with the tyrosine kinases PTK 72 , p53 / 56 ( lyn ) and p 59 ( fyn ) . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| These transcripts included the B cell receptor components CD76a and b ( Ig alpha and Ig beta ) and accessory c Src family kinases Lyn and Blk . ^^^ |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| Despite the impaired BCR mediated signaling , concentrations of IgM and IgA in sera were remarkably elevated , and production of autoantibodies was detected in lyn / mice . ^^^ |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| In this report , we show that the Src family nonreceptor protein tyrosine kinase ( PTK ) Lyn associates with aggregated IgA Fc receptor ( Fc alpha R ) in the monocytic cell line THP 1 . ^^^ |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| B cell Ag receptor ( BCR ) signaling occurs via tyrosine phosphorylation of CD79a and CD79b ITAMs , leading to recruitment and activation of Lyn and Syk tyrosine kinases and subsequent downstream events . ^^^ Moreover , CD79a ITAM phosphopeptides failed to bind Lyn from the CD 45 cells . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| BCR induced tyrosine phosphorylation of CD79a , Lyn , B cell linker protein , and phospholipase Cgamma 2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag . ^^^ |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| Among the targets of mIg induced tyrosine phosphorylation are the tyrosine kinases encoded by the lyn , blk , fyn , and syk genes , the mIg associated proteins MB 1 and Ig beta , phospholipase C gamma 1 and gamma 2 , as well as many unidentified proteins . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| In this study , we confirm previous findings demonstrating that the B cell Ag receptor coprecipitates with the MB 1 / B29 heterodimer as well as the protein tyrosine kinases blk , lyn , and fyn under mild detergent conditions ( 1 % digitonin ) . ^^^ MB 1 and B 29 were however , found to coprecipitate with blk , lyn , and fyn isolated from B cell lysates containing 1 % NP 40 . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| These results suggested that src type tyrosine kinases as Fyn and Lyn are responsible for the phosphorylation of MB 1 and B 29 heterodimer , but anti MB 1 stimulation can induce tyrosine phosphorylation reaction mediated by other kinase molecule ( s ) in the progenitor type cells . . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| We found that cross linking B cell antigen receptors at 0 degree C resulted in the rapid association of the Src family protein tyrosine kinase , Lyn , with the antigen receptor complex as judged by the presence of Lyn in anti IgM and anti phosphotyrosine immune complexes and the presence of MB 1 in anti Lyn immune complexes . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| Down regulation of membrane immunoglobulin associated proteins , MB 1 , B 29 and Lyn , in AIDS lymphomas and related conditions . ^^^ Lyn is a src family gene product expressed in B cells submembranously , in association with mIg , possibly through Mb 1 / B29 heterodimer . ^^^ These mIg associated proteins ( Mb 1 , B 29 and Lyn ) are known to mediate antigenic stimulation through mIgs . ^^^ Five acquired immunodeficiency syndrome ( AIDS ) MLs and ten SCID EBV positive BMLs were first analysed by immunohistochemistry for the expression of Mb 1 , B 29 and Lyn . ^^^ In SCID EBV positive BMLs , Mb 1 was down regulated in six of ten , B 29 in nine of ten and Lyn in six of ten , whereas no down regulation was noted in eight EBV free B MLs that were also maintained in SCID mice . ^^^ |
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| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| Only NERF 2 and ELF 1 , and not NERF 1a and NERF 1b , function as transcriptional activators of the lyn and blk gene promoters , although all isoforms of NERF bind with affinities similar to those of ELF 1 to a variety of Ets binding sites in , among others , the blk , lck , lyn , mb 1 , and immunoglobulin H genes and are expressed at similar levels . ^^^ |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11912 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|