| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| Lyn promoted phosphorylation of c Kit and association of c Kit and Dok 1 . ^^^ |
|
| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| Lyn associates with the juxtamembrane region of c Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells . ^^^ Lyn coimmunoprecipitated with c Kit , and studies with GST fusion proteins demonstrated that Lyn readily associated with the juxtamembrane region of c Kit . ^^^ |
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| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| Studies using immobilized c Kit phosphopeptides show that Lyn is able to specifically associate with the tyrosine phosphorylated juxtamembrane 568Y * VY * IDPT sequence of c Kit which has previously been shown to associate with CHK . ^^^ |
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| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| Recently we found that the Src family member Lyn is highly expressed in SCF responsive cells , associates with c Kit and is activated within minutes of the addition of SCF . ^^^ |
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| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| SCF induced internalization of c Kit was also diminished in the D 33 3 lymphoid cell line in which expression of Lyn kinase was disrupted by homologous recombination . ^^^ |
|
| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| Short myristoylated peptides were derived from the target regions of the tyrosine kinases c Kit and Lyn and the serine / threonine kinases 3 phosphoinositide dependent kinase 1 ( PDK 1 ) and Akt / protein kinase B ( PKB ) . ^^^ |
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| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| We identified 30 tyrosine kinases expressed in these tissues : they include 10 non receptor tyrosine kinases ( yes , fyn , lyn , brk , abl , arg , jak 1 , jak 3 , tyk 2 and itk ) , 17 receptor tyrosine kinases ( erbB 2 , PDGF Ralpha , PDGF Rbeta , kit , c fms , met , ron , FGF R 1 , FGF R 2 , FGF R 3 , FGF R 4 , cek 5 , tie 1 , tkt , axl , sky and Ins R ) , 2 dual kinases ( mek and sek ) and one possible novel kinase . ^^^ |
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| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| In Y567F , Lyn activation on SCF stimulation decreased and C terminal Src kinase ( Csk ) suppressed KIT mediated Ca ( 2+ ) influx and cell migration , suggesting that Y 567 mediated Src family kinase ( SFK ) activation leads to Ca ( 2+ ) influx and migration . ^^^ |
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| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| Lyn contributes to regulation of multiple Kit dependent signaling pathways in murine bone marrow mast cells . ^^^ Previously we showed that Lyn is activated at multiple points during SCF induced cell cycle progression and contributes to SCF mediated growth , chemotaxis and internalization of Kit . ^^^ However , the Kit dependent biochemical events that require Lyn are unknown . ^^^ In this study , we used Lyn deficient bone marrow mast cells ( BMMC ) to examine the contribution of this Src family member to tyrosine phosphorylation of Kit and SCF induced activation of Jnks , Akt , Stat 3 and Erks . ^^^ Although surface expression of Kit was increased in Lyn deficient BMMC , SCF induced phosphorylation and growth was reduced compared to wild type BMMC . ^^^ |
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| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Kit modulated phosphorylation dependent interactions with pathways controlling focal adhesion ( paxillin , leupaxin , p130CAS , FAK 1 , the Src family kinase Lyn , Wasp , Fhl 3 , G25K , Ack 1 , Nap 1 , SH3P12 / ponsin ) and septin actin complexes ( NEDD 5 , cdc 11 , actin ) . ^^^ |
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| Interacting proteins: P10721 and P07948 |
Pubmed |
SVM Score :0.0 |
| During early development , Lyn / erythroblasts accumulated at a Kit ( pos ) CD 71 ( high ) stage , possessed decreased proliferative capacity , and were attenuated in entering an apparent G1 / S cell cycle phase . ^^^ Lyn , therefore , is proposed to function via erythroid cell intrinsic mechanisms to promote progenitor cell expansion beyond a Kit ( pos ) CD 71 ( high ) stage and to support subsequent late stage development . . ^^^ |
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