| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| Incubation of labeled ACC with snake venom phosphodiesterase and alkaline hydrolysis release 32P products tentatively identified by high performance liquid chromatography as 5 ' [ 32P ] AMP and [ 32P ] ADP ribose , respectively . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| Stimulation of Na+ transport across six skins with 1 mM serosal 8 p chlorophenylthio 3 , 5 ' cyclic AMP ( CPTcAMP ) increased acCa by a factor of 2 . 6 + / 0 . 6 . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| Likewise , when ACC phosphorylation and inactivation were induced by the use of 5 amino 4 imidazole carboxamide ribotide , an AMP analog and activator of 5 ' AMP protein kinase , the glucose induced insulin secretion was virtually nil . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| Evidence indicates that amphetamine ( AMP ) affects feeding in a baseline dependent fashion and that the nucleus accumbens ( Acc ) is an important site of action for AMP ' s effects on feeding . ^^^ Experiment 1 examined the contribution of Acc dopamine ( DA ) mechanisms to the baseline dependent feeding effects of a 0 . 125 mg / kg dose of AMP using intra Acc administrations of cis flupenthixol ( FLU ) . ^^^ Finally , it is speculated that Acc DAergic activity may play a role in the observed differences in baseline intake levels and in the response to AMP . . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| A third group of rats received intranucleus accumbens ( Acc ) microinjections of low to moderate ( 2 . 0 8 . 0 micrograms ) doses of AMP , because evidence indicates that this may be an important site of action for AMP ' s effects on feeding in LOW and HIGH rats . ^^^ Furthermore , intra Acc administration of AMP stimulated sugar intake in LOW rats and produced a slight , but nonsignificant , decrease in consumption in HIGH rats . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| Muscle malonyl CoA decreases during exercise or electrical stimulation , the exercise induced decline being accompanied by changes in the kinetic properties [ maximal velocity ( Vmax ) , activation constant ( Ka ) , and citrate concentration required to produce 50 % Vmax ( K0 . 5 ) ] of acetyl CoAcarboxylase ( ACC ) and by an increase in the AMP activated protein kinase activity ( AMPK ) . ^^^ Thus exercise induced changes in functional properties of ACC appear to be contraction mediated and are accompanied by increased AMPK activity and an increase in the estimated free AMP . . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| As muscle goes from a resting state to exercise , the following sequence of events occurs ( Figure 5 . 5 ) : ( 1 ) The rise in AMP accompanying contraction allosterically activates AMPK and an AMPK kinase ; ( 2 ) The activated AMPK kinase phosphorylates and further activates AMPK ; ( 3 ) The activated AMPK phosphorylates and inactivates ACC ; and ( 4 ) The consequent decline in malonyl CoA ( product of ACC reaction ) relieves inhibition of CPT 1 and allows an increased rate of fatty acid oxidation when fatty acids become available . . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| Results show that in cultured astrocytes ( a ) CPT 1 exerts a very high degree of control over ketogenesis from palmitate , ( b ) the ACC / malonyl CoA / CPT 1 system is similar to that of liver , and ( c ) the ACC / malonyl CoA / CPT 1 system is subject to regulation by cyclic AMP . . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| We conclude that physiological increments in AMP during the work transition are insufficient to promote ACC phosphorylation by AMP stimulated protein kinase . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| In our study , 5 amino imidazolecarboxamide ( AICA ) riboside , a stimulator of AMP kinase , significantly inhibited glucose mediated activation of ACC and insulin secretion from isolated beta cells . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| The decline in ACC activity was related to the decrease in PCr and the rise in AMP . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| Exposure of bovine aortic endothelial cells ( BAEC ) to chemically synthesized ONOO acutely and significantly increased phosphorylation of c Src , PDK 1 , AMPK , and its downstream target , acetyl CoA carboxylase ( ACC ) , without affecting cellular AMP . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| In contrast , exercise lowers the concentration of malonyl CoA , by activating an AMP activated protein kinase ( AMPK ) , which phosphorylates and inhibits ACC . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| These results suggest that 1 ) AMPKalpha 1 is the predominant isoform activated by AMP independent phosphorylation in low intensity contracting muscle , 2 ) AMPKalpha 2 is activated by an AMP dependent mechanism in high intensity contracting muscle , and 3 ) activation of each isoform enhances glucose transport and ACC phosphorylation in skeletal muscle . . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| In the intestinal rat epithelial cell line IEC 6 , addition of adenosine rapidly increases AMP intracellular concentrations and upregulates alpha1AMPK , thus promoting phosphorylation of its downstream target acetyl CoA carboxylase ( ACC ) . ^^^ |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and Q13085 |
Pubmed |
SVM Score :0.0 |
| NA |
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