| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The endocrine metabolic response to surgery , as expressed by changes in plasma ACTH , cortisol , insulin , growth hormone , cyclic adenosine 3 ' , 5 ' monophosphate ( cyclic AMP ) , glucose , free fatty acids , blood b hydroxybutyrate and cumulative nitrogen balance was measured before and during anaesthesia and surgery , and on the first five post operative days . ^^^ It was found that morphine anaesthesia blocked the increase in ACTH , cortisol , growth hormone , cyclic AMP , and glucose during surgery . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The effects of growth hormone dependent serum factors on amino acid transport and on cartilage cyclic AMP levels in embryonic chicken cartilage were studied in vitro . ^^^ The factors in serum which increase cartilage cyclic AMP and amino acid uptake are growth hormone dependent , since neither growth hormone itself nor serum from hypophysectomized rats restores these serum factors . ^^^ Studies comparing the ability of sera with varying amounts of growth hormone dependent factors to stimulate amino aminoisobutyrate transport and to increase cartilage cyclic AMP show a striking linear correlation between the two effects ( r=0 . 977 ) . ^^^ The data are compatible with the thesis that growth hormone dependent serum factors increase cartilage amino acid transport by elevating cartilage cyclic AMP . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The isolated somatotrophs also release immunoassayable growth hormone when incubated with 6 mM dibutyryl 3 ' , 5 ' cyclic AMP . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The action of PGs on hormonal release and cyclic AMP accumulation support the hypothesis of a role of PGs in the mechanism of anterior pituitary hormone ( particularly growth hormone ) release . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The effect of various prostaglandins and a prostaglandin synthetase inhibitor on rat anterior pituitary cyclic AMP levels and hormone release in vitro ( 38475 ) . ( U ) Prostaglandins E 1 , E 2 , F 1alpha or F 2 alpha significantly increased the release of GH , with a parallel increase in intracellular cAMP concentrations , while they only protentiated HE stimulated TSH release . ( 2 ) None of the prostaglandins examined consistently effected either the basal or HE altered release of LH , FSH or prolactin . ( 3 ) The prostaglandin synthetase inhibitor , indomethacin , inhibited GH and TSH release and , at high doses of the drug , inhibited prolactin release . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Ovine growth hormone , which caused no increase in adrenal cyclic AMP , stimulated adrenal ornithine decarboxyase activity . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Finally , addition of somatostatin to incubation media prevented PGE promoted GH release , and suppressed cyclic AMP accumulation , although to a lesser extent , in sheep anterior pituitary pieces . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| In vitro effects of growth hormone on cyclic AMP metabolism in the isolated rat diaphragm . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The effect of somatostatin on the responses of blood glucose , plasma immunoreactive insulin ( IRI ) , growth hormone ( GH ) , and free fatty acids ( FFA ) to the injection of dibutyryl cyclic AMP ( DBC ) was studied in six normal volunteers . ^^^ Inhibitory effect of somatostatin on dibutyryl cyclic AMP induced insulin and growth hormone release in human subjects . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| These findings provide further evidence that both calcium and cyclic AMP are important in the regulation of growth hormone release . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Basal and dibutyryl cyclic AMP stimulated release of newly synthesized and stored growth hormone from perifused rat pituitaries . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| A possible role of cyclic AMP in mediating the effects of thyrotropin releasing hormone on prolactin release and on prolactin and growth hormone synthesis in pituitary cells in culture . ^^^ Isobutylmethylxanthine , 8 bromo cyclic AMP and 8 methylthio cyclic AMP ( 0 . 4 MM ) increase prolactin synthesis , but do not significantly affect growth hormone synthesis . ^^^ Dibutyryl cyclic AMP ( 0 . 5 mM or more ) increases prolactin release and both growth hormone and prolactin synthesis , but equivalent amounts of sodium butyrate have the same effects . ^^^ We conclude that in GH cells under carefully defined experimental conditions : 1 ) TRH causes an increase in intracellular cyclic AMP concentrations ; 2 ) the increase in endogenous cyclic AMP and the effects of phosphodiesterase inhibitors are consistent with a model with cyclic AMP as a mediator of the effects of TRH on prolactin release ; however , they do not prove this model , because the interpretation of these results depends on assumptions which may not all be valid ; and 3 ) none of the analogs of cyclic AMP or the phosphodiesterase inhibitors tested mimic the decrease in growth hormone production caused by TRH . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Effects of alpha , beta methylene ATP on prostglandin induced GH release and cyclic AMP accumlation in rat anterior pituitary glands . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| At 10 min after the addition of growth hormone a slight decrese in cyclic AMP content and a large decrease in cyclic GMP were found , suggesting that the hormone ' s effect in stimulating protein synthesis may be mediated by a decrease in cyclic nucleotide concentrations or an increase in the [ cyclic AMP ] / [ cyclic |p ] ratio . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| When added simultaneously with epinephrine , growth hormone neither reduced the maximal accumulation of cyclic AMP which occurred at 3 min nor accelerated the return to basal levels . ^^^ Only when tissues were exposed to epinephrine 15 min after preincubation with growth hormone was cyclic AMP accumulation compromised . ^^^ Growth hormone also produced a delayed increase of about 20 % in the activity of a low Km cyclic nucleotide phosphodiesterase , which might have contributed to the decrease in cyclic AMP accumulation . ^^^ The antilipolytic effects of growth hormone similarly could not be attributed to the decrease in cyclic AMP concentrations , for when added simultaneously with epinephrine the antilipolytic effects did not occur until after the evanescent changes in cyclic AMP had passed . ^^^ Growth hormone added simultaneously with epinephrine or 30 min later significantly decreased the activity of protein kinase assayed in the absence of exogenous cyclic AMP , but did not change total protein kinase activity as measured in the presence of a saturating concentration of cyclic AMP . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The glucose , insulin , and adenosine 3 ' , 5 ' monophosphate ( cyclic AMP ) responses to intravenous glucagon were found to be impaired in growth hormone deficient children . ^^^ Growth hormone therapy resulted in a significant improvement in the glucose , insulin , and cyclic AMP responses to intravenous glucagon in the growth hormone deficient group of children . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Conversely , dibutyryl cyclic AMP ( 2 . 5 mM ) stimulated radioimmunoassayable prolactin release as well as [ 3H ] prolactin and [ 3H ] GH release . ^^^ Dopamine , ergocryptine and apomorphine all inhibited incorporation of [ 3H ] leucine into prolactin but not into GH , whereas 2 . 5 mM dibltyryl cyclic AMP with any one of the inhibitors restored total incorporation into [ 3H ] prolactin to levels insignificantly lower than the nucleotide stimulated incorporation . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Theophylline and dibutyryl cyclic AMP each provoked increased GH and Prl release from the tumour . ^^^ A second specimen of the MStT / W15 tumour and a specimen of the MStT / W5 tumour behaved in a manner identical to the original MStT / W15 , showing no response to TRH or SRIF , but releasing both GH and Prl when theophylline or dibutyryl cyclic AMP was given . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Thyrotropin , growth hormone and insulin had no stimulating effect . 3 Isobutyl 1 methylxanthine potentiated the gonadotropic hormone effect by increasing the concentration of cyclic AMP in the ovarian tissue . 4 . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Interaction of somatostatin inhibition and dibutyryl cyclic AMP or potassium stimulation of growth hormone release from perifused rat pituitaries . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Serial serum samples taken before and during the six hours of infusion were assayed for cyclic adenosine 3 , 5 monophosphate ( AMP ) , estradiol , estriol , progesterone , human placental lactogen ( hPL ) , thyrotropin ( TSH ) , follicle stimulating hormone ( FSH ) , and human growth hormone ( gGH ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Cyclic AMP is a common second messenger for a variety of hormones such as catecholamine , glucagon , and growth hormone , which are affected by cardiac surgery . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Activation of cyclic AMP dependent protein kinase ( s ) by growth hormone in the liver and adrenal gland of the rat . ^^^ A single dose of growth hormone ( 10 mg / kg , i . p . ) was injected into male weanling rats ( 50 60 g ) , and the temporal changes in cyclic AMP concentration , protein kinase activation , and ornithine decarboxylase activation were measured in the liver and adrenal gland . ^^^ The level of cyclic AMP did not change significantly from control values in either liver or adrenal following growth hormone administration . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Synthetic somatostatin ( 10 and 100 nM ) suppressed the basal and stimulated by 2 0 dibutyril AMP , theophylline , and prostaglandins of E series GH labeled secretion . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Highly purified growth hormone ( lot B1003A ) increased adenylate cyclase activity in plasma membranes from bovine renal medulla from 132+ / 6 pmol cyclic AMP formed / mg protein per 10 min to 364+ / 10 pmol cyclic AMP formed / mg protein per 10 min . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Pre somatotroph proliferation is stimulated by increased intracellular levels of cyclic AMP , normally induced by growth hormone releasing factor ( GRF ; refs 7 17 ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| On another day , blood pressure ( BP ) , PR , plasma norepinephrine ( PNE ) , cyclic AMP ( p cAMP ) , renin activity ( PRA ) , aldosterone ( PAC ) and growth hormone ( p GH ) were measured at 0 , 30 , 60 , 90 , 120 , 150 , 180 minutes following the oral administration of clonidine ( 150 micrograms ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the effect of changes in intracellular pH ( pHi ) on basal and GH releasing factor ( GRF ) stimulated cyclic AMP ( cAMP ) , intracellular Ca2+ and GH release using a static monolayer culture prepared from dispersed rat anterior pituitary cells . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| We have demonstrated that the novel hypothalamic peptide pituitary adenylate cyclase activating polypeptide ( PACAP 38 ; 0 . 1 100 nmol / l ) caused an increase in the release of GH , ACTH , LH and alpha subunit and accumulation of intracellular cyclic AMP from dispersed rat anterior pituitary cells in static culture for 24 h . ^^^ PACAP 38 ( 10 nmol / l ) increased the release of GH by 1 . 3 fold ( P less than 0 . 05 ) , ACTH by 1 . 9 fold ( P less than 0 . 05 ) , LH by 3 . 5 fold ( P less than 0 . 001 ) and alpha subunit by 2 . 0 fold ( P less than 0 . 005 ) and the accumulation of intracellular cyclic AMP by greater than 2 fold ( P less than 0 . 001 ) after 24 h . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Dibutyryl cyclic AMP ( DBcAMP ) induced GH secretion was less sensitive to inhibition by nimodipine . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| A static incubation system was used to study the release of GH and peptidyl glycine alpha amidating enzyme ( PAM ; a component of secretory granules ) and the cellular concentration of cyclic AMP ( cAMP ) in basal and stimulated cells . ^^^ Effect of cell density on growth hormone release from , cyclic AMP levels in and peptide alpha amidation activity of primary cultured rat anterior pituitary cells . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| After 3 days , the acute effects of glucose , growth hormone releasing factor ( GRF ) , dibutyryl cyclic AMP ( db cAMP ) and somatostatin were studied during 2 hour incubations . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| R GAL modestly but significantly stimulated GH release without an increase in intra and extracellular cyclic AMP levels in monolayer cultures of rat anterior pituitary cells . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Measurements of cholera toxin and VIP enhanced cyclic AMP levels in intact cells confirmed these results , and VIP appeared to have no stimulatory effect on GH secretion after 5 azacytidine treatment . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| RVV failed to increase the formation of basal or IBMX stimulated intracellular cyclic AMP ( cAMP ) , confirming that RVV affects GH release through a cAMP independent pathway . 12 0 Tetradecanoylphorbol 13 acetate ( TPA ; 0 . 1 mumol / l ) , added simultaneously with various doses of RVV ( 0 . 1 10 micrograms / ml ) , did not increase GH release beyond the maximal effect of RVV . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| We have used a recombinant human basic fibroblast growth factor ( basic FGF ) to study its effects on cell proliferation , gene expression and accumulation of cyclic AMP ( cAMP ) and inositol phosphates in two well characterized endocrine cell lines , FRTL 5 rat thyroid and GH 3 rat pituitary cells . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Forskolin ( an adenyl cyclase activator ; 10 mumol / l ) and the synthetic cyclic AMP analogue dibutyryl cyclic AMP ( dbcAMP ; 1 mmol / l ) increased secretion of GH by 1 . 9 and 1 . 7 fold respectively , relative to control . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| A subset of human growth hormone ( GH ) secreting pituitary tumours , characterized by elevated GH secretion , cyclic AMP levels , and adenylyl cyclase activity , carries mutations in the gene that encodes the alpha chain of Gs . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The counter regulatory effects of beta adrenergic stimulation and cyclic AMP on the insulin like action of growth hormone ( GH ) on the subcellular distribution of insulin like growth factor 2 ( IGF 2 ) receptors were studied in fat cells from hypophysectomized ( Hx ) and sham operated rats . ^^^ GH exerted an acute insulin like effect in cells from Hx rats and stimulated the translocation of IGF 2 receptors from an intracellular pool to the plasma membrane . beta Adrenergic stimulation with isoprenaline or addition of the non metabolizable cyclic AMP analogue N 6 monobutyryl cyclic AMP induced a cellular resistance to both GH and insulin and also reduced the responsiveness to these hormones . ^^^ It is concluded that : ( 1 ) beta adrenergic stimulation and cyclic AMP induce a cellular GH resistance at a level distal to the GH binding site , and ( 2 ) the insulin like effect of GH shares a common pathway with insulin which occurs at the post binding level . . ^^^ The insulin like effect of growth hormone on insulin like growth factor 2 receptors is opposed by cyclic AMP . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Human GH did not alter basal cyclic AMP levels in mouse osteoblasts . ^^^ Activation of mouse osteoblast growth hormone receptor : c fos oncogene expression independent of phosphoinositide breakdown and cyclic AMP . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Upon first exposure , synthetic human growth hormone releasing factor ( GRF ) and prostaglandin E 2 ( PGE 2 ) cause a rapid and marked stimulation of cyclic AMP accumulation and GH release in rat adenohypophysial cells in primary culture . ^^^ A 50 % desensitization of the cyclic AMP and GH responses is observed after 100 and 150 min of preincubation with 300 nM GRF , respectively . ^^^ After a prior exposure to 3 microM PGE 2 , a 50 % maximal decrease of the cyclic AMP and GH responsiveness to a subsequent 3 h incubation with PGE 2 is obtained at 90 and 120 min , respectively . ^^^ Following preincubation with GRF , a loss of responsiveness of the cyclic AMP and GH responses is also observed after heterologous stimulation with PGE 2 . ^^^ The desensitizing action of GRF on the cyclic AMP and GH responses is obtained at respective IC 50 values of 2 and 7 nM for both the homologous and heterologous responses . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Regulation of growth hormone mRNA and pro opiomelanocortin mRNA levels by cyclic AMP in rat anterior pituitary cells in culture . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| On the involvement of cyclic AMP and extracellular Ca2+ in the regulation of hormone release from rat pituitary tumour ( GH 3 ) cells in culture . ^^^ Thyroliberin ( TRH ) , dibutyryl cyclic AMP ( db cAMP ) , and 3 isobutyl 1 methylxanthine ( MIX ) had a stimulatory effect on prolactin ( PRL ) and growth hormone ( GH ) release from GH 3 cells . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Regulation of growth hormone secretion and cyclic AMP metabolism in ovine pituitary cells : interactions involved in activation induced by growth hormone releasing hormone and phorbol esters . ^^^ Effects of the releasing hormone on growth hormone secretion were associated with a concurrent , large increase in cellular cyclic AMP accumulation . ^^^ Forskolin and isobutylmethylxanthine ( IBMX ) also stimulated growth hormone secretion and cyclic AMP accumulation . ^^^ When combined with a maximally effective concentration of GHRH these compounds did not further elevate growth hormone secretion even though they induced further increases in cyclic AMP concentration ; this is consistent with activation occurring via a common cyclic AMP dependent pathway . ^^^ In contrast TPA when combined with maximally effective concentrations of either GHRH , forskolin or IBMX caused additional release of growth hormone , suggesting that the TPA induced secretion involved a cyclic AMP independent process . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with TPA attenuated actions of GH releasing hormone on GH release ( but not actions on cyclic AMP levels ) , possibly due to depletion of cellular stores of GH . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Leydig cells from 40 days old rats were incubated with or without human growth hormone ( hGH ) or insulin like growth factor 1 ( IGF 1 ) in the presence or absence of human chorionic gonadotropin ( hCG ) , and testosterone and cyclic AMP ( cAMP ) levels in the medium were measured . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Incubation with somatostatin lowered the cyclic AMP content of the cells and depressed GH output without altering output of TSH or Prl . ^^^ When somatostatin and cachectin were incubated together with the cells , the suppression of cyclic AMP production was abolished ; TSH and Prl release were stimulated , but the action of cachectin to stimulate GH release was blocked . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The administration of dibutyryl cyclic AMP to the transgenic mice caused a 2 fold induction in the level of bovine growth hormone in the serum within 90 min . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Human pancreatic growth hormone releasing factor ( GRF 44 NH 2 ) stimulated growth hormone ( GH ) secretion and intracellular cyclic AMP levels in cultured pituitary cells from both sheep and rat . ^^^ Somatostatin ( SRIF ) , over a wide range of doses and time , showed no significant effect on the elevated cyclic AMP levels in sheep cells , but did block the GH release in a dose dependent manner . ^^^ In rat cells , however , SRIF inhibited GRF stimulated cyclic AMP levels by 75 % maximum ( still 8 fold greater than the basal levels ) and GH release to almost half the basal value . ^^^ Effects of growth hormone releasing factor and somatostatin on growth hormone secretion and cellular cyclic AMP levels . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Although S 14 consistently inhibits basal GH secretion , its effects on basal cyclic AMP levels in normal pituitary cells are variable and often not significant ( 10 14 ) . ^^^ In contrast , S 14 inhibits prostaglandin and growth hormone releasing factor ( GRF ) stimulated cyclic AMP accumulation and GH release in parallel . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Cultured pituitary cells from Tx rats exhibited reduced GRH sensitivity , maximal GH responsiveness , and intracellular cyclic AMP accumulation to GRH , while somatostatin ( SRIF ) suppressive effects on GH secretion were increased . ^^^ T4Rx completely restored hypothalamic GRH content and spontaneous GH secretion despite only partial recovery of pituitary GH content , GRH and SRIF sensitivity , and intracellular cyclic AMP response to GRH . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Dopamine and somatostatin inhibit forskolin stimulated prolactin and growth hormone secretion but not stimulated cyclic AMP levels in sheep anterior pituitary cell cultures . ^^^ Forskolin , an activator of adenylate cyclase , has been used to investigate the effects of raising pituitary cell cyclic AMP concentrations on prolactin and growth hormone secretion and to examine the role of cyclic AMP in the inhibitory actions of dopamine and somatostatin . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Protein kinase C enhances growth hormone releasing factor ( 1 40 ) stimulated cyclic AMP levels in anterior pituitary . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Although this might be explained by a reduction in the pool of releasable GH , an alternative explanation is that pretreatment with GRF d disrupts the GH release mechanism ( s ) at a common step ( s ) beyond cyclic AMP generation and Ca2+ influx . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| GH release was increased by the presence of dibutyryl cyclic AMP . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| We have investigated the effect of prior exposure to somatostatin ( SRIF ) alone or in combination with growth hormone releasing factor ( GRF ) on the subsequent cyclic AMP and GH responses to GRF in rat anterior pituitary cells in primary culture . ^^^ The prevention by SRIF of the desensitizing action of GRF on GH release is not observed on the cyclic AMP response which remains almost completely inhibited in GRF pretreated cells . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Dopamine and somatostatin inhibit release of prolactin and GH respectively , after stimulation by these agents , but without effects on intracellular cyclic AMP concentrations . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The relative importance of several phospholipid pathways in cyclic AMP ( cAMP ) metabolism and growth hormone ( GH ) release was determined by an indirect , pharmacological approach in cultured anterior pituitary cells . ^^^ Modification of basal and GRF stimulated cyclic AMP levels and growth hormone release by phospholipid metabolic enzyme inhibitors . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The effect of increased levels of growth hormone on glucagon binding by isolated hepatocytes and on the cellular cyclic AMP response to glucagon was evaluated in rats bearing growth hormone secreting tumor ( Mt T W 15 ) and in rats treated with rat growth hormone . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| In cultures of rat pituitary cells , hpGRF stimulates GH but affects neither basal and dopamine inhibited prolactin release nor basal and gonadotropin releasing hormone ( GnRH ) stimulated luteinizing hormone ( LH ) release . hpGRF stimulates cyclic AMP production within seconds , an effect which is blocked by somatostatin . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Cyclic AMP stimulated growth hormone gene transcription and phosphorylation of a 19 , 000 dalton nuclear protein ; this appears to reflect direct nuclear actions of the cyclic AMP dependent protein kinase . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Tumor promoters enhance basal and growth hormone releasing factor stimulated cyclic AMP levels in anterior pituitary cells . ^^^ Tumor promoters , such as phorbol esters and teleocidin , amplified the ability of growth hormone releasing factor to increase pituitary cyclic AMP levels . ^^^ Due to the known stimulation of protein kinase C by both tumor promoters and diacylglycerols , we suggest that this calcium and phospholipid dependent protein kinase C can enhance the ability of the growth hormone releasing factor receptor to activate the cyclic AMP generating system . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The changes in selected muscle and blood metabolites blood catecholamines , cyclic AMP , glucagon , growth hormone , insulin , and C peptide were measured in five male long distance runners after moderate 90 min ( 4 . 3 min / km ) and intense 45 min ( 3 . 3 min / km ) of continuous running exercises . ^^^ The respective changes of plasma cyclic AMP were 2 . 5 and 2 . 7 fold , and the increase in the concentration of plasma growth hormone was 5 . 8 fold after the 45 min exercise . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The subjects pedalled at three different work loads , corresponding to 63 % of VO2max ( duration 10 min ) , 86 % of VO2max ( duration 10 min ) and maximal work load ( tolerated 5 7 min ) The increases in blood adrenaline , noradrenaline , growth hormone , cyclic AMP , glycerol and lactate concentrations were remarkably similar and exponentially related to the work load . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Dibutyryl cyclic AMP , as well as the adenylate cyclase stimulators forskolin and cholera toxin , markedly stimulated growth hormone ( GH ) release . ^^^ Anterior pituitaries from the dwarf mouse strain `` little ' ' did not release growth hormone or accumulate adenosine 3 ' , 5 ' monophosphate ( cyclic AMP ) in response to human and rat growth hormone releasing factor ( GRF ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| We have also compared the effects of hGRF , VIP , PHI and secretin on Growth Hormone ( GH ) release and cyclic AMP levels in anterior pituitary cells in vitro . ^^^ This GH release is accompanied by increases in cyclic AMP levels . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| These data suggest that GRF and somatostatin regulate the mitotic activity of GH producing cells and that the effect of GRF is possibly mediated by cyclic AMP . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Effects of calmodulin antagonists on hormone release and cyclic AMP levels in GH 3 pituitary cells . ^^^ Hydrolysis of cyclic AMP by GH 3 cytosol was reduced after incubation of intact GH 3 cells with trifluoperazine ( 15 60 microM ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Above all binding of GHRH to a specific receptor stimulates growth hormone secretion through formation of cyclic AMP . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The effect of phorbol ester pretreatment on rat ( r ) GH release induced by GH releasing factor ( GRF ) or 8 bromo cyclic ( c ) AMP was investigated using rat pituitary cells cultured in monolayers . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Mediation of the mitogenic action of growth hormone by adenosine 3 ' 5 ' monophosphate ( cyclic AMP ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Dissociation of lipolysis and protein anabolism by ACTH , bovine growth hormone , and thyroid stimulating hormone in adipose tissue with dibutyryl cyclic AMP and theophylline . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Study of the action of some new analogues of cyclic AMP on the release of growth hormone and prolactin in vitro ] . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Uptake of sugars by isolated rat diaphragm under the influence of somatotropin ( STH ) : possible role of adenosine 3 ' 5 ' monophosphoric acid ( cyclic AMP ) ] . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Relationship of protein synthesis and cyclic AMP to lipolytic action of growth hormone and glucocorticoids . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Effects of dibutyryl cyclic AMP , theophylline , epinephrine , ammonium ion , and hypothalamic extracts on the release of growth hormone from rat anterior pituitaries in vitro . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Effects of cyclic AMP and epinephrine on insulin and growth hormone secretion in sheep . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Inhibition of prostaglandin , theophylline and cyclic amp stimulated growth hormone release by valinomycin in vitro . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Stimulation of lipolysis and cyclic AMP accumulation in rabbit fat cells by human growth hormone . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The involvement of RNA synthesis and cyclic AMP in the activation of fat cell lipolysis by growth hormone and glucocorticoids . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Antagonism of prostaglandin promoted pituitary cyclic AMP accumulation and growth hormone secretion in vitro by 7 oxa 13 prostynoic acid . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Influence of cyclic AMP on hypothalamo hypophyseal regulation of secretion of somatotropin ] . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Effect of a new derivative of cyclic AMP on the liberation and synthesis of growth hormone and pituitary prolactin ] . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| In vitro effects of synthetic somatotropin release inhibiting factor on cyclic AMP level and GH release in rat anterior pituitary gland . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The effect of glucagon on adenosine 3 ' , 5 ' monophosphate ( cyclic AMP ) , glucose , insulin and growth hormone in the full term newborn and children . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Proceedings : Formation of cyclic AMP and glucose uptake by the isolated diaphragm of hypophysectomized rats : action of insulin and growth hormone ] . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Growth hormone and cyclic AMP in rat diaphragm muscle . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The stimulatory effect of maximal concentrations of synthetic human pancreatic growth hormone ( GH ) releasing factor ( GRF ) ( 1 40 ) NH on cyclic AMP accumulation in rat anterior pituitary cells in culture is 4 . 5 fold increased following a 48 h preincubation with the potent glucocorticoid dexamethasone while the sensitivity of GRF action is increased by approximately 4 fold . ^^^ Dexamethasone pretreatment , on the other hand , has no effect on basal cyclic AMP levels but approximately doubles both basal and GRF induced GH release . ^^^ The present data suggest that the potent stimulatory effect of glucocorticoids on GH secretion is exerted on the adenylate cyclase system at a step preceding cyclic AMP formation . . ^^^ Dexamethasone is a potent stimulator of growth hormone releasing factor induced cyclic AMP accumulation in the adenohypophysis . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Stimulation of growth hormone ( GH ) secretion by synthetic GHRH is also blunted by Ni++ , although basal GH release and stimulated GH release due to theophylline or dibutyryl cyclic AMP are not suppressed . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Growth hormone ( GH ) release from Rat pituitary cell monolayers in response to synthetic somatocrinin ( 7 . 8 to 1 , 000 pmol / l ) is paralleled with an increase in cellular cyclic AMP ( cAMP ) content and efflux of cAMP in the extracellular medium . ^^^ Roles of cyclic AMP and calcium in the mechanism of the release of growth hormone by somatocrinin ] . ^^^ Growth hormone ( GH ) release from Rat pituitary cell monolayers in response to synthetic somatocrinin ( 7 . 8 to 1 , 000 pmol / l ) is paralleled with an increase in cellular cyclic AMP ( cAMP ) content and efflux of cAMP in the extracellular medium . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Human pancreas tumor growth hormone releasing factor ( hpGRF ) induced more cellular cyclic adenosine 3 ' : 5 ' monophosphate ( AMP ) accumulation and growth hormone release from male than female rat anterior pituitaries in vitro . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| To assess the activity of synthetic somatostatin , the plasma levels of growth hormone ( GH ) and cyclic AMP were measured . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , in rats continuously infused with somatostatin for 4 days , no effect was found either on plasma concentrations of glucose , insulin , glucagon , growth hormone and cyclic AMP , or on body weight gain , food consumption or water intake . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Selective growth hormone and cyclic AMP stimulating activity is present in human pancreatic islet cell tumor . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The early , rapid [ 3H ] GH release phase of 1 mM dibutyryl cyclic AMP ( dbcAMP ) stimulation is potentiated by verapamil pretreatment , but only if the verapamil is continued during dbcAMP stimulation . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Somatostatin ( 10 nM ) causes a 40 60 % inhibition of GRF induced cyclic AMP accumulation while GH release is inhibited by 90 95 % at all time intervals . ^^^ The inhibitory effect of somatostatin is exerted on the maximal effect of GRF while the ED 50 values of GRF action on cyclic AMP cell content ( approximately 1 nM ) and GH release ( approximately 0 . 1 nM ) are not affected by the tetradecapeptide . ^^^ Although not completely additive , the stimulatory effects of PGE 2 and GRF together on cyclic AMP cell content and GH release are more potent than when either substance is present alone . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Somatostatin ( 30 nM ) did not affect basal or hpGRF stimulated phosphatidylinositol labeling but inhibited the hpGRF stimulation of cyclic AMP accumulation and growth hormone release . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| A synthetic form of human pancreatic growth hormone releasing factor ( GRF 44 NH 2 ) was shown to be a potent stimulator of growth hormone ( GH ) secretion and cellular cyclic AMP levels in cultured sheep pituitary cells . ^^^ Dopamine ( 0 . 1 microM ) inhibited the GRF elevated GH secretion by 50 % and lowered cyclic AMP levels by 30 % . ^^^ The data support the hypothesis that cyclic AMP is involved in the action of GRF but suggest that somatostatin can inhibit GRF induced secretion of GH independently of cyclic AMP . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| GRF stimulated growth hormone release by about 3 fold ( ED 50 1 . 6 10 10 ( 12 ) M ) and caused a rapid 15 fold increase in cyclic AMP production ( ED 50 6 . 0 10 10 ( 12 ) M ) . ^^^ These studies demonstrate that GRF stimulates growth hormone release via activation of adenylate cyclase and a rise in intracellular cyclic AMP . ^^^ In addition , these findings indicate that the inhibitory action of somatostatin on growth hormone release is exerted at two levels , one at the level of adenylate cyclase affecting the production of cyclic AMP , and the other beyond the formation of the nucleotide , at a site which modulates the release of growth hormone from the cell . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The effects of somatostatin on GH secretion , cyclic AMP and cyclic GMp concentrations in dispersed bovine anterior pituitary cells were studied following activation of adenylate cyclase with cholera toxin and inhibition of phosphodiesterase with isobutylmethylxanthine ( IBMX ) . ^^^ Cholera toxin ( 10 ( 5 ) M ) increased intracellular cyclic AMP concentration 10 fold and cyclic GMP concentration 3 fold relative to control , and stimulated the secretion of GH . ^^^ IBMX ( 10 ( 4 ) M ) als increased intracellular concentrations of both cyclic AMP and cyclic GMP and the secretion of GH and potentiated the actions of cholera toxin particularly in raising intracellular cyclic AMP concentrations which were elevated 40 fold in the presence of cholera toxin and IBMX . ^^^ The data suggest that bovine GH secretion is increased when concentrations of either or both cyclic nucleotides are elevated within the cells , although incubation of cells with extracellular concentrations of cyclic AMP and cyclic GMP derivatives up to 2 10 10 ( 3 ) M caused only small changes in GH release . ^^^ We suggest that somatostatin inhibits cholera toxin induced bovine GH secretion by preventing activation of the secretory process by either cyclic AMP or cyclic GMP . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| No effect on the enzyme activity was observed with triiodothyronine , hydrocortisone , growth hormone , cyclic AMP , or cyclic GMP . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Muscarinic acetylcholine receptor activation causes inhibition of cyclic AMP accumulation , prolactin and growth hormone secretion in GH 3 rat anterior pituitary tumour cells . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| On the other hand , growth hormone and prolactin are readily phosphorylated in cell extracts by cyclic AMP dependent protein kinase ( although they are not phosphorylated in vivo ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Multiple mechanisms of growth inhibition by cyclic AMP derivatives in rat GH 1 pituitary cells : isolation of an adenylate cyclase deficient variant . ^^^ Studies reported here were motivated by the desirability of isolating characterized GH clones defective in cyclic AMP synthesis or action . ^^^ Spontaneously occurring GH 1 cell variants resistant to the growth inhibitory effects of cyclic AMP analogs were isolated . ^^^ We conclude that cyclic AMP derivatives inhibit growth of GH cells by an unanticipated mechanism that is , nonetheless , related to endogenous cyclic AMP synthesis . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Despite a hyperglycemia , plasma immunoreactive insulin and C peptide showed no change during the cooling period , while with the exception of plasma human growth hormone , dopamine beta hydroxylase , immunoreactive glucagon , cortisol and cyclic AMP in plasma , either showed no change , or a decrease during the cooling period . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Thyrotropin releasing hormone and cyclic AMP activate distinctive pathways of protein phosphorylation in GH pituitary cells . ^^^ The studies reported here were undertaken to clarify the cellular mechanism of the hypothalamic tripeptide , thyrotropin releasing hormone ( TRH ) , in clonal , hormone responsive GH pituitary cells and to assess the possibility of a role for cyclic AMP as a mediator of TRH action . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Relationship between stimulated prolactin release from GH cells and cyclic AMP degradation and formation . ^^^ We have studied the relationship between the prolaction ( PRL ) release induced by thyroliberin ( TRH ) and theophylline and the formation and inactivation of adenosine 3 ' , 5 ' cyclic monophosphate ( cyclic AMP ) in cultured rat pituitary cells ( GH 3 cells ) . ^^^ Treatment of GH 3 cells with theophylline stimulated the release of PRL and inhibited cyclic AMP degradation probably leading to the measured increase in cellular concentrations of the nucleotide . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Cells in band A appeared more responsive to secretagogues than those in band B ; growth hormone secretion was stimulated markedly by cyclic AMP derivatives and prostaglandin E 2 , and inhibited by somatostatin . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Although cellular cyclic AMP and growth hormone were increased rapidly by cholera toxin and forskolin , enhanced LH release occurred significantly later with no change in total radioimmunoassayable LH ( i . e . , released plus stored ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Effects of repeated stress on pituitary cyclic AMP , and plasma prolactin , corticosterone and growth hormone in male rats . ^^^ The effects of five putative stressors ( saline injection , cold exposure , forced running , immobilization , and footshock ) on levels of pituitary cyclic AMP , plasma prolactin , corticosterone and growth hormone were examined . ^^^ In naive rats exposed to 15 min of these stressors for the first time , running , immobilization and footshock increased levels of pituitary cyclic AMP , plasma corticosterone and prolactin and decreased growth hormone , typical of stress response in the rat . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| This study shows that the growth hormone hypothalamic releasing factor ( somatocrinin ) stimulates the activity of cyclic AMP dependent protein kinase associated with a purified fraction of hog anterior pituitary secretory granules . ^^^ Threshold , half maximal and maximal concentrations ( 0 . 3 , 35 pM and 10 nM , respectively , in the presence of 50 nM cyclic AMP ) are similar to those observed for in vitro stimulation of growth hormone release by somatocrinin . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Effect of liberins and cyclic AMP on the biosynthesis of luteinizing hormone , prolactin and growth hormone in the rat pituitary ] . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| GH also interacted with 10 ( 6 ) and 10 ( 5 ) M dibutyryl cyclic AMP ( dbcAMP ) to augment synthesis of corticosterone . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Comparison of stress response in male and female rats : pituitary cyclic AMP and plasma prolactin , growth hormone and corticosterone . ^^^ There was no clear cause and effect relationship between elevations of pituitary cyclic AMP and changes in plasma levels of prolactin , corticosterone , and growth hormone . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Both newly synthesized and total rat growth hormone ( GH ) release as well as cellular cyclic AMP accumulation were stimulated in a dose dependent manner by the tumor medium . ^^^ The increase of cyclic AMP preceded the enhanced GH release , indicating that cyclic AMP may be a second messenger for the tumor factor ( s ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The following agents were added to the culture medium in a range of concentrations from physiological to pharmacological : adrenaline , 5 hydroxytryptamine , 2 , 3 DPG , cyclic AMP , thyroxine , hydrocortisone , and human growth hormone . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| This rate was not significantly altered by the hormones thyroxine , estradiol , angiotensin 2 , growth hormone , and prostaglandins or by increased levels of intracellular cyclic AMP . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The involvement of cyclic AMP ( cAMP ) in the GH stimulatory effect of tau aminobutyric acid ( GABA ) and of growth hormone releasing hormone ( GHRH ) was studied in neonatal rat pituitaries . ^^^ Growth hormone secretion and activation of cyclic AMP by growth hormone releasing hormone and gamma aminobutyric acid in the neonatal rat pituitary . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| In short term culture GHRH , forskolin and dibutyryl cyclic AMP stimulated GH release were inhibited by cortisol , suggesting an effect distal to the membrane and involving a protein kinase A ( PKA ) dependent pathway . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Among the many peptides tested , calcitonin gene related peptide ( CGRP ) , vasoactive intestinal polypeptide ( VIP ) , peptide histidine methionine ( PHM ) , and growth hormone releasing factor ( GRF ) stimulated a rapid and marked formation of intracellular cyclic AMP in keratinocytes in a dose dependent manner . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| In addition , a number of other adaptations in the beta adrenergic signal transduction system occur during the lactation cycle and in response to growth hormone treatment , including changes in receptor number , adenylate cyclase activity and cyclic AMP phosphodiesterase activity , but a defect in the ability of hormone sensitive lipase to associate with the lipid droplet appears to be the major reason for the diminished response to catecholamines on litter removal . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Distance dependent interactions between basal , cyclic AMP , and thyroid hormone response elements in the rat growth hormone promoter . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| It was previously suggested that cyclic AMP ( cAMP ) responsive protein kinase A ( PKA ) phosphorylates GHF 1 at a site within the N terminal arm of its homeodomain , thereby inhibiting its binding to the GH promoter . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| In partially purified sheep somatotrophs , GHRP 2 and GH releasing factor ( GRF ) increased intracellular cyclic AMP ( cAMP ) concentrations and caused GH release in a dose dependent manner ; GHRP 6 did not increase cAMP levels . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Growth hormone releasing hormone ( GHRH ) stimulated growth hormone ( GH ) release from the sheep pituitary is mediated through Ca ( 2+ ) and cyclic AMP dependent mechanisms . ^^^ The data also suggest that PKA activation by cyclic AMP alone is insufficient to reproduce either the effects of GHRH stimulation or the combined effects of Ca2+ influx plus PKA activation on GH release . ^^^ Interaction of cyclic AMP and calcium dependent mechanisms in the regulation of growth hormone releasing hormone stimulated growth hormone release from ovine pituitary cells . ^^^ Growth hormone releasing hormone ( GHRH ) stimulated growth hormone ( GH ) release from the sheep pituitary is mediated through Ca ( 2+ ) and cyclic AMP dependent mechanisms . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| It is noteworthy that GH secreting adenoma tissues had high content of activated cyclic AMP responsive element binding proteins ( CREB ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis of the 5 ' flanking region revealed that PACE 4 gene lacks TATA and CCAAT boxes in the proximal upstream region of the start site , although potential binding sites for several transcription factors including SP 1 , AP 1 , AP 2 , PEA 3 , Ets 1 , GHF ( growth hormone factor ) 1 , CREB ( cyclic AMP response element binding protein ) , and basic helix loop helix proteins , were present . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Cyclic AMP potentiated the priming action of GH but exerted an inhibitory effect on terminal differentiation when added to cells which had previously been primed with GH showing that the effects of cyclic AMP on preadipocyte differentiation are stage dependent . ^^^ We analysed the stimulatory effects of cyclic AMP during GH priming and found that cyclic AMP induced phosphorylation of the cyclic AMP response element ( CRE ) binding protein CREB and activated transcription of a CRE linked reporter gene . ^^^ Furthermore , GH also stimulated CREB phosphorylation and activation and this effect was potentiated by cyclic AMP . ^^^ These results suggest a mechanism for the synergistic priming of preadipocytes for terminal differentiation by cyclic AMP and GH via the activation of differentiation genes containing CREs . . ^^^ Cyclic AMP potentiates growth hormone dependent differentiation of 3T3 F442A preadipocytes : possible involvement of the transcription factor CREB . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| The relationship between rat beta ( 1 ) and beta ( 2 ) adrenergic receptors ( ARs ) and cyclic AMP ( cAMP ) responses was examined by inducible expression of each subtype in transfected GH ( 3 ) pituitary cells . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Antagonistic analogs of growth hormone releasing hormone ( GHRH ) inhibit cyclic AMP production of human cancer cell lines in vitro . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Rat anterior pituitary tissue responded in vitro to growth hormone releasing hormone , forskolin , 8 Bromo cyclic adenosine 3 ' 5 ' monophosphate ( 8 Br cyclic AMP ) and an L Ca ( 2+ ) channel opener ( BAY K 8644 ) with concentration dependent increases GH release which were readily inhibited by corticosterone and dexamethasone . 3 . ^^^ The results provide novel evidence for a role for annexin 1 as a mediator of the inhibitory actions of glucocorticoids on the secretion of GH by the anterior pituitary gland and suggest that its actions are effected at a point distal to the formation of cyclic AMP and Ca ( 2+ ) entry . . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Using specific inhibitors it has been shown that the effect of GH on oocyte maturation and cumulus expansion is mediated by the cyclic AMP signal transduction pathway . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| GHRH , SRIH , and ghrelin act through G protein coupled receptors ( GPCR ) ; GHRH activates adenylyl cyclase , cyclic AMP , and protein kinase A pathways , while ghrelin stimulates phospholipase C activity leading to production of inositol 1 , 4 , 5 trisphophate and diacylglycerol , increase in cytosolic calcium levels , and GH release ; SRIH acts though an inhibitory GPCR to prevent depolarization of the somatotroph thus blocking GH secretion . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| In 1999 a model was published for prediction of growth in children with idiopathic GH deficiency ( IGHD ) during GH therapy , derived using data from the Kabi Pharmacia International Growth Study ( KIGS ) database ( Pharmacia \ | [ amp ] \ | Upjohn , Inc . , International Growth Database ) . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Quercetin mediated stimulation of 1 ( Ca , L ) in GH ( 3 ) cells was presumably not associated with the level of intracellular cyclic AMP , or with the activity of tyrosine or phosphoinositide 3 kinases . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| We investigated the action of bisphenol A ( BPA ) on cellular GH release and content , cell number , GHmRNA expression , and concentrations of cellular cyclic AMP ( [ cAMP ] c ) and calcium ion ( [ Ca2+ ] c ) in primary cultured ovine anterior pituitary cells . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| Administration of dibutyryl cyclic AMP and cortisol produced a significant elevation of GH mRNA levels in trout leucocytes , although the levels were unchanged by T 3 . ^^^ |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07741 and P01241 |
Pubmed |
SVM Score :0.0 |
| NA |
|