| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| The amino acid sequence of mature cathepsin C has 39 . 5 % identity to that of cathepsin H , 35 . 1 % to that of cathepsin L , 30 . 1 % to that of cathepsin B , and 33 . 3 % to that of papain . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| The specificity of purified rat brain cathepsin L ( EC 3 . 4 . 22 . 15 ) was mapped by the use of synthetic and opioid peptides and some properties were compared to rat brain cathepsin B , rat kidney cathepsin L , and bovine spleen cathepsin C . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| The method produced 25 mg of cathepsin B , 6 . 5 mg of cathepsin H , 1 . 5 mg of cathepsin L and 3 . 8 mg of cathepsin C from 3 . 5 kg of human kidney . . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| Most significantly , given the common ancestry of cathepsin B and cathepsin C , the prosegment of cathepsin C included ERFNIN like motifs and other residues more characteristic of non cathepsin B like members of the papain superfamily such as cathepsin L . . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| In this study we investigated the levels of two lysosomal cysteine protease proteins cathepsin B ( CB ) and cathepsin L ( CL ) and the levels of three cysteine protease inhibitor proteins stefin A ( SFA ) , stefin B ( SFB ) and cystatin C ( CNC ) in squamous cell lung carcinoma ( SQCLC ) and matched lung parenchyma specimens and examined the inhibition of CB and cathepsin C ( CC ) activities by endogenous inhibitors in extracts from SQCLC , lung adenocarcinoma ( LAC ) and lung parenchyma specimens . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| Injured muscle showed increased cathepsin B activity ( +327 % ) and mRNA encoding cathepsin B ( +670 % ) , cathepsin L ( +298 % ) , cathepsin H ( +159 % ) , and cathepsin C ( +268 % ) . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| The importance of regulated proteolysis in epithelia is well demonstrated by the recent identification of the SPINK 5 serine proteinase inhibitor as the defective gene in Netherton syndrome , cathepsin C mutations in Papillon Lefevre syndrome , cathepsin L deficiency infurless mice , targeted ablation of the serine protease Matriptase / MTSP1 , targeted ablation of the aspartate protease cathepsin D , and the phenotype of targeted epidermal overexpression of stratum corneum chymotryptic enzyme in mice . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| The results suggest that cathepsin L could be an important activator of DPPI in vivo and that cathepsin D and possibly the cystatins may contribute to DPPI downregulation . . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| To ascertain the critical thresholds of intracranial pressure ( ICP ) and cerebral perfusion pressure ( CPP ) for cerebral circulation and brain function , the extra and intracranial haemodynamics and electrical brain responses were evaluated noninvasively with Doppler ultrasonography and multimodality evoked potentials ( MEP ' s ) in 50 patients with severe head injury . ^^^ The frequency and degree of abnormalities of MEP ' s were proportionally increased with the rise of ICP and reduction of CPP . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| Continuing our theoretical studies of the oxytocin and vasopressin analogues , we have analysed the molecular electrostatic potential ( MEP ) and the norm of the molecular electrostatic field ( MEF ) of [ 1 beta mercaptopropionic acid ] arginine vasopressin ( [ Mpa 1 ] AVP ) , [ 1 ( beta mercapto beta , beta cyclopentamethylene ) propionic acid ] arginine vasopressin ( [ Cpp ' ] AVP ) , and [ 1 thiosalicylic acid ] arginine vasopressin ( [ Ths ' ] AVP ) whose low energy conformations were calculated in our previous work . ^^^ The results obtained show that the shapes of both MEP and MEF are similar in the case of [ Mpa 1 ] AVP and [ Cpp 1 ] AVP ( biologically active ) , while some differences emerge when comparing these compounds with [ Ths 1 ] AVP ( inactive ) . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| Four phthalate esters , namely , di ( 2 ethylhexyl ) phthalate ( DEHP , di n pentyl phthalate ( DPP ) . , di n octyl phthalate ( DOP ) , and diethyl phthalate ( DEP ) were investigated in vivo and their monoesters ( MEHP , MPP , MOP , and MEP , respectively ) in vitro for indications of Leydig cell toxicity in the rat . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| To test this possibility , we examined the activities of aminopeptidase M ( APM ) , dipeptidyl peptidase 4 ( DPP 4 ) , metalloendopeptidase 24 . 15 ( MEP 24 . 15 ) and neutral endopeptidase 24 . 11 ( NEP 24 . 11 ) in rat brain , heart , kidney , liver , lung and thoracic aorta . ^^^ In contrast , in aorta , the activity of APM was slightly but significantly reduced whereas those of DPP 4 and MEP 24 . 15 were markedly enhanced ; NEP 24 . 11 was not detected in this tissue . ^^^ Immunoblotting for DPP 4 and MEP 24 . 15 showed increased expression in aortic tissue . ^^^ Neither L NAME ( 1 100microM ) nor the NO donors sodium nitroprusside and 3 morpholinosydnonimine ( SIN 1 ; 1 100microM ) had any consistent effect on the activity of recombinant MEP 24 . 15 or renal DPP 4 . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| Cathepsin J represents the murine homologue of a previously described rat cathepsin L related protein . ^^^ Mature cathepsin J shows 59 . 3 % identity to mouse cathepsin L and contains the characteristic ER ( F / W ) NIN motif within the propeptide indicating that this protease belongs to the subgroup of cathepsin L like cysteine proteases . ^^^ Ctsj was mapped to mouse chromosome 13 in the vicinity of cathepsin L suggesting that cathepsin J may have arisen by gene duplication from cathepsin L or a common ancestral gene . . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| To compare the behaviour of motor evoked potentials ( MEP ) with transcranial magnetic stimulation ( TMS ) in patients with ALS and PLS . ^^^ PATIENTS AND METHODS : It was performed a retrospective analysis of MEP recordings of 11 patients with PLS and 10 patients with sporadic ALS . ^^^ CONCLUSION : Corticoespinal dysfunction has different characteristics in ALS and PLS patients , and the analysis of MEP could add useful information for differential diagnosis of these diseases . . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| The combination of molecular electrostatic potential ( MEP ) surface properties ( autocorrelation vectors ) with the conventional partial least squares ( PLS ) analysis has been used for the prediction of the human A ( 3 ) receptor antagonist activities . ^^^ The proposed MEP / PLS approach can be considered as an alternative hit identification tool in virtual screening applications . . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| We have recently reported that the combination of molecular electrostatic potential ( MEP ) surface properties ( autocorrelation vectors ) with the conventional partial least squares ( PLS ) analysis can be used to produce a robust ligand based 3D structure activity relationship ( autoMEP / PLS ) for the prediction of the human A 3 receptor antagonist activities . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| PLS can be distinguished from ALS by its slow clinical course , a severely prolonged MEP , and a more extensive focal cortical atrophy . . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| It has been found that the results of the PLS analysis of the series of the comparative matrices of the molecular electrostatic potential ( MEP ) are quite stable . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| Then , the correlation between the MEP values of all 2D maps and D 2 receptor antagonist activities was analyzed by 3 way PLS . ^^^ |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53634 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|