| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| In six pigs intravenous administration of Escherichia coli endotoxin caused septic shock and a significant increase in serum cationic trypsin like immunoreactivity ( CTLI ) , with activation of cationic trypsinogen to trypsin and formation of complexes between cationic trypsin , on the one hand , and alpha 2 macroglobulin and alpha 1 antitrypsin , on the other , compatible with acute pancreatitis . ^^^ |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| To characterize this trypsin , we developed a sensitive time resolved immunofluorometric assay for trypsin 1 complexed with alpha ( 1 ) antitrypsin ( AAT ) and studied the concentrations of this complex in sera from healthy individuals ( n = 130 ) and patients with benign biliary disease ( n = 32 ) , biliary tract cancer ( n = 17 ) , pancreatic cancer ( n = 27 ) , and hepatocellular cancer ( n = 12 ) . ^^^ METHODS : We used a trypsin 1 specific monoclonal antibody on the solid phase and a europium labeled polyclonal antibody to AAT as tracer . ^^^ The validity of the trypsin 1 AAT test for detection of biliary tract cancer was compared with trypsin 2 AAT and CA 19 9 . ^^^ RESULTS : Increased concentrations of trypsin 1 AAT ( > 33 microgram / L ) were found in 76 % of patients with biliary tract cancer , and the concentrations were significantly higher than in those with benign biliary disease ( P < 0 . 0001 ) . ^^^ The median concentration of trypsin 1 AAT in serum from patients with biliary tract cancer was 3 . 7 fold higher than in healthy controls , 2 . 6 fold higher than in patients with benign biliary tract disease , 1 . 7 fold higher than in patients with pancreatic cancer , and 2 . 0 fold higher than in patients with hepatocellular cancer . ^^^ |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| METHODS : 124 patients with non alcoholic chronic pancreatitis ( with PRSS 1 or SPINK 1 mutations or idiopathic pancreatitis ) and 64 healthy controls were investigated for the AAT mutations PiS and PiZ , and the PiM determining variants R101H , V213A , E376D . ^^^ |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| Analysis of CFTR , SPINK 1 , PRSS 1 and AAT mutations in children with acute or chronic pancreatitis . ^^^ OBJECTIVES : Defects of PRSS 1 , SPINK 1 , CFTR and AAT are considered causative or predisposing to pancreatitis . ^^^ The subjects were screened for PRSS 1 mutations : R122H , R122C , A16V , N29I ; SPINK 1 N34S variant ; panel of 14 CFTR defects : INNOLiPA CFTR 12 , CFTRdele 2 , 3 and IVS 8 T variant or panel of 3 CFTR defects F508del , CFTRdele 2 , 3 and IVS 8 T ; AAT mutations : E264V , E342K . ^^^ |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07477 and P01009 |
Pubmed |
SVM Score :0.0 |
| NA |
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