| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.75430422 |
| We conclude that GpIX is strongly associated with GpIb alpha in the purified platelet GpIb complex and in the platelet membrane . . 0.75430422^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The combined data suggest that one quinine dependent antibody ( BU ) recognizes an epitope in the peptide tail region of GPIb alpha and the other five quinine dependent antibodies react with a complex specific epitope on the membrane associated region of GPIb 9 complex , whereas each of the six quinidine induced sera contain two drug dependent antibodies , one reactive with the GPIb 9 complex specific epitope and the other reactive with GPIX . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The primary sequences of the three individual glycoprotein ( GP ) chains , GPIb alpha , GPIb beta , and GPIX , comprising the normal platelet GPIb / IX receptor for von Willebrand factor ( vWF ) have recently been determined , opening the possibility for characterization of disorders of this receptor at the molecular level . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Anti PlE 1 antibody bound specifically to both the GPIb complex and glycocalicin . 3H labelled platelet membrane glycoproteins with apparent molecular weights of 130k , 25k , and 21k ( under reduced conditions ) corresponding to GPIb alpha , GPIb beta , and GPIX were immunoprecipitated by anti PlE 1 plasma . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Anti GPIX Mab ( FMC 25 ) was not inhibitory with either normal or BSS platelets . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Using platelets from patients with Glanzmann ' s thrombasthenia or Bernard Soulier syndrome and purified GPIIIa , these proteins were shown to be GPIb , GPIIb , GPIIIa , GPIX , and an unidentified 57 Kd protein missing in Bernard Soulier syndrome . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| On one dimensional analysis , Bernard Soulier ' s syndrome ( BSS ) platelets also lacked the peripheral membrane glycoprotein , GPV ( mol wt 82 , 000 ) and a low molecular weight glycoprotein , GPIX , ( nonreduced or reduced , mol wt congruent to 22 , 000 ) . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| In contrast to its proteolytic effect on GPIb alpha , the cathepsin G induced decrease in platelet surface GPIX and the remnant of the GPIb 9 complex ( defined by MoAbs FMC 25 and AK 1 ) was via a cytoskeletal mediated redistribution , as determined by lack of change in the total platelet content of GPIX and the GPIb 9 complex ; complete inhibition by cytochalasin B , prostaglandin I 2 , and prior fixation of platelets . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Bernard Soulier syndrome Kagoshima : Ser 444 > stop mutation of glycoprotein ( GP ) Ib alpha resulting in circulating truncated GPIb alpha and surface expression of GPIb beta and GPIX . ^^^ The platelet membrane glycoprotein ( GP ) Ib / IX complex is composed of three polypeptides , GPIb alpha , GPIb beta , and GPIX , and functions as a platelet receptor for von Willebrand factor . ^^^ Her platelets completely lacked the surface expression of GPIb alpha , but expressed a residual amount of GPIb beta and GPIX . ^^^ Furthermore , the truncated GPIb alpha might be associated with the process of the surface expression of incomplete GPIb / IX complex , GPIb beta and GPIX . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Using flow cytometry , we found transfected GPV was surface expressed in HEL cells ; this , in turn , led to increased surface expression of the ligand binding GPIb alpha and GPIX subunits . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The complex is composed of four glycoprotein subunits , GPIb alpha , GPIb beta , GPIX and GPV , each with a variable number of leucine rich repeats . ^^^ GPIb alpha and GPIb beta are linked by a disulphide bridge while GPIX and GPV associate noncovalently with the complex . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Western blotting revealed normal levels of GPIX , decreased levels of GPIb beta and GPV , and < 1 % of GPIb alpha . ^^^ RT PCR studies showed the presence of mRNA coding for GPIb alpha , GPIb beta , GPIX and GPV . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Surface labeling of the platelets and two dimensional gel electrophoresis showed reduced but detectable amounts of glycoprotein ( GP ) Ib 9 5 present ; however , there was markedly less GPIX ( 2 % + / 1 % of normal ) than GPIb alpha , Ib beta , or 5 ( 7 % + / 2 % of normal ) . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Like the genes encoding GPIb alpha , GPIX , and GPV , the GPIb beta gene appears simple in structure . ^^^ When we examined poly ( A ) + RNA from several human tissues for GPIb beta mRNA expression , we found that GPIb beta mRNA was expressed in a variety of tissues but was most abundant in heart and brain , while GPIb alpha and GPIX mRNA expression was found only in lung and placenta at very low levels . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| We propose that expression of abnormal GPIX prevents stable assembly of the GPIb / IX complex , causing BSS in the doubly heterozygous individuals in this family . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Cathepsin G proteolysed platelet surface GPIb alpha , but redistributed platelet surface GPIX and GPV to the SCCS . ^^^ Elastase proteolysed platelet surface GPIb alpha and GPV , but , unlike the other agonists tested , neither proteolysed nor redistributed platelet surface GPIX . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| To date , only mutations in GpIbalpha or GpIX have been reported in patients with BSS . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Surface expression of GpIb alpha depends on the correct intracellular assembly with the GpIb beta and GpIX chains . ^^^ This study indicates that functional expression of the vWF binding domain of GpIb alpha on the surface of mammalian cells can be obtained in the absence of GpIb beta and GpIX . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| We concluded that this novel point mutation of the GPIX gene was responsible for BSS in these families . . ^^^ Flow cytometric analysis showed that GPIX was completely absent but residual amounts of GPIb alpha and GPV were detectable in these patients . ^^^ We analyzed all coding regions of GPIb alpha , GPIb beta , GPV and GPIX which were amplified from the patients ' genomic DNA by the polymerase chain reaction ( PCR ) . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The anti GPIb alpha antibody coprecipitated GPIb beta and GPIX , although the ratios of these polypeptides to GPIb alpha was greatly decreased compared with the ratio in normal platelets . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Several point mutations and deletions affecting the GPIb alpha gene have been identified as the cause of BSS , whilst in four BSS families a GPIX gene defect has been reported . ^^^ We investigated the molecular basis of another case of BSS with a deficient expression of GPIX , as detected by immunofluorescence studies . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| It is composed of GPIb alpha , GPIb beta , GPIX , and GPV . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The platelet membrane glycoprotein ( GP ) Ib 5 9 complex is the receptor for von Willebrand factor and is composed of four membrane spanning polypeptides : GPIb alpha , GPIb beta , GPIX , and GPV . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The platelet glycoprotein Ib ( GpIb ) complex is composed of four polypeptides : the disulfide linked GpIb alpha and GpIb beta and the noncovalently associated GpIX and GpV . ^^^ Furthermore , using two color fluorescence , we have shown that all ECs expressing GpIb alpha also express GpIX and GpV on their surface . ^^^ The ratio of GpIb alpha : GpIX : GpV is 1 : 1 : 0 . 5 , which is identical to the ratio present in platelets . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| In case 1 , GPIX was completely absent but residual amounts of GPIb alpha and GPV were detectable ; in case 2 , GPIb alpha was completely absent . ^^^ We amplified the coding regions of GPIb alpha , GPIb beta , GPV , and GPIX from the patients ' genomic DNA with the polymerase chain reaction ( PCR ) and sequenced the PCR products . in case 1 , we identified a point mutation in the GPIX coding region that changes the codon for tryptophan 126 ( TGG ) to a nonsense codon ( TGA ) . ^^^ These genetic changes alter the transmembrane domain of GPIX or GPIb alpha and , therefore , would prevent proper insertion of the proteins in the plasma membrane . ^^^ Thus , abnormality of a single component protein ( GPIX or GPIb alpha ) alters the assembly of the GPIb / IX / V complex and causes heterogeneous surface expression of GPIb alpha , GPV and GPIX . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Transient transfection studies confirmed that mutant GPIX was not expressed on the transfected cells , showing that the mutation was responsible for the BSS phenotype observed in the patient . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Deficiency of GPIb or GPIX results in Bernard Soulier syndrome ( BSS ) , a bleeding disorder in which platelets are giant and have multiple functional defects . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| After 48 h of shear stress , cell surface GpIb alpha , GpIX , and GpV , analyzed by flow cytometric analysis , were further increased over the levels observed at 24 h . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| In this study we demonstrate that expression of Fli 1 in the leukemia cell line K 562 induces a megakaryocytic phenotype and the expression of the platelet markers GPIX , GP1balpha , and GPIIb . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The complex , which serves as a platelet receptor for von Willebrand factor , is composed of 4 subunits : GPIb alpha , GPIb beta , GPIX , and GPV . ^^^ DNA sequence analysis revealed normal sequences for GPIb alpha and GPIX . ^^^ Thus , we found that GPIbbeta affects the surface expression of the GPIb 9 complex by failing to support the insertion of GPIb alpha and GPIX into the platelet membrane . ( Blood . 2000 ; 96 : 532 539 ) . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Mutations in both GPIb alpha ( CD42b ) and GPIX ( CD42a ) have been described . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Since this mutation is located in the leucine rich motif ( LRM ) of the GPIX polypeptide , the Phe 55 > Ser substitution may result in an alteration of the LRM which leads to the impaired surface expression of GPIb / IX / V complex , a characteristic of BSS . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| This was demonstrated by the increase in MK markers ( GPIIb , GPIIIa , GPIb alpha , GPIX and vWF ) , the appearance of cytoplasmic alpha granules , intracellular membranes resembling demarcation membranes which were immunologically labeled with an GPIIb / IIIa anti antibody , and a small percentage of polyploid cells ( 8N and 16N ) . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Infusion of 1 desamino 8 D arginine vasopressin normalized bleeding time in the two severely affected patients , although it did not modify ristocetin induced platelet agglutination or membrane expression of GPIbalpha , GPIX , GPIIb IIIa and GMP 140 . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| We previously reported a patient with Bernard Soulier syndrome ( BSS ) who had a homozygous missense mutation in the GPIX gene Phe 55 ( TTT ) to Ser ( TCT ) replacement in the leucine rich motif ( LRM ) of the GPIX polypeptide , as a probable cause of BSS phenotype . ^^^ These findings indicate that this substitution is responsible for BSS phenotype and that the LRM of GPIX is a critically important element for an efficient expression of the GPIb / IX complex . ^^^ Mutant GPIX could not increase the surface expression of GPIb alpha , but also surface expression of GPIX itself . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| We report the molecular genetic analysis of the Bernard Soulier syndrome ( BSS ) phenotype in two related patients showing absence of glycoprotein ( GP ) Ibalpha and detectable amounts of GPIX on the platelet surface , and a truncated form of GPIbalpha in solubilized platelets and plasma . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Blood platelet activity was also evaluated as well as the expression of platelet glycoproteins ( GPIIb , GPIIIa , and GPIX ) in platelets of the patients and the controls . ^^^ Expression on GPIIb platelet receptors was markedly increased and GPIX decreased in patients in comparison to the controls . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The glycoprotein Ib ( GPIb ) complex is composed of GPIb alpha covalently attached to GPIb beta and noncovalently complexed with GPIX and GPV . ^^^ Patients with Bernard Soulier syndrome demonstrate that mutations in either GPIb beta or GPIX result in an absence of platelet GPIb alpha . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Tests with GPV transfectants revealed that the antibodies reacted with GPV independent of GPIb alpha , GPIb beta , or GPIX . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Lesions in the genes for GPIb alpha , GPIb beta or GPIX result in a bleeding diathesis , the Bernard Soulier syndrome ( BSS ) , which associates a platelet adhesion defect with thrombocytopenia , giant platelets and abnormal megakaryocytes ( MK ) . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Both the GPIb alpha and the GPIX promoters have been analyzed by transfection of reporter constructs into hematopoietic and nonhematopoietic cells . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Surface marker analysis indicated that most of the leukemic cells expressed platelet markers , gpIIb , gpIIb / IIIa , gpIX , and gpIbalpha . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Analysis of genes encoding for GPIb alpha and beta , GPV , and GPIX ruled out the possibility that the observed platelet abnormality is a variant of Bernard Soulier syndrome . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| We describe a new mutation in glycoprotein 9 ( GPIX ) in a patient with Bernard Soulier syndrome ( BSS ) . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| After sequence analysis of the GPIb alpha , GPIb beta and GPIX genes , only a mutation in the GPIX gene at position 1826 ( A > G ) was identified , changing Asn 45 > Ser . ^^^ Our present observation of a decreased disulfide bridge formation between GPIb alpha and GPIb beta shows that GPIX is not only needed for the correct assembly of the complex but might also be needed for the disulfide bridge formation between GPIb alpha and GPIb beta . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis showed normal electrophoretic mobility of GPIb alpha , GPIb beta , and GPIX . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : Ala 139 Thr mutation of the GPIX gene in this patient is a novel missense mutation , which has not been reported in BSS . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Flow cytometric analysis showed that TMVA did not bind to platelet GPIX , GPIIb , GPIIIa , GPIa , GPIIa and GPIV . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Bernard Soulier Syndrome ( BSS ) is a severe congenital platelet disorder that results from a deficiency of the platelet membrane glycoprotein ( GP ) Ib / IX complex that is composed of four subunits ( GPIbalpha , GPIbbeta , GPIX , and GPV ) . ^^^ Mutations in either GPIbalpha , GPIbbeta , or GPIX can result in BSS with many of the known mutations occurring in GPIbalpha . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Our findings suggest that the additive effects of both mutations in the GPIX gene are responsible for the BSS phenotype of the patient . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The GPIX mutation was recently identified in a Chinese patient with Bernard Soulier syndrome ( BSS ) , a rare recessive bleeding disorder characterized by thrombocytopenia and giant platelets . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Transient transfection studies revealed that the mutant GPIbbeta polypeptide was not detected in the transfected 293T cells , suggesting that null expression of the mutant GPIbbeta impairs expression of the GPIbalpha and GPIX subunits and results in a BSS phenotype in the patient . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Thus far , more than 30 mutations of the GPIbalpha , GPIbbeta , or GPIX genes have been described in BSS . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| We now report a BSS variant whose platelets have little or no GIbbeta or GPIX , but where residual GPIbalpha was selectively located in flow cytometry by monoclonal antibodies ( WM 23 and Bx 1 ) recognizing denatured epitopes . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : The mutation of Ala 139 ( GCC ) > Thr ( ACC ) in the GPIX did not affect synthesis and assembly of GPIb / IX complex but influence its anchoring and expression on the cell surface , which was responsible for BSS . . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| The complex consists of four polypeptides GPIb alpha , GPIb beta , GPIX and GPV . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| We characterized the mutant GP1BB allele by expression in a cell line ( CHO alpha 9 ) that stably expresses two other components of the vWF receptor , GPIb alpha and GPIX . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Fli 1 and GATA 1 transcription factors are required for development of megakaryocytes and promoter analysis has defined in vitro functional binding sites for these factors in several megakaryocytic genes , including GPIIb , GPIX , and C MPL . ^^^ Fli 1 and Ets 1 occupy the promoters of GPIIb , GPIX , and C MPL genes in both Meg 01 and CMK 11 5 cells . ^^^ Whereas GPIIb is expressed in both Meg 01 and CMK 11 5 cells , GPIX and C MPL are only expressed in the more differentiated CMK 11 5 cells . ^^^ Whereas GPIIb , GPIX , and C MPL are direct target genes for Fli 1 , both Fli 1 and GATA 1 are required for formation of an active transcriptional complex on the C MPL and GPIX promoters in vivo . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| MLSC was able to measure antigens CD 9 , CD 29 , CD 36 , CD 41 , CD42a , CD42b , and CD 61 on platelets and determine an average of 2 . 3 10 10 ( 5 ) + / 7 10 10 ( 4 ) platelets per microliter . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| PLZF overexpression upmodulates the megakaryocytic specific markers ( CD42a , CD42b , CD 61 , PF 4 ) and induces the thrombopoietin receptor ( TpoR ) . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Adhesion molecules , receptor expression ( CD42a , CD42b , CD 36 , CD 29 , PAR 1 ) , and alpha granule secretion detected by P selectin expression remained unchanged but the release of growth factors was differentially regulated with increased VEGF and unchanged PDGF after agonist activation even in uncomplicated sepsis . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Flow cytometric quantitation of CD 41 , CD42a , CD42b and CD 61 was carried out using a Becton Dickinson FACScan . ^^^ On the other hand , the expression of CD42a , CD42b , and CD 61 showed no significant change in HD and CAPD patients when compared with normal control levels , but there was a significant decrease in transplant patients when compared to the normal control levels . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| With addition of rhIL 3 to the CMK cell culture system , increments in cell size , a significant shift toward high ploidy classes , and an increased expression of platelet glycoproteins CD 29 , CD 41 , CD42a , CD42b and CDw49f were newly observed . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Platelet glycoproteins Ib beta ( CD42c ) , 9 ( CD42a ) , and 5 ( CD42d ) , together with GP Ib alpha ( CD42b ) , form a receptor whose interaction with the von Willebrand factor is essential in the initial stages of haemostasis . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| An enzyme linked immunosorbent assay ( ELISA ) method in which PDMP are detected with the antibody of CD42a and CD42b , was recently reported . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| AP 2 ( anti GP IIb IIIa ) and FMC 25 ( anti GP 9 ) in immunofluorescence and immunocytochemical studies on megakaryocytes ( MK ) isolated from a Bernard Soulier syndrome ( BSS ) patient whose giant platelets were characteristically deficient in GP Ib 9 complexes . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Fresh bone marrow cells or plasma cells enriched bone marrow cells after a 48 h in vitro culture in the presence of interleukin 6 were stained by an immuno alkaline phosphatase technique using monoclonal antibodies ( mAb ) to von Willebrand factor , GpIb alpha and beta chain , GpIIb / IIIa and Gp 9 . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Glycoprotein Ibalpha contains a binding site for von Willebrand factor through which it mediates platelet adhesion ; GP 5 is required for the complex to bind thrombin with high affinity ; and both GP Ibbeta and GP 9 are necessary for efficient plasma membrane expression of the complex . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Molecular characterization of individuals with BSs has identified mutations in the GP Ib alpha , GP Ib beta , and GP 9 genes responsible for the expressed phenotype . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| Bernard Soulier syndrome ( BSS ) is an extremely rare hereditary bleeding disorder , caused by mutations occurring in the Glycoprotein ( GP ) Ibalpha , GPIbbeta and GP 9 genes that encode for the corresponding subunits of platelet GPIb 5 9 adhesion receptor complex . ^^^ While the great majority of BSS mutations are unique to a single individual or family , the GP 9 1828A > G Asn45Ser mutation , which we have identified in an undocumented Australian Caucasian , has already been reported in multiple unrelated Caucasian families from various Northern and Central European countries . ^^^ Haplotype analysis of 19 BSS patients from 15 unrelated Northern European families ( including 2 compound heterozygote siblings from a British family previously published , and 17 1828A > G Asn45Ser homozygotes ) , showed that 14 of these BSS patients from 11 of the 1828A > G Asn45Ser homozygote families share a common haplotype at the chromosomal region 3 ' to the GP 9 gene . ^^^ |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P07359 |
Pubmed |
SVM Score :0.0 |
| NA |
|