| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| We conclude that 1 ) the formation of discrete iodopeptides precedes the release of iodothyronines and iodotyrosines from Tg ; 2 ) the cysteine proteinases are more important than cathepsin D in this process ; and 3 ) these endopeptidases selectively cleave Tg to favor the production of hormone containing intermediates for subsequent processing by exopeptidases . . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| Pepstatin , an inhibitor of cathepsin D , markedly inhibited lysosomal digestion of [ 131I ] Tg at concentrations as low as 0 . 01 micrograms / ml . ^^^ We conclude from these results that both cathepsin D and thiol proteases play a role in lysosomal digestion of Tg . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 overexpression maintains Ca2+ uptake in the ER of TG treated cells and prevents a TG imposed delay in intralumenal processing of the endogenous glycoprotein cathepsin D . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| Moreover , after accumulation in the trans Golgi network ( TGN ) at 20 degrees C , cathepsin D was rapidly missorted to the secretory pathway after addition of wortmannin and shifting to 37 degrees C . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| However , delivery of newly synthesized cathepsin D to lysosomes was slowed in cells expressing active M 2 , suggesting that acidification of the TGN and endosomes is important for efficient delivery of lysosomal hydrolases . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| ASFV markedly slowed transport of cathepsin D to lysosomes , demonstrating that loss of TGN structure correlated with loss of TGN function . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| This was associated with impaired incorporation of the cation independent mannose 6 phosphate receptor into clathrin coated vesicles at the TGN , partial redistribution of the receptor to endosomes , and missorting of cathepsin D . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| Hip1R silencing and actin poisons slowed cathepsin D exit from the TGN . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| Overexpression or downregulation of 2c18 leads to an increased secretion of the lysosomal hydrolase cathepsin D , which is sorted by the mannose 6 phosphate receptor at the TGN , which itself involves AP 1 function for trafficking between the TGN and endosomes . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| By contrast , the suppression of hVps 34 expression did not block trafficking of cathepsin D between the TGN and late endosomes , or endocytic uptake of fluid phase markers , or association of a PtdIns ( 3 ) P binding protein , EEA 1 , with early endosomes . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| In the present study on HepG 2 cells , we have observed a differential effect of BFA on transport from the TGN of two soluble proteins : alpha 1 antitrypsin as a representative of secretory proteins and cathepsin D as a prototype of lysosomal enzymes . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| In the trans Golgi network ( TGN ) , MHC class 2 invariant chain complexes colocalized with the lysosomal hydrolase cathepsin D in buds and vesicles that lacked markers of clathrin coated vesicle mediated transport . ^^^ Metabolic labeling and subcellular fractionation experiments indicated that newly synthesized cathepsin D and MHC class 2 invariant chain complexes enter a non clathrin coated vesicular structure after their passage through the TGN and segregation from the secretory pathway . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| Confocal analysis revealed that these vesicles were devoid of TGN 38 and of Texas Red coupled transferrin and cathepsin D , markers of the endosomal / lysosomal pathway . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| The transport of pro cathepsin D from the trans Golgi network ( TGN ) to the endosomal pathway is dependent on binding to the calcium independent mannose 6 phosphate receptor ( ci M6PR ) , which is incorporated into TGN derived clathrin coated transport vesicles ( CCVs ) . ^^^ |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01266 and P07339 |
Pubmed |
SVM Score :0.0 |
| NA |
|