| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| Analysis of the sequences of thrombomodulin , thrombospondin complement components C 9 , C 8 alpha and C 8 beta , vitronectin and plasma cell membrane glycoprotein PC 1 . ^^^ In this paper we show that thrombomodulin contains a domain homologous with animal lectins , that complement components C 9 , C 8 alpha and C 8 beta have modules homologous with one of the repeat units of thrombospondin and that the somatomedin B module of vitronectin is homologous with the internal repeats of plasma cell membrane glycoprotein PC 1 . . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| The effects of antithrombin heparin , thrombomodulin , vitronectin and leukocyte elastase on PCI thrombin and PCI activated protein C ( APC ) interactions were investigated . ^^^ Thrombomodulin , a chondroitin sulphate containing proteoglycan , accelerated PCI inhibition of thrombin and APC . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| EPCR did not prevent protein C activation by the soluble thrombin thrombomodulin complex , did not alter the inactivation of APC by alpha 1 antitrypsin or protein C inhibitor , and did not influence the kinetics of peptide paranitroanilide substrate cleavage significantly . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor like domains 4 6 of thrombomodulin ( TM 4 6 ) accelerated the PCI inhibition of wild type and L99G thrombins 73 . 9 and 5 . 3 fold , respectively . ^^^ These results indicate that ( 1 ) Leu 99 of thrombin is critical for determination of the P 2 specificity of serpins , AT and PCI , ( 2 ) increasing the polarity of the S 2 pocket of thrombin by introduction of a hydrophilic residue into this pocket is detrimental for reaction with AT , but it is tolerated in reaction with PCI , so that only the size of the S 2 pocket of thrombin determines the P 2 specificity of PCI , and ( 3 ) the thrombomodulin induced conformational change that results in acceleration of thrombin inhibition by PCI involves Leu99 . . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| Recently it was found , using purified proteins , that the anticoagulant thrombin thrombomodulin complex was also inhibited by PCI . ^^^ We studied the role of thrombomodulin ( TM ) dependent inhibition of thrombin by PCI in a plasma system . ^^^ Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin induced activation of protein C in human plasma . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| The genes considered are ; alpha fibrinogen , beta fibrinogen , gamma fibrinogen , prothrombin , tissue factor , factor 5 , protein S , complement component 4 binding protein , factor 11 , factor 12 , factor XIIIa , factor XIIIb , histidine rich glycoprotein , high molecular weight kininogen , kallikrein , von Willebrands factor , platelet factor 4 , thrombospondin , antithrombin 3 , alpha 1 antitrypsin , thrombomodulin , plasminogen , tissue plasminogen activator , urokinase plasminogen activator , plasminogen activator inhibitor 1 , plasminogen activator inhibitor 2 , protein C inhibitor , alpha 2 plasmin inhibitor , kallistatin , lipoprotein a , interleukin 6 , interleukin 1 , cystathionine beta synthase , and methylenetetrahydrofolate reductase . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| Protein C inhibitor regulates the thrombin thrombomodulin complex in the up and down regulation of TAFI activation . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin ( TM ) ( with or without the chondroitin sulfate moiety ) accelerated PCI inhibition of both wild type and R93A / R97A / R101A thrombins . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| Plasma fibrinogen , thrombin antithrombin complex ( TAT ) , plasmin plasmin inhibitor complex , fibrin D dimer , activated protein C ( APC ) protein C inhibitor ( PCI ) complex , von Willebrand factor ( vWf ) , tissue plasminogen activator ( t PA ) , PA inhibitor 1 ( PAI 1 ) , and thrombomodulin levels in both PE and DVT patients were significantly increased compared with normal volunteers . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| Several serpins are involved in hemostasis : antithrombin ( AT ) inhibits many coagulation proteases , most importantly factor Xa and thrombin ; heparin cofactor 2 ( HCII ) inhibits thrombin ; protein C inhibitor ( PCI ) inhibits activated protein C and thrombin bound to thrombomodulin ; plasminogen activator inhibitor 1 inhibits tissue plasminogen activator ; and alpha 2 antiplasmin inhibits plasmin . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin ( TM ) , or its epidermal growth factor like domains 456 ( TM 456 ) , enhances the catalytic efficiency of thrombin toward both protein C and protein C inhibitor ( PCI ) by 2 3 orders of magnitude . ^^^ Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| Thirty nine patients ( 12 with VTE ) and 78 age and sex matched controls were included in the study , and levels of protein C , protein S , activated protein C ( APC ) , protein C inhibitor ( PCI ) , soluble thrombomodulin ( TM ) , antithrombin ( AT ) , alpha ( 1 ) antitrypsin , fibrinogen , factor 8 , von Willebrand factor ( VWF ) and C reactive protein ( CRP ) were measured . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| Then , we hypothesized that PCI possibly acts as an anti DIC agent rather than an inhibitor of the protein C anticoagulant pathway under the pathophysiology of DIC , accompanied by the decrease in the thrombomodulin expression on endothelial cells . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| The convertases furin and PC 1 can both cleave the human immunodeficiency virus ( HIV ) 1 envelope glycoprotein gp 160 into gp 120 ( HIV 1 SU ) and gp 41 ( HIV 1 TM ) . ^^^ Purified PC 1 and furin cleaved specifically in vitro gp 160 into gp 120 ( HIV 1 SU ) and gp 41 ( HIV 1 TM ) . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| HYPOTHESIS : This prospective study investigated the relation of the elevated levels of plasma soluble TM and inflammatory and myonecrotic markers in patients undergoing percutaneous coronary intervention ( PCI ) . ^^^ METHODS : Plasma levels of soluble TM , C reactive protein ( CRP ) , and creatine kinase and its MB isoenzyme were measured before and after PCI in 100 patients undergoing PCIs . ^^^ CONCLUSIONS : Soluble TM levels increase significantly after PCI . ^^^ The elevation of the soluble TM after PCI shows better correlation with inflammation than myocardial injury , indicating an endothelial origin . ^^^ |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
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