| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin is an essential cofactor for the activation of the anticoagulant protein C by thrombin . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin , an endothelial thrombin receptor , acts as a cofactor for the thrombin catalyzed activation of anticoagulant protein C . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| The gene coding for human thrombomodulin , a thrombin receptor on endothelial cells and a cofactor for the activation of anticoagulant protein C zymogen , was isolated from a human genomic library by employing human thrombomodulin cDNA as a probe . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| The endothelial cell surface contains a thrombin binding protein , thrombomodulin , which , when complexed with thrombin , activates vitamin K dependent protein C , an endogenous anticoagulant . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin ( TM ) is the endothelial cofactor of the anticoagulant protein C system . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| High affinity binding of proteolytic active thrombin to thrombomodulin at the cell surface effectively facilitates the activation of the potent anticoagulant protein C ( PC ) . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin is an endothelial cell surface glycoprotein that inhibits the procoagulant activities of thrombin and accelerates activation of the anticoagulant protein C . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin ( TM ) is an essential cofactor for the physiologic activation of the anticoagulant protein C by thrombin . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin ( TM ) is a cofactor for the thrombin catalyzed activation of anticoagulant protein C . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin acts as an essential membrane cofactor of thrombin in the triggering of the natural anticoagulant protein C pathway responsible for the inactivation of procoagulant cofactors VIIIa and Va . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin is a cofactor protein on vascular endothelial cells that inhibits the procoagulant functions of thrombin and enhances thrombin catalyzed activation of anticoagulant protein C . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Rat primary MCs were stably transfected ( using strontium phosphate DNA coprecipitation ) with a plasmid containing the gene for rat thrombomodulin ( TM ) , a transmembrane glycoprotein that functions as an essential cofactor for the physiological activation of the anticoagulant protein C by the enzyme thrombin . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Because thrombomodulin ( TM ) is one of the major mediators of the activation of the anticoagulant protein C by thrombin , we examined 136 primary tumor tissues and 45 metastatic lymph node tissues of lung squamous cell carcinomas for TM expression using immunohistochemical methods . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Concerning anticoagulants , inhibitors of tissue factor induced clotting activation , selective inhibitors of thrombin and factor Xa , and components of the anticoagulant protein C system ( recombinant activated human protein C or human soluble thrombomodulin ) have been studied . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin ( TM ) is a vascular endothelial cell ( EC ) receptor that is a cofactor for thrombin mediated activation of the anticoagulant protein C . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| The endothelial cell Protein C receptor ( EPCR ) functions to enhance activation of anticoagulant Protein C ( PC ) by the thrombin / thrombomodulin ( Tm ) complex on the surface of the endothelium . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Thrombomodulin ( TM ) , a key component of the anticoagulant protein C pathway , is a major contributor to vascular thromboresistance . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| The factors that influence plasma levels of thrombomodulin ( TM ) , an initiator of the anticoagulant protein C pathway , and those of tissue factor ( TF ) , which triggers the extrinsic coagulation pathway , were assessed . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| The thrombin mutant W215A / E217A features a drastically impaired catalytic activity toward chromogenic and natural substrates but efficiently activates the anticoagulant protein C in the presence of thrombomodulin . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Endothelial cell expression of thrombomodulin ( TM ) , a key component of the anticoagulant protein C pathway , is potently inhibited by inflammatory cytokines . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| The pure virus coat protein can also be incorporated into synthetic lecithin vesicles near the lipid phase transition temperature ( Tm ) , spanning the bilayer with its N terminus exposed on the outside and its C terminus inside ( Wickner , W . ( 1976 ) , Proc . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| S 1 titrations in the absence and presence of Tn and Ca2+ indicated that the excimer fluorescence probes the state change of Tm from the weak S 1 binding state to the strong S 1 binding state which is facilitated by Ca2+ [ Hill et al . ( 1980 ) Proc . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| Turnover measurements on cell surface H 2Ld proteins suggest that the basic residues following the TM segment are not a `` stop transfer ' ' sequence ( Blobel , G . , 1980 , Proc . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| By means of the expression of two chimeric receptors , alpha2 / m3 and m3 / alpha2 , in which the carboxyl terminal receptor portions , containing transmembrane ( TM ) domains 6 and 7 , were exchanged between the alpha2C adrenergic and the m 3 muscarinic receptor , Maggio et al . ( Maggio , R . , Vogel , Z . , and Wess , J . ( 1993 ) Proc . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| We have earlier shown that green tea ( Camellia sinensis ) polyphenol epigallocatechin 3 gallate ( EGCG ) was non toxic to human chondrocytes [ Singh R , Ahmed S , Islam N , Goldberg VM , and Haqqi TM ( 2002 ) Arthritis Rheum 46 : 2079 2086 ] and inhibits the expression of inflammatory mediators in arthritic joints [ Haqqi TM , Anthony DD , Gupta S , Ahmed N , Lee MS , Kumar GK , and Mukhtar H ( 1999 ) Proc Natl Acad Sci USA 96 : 4524 4529 ] . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| The thrombin / TM complex promotes activation of plasma anticoagulant protein C ( PC ) and negatively regulates blood coagulation . ^^^ |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P04070 |
Pubmed |
SVM Score :0.0 |
| NA |
|