| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| To study factor 7 ( F 7 ) hyperactivity in chronic dialysis patients , we measured the plasma levels of F 7 activity ( F 7 c ) and antigen ( F 7 Ag ) , prothrombin activation fragments 1 + 2 ( F 1 + 2 ) , thrombin antithrombin 3 complexes ( TAT ) , and thrombomodulin in 28 patients on hemodialysis . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| When 200 micrograms / kg 125I thrombomodulin was injected into rabbits , the APTT and TCT were immediately prolonged , whereas no effect on the prothrombin time was seen . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In a purified human system , vitamin K dependent proteins such as factor 10 , prothrombin and prothrombin fragment 1 were able to inhibit protein C activation by the thrombin thrombomodulin complex , using either detergent solubilized thrombomodulin or thrombomodulin reconstituted into vesicles consisting of phosphatidylcholine and phosphatidylserine ( 1 : 1 , w / w ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Inhibition by human thrombomodulin of factor Xa mediated cleavage of prothrombin . ^^^ Human thrombomodulin significantly inhibited the rate of prothrombin conversion to thrombin by Factor Xa in the presence of phospholipid or platelets , calcium , and Factor Va . ^^^ Sodium dodecyl sulfate polyacrylamide gel electrophoresis of 125I prothrombin activation revealed that thrombomodulin reduced the rate of prothrombin activation but did not alter the cleavage pattern . ^^^ If thrombomodulin was replaced by hirudin , the rate of thrombin generation was not decreased excluding the possibility that the inhibition by thrombomodulin was secondary to the binding of small amounts of thrombin formed early in the reaction and the prevention of feedback breakdown of prothrombin by thrombin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Because many commercial thromboplastins are prepared from vessel rich tissues / organs ( lung , brain , placenta ) , it was hypothesized that some preparations may contain significant amounts of thrombomodulin ; theoretically , thrombomodulin contaminations may enhance the prothrombin time . ^^^ However , we were unable to demonstrate that the presence of the thrombomodulin activity in these thromboplastins could affect the prothrombin time either by delaying fibrin formation ( formation of thrombin thrombomodulin complexes ) or by inhibiting activated factor 5 ( formation of activated protein C ) . . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In conclusion , high levels of ( s ) thrombomodulin antigen in the early reperfusion phase and in the perfusate strongly indicate endothelial damage to the graft liver vascular bed , paralleled and followed by signs of prothrombin activation . . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| To understand how these cleavages lead to the exposure of the thrombin anion binding exosite , a major macromolecular recognition site , interactions of recombinant human prothrombin derivatives with thrombomodulin , and an exosite specific antibody were studied by competition binding and immunoprecipitation . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The clinical significance of markers , such as , soluble fibrin monomer complex , FDP D dimer , prothrombin fragment 1 + 2 , thrombin antithrombin 3 complex , plasmin alpha 2 plasmin inhibitor complex and plasma thrombomodulin in our patients with disseminated intravascular coagulation ( DIC ) due to abdominal sepsis and malignancy is discussed . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| On examining the relationship between outcome and hemostatic indicators , we found that the PT ratio and the levels of antithrombin , plasminogen , PPIC , the PPIC / TAT ratio , and thrombomodulin were related to outcome , suggesting that very high consumption of blood coagulation factors , liver dysfunction , hypofibrinolysis , or organ failure caused a poor outcome . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Exosite 2 interacts with heparin , the chondroitin sulfate moiety of thrombomodulin and prothrombin activation fragment 2 . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The data are consistent with a mechanism whereby thrombomodulin alters thrombin specificity by either binding to or allosterically altering a site on thrombin distinct from the catalytic center required for binding or steric accommodation of fibrinogen , prothrombin fragment 2 , heparin cofactor 2 , and hirudin . . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| To study this , a cross sectional comparison of the plasma levels of thrombomodulin ( TM ) , platelet factor 4 ( PF 4 ) , beta thromboglobulin ( beta TG ) , prothrombin fragment 1 + 2 ( F 1 + 2 ) and total degradation products of fibrin ( ogen ) ( TDP ) was made between 5 ET patients suffering from erythromelalgia , 16 asymptomatic ET patients and 20 control subjects , and after treatment with aspirin , respectively . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In recent years , such a role has been reported also for prothrombin , activated Protein C , Protein S , Annexin 5 , Thrombomodulin , high and low molecular weight kininogens . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Protein C and S activity , antithrombin 3 , thrombomodulin and prothrombin fragments 1 + 2 ( F 1 + 2 ) were assessed together with fibrinogen , triglycerides , total and high density lipoprotein ( HDL ) cholesterol concentrations . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The plasma levels of fibrinogen ( p < 0 . 02 ) , prothrombin fragment 1 + 2 ( p < 0 . 05 ) , fibrin monomer ( p < 0 . 0001 ) , protein C antigen ( p < 0 . 005 ) , total protein S antigen ( p < 0 . 02 ) , soluble thrombomodulin ( p < 0 . 005 ) and soluble E selectin ( p < 0 . 005 ) were significantly higher in diabetic patients than in healthy subjects . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| This review summarizes data on changes in thrombin conformation induced by various ligands including hirudin , hirugen , similar acidic peptides , fibrinogen , thrombomodulin , heparin , antithrombin , prothrombin , and platelet receptor . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In the absence of other inhibitors , protein C ( 65 nM ) in combination with high concentrations of soluble thrombomodulin ( 10 nM ) resulted in a reduced rate of thrombin generation during the propagation phase without affecting the initiation phase ; the activated protein C generated failed to neutralize prothrombinase activity and did not prevent prothrombin consumption . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Prothrombin , antithrombin and thrombomodulin were also determined . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Prothrombin fragment 1 + 2 , thrombin antithrombin 3 complex and fibrinopeptide A were tested for coagulation , platelet factor 4 and beta thromboglobulin for platelet activation , glycoprotein IIb IIIa , glycoprotein Ib and P selectin for platelet membrane glycoproteins , D dimers for fibrinolysis , thrombomodulin for activation of endothelial cells and thrombospondin and von Willebrand factor for adhesive proteins . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We conducted brain magnetic resonance imaging and measured the levels of fibrinogen , molecular markers of coagulation activation [ prothrombin fragment 1 + 2 ( F 1 + 2 ) ] and endothelial cell damage [ von Willebrand factor ( vWF ) and thrombomodulin ] , and lipid profiles including lipoprotein ( a ) [ Lp ( a ) ] in 178 asymptomatic , high risk , Japanese subjects aged 44 to 93 years . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The new molecular markers recently introduced can show the existence of a preclinical state of blood activation at the plasma level ( fibrinopeptide A , thrombin antithrombin complexes , modified antithrombin 3 , fragments 1 + 2 of prothrombin , D dimer ) or at the platelet level ( B thromboglobulin , platelet factor 4 , and thrombospondin ) , and promising developments concern the endothelial level ( soluble thrombomodulin ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| All patients had serial coagulation studies , including prothrombin split products ( F1 / F2 ) , fibrinopeptide A ( FPA ) , protein C ( PC ) , thrombomodulin ( TM ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , fibrinopeptide B beta 15 42 ( FPB beta 15 42 ) , haemoglobin and platelet counts determined intra and postoperatively . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Plasma levels of fibrin D dimer , thrombin antithrombin complex ( TAT ) , plasmin plasmin inhibitor complex ( PPIC ) , soluble fibrin monomer ( sFM ) , prothrombin activated peptide F 1 + 2 ( F 1 + 2 ) , thrombomodulin ( TM ) , tissue type plasminogen activator ( t PA ) , and PA inhibitor ( PAI 1 ) in DIC patients were significantly higher than levels in Non DIC patients . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We typed 7 additional genes in the CEPH reference families , i . e . the factor 5 , factor 12 , protein C , protein S , prothrombin , thrombomodulin , and heparin cofactor 2 gene . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Laboratory investigation included aCL , thrombin generation markers , such as thrombin antithrombin 3 complexes and prothrombin fragments 1+2 , as well as thrombomodulin , soluble P selectin , E selectin and the vascular cell adhesion molecule 1 , as endothelial activation markers . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In order to elucidate the underlying mechanism of hypercoagulable state , was studied following markers of coagulation and fiblinolysis in 69 DMD and 50 control patients showing no signs of thrombosis : prothrombin time , activated partial thrombin time , thrombotest , fibrinogen , fibrinogen degradation product , thrombin antithrombin 3 complex ( TAT ) , alpha 2 plasmin inhibitor plasmin complex ( PIC ) , D dimer , protein C activity , protein S , antithrombin 3 , 12 factor , thrombomodulin and plasminogen activity . 66 out of 69 patients ( 96 % ) showed abnormal results in more than one of these studies , among which abnormally low thrombotest ( 78 % ) , high TAT ( 61 % ) and high PIC ( 40 . 3 % ) , were very frequently observed . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Components of the coagulation ( thrombin antithrombin complexes , prothrombin fragment F 1 + 2 , activated factor 7 , and factor 7 antigen ) and fibrinolytic ( fibrin split product D dimer , plasmin plasmin inhibitor complex , tissue type plasminogen activator , urokinase type plasminogen activator , and plasminogen activator inhibitor 1 ) systems and markers of endothelial cell perturbation / dysfunction ( von Willebrand factor and thrombomodulin ) were measured before the start of infusion and after 2 , 6 , 12 , and 24 hours . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Other causes of inherited thrombophilia include abnormalities in the proteins of the fibrinolytic system , dysfibrinogenemias , deficiency of heparin cofactor 2 , abnormal thrombomodulin , elevated levels of histidine rich glycoprotein , and the recently described variation in the prothrombin gene . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We examined the systemic lupus erythematosus ( SLE ) patients with aCL and / or LA for differences in the markers for hypercoagulable state , including thrombin antithrombin complex ( TAT ) , prothrombin fragment 1 + 2 ( F 1 + 2 ) , thrombomodulin ( TM ) and activated factor 7 ( FVIIa ) , and lipoprotein ( a ) ( Lp ( a ) ) , which is a well known risk factor for thrombosis . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| This study reports on the predictive value of some haemostatic factors [ fibrinogen , factor 7 and plasminogen activator inhibitor ( PAI ) ] , a marker of endothelial damage ( soluble thrombomodulin ) and several markers of haemostatic system activation ( factor VIIa , prothrombin fragment 1+2 , thrombin antithrombin complexes and D dimers ) on the incidence of vascular events in male , non diabetic patients with chronic ischaemia of the lower limbs . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In particular , we describe tissue factor , tissue factor pathway inhibitor , prothrombin fragment 1 . 2 , thrombin antithrombin complex , fibrinopeptide A , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , t PA PAI complex , Bbeta 15 42 related peptides , fibrinogen degradation products , fibrin degradation products , D dimer , platelet factor 4 , beta thromboglobulin , 5 hydroxytryptamine , thromboxane B 2 , prostacyclin , endothelin , angiotensin converting enzyme , soluble thrombomodulin , C 1 esterase inhibitor , anaphylotoxins C3a , C4a , and C5a , bradykinin , tumor necrosis factor , leukotriene C 4 , platelet activating factor , anti phospholipid antibody , and von Willebrand factor . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| METHODS : We identified the ACE I / D genotype and measured the plasma levels of markers of endothelial cell damage ( von Willebrand factor [ vWF ] and thrombomodulin ) and of coagulation activation ( prothrombin fragment F 1 + 2 [ F 1 + 2 ] ) in 318 asymptomatic elderly patients with hypertension , aged 59 93 years . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| There are no functional tests for the prothrombin mutant G20210A and thrombomodulin mutations , which can be diagnosed by a PCR based test or by gene analysis , respectively . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Plasma concentrations of thrombin antithrombin 3 complex ( TAT ) , modified antithrombin ( ATM ) , prothrombin fragment F1+2 , free protein S , thrombomodulin , and protein C antigen were determined by ELISA . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Other causes of inherited thrombophilia include hyperhomocysteinemia , abnormalities in the proteins of the fibrinolytic system , dysfibrinogenemias , deficiency of heparin cofactor 2 , abnormal thrombomodulin , and the recently described variation in the prothrombin gene . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The plasma levels of von Willebrand factor ( vWF ) antigen ( P < 0 . 01 ) and thrombomodulin ( TM ) ( P < 0 . 05 ) , as well as those of thrombin antithrombin 3 ( TAT ) complex ( P < 0 . 05 ) , prothrombin fragment 1+2 ( F1+2 ) ( P < 0 . 02 ) , D dimer products of crosslinked fibrin degradation products ( D dimer ) ( P < 0 . 01 ) , and plasmin antiplasmin ( PAP ) complex ( P < 0 . 05 ) in the patients were also significantly higher than those in the controls . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Platelet count , antithrombin , fibrinogen , prothrombin fragment F1+2 , soluble thrombomodulin , tissue plasminogen activator , D dimer , and plasminogen activator inhibitor 1 antigen were investigated . ^^^ RESULTS : Forty five percent of our patients showed an increase in fibrinogen , 29 % in prothrombin fragment F1+2 , and 20 % in platelet count , plasminogen activator inhibitor antigen , and soluble thrombomodulin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In this study , protein C ( PC ) , protein S ( PS ) , heparin cofactor 2 ( HCFII ) , prothrombin fragment 1+2 ( PF 1 , 2 ) , thrombin antithrombin 3 complex ( TAT ) , von Willebrand factor ( vWF ) and thrombomodulin ( TM ) were investigated in 19 patients with acute lymphoblastic leukemia , ( ALL ) receiving combined chemotherapy including L asparaginase ( L ASP ) and high dose methylprednisolone ( HDMP ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Prothrombin fragment 1+2 ( F1+2 ) , thrombin antithrombin 3 complexes ( TAT ) , tissue type plasminogen activator ( t PA ) functional and antigen , plasminogen activator inhibitor 1 ( PAI 1 ) , plasminalpha 2 antiplasmin complexes ( PAP ) , D Dimer , thrombomodulin ( TM ) and von Willebrand factor ( vWF ) were measured in patients and in 30 healthy subjects . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We sought evidence for changes in the following parameters : platelet count , von Willebrand factor antigen ( vWF : Ag ) and activity ( vWF activity ) , beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) , platelet activation markers ( GMP 140 and PAC 1 ) , activated partial thromboplastin time ( aPTT ) , prothrombin time ( PT ) , coagulant factor 8 ( FVIII : C ) , thrombin antithrombin complex ( TAT ) , prothrombin fragment 1+2 ( F1+2 ) , thrombomodulin ( TM ) and tissue plasminogen activator antigen ( tPA : Ag ) prior to G CSF and immediately before leukapheresis . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We have recently demonstrated the inability of porcine tissue factor pathway inhibitor ( TFPI ) to adequately neutralize human factor Xa ( FXa ) , the aberrant activation of both human prothrombin and FXa by porcine EC and the failure of the porcine natural anticoagulant , thrombomodulin to bind human thrombin and hence activate human protein C . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Activated partial thromboplastin time , PT INR , TT % and protein C activity were significantly correlated with the dose of warfarin ; fibrinogen , activated thromboplastin , TAT , PPIC , D dimer , sFM , protein S and thrombomodulin were not significantly correlated with the dose of warfarin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In this study , protein C ( PC ) , protein S ( PS ) , heparin cofactor 2 ( HCFII ) , prothrombin fragment 1+2 ( PF 1 , 2 ) , thrombin antithrombin 3 complex ( TAT ) , von Willebrand factor ( vWF ) and thrombomodulin ( TM ) were investigated in 13 patients with beta thalassemia intermedia ( TI ) not requiring transfusion , six patients with sickle cell disease ( SCD ) , and seven patients with HbS beta thalassemia ( S BT ) who were not in crisis . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We found normal plasma fibrinogen , protein C , protein S , C4b binding protein , thrombomodulin , antithrombin 3 , thrombin antithrombin 3 complex , prothrombin fragment 1 . 2 , plasminogen , tissue plasminogen activator , alpha 1 antitrypsin , alpha 2 macroglobulin and protein Z . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Hereditary predisposition to venous thrombosis may be related to lesions in one or more of 10 15 genes encoding antithrombin , Protein C , Protein S , Factor 5 , prothrombin , enzymes of the homocysteine metabolic pathway , fibrinogen , heparin cofactor 2 , plasminogen and thrombomodulin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| METHODS : prothrombin fragment 1+2 tissue plasminogen activator , protein S and C , antithrombin , fibrinogen , von Willebrand factor , thrombomodulin and prothrombin time ( PT ) were measured in patient plasma . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Plasma levels of : von Willebrand Factor ( vWF ) , thrombomodulin , plasminogen activity inhibitor type 1 ( PAI 1 : antigen and activity ) , tissue type plasminogen activator ( t PA : antigen ) , prothrombin fragment 1+2 ( F1+2 ) and thrombin antithrombin complexes ( TAT ) were measured previously to CRRT ( base line ) , and after 24 and 48 hours of therapy . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Patients with SIRS presented significantly higher values ( p < 0 . 001 ) for factors related to endothelial damage [ von Willebrand factor ( vWF ) , thrombomodulin , tissue plasminogen activator ( t PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen ] , hypercoagulability [ prothrombin fragment 1+2 ( F1+2 ) and thrombin antithrombin complexes ( TAT ) ] , and fibrinolysis ( D dimer and PAI activity ) with respect to the control group . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In patients with ET ( n = 37 ) and PV ( n = 34 ) , a series of PMN activation parameters ( PMN membrane CD11b and leukocyte alkaline phosphatase [ LAP ] antigen expression , cellular elastase content , plasma elastase , and myeloperoxidase levels ) was evaluated simultaneously with the levels of plasma markers of endothelial damage ( thrombomodulin and von Willebrand factor antigen ) and hypercoagulation ( thrombin antithrombin complex , prothrombin fragment 1 + 2 , and D dimer ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The genes considered are ; alpha fibrinogen , beta fibrinogen , gamma fibrinogen , prothrombin , tissue factor , factor 5 , protein S , complement component 4 binding protein , factor 11 , factor 12 , factor XIIIa , factor XIIIb , histidine rich glycoprotein , high molecular weight kininogen , kallikrein , von Willebrands factor , platelet factor 4 , thrombospondin , antithrombin 3 , alpha 1 antitrypsin , thrombomodulin , plasminogen , tissue plasminogen activator , urokinase plasminogen activator , plasminogen activator inhibitor 1 , plasminogen activator inhibitor 2 , protein C inhibitor , alpha 2 plasmin inhibitor , kallistatin , lipoprotein a , interleukin 6 , interleukin 1 , cystathionine beta synthase , and methylenetetrahydrofolate reductase . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Soluble thrombomodulin ( sTM ) , prothrombin fragments F1+2 ( F1+2 ) , thrombin antithrombin complexes ( TAT ) , plasmin antiplasmin complexes ( PAP ) , and TAFI were measured with commercially available kits . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We measured plasma prothrombin fragment 1 . 2 ( PF1 . 2 ) and p selectin , fibrinogen , thrombomodulin , and d dimer . ^^^ With multivariate analysis , both p selectin and prothrombin fragment levels significantly predicted rejection . p Selectin levels were predictive of prothrombin fragment levels ( P < 0 . 0001 ) but not of d dimer , fibrinogen , or thrombomodulin levels . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The main outcome measures were N 3 fatty acid proportions of platelet lipids , transcapillary escape rate of albumin , prothrombin fragment 1 + 2 , thrombin antithrombin complexes , markers of fibrinolysis , fibrinogen , factor 7 antigen and activity , thrombomodulin , von Willebrand factor , platelet factor 4 and beta thromboglobulin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Levels or presence of protein C , protein S , antithrombin , methylenetetrahydrofolate reductase C677T , factor 5 Leiden , prothrombin gene G20210A , antiphospholipid antibodies , plasminogen , tissue type plasminogen activator ( tPA ) , type 1 tPA inhibitor ( PAI 1 ) , PAI 1 4G / 5G polymorphism , prothrombin fragment 1+2 , plasmin / alpha ( 2 ) antiplasmin complexes , thrombomodulin , and activated factors 7 and 12 were determined . ^^^ Compared with control subjects , however , the Behet ' s disease group had elevated mean ( + / SD ) levels of prothrombin fragment 1+2 ( 2091 + / 1323 pmol / L vs . 804 + / 398 pmol / L , P < 0 . 001 ) , plasmin / alpha2 antiplasmin complexes ( 410 + / 220 microg / L vs . 214 + / 92 microg / L , P < 0 . 001 ) , and thrombomodulin ( 37 + / 24 ng / mL vs . 27 + / 10 ng / mL , P < 0 . 001 ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Using a multivariate analysis the carbonyl content of plasma protein was positively associated with procoagulant markers such as prothrombin F 1 + 2 ( r = 0 . 28 , P = 0 . 0019 ) and fibrinopeptide A , ( FpA ) ( r = 0 . 278 , P = 0 . 003 ) , as well as with the soluble derivative of the endothelial protein thrombomodulin ( TM ) ( r = 0 . 469 , P < 0 . 0001 ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The inability of porcine tissue factor pathway inhibitor ( TFPI ) to adequately neutralize human factor Xa ( FXa ) , the aberrant activation of both human prothrombin and FXa by porcine EC and the failure of the porcine natural anticoagulant , thrombomodulin to bind human thrombin and hence activate human protein C may all be pathogenetic in the DIC following xenograft rejection . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| This pilot study examined Factor 5 Leiden ( R506Q ) , prothrombin ( 20210G > A ) , thrombomodulin ( A455V ) and MTHFR ( 677C > T ) in 100 Zulu speaking black South African women with placental abruption and 217 controls . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The plasmatic levels of the following haemostatic factors were measured within the first 6 h of the SIRS evolution : von Willebrand Factor ( vWF ) , thrombomodulin , plasminogen activity inhibitor type 1 ( PAI 1 antigen ) , tissue type plasminogen activator ( t PA antigen ) , prothrombin fragment 1 + 2 ( F 1 + 2 ) , thrombin antithrombin complexes ( TAT ) and D dimer . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The characterized binding interfaces have included those between thrombin and fibrinogen , between thrombin and thrombomodulin , between factor VIIIa and the cell membrane , between tissue factor and factor VIIa , and most recently between factor Va and prothrombin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| METHODS : The effects of 3 month erythropoietin treatment on some hemostatic parameters TAFI , fibrinolytic activity index ( FAI ) , markers of ongoing coagulation ( thrombin antithrombin complexes and prothrombin fragments 1 + 2 ) , marker of ongoing fibrinolysis ( plasmin antiplasmin complexes ) and marker of endothelial cell injury ( thrombomodulin ) were studied in 17 patients on continuous ambulatory peritoneal dialysis ( CAPD ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The most common inherited thrombotic disorders include activated protein C ( APC ) resistance ( factor 5 Leiden ) , hyperhomocysteinemia , the prothrombin gene variant G20210A , elevated factor 8 levels , and deficiencies of thrombomodulin , protein C , protein S , and antithrombin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| None of the endothelial cell markers ( thrombomodulin , P selectin , E selectin , intracellular adhesion molecule , vascular cell adhesion molecule ) , thrombin and plasmin generation markers ( thrombin antithrombin complexes , prothrombin fragments 1 + 2 , plasmin antiplasmin complexes , D dimers ) , protein C , protein Z , vascular endothelial growth factor , and TAFI concentration and activity were directly correlated with the level of proteinuria , albumin , cholesterol , triglycerides or creatinine , except significant positive correlations between TAFI activity and serum creatinine , E selectin and albumin as well as negative correlations between plasmin antiplasmin complexes and proteinuria . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The aim of the study was to assess whether 6 months of EPO therapy affects platelet function , that is , platelet aggregation and P selectin level ; moieties of the extrinsic coagulation pathway : TF , TFPI , and TFPI / Xa complexes , and factors 7 and 10 ; markers of ongoing coagulation : thrombin antithrombin complexes ( TAT ) and prothrombin fragments 1+2 ; a marker of ongoing fibrinolysis : plasmin antiplasmin complexes ( PAP ) ; fibrinolytic activity : euglobulin clot lysis time ( ECLT ) ; and markers of endothelial cell injury : von Willebrand factor , thrombomodulin , E selectin , and TAFI , in continuous ambulatory peritoneal dialysis ( CAPD ) patients . ^^^ Thrombomodulin , von Willebrand factor concentration and activity , PAP , TAT , TFPI / Xa complexes , prothrombin fragments 1+2 , factor 10 activity , P selectin , E selectin , and lipoprotein ( a ) did not change significantly during EPO treatment . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We also measured D dimer , lipid pattern , soluble E selectin , platelet surface P selectin , prothrombin fragments 1 + 2 ( F 1 + 2 ) , lipoprotein ( a ) , factor 7 , von Willebrand factor , plasma insulin , fibrinogen , homocysteine , thrombin activable fibrinolysis inhibitor ( TAFI ) activity , thrombomodulin , factor 13 , urokinase type plasminogen activator . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We evaluated thrombin antithrombin ( TAT ) complexes , prothrombin fragments 1+2 , thrombomodulin , plasmin antiplasmin ( PAP ) complexes , TAFI , P selectin , and lipoprotein ( a ) , 1 , 2 , and 3 months before and after fluvastatin treatment and in normolipaemic kidney transplant recipients and healthy volunteers . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Exosite interactions can be with the substrate , cofactors such as thrombomodulin , or fragments from prothrombin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Absence of Factor 5 Leiden , thrombomodulin and prothrombin gene variants in Black South African women with pre eclampsia and eclampsia . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The changes in prothrombin time ( PT ) ratio , fibrinogen , fibrin and fibrinogen degradation products ( FDP ) , antithrombin , and protein C , thrombin antithrombin complex ( TAT ) , plasmin plasmin inhibitor complex ( PPIC ) , and soluble fibrin monomer complex ( SFMC ) in all patients with DIC were significant during the clinical course of DIC , but those of D dimer , thrombomodulin ( TM ) , tissue factor ( TF ) , and tissue factor pathway inhibitor ( TFPI ) were not . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In mammalian blood coagulation , five proteases ( factor 7 [ FVII ] ; factor 9 [ FIX ] ; factor 10 [ FX ] ; protein C [ PC ] and prothrombin [ PT ] ) act with five cofactors ( tissue factor [ TF ] ; factor 5 [ FV ] ; factor 8 [ FVIII ] ; thrombomodulin and protein S ) to control the generation of fibrin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The polymorphisms include mutations in coagulation factor genes ( Factor 5 , Prothrombin , Fibrinogen , Factor 7 , Factor 13 , PAI 1 ) , platelet activation / function ( GpIIb / IIIa , GpIb 9 5 , GpIa / IIa ) , vascular reactivity ( ACE ) , endothelial cell function ( MTHFR , thrombomodulin , VCAM 1 , E Selectin , L Selectin , P Selectin , ICAM 1 ) , inflammation ( TNFalpha ) , lipid metabolism ( Apo A 1 , Apo E ) , and cell adhesion ( VCAM 1 , E Selectin , L Selectin , P Selectin , ICAM 1 ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| MATERIAL / METHODS : We investigated the relationship between polymorphisms in the Factor 5 ( Leiden ) , prothrombin ( 20210 GgA ) and thrombomodulin ( Ala455Val ) genes in patients with a myocardial infarction ( MI ) < 45 years of age ( n=195 ) and in unaffected siblings ( n=107 ) and unrelated healthy race matched individuals drawn from the same community ( n=300 ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Additionally , we evaluated thrombin activity ( thrombin antithrombin complex TAT , prothrombin fragments 1 + 2 ) ; TAFI activator ; thrombomodulin ( TM ) , catalyzer of TAFI activation ; and the degree of plasmin generation ( plasmin antiplasmin complex PAP ) using commercially available kits . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The changes in prothrombin time , international normalized ratio and activated partial thromboplastin time as well as thrombomodulin , tissue factor and plasminogen activator inhibitor after the infusion are presented . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We assessed : TAFI concentration , markers of ongoing coagulation : thrombin antithrombin complexes , prothrombin fragments 1 + 2 ( markers of TAFI activation ) , a marker of ongoing fibrinolysis : plasmin antiplasmin complexes , a marker of TAFI cataliser to TAFIa thrombomodulin using commercially available kits . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The average values of prothrombin time ( international normalized ratio ) and plasma levels of prothrombin fragment ( 1+2 ) , D dimer , plasmin alpha 2 antiplasmin complex , thrombomodulin and E selectin were higher in patients receiving antiparkinsonian agents as compared to the patients without any medication or healthy controls . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Immediately prior to the infusion of rh FVIIa , the plasma levels of tissue factor ( TF ) , Thrombomodulin ( TM ) , human soluble ICAM 1 ( hs ICAM 1 ) , human soluble VCAM 1 ( hs VCAM 1 ) , human soluble L Selectin ( hs L Selectin ) , the prothrombin time and the activated partial thromboplastin time were determined . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical labeling for von Willebrand factor , tissue factor , factor 12 , tissue factor pathway inhibitor , thrombomodulin , protein C , protein S and prothrombin activation fragment F 1 + 2 was performed . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Both IMT and Cu / Zn superoxide dismutase were positively correlated with age , thrombomodulin , vWF : Ag , tissue factor , tissue factor pathway inhibitor , prothrombin fragment F 1 + 2 , monocte chemo attractant protein 1 , macrophage inflammatory protein 1 beta , and tumour necrosis factor alpha levels . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Factor 5 gene , prothrombin gene and tissue factor gene in clotting system , thrombomodulin gene and antithrombin 3 in anticlotting system , plasminogen activator inhibitor 1 gene in fibrinolytic system , are related with hypercoagulability tightly . . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In the atherosclerotic patients prothrombin fragment F1+2 and soluble thrombomodulin ( sTM ) were associated with homocysteine in univariate analyses ( P = 0 . 003 and P = 0 . 001 , respectively ) , but not in multivariate analyses . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Levels of platelet ( PLT ) , D dimer , protein C ( PC ) , protein S ( PS ) , antithrombin 3 ( ATIII ) , thrombomodulin ( TM ) , tissue plasminogen activator ( TPA ) , plasminogen activator inhibitor ( PAI 1 ) , prothrombin test ( PT ) , thrombin time ( TT ) , activated partial thromboplastin time ( APTT ) and fibrinogen ( FBG ) were measured in all the patients and healthy persons . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The results of this study demonstrated that the levels of prothrombin activation fragment 1+2 ( F1+2 ) , thrombin antithrombin 3 complex ( TAT ) and Beta thromboglobulin ( beta TG ) in the left atrium of the patients with mitral stenosis were significantly higher than those in the femoral vein and femoral artery , whereas the level of thrombomodulin was significantly lower in the left atrium compared with the femoral artery and vein . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The most common inherited thrombotic disorders include activated protein C resistance ( factor 5 Leiden ) , prothrombin G20210A mutation , hyperhomocysteinemia , deficiencies of protein C , protein S , antithrombin 3 , and thrombomodulin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Using commercially available kits we evaluated thrombin activity as thrombin antithrombin complexes ( TAT ) , prothrombin fragments ( 1 + 2 ) , thrombin activatable fibrinolysis inhibitor ( TAFI ) , TAFI activator , thrombomodulin ( TM ) a marker for endothelial cell injury , plasmin generation ( plasmin antiplasmin complex PAP ) , a glycoprotein linking coagulation and fibrinolysis . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Significant positive correlations between M CSF , and plasma levels of thrombomodulin ( TM ) , von Willebrand factor antigen ( vWF ) , thrombin antithrombin 3 complex ( TAT ) , prothrombin fragment 1+2 ( F1+2 ) , d dimer products cross linked fibrin degradation products ( d dimer ) and plasmin antiplasmin complex ( PAP ) were also found . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We also evaluated thrombin activity ( thrombin antithrombin complexes , prothrombin fragments 1 + 2 ) , TAFI activator , thrombomodulin , a catalyzer of TAFI activation and a marker of endothelial cell injury , and the degree of plasmin generation ( plasmin antiplasmin complexes ) . ^^^ Thrombin antithrombin complexes , plasmin antiplasmin complexes , prothrombin fragments 1 + 2 , and thrombomodulin did not differ between patients anticoagulated with dalteparin and enoxaparin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Biological markers of EC and hypercoagulability were measured and included thrombomodulin , tissue factor , tissue factor pathway inhibitor , von Willebrand factor ( vWF ) , coagulation factor 7 ( FVII ) , activated factor 7 , prothrombin fragment 1 + 2 ( F 1 + 2 ) , and D dimer . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The following were measured on baseline plasma samples : intercellular adhesion molecule ( ICAM ) , thrombomodulin , tissue factor plasma inhibitor , prothrombin fragments 1 and 2 , and D dimers . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These data demonstrate that rhFVIIa administration to individuals with liver disease results in ( 1 ) a transient improvement in the prothrombin time ; ( 2 ) no change in the activated partial thromboplastin time ; and ( 3 ) a marked reduction in the levels of thrombomodulin and tissue factor . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| METHODS : Hemostatic status of 32 asymptomatic young individuals carrying these mutations and of 18 normal control individuals was investigated through the determination of plasma thrombomodulin ( TM ) , prothrombin fragment 1+2 ( F1+2 ) , thrombin antithrombin complex ( TAT ) and D dimer . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Additionally , we evaluated thrombin activity ( thrombin antithrombin complex [ TAT ] , prothrombin fragments 1+2 [ F1+2 ] ) , thrombomodulin ( TM ) , and the degree of plasmin generation ( plasmin antiplasmin complex [ PAP ] ) using commercially available kits . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Of the four participants , participant 10 had the highest baseline values of prothrombin fragments 1 and 2 , thrombin antithrombin 3 complexes , tissue plasminogen activator , plasminogen activator inhibitor 1 , D dimer and soluble thrombomodulin . ^^^ Over time , in participant 10 , venous prothrombin fragments 1 and 2 , thrombin antithrombin 3 complexes , and soluble thrombomodulin decreased in both limbs ; D dimer decreased in the lower limbs but increased in the upper limbs ; the tissue plasminogen activator / plasminogen activator inhibitor 1 molar ratio increased in both limbs ; and minimal changes were noted in haematocrit . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We have therefore examined human scars for the expression of thrombin , its precursor prothrombin and the thrombin receptors , thrombomodulin ( TM ) and protease activated receptor 1 ( PAR 1 ) , compared with normal skin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The development of APCR led to many other investigations of gene polymorphism , such as prothrombin 20210 , thrombomodulin , factors in the coagulation and fibrinolytic system , glycoproteins of platelet membranes , as well as polymorphism C677T of methylene tetrahydrofolate reductase . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Ethidium bromide to DNA ratio of 1 . 25 and netropsin or Hoechst 33258 to DNA ratio of 0 . 1 the Tm of d ( pT ) 10 . poly ( dA ) was increased by 10 degrees and 25 degrees C respectively . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The fluorescence transition midpoints ( expressed as Tm ) occur at the following concentrations of ions : Ca2+ , 0 . 22 ( 0 . 35 ) mM ; Mg2+ , 0 . 22 ( 0 . 45 ) mM ; Mn2+ , 12 . 6 ( 12 . 6 ) muM ; and Gd3+ , 3 . 6 ( 5 . 3 ) muM ( the values in parentheses indicate the concentration of the respective ions bound to bovine prothrombin fragment 1 ) . ^^^ Tm values for Ca2+ binding in the presence of phospholipid are 0 . 21 mM and 0 . 22 mM for binding to human and bovine prothrombin fragment 1 , respectively . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| This rapid increase in TM occurred before the decrease in fibrinogen content and the prolongation of prothrombin time . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Sufficient concentrations of POPC / bovPS ( 75 / 25 ) large unilamellar vesicles to guarantee binding of 95 % of prothrombin resulted in an enthalpy loss in the main endotherm and a comparable enthalpy gain in the minor endotherm accompanying an upward shift in peak temperature ( Tm approximately 73 degrees C ) . ^^^ Peak deconvolution analysis on the prothrombin denaturation profile and comparison with isolated prothrombin fragment 1 denaturation endotherms suggested that the change caused by POPC / PS vesicles reflected a shift of a portion of the enthalpy of the prethrombin 1 domain to higher temperature ( Tm approximately 77 degrees C ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Substitution of glutamic acid 49 , which is located in the hydrophobic `` pit ' ' of an eight fold alpha / beta barrel , by a hydrophobic phenylalanine residue increases the tm from 56 to 60 degrees C . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Ca2+ titrations of the intrinsic fluorescence of a series of gamma carboxyglutamic acid ( GLA ) deficient bovine prothrombin fragments 1 yield response Hill plot parameters useful for characterization of the metal ion binding process . 11 , 10 , and 9 GLA fragments 1 exhibit Tm ( the ( Ca2+ ) total concentration at which ln ( B / F ) = 0 in the response Hill plot ) values between 0 . 2 and 0 . 3 mM . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In support of this concept , we observed that prothrombin and fragment 1 , which bind to negatively charged phospholipids , do not inhibit protein C activation on endothelial cells or TM incorporated into phosphatidylcholine vesicles , but do inhibit when TM is incorporated into phosphatidylcholine : phosphatidylserine vesicles . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The [ cis Pt ( NH 3 ) 2 ( d ( GCCGGATCGC ) N 7 ( 4 ) , N 7 ( 5 ) ) ] d ( GCGATCCGGC ) duplex has been prepared with Tm = 49 degrees C ( vs 58 degrees C for the unplatinated form ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In cultures of lymphocytes from 12 healthy donors and 12 patients with nettle rash ( NR ) the anticlastogenic effect of the antimutagens WR 2721 ( WR ) , bemitil ( BM ) , tomerzol ( TM ) and interferon ( IF ) on the induction of chromosomal aberrations by photrin ( PT ) and dioxidine ( DX ) was investigated . ^^^ Statistically significant protective effects of BM , WR , TM and IF were demonstrated in cells of healthy donors after treatment with PT or DX , and after modification of the clastogenic action of PT in lymphocytes of NR patients . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Anion binding exosite 1 interacts with the growth factor region of TM while exosite 2 is involved in binding prothrombin activation fragment 2 or heparin . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| J . 60 , 70 ] that binding to PS / POPC ( 25 / 75 ) large unilamellar vesicles resulted in an enthalpy loss in the main endotherm of prothrombin denaturation ( Tm approximately 57 58 degrees C ) and a comparable enthalpy gain in a minor endotherm ( Tm approximately 59 degrees C ) accompanying an upward shift in peak temperature ( Tm approximately 73 degrees C ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The uptake and excretion rates of 23 elements , Be , Mn , Co , Zn , As , Rb , Sr , Y , Zr , Ce , Pm , Eu , Gd , Tb , Er , Tm , Yb , Lu , Hf , W , Re , Ir and Pt , were simultaneously determined under strictly identical experimental conditions . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The morphology of the tympanic membrane ( TM ) and external auditory canal ( EAC ) in mice was examined by transmission electron microscopy , in seven different regions : the handle of the malleus ( HM ) region , the intermediate and annular regions of the pars tensa ( PT ) , the region of the pars flaccida ( PF ) , the annular and osseous regions of the EAC and the cartilaginous region of the EAC . ^^^ In most regions of the TM and EAC except the intermediate region of the PT basal layer cells formed cytoplasmic processes ( CPs ) on their basal surface and adhered to the basement membrane ( BM ) by means of hemidesmosomes ( HDs ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The percentage of administered dose of the 17 elements , Mn , Co , Zn , As , Rb , Sr , Y , Eu , Gd , Er , Tm , Yb , Lu , W , Re , Ir and Pt in the organs blood and excreta were determined using gamma ray spectrometry . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that isolated TM red blood cells ( RBC ) strongly enhance prothrombin activation , suggesting an increased membrane exposure of procoagulant phospholipids ( i . e . phosphatidylserine ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Intravenous dose response studies were performed and thrombus mass ( TM ) , activated partial thromboplastin time ( APTT ) , prothrombin time ( PT ) , inhibition of ex vivo fXa activity and plasma drug levels ( PDL ) were determined . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| As a whole , the pTM pattern during foetal maturation appears totally different from that of protein C , prothrombin and other coagulation activators and inhibitors and thus , TM may play in the foetus another role in addition to its well known anticoagulant function . . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The multi element ( Ag , Al , Au , Ba , Bi , Ca , Cd , Co , Cr , Cs , Cu , Dy , Er , Fe , Ga , Gd , Ho , In , Ir , La , Lu , Mn , Mo , Nb , Nd , P , Pb , Pd , Pr , Pt , Rb , Re , Rh , Ru , Sb , Sc , Sm , Sn , Sr , Ta , Tb , Th , Ti , Tl , Tm , U , 5 , Y , Yb , and Zn ) concentrations ( microg / kg , fresh weight ) in potatoes ( Solanum tuberosum , Folva ) were investigated in this study . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| INTERVENTIONS : Quantitative assessment of ME volume displaced by retraction of the PT was achieved by measuring the amount of fluid needed to fill up the retracted part of a TM . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Reactivity of the free enzyme toward substrates and inhibitors is attenuated 4 20 fold ; relative to wild type fXa , Spectrozyme Xa ( TM ) hydrolysis is 25 % , inhibition by antithrombin 3 and the tissue factor pathway inhibitor is approximately 20 % , and prothrombin activation in the absence of the cofactor Va is only 5 % . ^^^ Q333D fXa is approximately 1 . 6 fold more reactive with Spectrozyme Xa ( TM ) , antithrombin 3 and tissue factor pathway inhibitor , and prothrombin than its glycosylated counterpart , Q333N fXa , but still quite abnormal relative to wild type fXa . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| To evaluate the relationship of soluble TM in plasma between coagulation and / or fibrinolysis system in patients with diabetes , we measured plasma soluble TM , protein C activity ( a natural anticoagulant induced by thrombin TM complex ) , prothrombin F1+2 ( a direct marker of thrombin generation ) , and plasmin alpha 2 antiplasmin complex ( PAP ) and D dimer ( measures of fibrinolytic activity ) in 55 patients with type 2 diabetes mellitus . ^^^ The plasma concentrations of soluble TM ( P < 0 . 01 ) , protein C activity ( P < 0 . 01 ) , prothrombin F1+2 ( P < 0 . 05 ) , PAP ( P < 0 . 001 ) and D dimer ( P < 0 . 001 ) were significantly higher in the diabetic patients than the 48 age matched control subjects . ^^^ In the diabetic patients , the plasma concentrations of soluble TM were inversely correlated with the protein C activity ( r= 0 . 43 , P < 0 . 005 ) , and were positively correlated with the plasma concentrations of prothrombin F1+2 ( r=0 . 63 , P < 0 . 0001 ) and the plasma PAP concentrations ( r=0 . 30 , P < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| In addition , platelet aggregometry , celite activated clotting time ( Hepcon ( TM ) ACT ) , prothrombin time ( PT ) , and partial thromboplastin time ( PTT ) were measured . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The plasma TM and TF concentrations correlated with prothrombin time , activated partial thromboplastin time , and inversely with factor 7 activity , cholinesterase serum activity , and serum albumin concentration . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Moreover , addition of carboxy terminal c tail to TM substitution mutant , which did not induce the PT and cytochrome c release , restored PT inducing activity . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the previously reported mutations in the TM and EPCR genes , and present the design and evaluation of a new strategy to investigate TM , EPCR , PC and prothrombin gene mutations in arterial and venous thrombosis . . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The hBMP 12 preprotein cDNA was obtained by reverse transcriptional ( RT ) PCR from the mRNA extracted from human placenta , followed by cloning into pTARGETTM plasmid and sequence analysis of the plasmid pT ( ARGE ) T ( TM ) BMP 12 . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| No difference between the groups was observed in plasma thrombus precursor protein , prothrombin fragment 1+2 , D dimer , t PA , PAI 1 , TM and thrombin activatable fibrinolysis inhibitor . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| The activated prothrombin complex concentrate , FEIBA ( TM ) , and recombinant activated factor 7 ( rFVIIa ) are available as haemostatic cover during surgery . ^^^ |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07204 and P00734 |
Pubmed |
SVM Score :0.0 |
| NA |
|