| Interacting proteins: P07199 and P09874 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation and Western blot analyses demonstrate that Cenpa , Cenpb , and Bub 3 , but not Cenpc , interacted with PARP 1 , and are poly ( ADP ribosyl ) ated following induction of DNA damage . ^^^ Centromere proteins Cenpa , Cenpb , and Bub 3 interact with poly ( ADP ribose ) polymerase 1 protein and are poly ( ADP ribosyl ) ated . ^^^ Here we investigated the interaction of this protein with , and poly ( ADP ribosyl ) ation of , three constitutive centromere proteins , Cenpa , Cenpb , and Cenpc , and a spindle checkpoint protein , Bub 3 . ^^^ |
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| Interacting proteins: P07199 and P09874 |
Pubmed |
SVM Score :0.0 |
| Poly ( ADP ribose ) polymerase 2 localizes to mammalian active centromeres and interacts with PARP 1 , Cenpa , Cenpb and Bub 3 , but not Cenpc . ^^^ Co immunoprecipitation assay demonstrates interaction between PARP 2 and its functional homolog PARP 1 , constitutive centromere proteins Cenpa and Cenpb , and spindle checkpoint protein Bub 3 , but not with a third constitutive centromere protein Cenpc . ^^^ These results , together with our previous demonstration that PARP 1 displays an identical binding pattern with Cenpa , Cenpb and Bub 3 , but not Cenpc , and that all three proteins undergo significant poly ( ADP ribosyl ) ation upon gamma irradiation of cells , point to possible diverse roles of PARP 2 and PARP 1 in modulating the structure and checkpoint functions of the mammalian centromere , in particular during radiation induced DNA damage . . ^^^ Poly ( ADP ribose ) polymerase 2 localizes to mammalian active centromeres and interacts with PARP 1 , Cenpa , Cenpb and Bub 3 , but not Cenpc . ^^^ |
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| Interacting proteins: P07199 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
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