| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| Similarities between the elements present in Gm2a and Hexa promoters might in part explain their similar expression patterns in mouse tissues . ^^^ |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| Mice with disrupted genes for activator proteins ( SAP precursor / , GM2A / ) as well as disrupted genes for ganglioside GM 2 degrading hexosaminidases ( HEXA / , HEXB / ) turned out to be useful models for known human diseases whereas double knock out mice ( HEXA / and HEXB / ) show a new phenotype of both mucopolysaccharidosis and gangliosidosis . . ^^^ |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| Whereas two of these proteins are the alpha ( HEXA gene ) and beta ( HEXB ) subunits of beta hexosaminidase A , the third is a small glycolipid transport protein , the GM 2 activator protein ( GM2A ) , which acts as a substrate specific co factor for the enzyme . ^^^ The few exceptions to this generalization are missense mutations at two codons in HEXA , causing the unique biochemical phenotype known as the B 1 variant , and one codon in both the HEXB and GM2A genes . ^^^ |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| The GM 2 gangliosidoses databases : allelic variation at the HEXA , HEXB , and GM2A gene loci . ^^^ The genes responsible for these disorders are HEXA ( Tay Sachs disease and variants ) , HEXB ( Sandhoff disease and variants ) , and GM2A ( AB variant of GM 2 gangliosidosis ) . ^^^ We report the establishment of three relational locus specific databases recording allelic variation at the HEXA , HEXB , and GM2A genes and accessed at the GM 2 gangliosidoses home page ( http : / / data . mch . mcgill . ca / gm2 gangliosidoses ) . ^^^ |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| The mice under study lacked the genes encoding either beta hexosaminidase alpha subunit ( Hexa / ) , the beta hexosaminidase beta subunit ( Hexb / ) , both beta hexosaminidase alpha and beta subunits ( Hexa / and Hexb / ) , GD 3 synthase ( GD3S / ) , GD 3 synthase and GalNAc transferase ( GD3S / and GalNAcT / ) , GM 2 activator protein ( Gm2a / ) , or arylsulfatase A ( ASA / ) . ^^^ |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06865 and P17900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| Similarities between the elements present in Gm2a and Hexa promoters might in part explain their similar expression patterns in mouse tissues . ^^^ |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| Mice with disrupted genes for activator proteins ( SAP precursor / , GM2A / ) as well as disrupted genes for ganglioside GM 2 degrading hexosaminidases ( HEXA / , HEXB / ) turned out to be useful models for known human diseases whereas double knock out mice ( HEXA / and HEXB / ) show a new phenotype of both mucopolysaccharidosis and gangliosidosis . . ^^^ |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| Whereas two of these proteins are the alpha ( HEXA gene ) and beta ( HEXB ) subunits of beta hexosaminidase A , the third is a small glycolipid transport protein , the GM 2 activator protein ( GM2A ) , which acts as a substrate specific co factor for the enzyme . ^^^ The few exceptions to this generalization are missense mutations at two codons in HEXA , causing the unique biochemical phenotype known as the B 1 variant , and one codon in both the HEXB and GM2A genes . ^^^ |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| The GM 2 gangliosidoses databases : allelic variation at the HEXA , HEXB , and GM2A gene loci . ^^^ The genes responsible for these disorders are HEXA ( Tay Sachs disease and variants ) , HEXB ( Sandhoff disease and variants ) , and GM2A ( AB variant of GM 2 gangliosidosis ) . ^^^ We report the establishment of three relational locus specific databases recording allelic variation at the HEXA , HEXB , and GM2A genes and accessed at the GM 2 gangliosidoses home page ( http : / / data . mch . mcgill . ca / gm2 gangliosidoses ) . ^^^ |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| The mice under study lacked the genes encoding either beta hexosaminidase alpha subunit ( Hexa / ) , the beta hexosaminidase beta subunit ( Hexb / ) , both beta hexosaminidase alpha and beta subunits ( Hexa / and Hexb / ) , GD 3 synthase ( GD3S / ) , GD 3 synthase and GalNAc transferase ( GD3S / and GalNAcT / ) , GM 2 activator protein ( Gm2a / ) , or arylsulfatase A ( ASA / ) . ^^^ |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17900 and P06865 |
Pubmed |
SVM Score :0.0 |
| NA |
|