| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| CD 3 stimulation is known to enhance CD 2 avidity for its ligand and to induce the binding of the CD2AP protein to the CD 2 cytoplasmic tail . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| This gene encodes an SH 3 domain containing adapter protein with sequence similarity to the CD2AP ( CD 2 adapter protein ) and CMS ( Cas ligand with multiple Src homology ) genes . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| Mice lacking the 80 kDa CD 2 associated protein ( CD2AP ) develop progressive renal failure that starts soon after birth with proteinuria and foot process effacement by unknown mechanisms . ^^^ CD2AP has been identified and cloned independently by virtue of its interaction with the T cell protein CD 2 and with the docking protein p130Cas . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| Inhibition of CD 2 CD58 interaction markedly affected segregation of CD 2 and CD2AP from CD 45 . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| The Wiskott Aldrich syndrome protein acts downstream of CD 2 and the CD2AP and PSTPIP 1 adaptors to promote formation of the immunological synapse . ^^^ Here , we show that antigen induced formation of T cell : APC conjugates and synapses is abrogated in WASp deficient T cells and that CD 2 engagement evokes interactions between the proline rich region required for WASp translocation to the synapse and the PSTPIP 1 adaptor SH 3 domain and between the PSTPIp 1 coiled coil domain and both CD 2 and another CD 2 binding adaptor , CD2AP . ^^^ These data , together with the impairment in CD 2 induced actin polymerization observed in WASp deficient cells , suggest that PSTPIP 1 acts downstream of CD2 / CD2AP to link CD 2 engagement to the WASp evoked actin polymerization required for synapse formation and T cell activation . . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| CD2BP3 , CIN 85 and the structurally related adaptor protein CMS bind to the same CD 2 cytoplasmic segment , but elicit divergent functional activities . ^^^ CD2BP3 has 35 % amino acid identity to CMS , a structurally related protein binding to the same highly conserved segment of the CD 2 tail and known to be involved in T cell polarization / cytoskeletal interactions . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| A peptide from this region ( CD 2 : 322 339 ) isolated CMS ( human CD2AP ) ; a related protein , CIN 85 ; and the actin capping protein , CAPZ from a T cell line . ^^^ Linking the T cell surface protein CD 2 to the actin capping protein CAPZ via CMS and CIN 85 . ^^^ In BIAcore analyses , the N terminal SH 3 domains of CMS and CIN 85 bound CD 2 : 322 339 with similar dissociation constants ( KD = approximately 100 microm ) . ^^^ These adaptor proteins are important in T cell signaling consistent with a role for CD 2 in regulating pathways initiated by CMS / CIN85 and CAPZ . . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| This review will focus on the remnant kidney model , the podocyte injury models of puromycin aminonucleoside or adriamycin injection , and examples of newly developed genetic models , such as knockout of CD 2 associated protein ( CD2AP ) . . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| CD 2 associated protein ( CD2AP ) is an adapter protein originally identified as a novel ligand interacting with the T cell adhesion protein CD 2 . ^^^ CD 2 associated protein and glomerular disease . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| Podocytes are critical in maintaining the filtration barrier of the glomerulus and are dependent on the slit diaphragm ( SD ) proteins nephrin , podocin , and CD 2 associated protein ( CD2AP ) to function optimally . ^^^ Nephrotic plasma alters slit diaphragm dependent signaling and translocates nephrin , Podocin , and CD 2 associated protein in cultured human podocytes . ^^^ |
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| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06729 and Q9Y5K6 |
Pubmed |
SVM Score :0.0 |
| NA |
|