| Interacting proteins: P06729 and Q96B97 |
Pubmed |
SVM Score :0.0 |
| CD2BP3 , CIN 85 and the structurally related adaptor protein CMS bind to the same CD 2 cytoplasmic segment , but elicit divergent functional activities . ^^^ CD2BP3 , CIN 85 and the structurally related adaptor protein CMS bind to the same CD 2 cytoplasmic segment , but elicit divergent functional activities . ^^^ Interaction trap cloning was used to identify a CD 2 cytoplasmic tail binding protein termed CD2BP3 . ^^^ CD2BP3 has 35 % amino acid identity to CMS , a structurally related protein binding to the same highly conserved segment of the CD 2 tail and known to be involved in T cell polarization / cytoskeletal interactions . ^^^ |
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| Interacting proteins: P06729 and Q96B97 |
Pubmed |
SVM Score :0.0 |
| Linking the T cell surface protein CD 2 to the actin capping protein CAPZ via CMS and CIN 85 . ^^^ A peptide from this region ( CD 2 : 322 339 ) isolated CMS ( human CD2AP ) ; a related protein , CIN 85 ; and the actin capping protein , CAPZ from a T cell line . ^^^ In BIAcore analyses , the N terminal SH 3 domains of CMS and CIN 85 bound CD 2 : 322 339 with similar dissociation constants ( KD = approximately 100 microm ) . ^^^ |
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| Interacting proteins: P06729 and Q96B97 |
Pubmed |
SVM Score :0.0 |
| Confirmed by mutagenesis and in vitro binding experiments , the novel consensus allowed for the accurate mapping of CIN 85 SH3 binding sites within known CIN 85 interactors , c Cbl , BLNK , Cbl b , AIP1 / Alix , SB 1 , and CD 2 proteins , as well as the prediction of CIN 85 novel interacting partners in protein databases . ^^^ |
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