| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.71230811 |
| A soluble multimeric recombinant CD 2 protein identifies CD 48 as a low affinity ligand for human CD 2 : divergence of CD 2 ligands during the evolution of humans and mice . 0.71230811^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.59603938 |
| By making complementary mutations , we have shown that two charged residues in the CD 48 ligand binding site interact directly with two oppositely charged residues in CD 2 ' s ligand binding site . 0.59603938^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.62529193 |
| Monoclonal antibodies ( mAb ) against the adhesion molecules CD 2 and CD 28 are likely to mimic the interaction with their respective physiological ligands [ lymphocyte function associated antigen 3 ( LFA 3 ) / CD58 , CD 59 and CD 48 for CD 2 , B7 / BB1 for CD 28 ] . 0.62529193^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.81076368 |
| These results show that rat CD 48 binds CD 2 on its NH 2 terminal IgSF domain with a low affinity and that binding is independent of glycosylation . . 0.81076368^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :1.2437056 |
| In this paper the authors show that CD 2 interaction with its ligand CD 48 also reduces the apoptosis induced by forskolin and the phosphodiesterase inhibitor 3 isobutyl 1 methylxanthine and , to a much lesser extent , the apoptosis induced by cholera toxin in murine B splenocytes . 1.2437056^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.99505578 |
| Anti CD 2 monoclonal antibody ( mAb ) blocks the interaction of the antigen presenting cell receptor CD 48 with its ligand CD 2 , whereas CTLA4Ig binds with high affinity to the antigen presenting cell ligands B 7 1 and B 7 2 , blocking their interaction with CD28 / CTLA4 . 0.99505578^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The mouse BCM 1 ( OX 45 , Blast 1 ) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM 1 , LFA 3 , and CD 2 constitute a subgroup within the Ig superfamily . ^^^ Taken together , the data suggest duplication of a chromosome region including the precursors of the genes for BCM 1 , CD 2 , and LFA 3 , and the ATPase genes to give rise to the linkage groups now observed . ^^^ CD 2 and LFA 3 are more dissimilar in sequence than BCM 1 and LFA 3 , and if the precursors of the CD 2 and LFA 3 loci formed before the proposed chromosome segment duplication , then a gene encoding a recognizer molecule for BCM 1 may exist in linkage with Bcm 1 / BCM1 on chromosome 1 ( mouse ) and 1q ( human ) . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| After removal of SRBC rosette forming T cells from the peripheral blood , the residual , largely B lymphocyte fraction of five infectious mononucleosis patients was found to contain 0 . 5 2 % blast cells , positive for the EBV determined nuclear antigen ( EBNA ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Immunophenotyping revealed in all four cases that the blast population had T lymphoid ( CD 2 , CD 5 , CD 7 and cytoplasmic CD 3 ) markers . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Blast cells were CD 2 , CD 7 , TDT positive , and negative for myeloid and mature lymphoid antigens . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| A monoclonal antibody ( mAb 12 15 ) reactive with the mouse CD 2 was found to co precipitate a high molecular weight glycoprotein from mouse thymocyte , splenic lymphocyte , Con A blast , and T cell tumor detergent lysates which was identified as the leukocyte common T 200 glycoprotein ( CD 45 ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence and immunohistochemical analysis revealed that each blast population had both T lymphoid ( CD 2 , cytoplasmic CD 3 ) and myeloid ( CD 11 , CD 13 , CD 15 ) markers . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Purification of sgp 60 and protein sequencing demonstrate that sgp 60 is identical to the CD 48 antigen , a ligand for the CD 2 antigen , which is also called Blast 1 in humans , BCM 1 in mice , and OX 45 in rats . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The sequence data also support the view that Ly 9 belongs to the subgroup of the Ig superfamily that includes Bcm 1 , CD 2 , and LFA 3 . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| After short term culture without an addition of any differentiation stimulators , the blast cells expressed CD 2 , CD 3 , CD 4 , CD 8 , and CD 25 antigens . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Single parameter immunophenotyping results determined that the granulated as well as the agranulated blast cells were NK lymphocytes ( CD 45 , NKH 1 , CD 2 , LEU 17 , and CD 16 positive ; CD 3 , CD 8 , and LEU 7 negative ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| It is noteworthy that in 6 cases myeloid and lymphoid markers ( E rosette receptor , common acute lymphoblastic leukemia antigen ( cALLA ) , CD 9 , CD 19 antigens ( anti B 4 MoAb ] were detected on a fraction of blast cells , suggesting a bilineage leukemia . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Neither mixtures of anti CD 5 and anti CD 7 nor anti CD 2 , anti CD 5 , and anti CD 7 immunotoxins were more effective against blast progenitor cells than the individual immunotoxins alone , confirming that CD 2 , CD 5 , and CD 7 are not expressed on non overlapping progenitor cell subpopulations . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| We studied the clinical and biologic features of 10 cases of acute leukemia that met standard French American British ( FAB ) criteria for acute myeloid leukemia ( AML ) but in which the blast cells also expressed the T cell associated CD 2 surface antigen . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Among the lymphoid markers , CD 4 and CD 7 were those most frequently expressed by AML blast cells ( 58 % and 21 . 6 % , respectively ) while the incidence of positivity for the other markers was lower : CD 19 ( 7 . 8 % ) , CD 10 ( 10 . 9 % ) , CD 2 ( 11 . 4 % ) , and TDT ( 11 . 3 % ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| This IA 4 increased expression is correlated with the morphologic change in blast cells and with the expression of activation markers such as CD 2 and MHC class 2 antigens , therefore suggesting that IA 4 is an activation marker on T lymphocytes . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The leukemic blast cells expressed both myeloid antigens ( CD11b , CD 13 , CD 14 , CD 15 , CD 33 and CD 34 ) and T / B lymphoid antigens ( CD 2 , CD 4 , CD 22 and PCA 1 ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Several factors , including chromosomal abnormalities [ t ( 8 ; 21 ) , inv ( 16 ) ] , cell surface markers ( CD 56 , CD 2 , CD 4 , CD 7 ) , French American British ( FAB ) subtype ( M 2 , M 4 , M 5 ) , blast differentiation and maturation , patient nutritional status , age , cellular immune dysfunction , high presenting leukocyte count , and decreased blast Auer rods , have been associated with a higher incidence of EML . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Overall , our findings might suggest a role of CD 2 epitopes in the regulation of adhesion properties of APL blast cells . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Twenty nine of the 40 AML cases analyzed ( 73 % ) showed the existence of at least one aberrant phenotype : in 15 cases the myeloid blast cells co expressed lymphoid associated antigens ( CD 2 , CD 5 , CD 7 , and / or CD 19 ) lineage infidelity ; asynchronous antigen expression was detected in 25 patients ( CD34+CD56+ , CD34+CD11b+ , CD34+CD14+ , CD117+CD15+ , CD 33 CD13+ , CD 13 CD15+ , HLADR + CD 15 , HLADR CD14+CD11b+ CD4+ ) ; seven cases displayed antigen overexpression ( CD 13 , CD 33 , CD 15 , or CD 14 ) ; and in 13 patients leukemic cells had an abnormal FSC / SSC distribution according to their phenotype . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| In addition , the leukemic cells occurring during blast crisis of one of our patients displayed the typical features of a stem cell leukemia ( CD34+ , CD 19 , CD 2 , myeloperoxidase ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Both , primary and secondary responder T cells upregulate the expression of CD 2 and CD 25 and turn into blast cells with superimposable time kinetics . ^^^ Secondary responder T cells terminate DNA synthesis , blast formation and the upregulation of CD 25 and CD 2 expression earlier than primary responder T cells and become more rapidly deleted . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| In contrast , M 3 leukemic cells and other blast cells displaying lymphoid markers such as TdT ( + ) and / or CD 2 ( + ) did not express intracellular or cell surface associated uPAR , indicating an heterogeneity among these promyelocytic cells and suggesting that uPAR may be a useful marker for leukemia typing . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Two immunologically distinct blast cell subsets expressed T markers ( CD 2 , CD 5 , CD 7 ) and common ALL markers ( TdT , CD 19 , CD 22 , CD 10 ) , respectively . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Although gammadelta CD 2 and CD2+ T cells expressed MHCII and IL 2R alpha following stimulation with SEC 1 , only a few cells increased to blast size , suggesting that they were only partially activated . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| A three color flow cytometric analysis was performed and revealed two different CD 45 dim , CD 34 ( + ) , CD 117 ( + ) , CD 56 ( + ) immature subpopulations : the normal immature myeloid precursor and an immature blast cell population that expressed CD 41 , CD 42 , CD 61 , CD 36 , CD 13 , CD1a , and CD 2 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Blast cells showed strong positive expression of CD 7 and HLA DR , and weakly expressed CD 2 , CD 5 and CD 10 , as well . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Immunophenotypic analysis revealed that blast cells were positive for myeloid antigens ( CD 13 , CD 33 ) , and natural killer ( NK ) cell antigen ( CD 56 ) , but negative for T cell antigens ( CD 2 , CD 5 , CD 7 ) , B cell antigens ( CD 19 , CD 20 ) , CD 34 , and HLA DR . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 48 is a counter receptor for mouse CD 2 and is involved in T cell activation . ^^^ These results indicate that CD 48 is a ligand for mouse CD 2 and is involved in regulating T cell activation . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Murine epidermal Langerhans cells express CD 48 , which is a counter receptor for mouse CD 2 . ^^^ It has recently been demonstrated that CD 48 , which is expressed on T cells , B cells , thymocytes and splenocytes , is a ligand for mouse CD 2 and that it can function as one of the costimulatory molecules in the activation of T cells . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The CD 48 chimeric protein has been used both as multivalent complexes produced by cross linking with mAbs recognizing CD 4 and in a monomeric form to analyse the kinetics of the interaction between CD 48 and CD 2 [ van der Merwe et al . ( 1993 ) EMBO J . , 12 , 4945 4954 ] . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Human cell adhesion molecule CD 2 binds CD 58 ( LFA 3 ) with a very low affinity and an extremely fast dissociation rate but does not bind CD 48 or CD 59 . ^^^ Reported ligands for human CD 2 include the structurally related IgSF CAMs CD 58 ( LFA 3 ) and CD 48 as well as , more controversially , the unrelated cell surface glycoprotein CD 59 . ^^^ Using surface plasmon resonance technology , which avoids several pitfalls of conventional binding assays , we recently reported that rat CD 2 binds rat CD 48 with a very low affinity ( Kd 60 90 microM ) and dissociates rapidly ( koff > or = 6 s 1 ) [ van der Merwe , P . ^^^ In contrast , a study using conventional equilibrium binding methods reported a much higher affinity ( Kd 0 . 4 microM ) for human CD 2 binding CD 58 which suggested that the weak binding of rat CD 2 to CD 48 may not represent a typical CAM interaction . ^^^ In the present study we have used surface plasmon resonance to obtain definitive affinity and kinetic data on the interactions of a soluble , recombinant form of human CD 2 with soluble forms of CD 58 , CD 48 , and CD 59 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 58 is the principal ligand for human CD 2 ; CD 59 and CD 48 are two additional , low affinity ligands that have been defined for CD 2 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Anti CD 48 ( murine CD 2 ligand ) mAbs suppress cell mediated immunity in vivo . ^^^ With the identification of murine CD 48 as a homolog of the human CD 2 ligand LFA 3 ( CD 58 ) and as a ligand itself for murine CD 2 , the anti murine CD 48 mAb HM 48 1 was administered intravenously to investigate the role of CD 48 in cell mediated immunity in vivo . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Here we have identified the other binding surface of the CD 2 CD58 adhesion pair by mutating charged residues shared among CD 2 ligands ( human CD 58 , sheep CD 58 , and human CD 48 ) that are predicted to be solvent exposed on a molecular model of the Ig like adhesion domain of human CD 58 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The expression of other adhesion molecules , LFA 1 alpha ( CD11a ) , LFA 1 beta ( CD 18 ) , Pgp 1 ( CD 44 ) , CD 45 , MEL 14 ( L selectin ) , and VLA 4 alpha ( CD49d ) , were all increased as a result of anti CD 2 treatment , whereas CD 25 ( IL 2R ) , CD 48 ( CD 2 ligand ) , and ICAM 1 ( CD 54 ) remained unchanged . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of the epitopes recognized by anti ( rat CD 2 ) and anti ( rat CD 48 ) monoclonal antibodies . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| In the absence of gp 120 , CD 4 displayed high association with CD 3 , CD 5 , CD45RC , CD 25 , CD 28 , CD 44 , and CD 53 ; weak association with CD 2 , CD 38 , CD45RB , CD62L , and CD 26 ; and no association with CD45RA , CD45RO , CD11b , CD11a , CD 54 , CD 7 , CD 48 , CD 98 , CD 59 CD55 , HLA class 1 and class 2 molecules . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Identification of the T cell surface signal transducing glycoprotein sgp 60 as CD 48 , a counter receptor for mouse CD 2 . ^^^ We recently showed that CD 48 is the major counter receptor for CD 2 in the murine system . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 48 is a low affinity ligand for human CD 2 . ^^^ Binding of PBL to CD 48 transfectants was almost totally inhibited by either CD 48 mAb pretreatment of COS cells or CD 2 mAb pretreatment of PBL , implying an interaction between CD 2 and CD 48 . ^^^ Additional mAb blocking studies revealed that CD 48 interacts with the T 11 ( 1 ) region of CD 2 , the same region of CD 2 that binds LFA 3 ( CD 58 ) . ^^^ Thus , CD 48 and CD 58 represent alternative and possibly competing ligands for CD 2 , although based on blocking studies with soluble CD 2 , CD 48 interacts with CD 2 with approximately a 100 fold lower affinity that CD58 . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Whereas CD 2 was not expressed at the time of initiation of thymic lymphopoiesis , a second CD 58 ligand , CD 48 , was expressed at 8 . 2 wk , suggesting a role for CD 48 early in thymic development . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| By virtue of sequence similarity , the genes encoding CD 2 , CD 48 , CD 58 , and Ly 9 have been assigned to a distinct subset within the immunoglobulin superfamily . ^^^ Previous gene mapping studies in human and mouse have suggested that CD 2 , CD 48 , and CD 58 arose by gene duplication . ^^^ The proximity in human and mouse genomes of the genes encoding CD 2 , CD 58 , and the Na , K ATPase alpha 1 subunit , and of the Ly 9 , CD 48 , and the Na , K ATPase alpha 2 subunit genes may be explained by the occurrence of two , successive duplication events during vertebrate evolution , and suggest that Ly 9 may also participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD 2 and CD 48 . ^^^ The CD 2 counter receptor in rodents is the structurally related CAM CD 48 . ^^^ A soluble chimeric protein , comprising the extracellular portion of rat CD 48 and domains 3 and 4 of rat CD 4 ( sCD 48 CD4 ) , bound to immobilized soluble CD 2 ( sCD 2 ) with a KD of 90 microM . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Anti CD 2 receptor and anti CD 2 ligand ( CD 48 ) antibodies synergize to prolong allograft survival . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Activation of T cells enhanced their interaction with mesenchymal cell targets ( fibroblasts ) via a CD 2 dependent adhesion pathway which was not inhibited by the anti mouse CD 48 ( sgp 60 ) mAb OX 78 , the only counter receptor thus far identified on other cells as a ligand for the mouse CD 2 receptor . ^^^ Moreover , since murine fibroblasts were found not to express CD 48 , our results implicate a novel ligand for CD 2 , possibly a homologue of the human LFA 3 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| In contrast , rat CD 2 does not require N linked carbohydrate , and binds to a different ligand , CD 48 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 2 CD 48 interaction prevents apoptosis in murine B lymphocytes by up regulating bcl 2 expression . ^^^ Here we show that occupancy of CD 2 in mouse B cells by the presence of either monoclonal antibody ( mAb ) specific for CD 2 , or soluble recombinant mouse CD 48 , its natural ligand in mouse , prevents the induction of apoptosis . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Demonstration that CD 48 is a ligand for CD 2 and that CD 48 adhesion is regulated by CD 2 . ^^^ The ligand for CD 2 is shown to be CD 48 . ^^^ Purified , soluble CD 2 also inhibits the binding of anti CD 48 mAb to the cell surface . ^^^ The use of cells expressing CD 2 and / or CD 48 provides evidence for a cis CD 2 CD48 interaction on the cell surface in which CD 2 negatively regulates CD 48 adhesion properties . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The protein sequence data support the view that Humly 9 belongs to the immunoglobulin superfamily subgroup which includes CD 48 , CD 2 , and LFA 3 . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| A sensitive assay for detecting low affinity interactions at the cell surface reveals no additional ligands for the adhesion pair rat CD 2 and CD 48 . ^^^ The ligand for the T cell antigen CD 2 is CD 48 in rodents , but CD 58 in humans . ^^^ We describe the analysis of ligands for rat CD 2 and CD 48 using fluorescent beads capable of displaying a high ligand density and detecting low affinity interactions like that of CD 2 with CD 48 ( Kd = 60 90 microM ) . ^^^ Monovalent chimeric proteins containing the two IgSF domains of rat CD 48 or CD 2 and domains 3 and 4 of rat CD 4 ( CD4d3+4 ) were anchored to fluorescent covaspheres via a CD 4 monoclonal antibody ( mAb ) with the CD 48 or CD 2 domains available for ligand binding . ^^^ Multivalent CD 48 CD4d3+4 covaspheres gave strong specific binding to rat CD 2 expressed on the surface of transfected Jurkat cells . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Analysis of expression of other adhesion molecules demonstrated that CD11a , CD 18 , CD 44 , CD 45 , CD 48 , CD 54 , and CD62L were significantly increased by either anti CD 2 or anti CD 3 mAbs while the combination was not synergistic . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The T cell and NK cell adhesion molecule CD 2 interacts with different ligands , viz , CD 58 , CD 48 , and CD 59 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 59 and CD 48 expressed by rat retinal pigment epithelial cells are major ligands for the CD 2 mediated alternative pathway of T cell activation . ^^^ Rat RPE cells expressed high levels of CD 59 and low levels of another potential CD 2 ligand , CD 48 , both in vitro and in the in vivo model of experimental autoimmune uveoretinitis . ^^^ Ab cross linking of CD 48 but not CD 59 on the RPE was found to induce messenger RNA expression for IL 1 beta , which together with constitutively expressed IL 6 are required costimulatory factors for T cell activation through CD 2 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| We have described recently the prevention of apoptosis by CD 2 soluble CD 48 interaction on antigen B cell receptor occupancy . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| SPR has been combined with site directed mutagenesis to delineate the interacting surfaces of CD 2 and its ligand , CD 48 , quantify the contribution of individual residues to the binding energy , and determine the binding orientation of these surfaces in the CD 2 CD48 complex . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Taking into account the recent reports on CD 48 as an accessory molecule , our results suggest that by binding to CD 2 ( and / or an unknown ligand ) , CD 48 may serve to strengthen E / T interaction and may contribute to the activation of a minor subset of gamma / delta T cells . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| This effect is not observed with CHO cells expressing CD 48 , a second CD 2 ligand with a low avidity for CD 2 relative to CD 58 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Expression of other integrin , selectin , or immunoglobulin superfamily molecules ( CD11a , CD 18 , CD 44 , CD 45 , CD 48 , CD 54 and CD62L ) were all significantly increased by anti CD 2 or anti CD 3 mAbs . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Two types of large complexes containing protein tyrosine kinases were observed : the first one contained CD 3 and the transmembrane proteins CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , CD 8 , CD11a , CD 38 , CD 43 , CD 45 , CD 71 , CD 98 and CD 99 and the other contained mainly the GPI anchored proteins CD 48 , CD 55 , CD 59 and CDw 108 as well as a fraction of CD 4 and CD 8 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 48 , a glycosyl phosphatidylinositol anchored molecule has recently been shown to be a ligand for the T cell surface protein CD 2 in mouse , human , and rat . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| We report here that two such tumors , the Ag104A sarcoma and the K 1735 M2 melanoma , become immunogenic after transfection of the genes encoding murine B 7 1 together with CD 48 , which is the natural ligand for CD 2 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NMR analysis of interacting soluble forms of the cell cell recognition molecules CD 2 and CD 48 . ^^^ The ligands of murine and human CD 2 are CD 48 and CD 58 , respectively , and interactions between these molecules have been shown to influence antigen recognition and T cell activation . ^^^ The CD 58 binding site of human CD 2 has been characterized in mutational studies , and here we use heteronuclear NMR spectroscopy to identify the rat CD 48 binding site of the N terminal domain of rat CD 2 ( CD2d1 ) . ^^^ The analysis finds no evidence for any large scale structural changes in domain 1 of CD 2 to accompany CD 48 binding . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Prolonged allograft survival by the inhibition of costimulatory CD 2 signals but not by modulation of CD 48 ( CD 2 ligand ) in the rat . ^^^ Rejection occurred in the presence of complete CD 48 modulation and , therefore , despite disruption of the CD 2 CD48 interaction . ^^^ CD 48 mAb failed to inhibit lymphocyte activation via a mitogenic pair of CD 2 mAbs and inhibited mixed lymphocyte reaction ( MLR ) only by an unspecific mechanism . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Determination of the lifetime and force dependence of interactions of single bonds between surface attached CD 2 and CD 48 adhesion molecules . ^^^ We studied single molecular interactions between surface attached rat CD 2 , a T lymphocyte adhesion receptor , and CD 48 , a CD 2 ligand found on antigen presenting cells . ^^^ Spherical particles were coated with decreasing densities of CD 48 CD4 chimeric molecules then driven along CD 2 derivatized glass surfaces under a low hydrodynamic shear rate . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Various studies demonstrated that the murine CD 48 is the predominant counterreceptor for the mouse CD 2 and is involved in the regulation of T cell activation . ^^^ Since the murine CD 48 is functionally homologous to the human CD 2 ligand LFA 3 ( CD 48 ) , the function of the human CD 48 remains unknown . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The dependence of the association rate of surface attached adhesion molecules CD 2 and CD 48 on separation distance . ^^^ The kinetics of bond formation between spherical beads coated with CD 48 and CD 2 derivatized surfaces was studied with a flow chamber . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Characterisation of the low affinity interaction between rat cell adhesion molecules CD 2 and CD 48 by analytical ultracentrifugation . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The extracellular Ig like domains presented structural and sequence homology with a group of members of the Ig superfamily that included CD 2 , CD 48 , CD 58 , and Ly 9 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Antibodies to CD 2 and CD 48 partially suppress B cell apoptosis , whereas anti B7 . 1 and anti B7 . 2 antibodies have no effect . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| In rodents , CD 48 is the ligand for CD 2 whereas in humans , CD 58 is the ligand for CD 2 . ^^^ No interaction of human CD 48 with CD 2 was detected . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| In solution , the interaction of human CD 2 with its ligand CD 58 is of low affinity ( 500 mM 1 ) and the interaction of rat CD 2 with its ligand CD 48 is of still lower affinity ( 40 mM 1 ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 48 , the murine homolog of human CD 58 , binds to CD 2 in rats and mice . ^^^ Whereas inhibition of CD 2 signaling leads to profound immunosuppression , no information is available on CD 48 targeted therapy in the rat . ^^^ Combined application of CD 2 and CD 48 mAb did not enhance immunosuppression induced by CD 2 mAb alone . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| All glycosylphospha tidylinositol ( GPI ) anchored proteins ( CD 14 , CD16B , CD 48 , CD 59 , CD 87 and GPI anchored versions of CD 2 and CD 25 ) and protein tyrosine kinase ( PTK ) Lck but not transmembrane proteins ( CD 2 , CD 4 , CD 5 , CD 6 , CD 8 ) and PTK ZAP 70 were in part localized in buoyant , lipid rich , detergent resistant membrane GPI microdomains of the COS cells . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| We investigated the polymorphisms of 14 adhesion molecules ( CD 2 , CD 28 , CD 31 , CD 34 , CD 36 , CD 42 , CD 44 , CD 48 , CD49b , CD 54 , CD62L , CD 86 , CD 102 , and CD 106 ) in Japanese subjects and their association with the occurrence of GVHD after allogeneic HLA identical BMT . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Human b cell differentiation : dependence on interactions with monocytes and T lymphocytes via CD 40 , CD 80 ( B7 . 1 ) , and the CD 2 Ligands CD 48 and CD 58 ( LFA 3 ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The CD 48 molecule belongs to a subfamily of the Ig superfamily that also includes the CD 2 , CD 58 , 2B4 , Signaling lymphocyte activation molecule ( SLAM ) , and Ly 9 molecules . ^^^ In mice , the CD 48 molecule can bind to CD 2 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The binding of CD 2 , present on T cells , to its counterreceptor CD 48 facilitates adhesion , signaling , alloantigen induced cytokine production , and cytotoxic T lymphocyte responses . ^^^ Because these T cell functions have been implicated in graft versus host disease ( GVHD ) pathogenesis , we have analyzed the effects of the CD 2 : CD 48 pathway on GVHD mediated by CD 4 ( + ) and CD 8 ( + ) T cells infused into sublethally irradiated recipients . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| B4 , the natural killer and T cell immunoglobulin superfamily surface protein , is a ligand for CD 48 . 2B4 is a cell surface glycoprotein related to CD 2 and implicated in the regulation of natural killer and T lymphocyte function . ^^^ The finding of an additional ligand for CD 48 provides an explanation for distinct functional effects observed on perturbing CD 2 and CD 48 with mAbs or by genetic manipulation . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Enhanced murine CD4+ T cell responses induced by the CD 2 ligand CD 48 . ^^^ The physiological functions of murine CD 2 and its ligand CD 48 are uncertain . ^^^ The enhancing effects of CD 48 on T cell antigen presenting cell adhesion and T cell activation were inhibited by anti CD 2 monoclonal antibody . ^^^ This report provides the first evidence that the CD 2 ligand CD 48 contributes to the interactions of murine CD4+ T cells with antigen presenting cells . . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| We investigated the consequences of recruiting GPI linked CD 48 and associated rafts to the site of T cell : APC contact by stimulating T cells with APCs that express the CD 48 ligand CD 2 . ^^^ We demonstrate that CD 2 : CD 48 interactions enhance TCR mediated functions . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Chromosome localization studies mapped the mouse CD 84 gene to distal chromosome 1 adjacent to the gene for Ly 9 , placing it close to the region where other members of the CD 2 IgSF ( CD 48 and 2B4 ) have been mapped . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The major ligand of CD 2 is CD 48 , the murine analog of human leukocyte function associated antigen 3 ( LFA 3 ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| An analysis of the effect of mutations and ionic strength on CD 2 binding to its ligand , CD 48 , indicates that these charged residues contribute little , if any , binding energy to this interaction . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Here , we test this prediction by varying the dimensions of the CD 2 ligand , CD 48 , and examining how this affects T cell antigen recognition . ^^^ Although the interaction of CD 2 on T cells with wild type or shortened forms of CD 48 on APCs enhances T cell antigen recognition , the interaction of CD 2 with elongated forms of CD 48 is strongly inhibitory . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Recently , we determined binding of 2B4 to CD 48 with a much higher affinity than CD 2 to CD 48 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Ligation of 2B4 with monoclonal antibodies increases target cell lysis and IFN gamma production . 2B4 is the high affinity counter receptor for CD 48 in mice and humans . 2B4 L is a member of the CD 2 subgroup of the immunoglobulin supergene family , which includes CD 48 , LFA 3 , CD 84 , Ly 9 and SLAM . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The cell adhesion glycoproteins , such as CD 2 and CD 48 , help to form a cell junction , providing a molecular spacer between opposing cells . ^^^ The oligosaccharides located on the membrane proximal domains of CD 2 and CD 48 provide a scaffold to orient the binding faces , which leads to increased affinity . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| We have also shown 2B4 to interact with CD 48 with nine times more affinity than that of CD 2 CD48 interaction . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| B4 : an NK cell activating receptor with unique specificity and signal transduction mechanism . 2B4 is a cell surface glycoprotein of the Ig superfamily structurally related to CD 2 like molecules such as CD 2 , CD 48 , CD 58 , CD 84 , Ly 9 , and SLAM . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Members of this family are CD 2 , CD 48 , CD 58 , CD 84 , signaling lymphocytic activation molecule ( SLAM ) , 2B4 and Ly 9 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The ligand binding surface of the T lymphocyte glycoprotein CD 2 has an unusually high proportion of charged residues , and ionic interactions are thought to play a significant role in defining the ligand specificity and binding affinity of CD 2 with the structurally homologous ligands CD 48 ( in rodents ) and CD 58 ( in humans ) . ^^^ The implications of these observations are discussed with respect to recent structural and functional analyses of the interaction of rat CD 2 with CD 48 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Ly 9 consists of four Ig like domains with the structural features of the CD 2 subfamily , which includes CD 2 , CD 48 , CD 58 , 2B4 , CD 84 , and CDw15O ( SLAM ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Recombinant soluble forms of six leukocyte antigens belonging to the Ly 6 ( CD 59 ) , scavenger receptor ( CD 5 ) , and immunoglobulin ( CD 2 , CD 48 , CD 4 , and Thy 1 ) superfamilies were expressed in the same Chinese hamster ovary cell line , thus providing an opportunity to examine the extent to which N linked oligosaccharide processing might vary in a superfamily , domain , or protein dependent manner in a given cell . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Other members of this family include CD 2 , CD 48 , CD 58 , CD 84 , signaling lymphocytic activation molecule and Ly 9 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Consistent with the structural feature of the CD 2 family , the predicted 270 amino acid mature protein of CD 84 H1 contained two extracellular immunoglobulin like domains that shared homology with CD 2 family members , e . g . , CD 84 , Ly 9 , CD 48 , and signaling lymphocyte activation molecule . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Both CTL and antigen presenting dendritic cells were activated as indicated by a decisive increase in their respective activation markers CD 2 , CD 25 , CD 28 as well as CD 48 and CD 80 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The CD 2 subset of the immunoglobulin superfamily consists of a rapidly expanding family of leukocyte cell surface receptors , at least five of which ( CD 2 , CD 48 , CD 58 , CD 150 , and CD 244 ) are involved in lymphocyte activation as either receptors or ligands . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 2 and 2B4 ( CD 244 ) are members of the immunoglobulin gene superfamily and are both ligands for another family member , CD 48 . ^^^ Since indefinite allograft survival could be obtained by a combination of anti CD 48 plus anti CD 2 mAb administration , it was important to determine the role of 2B4 blockade in allograft rejection . ^^^ MAbs directed against CD 2 , CD 48 , or 2B4 were administered singly or in pairs to cardiac allograft recipients . ^^^ The experiments show that only anti CD 2 plus anti CD 48 mAbs result in indefinite allograft survival , while anti CD 2 plus anti 2B4 mAbs substantially prolong graft survival , and anti CD 48 plus anti 2B4 mAbs were no better than each mAb alone . ^^^ In general , anti CD 2 inhibited both anti CD 3 mAb and alloantigen driven responses , while anti CD 48 inhibited only anti CD 3 mAb but not alloantigen driven proliferative and cytokine responses . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Direct measurements of heterotypic adhesion between the cell surface proteins CD 2 and CD 48 . ^^^ Direct force measurements were used to investigate the molecular mechanism of heterophilic adhesion between the murine T cell adhesion glycoprotein CD 2 and its ligand CD 48 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Cell surface receptors belonging to the CD 2 subset of the Ig superfamily of molecules include CD 2 , CD 48 , CD 58 , 2B4 , signaling lymphocytic activation molecule ( SLAM ) , Ly 9 , CD 84 , and the recently identified molecules NTB A / Ly108 / SLAM family ( SF ) 2000 , CD84H 1 / SF2001 , B lymphocyte activator macrophage expressed ( BLAME ) , and CRACC ( CD 2 like receptor activating cytotoxic cells ) / CS 1 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Of the two main candidates , i . e . , CD 48 and CD 58 , the cDNA of the most likely ligand poCD 58 was cloned from CD 48 negative endothelial cells costimulating human CD 4 ( + ) T cells through the CD 2 pathway . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 2 ( cluster of differentiation 2 ) is a cell adhesion molecule expressed on T cells and is recognized as a target for CD 48 ( rats ) and CD 58 ( humans ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NTBA Fc * specifically binds to NTBA cell transfectants but not to cells transfected with other CD 2 family members including CD 2 , CD 48 , CD 84 , CD 150 , CD 229 , and CD 244 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NK cells from mice with targeted deletions of either the CD 2 or the CD 244 gene , both of which encode ligands for CD 48 , are compromised in their ability to induce B cell Igamma2a expression . ^^^ Interestingly , although CD 244 can bind to CD 48 with a higher affinity , the ability of NK cells from CD 244 ( / ) mice to stimulate Igamma2a is not as compromised as NK cells from CD 2 ( / ) mice . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Both 2B4 and CD 2 bind to CD 48 , another member of this family . ^^^ Because all 3 molecules are expressed on natural killer ( NK ) cells , it raises a possibility that the binding of 2B4 and CD 2 to CD 48 among NK cells may have functional consequences . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| Like rat CD 2 ( rCD 2 ) and human CD 2 ( hCD 2 ) , residues involved in the recognition of the target molecule CD 48 exhibit high flexibility . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| The 2B4 ( CD 244 ) , a member of the CD 2 subset of the Ig superfamily , is the high affinity ligand for CD 48 . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| CD 2 and 2B4 are known ligands for CD 48 , which themselves are expressed on the surface of hematopoietic cells . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| In addition eosinophils express 2B4 , CD 84 , CD 58 , and CD 48 , but not signaling lymphocytic activation molecule or CD 2 , on their surface ( FACS ) . ^^^ |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09326 and P06729 |
Pubmed |
SVM Score :0.0 |
| NA |
|