Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.59929409
In unstimulated CD2+ CD3+ Jurkat cells , CD 5 associates equivalently with CD 2 and CD 3 and is as efficiently phosphorylated in CD 2 as in CD 3 immune complexes . 0.59929409^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.58490822
CD 2 physically associates with CD 5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains . 0.58490822^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotyping revealed in all four cases that the blast population had T lymphoid ( CD 2 , CD 5 , CD 7 and cytoplasmic CD 3 ) markers . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The HT 1 cells expressed CD 1 , CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 57 , and terminal deoxynucleotidyl transferase ( TdT ) but lacked B cell associated antigens and myeloid associated antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In none of these patients did the leukemic cells react with CD 1 , CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 10 , CD 19 or CD 20 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
However , although they do not express the T cell markers Thy 1 , CD 2 , CD 3 , CD 4 and CD 5 , 20 % 30 % of dendritic cells are positive for the interleukin 2 receptor alpha chain ( CD 25 ) , and about 30 % express intermediate levels of CD 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
This was further supported by the detection of CD34bright , CD7+ , CD 2 , CD 5 , LECAM 1moderate cells in fetal specimens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The percentages of total B lymphocytes ( CD 19 ) , natural killer ( NK ) cells ( CD 16 ) , T lymphocytes and their subsets ( CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 ) , and IL 2R ( CD 25 ) were found to be within the range found in normal donors . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Molecular associations between the T lymphocyte antigen receptor complex and the surface antigens CD 2 , CD 4 , or CD 8 and CD 5 . ^^^ This provided a sensitive assay for molecular complexes , and associations were demonstrated between the TCR complex and the surface antigens CD 2 , CD 4 , or CD 8 and CD 5 in normal rat T cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We herein describe an unusual case of acute myeloid leukaemia ( AML ) showing strong cytochemical reactivity for myeloperoxidase ( MPO ) but surprisingly no reactivity using flow cytometry for any of the lineage specific cell surface markers , i . e . myelomonocytic antigens CD 13 , CD 14 and CD 33 ; or B lymphoid antigens CD 19 , CD 20 and immunoglobulins ; or T lymphoid antigens CD 2 , CD 3 and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunohistochemical analysis of six cases showed no reactivity with CD 1 , CD 2 , CD 4 , CD 5 , CD 8 , and CD 10 and high reactivity with CD 19 and CD 20 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These CD 4 CD8 T cells express surface markers characteristic of mature peripheral blood T cells ( CD 3 , CD 2 , CD 5 ) , express the alpha / beta form of the T cell receptor , and do not express surface markers characteristic of immature thymocytes ( CD 1 ) or NK cells ( CD 16 , CD 56 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Useful methods for characterizing AIDS related non hodgkin ' s lymphomas include immunophenotypic studies using B cell differentiation and activation antigens ( HLA DR , CD 10 , CD 19 , CD 20 , CD 21 , CD 22 , CD 23 , CD 38 ) , evaluation of expression of surface immunoglobulins ( IgS ) , activation and proliferation ( CD 25 , CD 30 , CD 71 , Ki 67 ) , and identification of T cell markers ( CD 1 , CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Leukocyte antigens investigated were CD 2 , CD 3 , CD 4 ( two antibodies ) , CD 5 , CD 8 , CD 25 , CD 30 , CD 63 antigens and HLA DR ; HIV 1 encoded antigens were gag p 24 , pol reverse transcriptase , and env gp 41 and gp 120 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Cells of the line stained positive for CD 2 and CD 5 determinants and demonstrated rearrangement of the T cell receptor beta chain . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The immunological behaviour of the host was assessed through the determination of lymphoid populations ( CD 2 , CD 4 , CD 5 and CD 8 ) and cytolytic cells were studied with monoclonal antibodies CD and CD 16 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
With a combination of 15 antibodies , including CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , and CD 8 for T cell marker analysis , CD 10 , CD 19 , CD 20 , surface immunoglobulins , and cytoplasmic mu chain for B cell marker analysis , CD 13 and CD 33 for myeloid marker analysis , and HLA DR and CD 25 for other marker analysis , acute lymphoblastic leukemias of T cell type , cALL type , pre B cell type and B cell type , acute myeloid leukemias , acute unclassified leukemias and adult T cell leukemias could be clearly diagnosed by immunophenotyping of cell membrane molecules . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotypically , the leukemic blasts demonstrated reactivity with CD 2 , CD 5 , and CD 7 and indicated on early stage of T cell . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Surface markers of the leukemic cells were CD 2 ( + ) , CD 3 ( + ) , CD 5 ( + ) , CD 7 ( + ) , CD 8 ( + ) , and CD 4 ( ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 2 , CD 5 , and CD 7 were present in 57 , 60 , and 37 % of the patients , respectively ) ; ( 2 ) asynchronous expression of myeloid associated antigens ( i . e . co expression of CD 34 and CD 15 in 25 % of the patients and expression of CD 16 on immature myeloid cells in 15 % of the cases ) ; ( 3 ) over expression of myeloid associated antigens ( e . g . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Additional double stainings showed that strong CD16+ NK cells coexpress the CD 56 , CD11b , and CD 2 antigens , while they lacked CD 3 , CD 5 , and WT 31 antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The level of cells defined by monoclonal antibodies ( CD 1 , CD 2 , CD 3 , CD 4 , WT 31 , and CD 5 ) was less than 3 % . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
However , blasts from 30 . 7 % of patients expressed surface antigens thought to be specific for lymphoid lineage differentiation ( CD 2 , 9 . 4 % ; CD 5 , 2 . 7 % ; CD 19 , 34 . 5 % ; CD 20 , 0 . 8 % ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These TCR alpha beta+CD4 8 T cells were found to express other mature T cell markers such as CD 2 , CD 3 , and CD 5 antigens , as well as natural killer ( NK ) cell markers ( CD11b , CD 16 , CD 56 , and CD 57 antigens ) for both individuals . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Three monoclonal antibodies anti CD 2 ( BH 1 ) , CD 5 ( BB 8 ) and CD 7 ( BF 12 ) were used . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
There were no significant differences between the three groups in the mean percentages of cells expressing surface immunoglobulin ( SIg ) , CD 5 , CD 19 , CD 20 , and CD 2 or in the frequency of cases with weak SIg . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Lack of antigens reactive with CD 2 , CD 3 , CD 5 , and WT 31 monoclonal antibody panels was one factor in bad prognosis , but the presence of CD 4 and CD 8 antigen abnormalities was much more significant . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A previously asymptomatic HIV infected man , who was seronegative for human T lymphotropic virus type 1 antibodies , developed a high grade peripheral T cell lymphoma of anaplastic large cell type which was Ki 1 + ( CD 30 + ) , HLA DR+ , epithelial membrane antigen + , CD 25 + , CD 71 + , CD 2 + and CD 5 + . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Myelomonocytic cells in peripheral blood expressed both myeloid antigens ( CD11b , CD 13 , CD 14 , CD 15 , CD 33 ) and T / B lymphoid antigens ( CD 2 , CD 4 , CD 5 , CD 7 , CD 10 , PCA 1 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
To investigate whether the retargeting of resting CTL can benefit from cooperative signaling between the TCR / CD3 complex and various accessory molecules , such as CD 2 , CD 4 , CD 5 , and CD 8 , we have constructed a series of trispecific F ( ab ' ) 3 derivatives . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Studies indicate that CD 5 functions both in mice and humans as a receptor , delivering co stimulatory signals to T cells in a manner similar to CD 2 ( ref . 11 ) and CD 28 ( ref . 12 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In all cases of LyP most larger cells expressed the activation antigen Ki 1 ( CD 30 ) and lacked expression of the T cell antigen CD 7 and at least one other T cell antigen ( CD 2 , CD 3 , CD 5 ) . ^^^ In contrast , CD 30 antigen expression was rare or absent in PLEVA , CD 3 and CD 7 antigen expression was found in all cases , and diminished expression of T cell antigens ( CD 2 and CD 5 ) was seen in only one case . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
None of the patients expressed the two other T cell antigens CD 2 or CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The mAb used in the panel were : CD 1 , ( T 6 ) , CD 2 ( T 11 , X 11 , D 66 , clone 2 ) , CD 3 ( T3 / Leu4 ) , CD 4 , ( T4 / Leu3a ) , CD 5 ( Leu 1 , T 1 , A 50 , I73D9 ) , CD 7 ( Leu 9 , I 21 ) , CD 8 ( T8 / Leu2a ) and HNK 1 . ^^^ The most frequently observed CD groups among T ALL cells were CD 5 ( 100 % and 88 . 9 % in children and adults respectively ) , CD 7 ( 93 . 1 % and 84 . 6 % ) and CD 2 ( 76 . 7 % and 76 . 9 % ) . ^^^ CD 5 , CD 7 and CD 2 were the most frequently detected antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The only in vitro parameter that predicted subsequent acute or chronic GvHD was the demonstration of viable CD 5 negative lymphocytes with T cell phenotype ( CD 2 , CD 3 , and / or CD 7 positive ) after 16 day culture with IL 2 of the T depleted bone marrow . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Biochemical studies included the CD 2 and CD 5 molecules and further demonstrated their similarity to equivalent molecules in other species , confirming the phylogenetic importance of these molecules in immune responses . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 2 , CD3 / TCR complex , CD 5 , CD 6 , and CD 7 are not involved in TRBC rosette formation ( Zheng , 1990 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Whereas CD 7 expression was increased 78 + / 25 % by 0 . 5 microM ionomycin , expression of CD 25 ( IL 2R alpha ) , class 2 MHC , 4F2 , transferrin receptor , CD 2 , CD 3 , CD 4 , CD 5 , and CD 8 molecules was not increased . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotyping of the blasts showed that most of the cells were positive for CD 2 , CD 5 , CD 7 , CD 10 ( CALLA ) , CD 34 , and HLA DR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Two clones contained RNA transcripts for CD 3 , TCR alpha and beta and were positive for CD 2 , CD 5 and CD 6 ; one of these was a typical CD4+ class 2 MHC restricted non cytotoxic clone while the other was a CD8+ class 1 MHC restricted cytotoxic clone . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We have examined the functional heterogeneity of 43 monoclonal antibodies which recognised CD 1 , CD 2 , CD 4 , CD 5 , CD 6 or CD 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
All the derivatives were designed to redirect the cytotoxic activity of circulating human T lymphocytes , via their CD 2 , CD 3 or CD 5 molecules , against 51Cr labeled chicken red blood cells ( CRBC ) or the human lymphoblastoid cell line , Namalwa . ^^^ No significant lysis was seen when recruiting PBL via CD 2 or CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The cytochemical pattern include tartrate sensitive acid phosphatase positivity , and the immunophenotype of such cells was CD22++ , CD11++ , CD 24 , CD 25 , CD 2 , CD 5 , CD19++ . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The immunological phenotype was J 5 ( CD 10 ) + , I 2 ( HLA DR ) + , SmIg , CyIgmu , Leu 1 ( CD 5 ) , OKT 11 ( CD 2 ) , MY 7 ( CD 13 ) , suggesting common ALL . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Transmembrane signaling of normal human T cells was explored with mAbs directed at TCR , CD 2 , CD 4 , CD 5 , or CD 8 antigens and highly purified CD4+ T cells and CD8+ T cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 2 is low or absent on CD 5 + TdT + cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In some clusters almost all antibodies cross reacted ( CD 2 , CD 8 ) , in others almost none cross reacted ( CD 4 , CD 5 ) and in cluster CD 6 , mAbs only reacted with buffalo but not waterbuck . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The relative molecular weight ( Mr ) of the CD 1 , CD 2 , CD 4 , CD 5 , CD 6 , CD 8 and additional molecules identified by monoclonal antibodies ( mAb ) submitted to the workshop was determined using 125I surface labelled leukocytes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
They demonstrated the T cell association antigens , CD 2 and CD 4 , but no CD 3 , CD 8 , CD 1 , CD 5 , CD 7 nor T cell antigen receptor on their cell surfaces . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Rare cases had CD 5 : CD 2 or CD 3 ratios of greater than 1 or `` monoclonal ' ' kappa to lambda ratios . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Staining for pan T cell ( CD 2 , CD 3 , CD 5 ) and pan B cell ( CD 19 , CD 22 ) antigens was negative in all lesions . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
After 15 days in vitro , 80 % of the developing rat cells were Thy 1 . 1+ lymphoid cells and about 70 % of the Thy 1 . 1+ cells expressed CD 5 , CD 2 and leukosialin . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A majority of the cells from peripheral blood coexpressed the antigens against MAbs CD 2 , CD 3 , CD 4 , CD 5 , Ti ( WT 31 ) , CD 25 , CD 38 , CD 45 , and CD 29 , but did not express the antigens against CD 1 , CD 13 , CD 14 , CD 33 , CD 36 , CD 10 , CD 19 , CD 20 , CD 21 , CD 24 , CD 41 , CD 42 , CD45RA , CD 56 , and CD 57 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Antigen specific nonresponsiveness was induced by both nonmitogenic and mitogenic anti CD 3 antibodies but not by antibodies against CD 2 , CD 4 , CD 5 , CD 8 , CD 18 , or CD 28 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We describe an example of CML in T lymphoblastic crisis with massive generalized lymphadenopathy in which the blasts were CD 2 ( + ) , CD 5 ( + ) , and CD 7 ( + ) , variably CD 1 ( + ) and CD 3 ( + ) , and both responded to and could be induced to produce the T cell growth factor , interleukin 2 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 7 , CD 5 , and CD 2 were the most frequently expressed T cell antigens , and CD 2 and CD 4 were more frequently observed in children than in adults . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Eight cases were assigned to the B cell lineage by demonstration of monotypic surface or cytoplasmic immunoglobulin or of the B cell phenotype CD22+ , CD 2 , CD 3 , CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The predominant cell population expressed CD 3 , CD 2 , CD 5 , and CD 4 , while results of testing for CD 8 were negative . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In order to remove T cells , 10 ( 8 ) cells were labeled with either a specific CD 3 monoclonal antibody or a cocktail of monoclonal CD 2 + CD 5 + CD 7 antibodies and biotin conjugated magnetic microparticles ( size 100 150 nm ) employing a streptavidin FITC complex . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Using immunohistochemical methods , the authors studied the expression of pan T and majority T cell antigens ( CD 5 , CD 2 , CD 3 , TCR beta , CD 7 ) and T cell subset antigens ( CD 4 , CD 8 ) in cutaneous T cells in mycosis fungoides ( MF ) ( 177 biopsies from 124 patients ) and a variety of inflammatory lesions ( 45 biopsies from 45 patients ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
T lymphocytes labelled to the same extent by CD 2 , CD 3 , CD 5 and CD 6 ( 28 % + / 10 % ) , B lymphocytes assessed by CD 19 and CD 20 ( 12 % + / 8 % ) , Pre B cells ( CD10+ = 8 % + / 7 % ) , less than 5 % of `` natural killer ' ' cells ( CD16+ or Leu7+ ) and finally , less than 6 % of myelomonocytes ( CD14+ and / or VIM2+ ) . 2 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The rates of degradation of radioiodinated monoclonal antibodies ( MoAbs ) by malignant T and B lymphoid cells were studied in the presence and absence of a variety of pharmacological agents known to affect the intracellular metabolism of internalized ligands . 125I MoAbs directed against the CD 2 , CD 3 , CD 5 , and anti mu surface antigens underwent rapid endocytosis , followed by prompt degradation with release of greater than or equal to 50 % of the initially bound radioactivity as free , trichloroacetic acid soluble 125I within 24 h . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The T cell surface antigens CD 5 and / or CD 2 and focal acid phosphatase were additional markers of this subgroup traditionally called pre T ALL , whereas thymocyte antigen CD 1 as well as CD 4 and CD 8 antigens were not expressed . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
On cryostat sections all CBCL so tested were positive for surface membrane immunoglobulins ( IgMk most often ) and B cell antigens ( CD22+ , CD37+ ) with a variable T cell reactive component identified by MoAbs against T cell antigens ( CD 2 , CD 3 , CD 4 , CD 5 , CD 8 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
At relapse the leukemic cells expressed CD 1 , CD 2 , CD 5 , CD 7 , and CD 4 or CD 8 , antigens of the common thymocyte compartment . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 2 , CD 3 , CD 4 , and CD 5 antigens were homogeneously expressed on all TLC in contrast to CD 6 and CD 7 antigens which were present on only a fraction of the cells in a given TLC . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In search for agents able to complement the signals provided by BMA 030 F ( ab ' ) 2 , several antibodies directed against CD 2 , CD 4 , CD 5 , CD 6 and CD 8 were used . ^^^ However , if BMA 030 F ( ab ' ) 2 and any other of these anti CD 2 , CD 4 , CD 5 , CD 6 or CD 8 antibodies were cross linked , then proliferation of T cells occurred . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MAbs ) directed against CD 3 , CD 8 , CD 2 , and lymphocyte function associated antigen 3 , but not against CD 5 , inhibited cytolytic activity . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Both immobilized and soluble MAb directed at CD 5 and CD 28 ( Tp 44 ) enhanced responses , but they were less effective than immobilized MAb to CD 2 , LFA 1 or HLA A , B , C . ^^^ The data suggest that when anti CD 3 stimulation is suboptimal , responses can be enhanced by MAb to CD 5 or CD 28 ( Tp 44 ) or by immobilized MAb to CD 4 , CD 2 , CD11a ( LFA 1 ) , or class 1 MHC encoded gene products . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Addition of 1F4 mAb to a culture of T cells resulted in the proliferation of T cells by a help of PMA or a solid support . 1F4 mAb also caused the modulation of the corresponding Ag but not other T cell markers such as CD 5 , CD 2 , and OX 52 defined Ag . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Activators of protein kinase C up regulate the cell surface expression of CD 2 and CD 5 T cell glycoproteins . ^^^ Activation of human T cells through the CD 3 T cell receptor complex caused an augmentation in the cell surface expression of CD 2 and CD 5 glycoproteins . ^^^ These changes in cell surface antigen expression appear to be caused by the concomitant increase in the mRNA levels for CD 2 and CD 5 . ^^^ Phosphorylation studies of the CD 2 and CD 5 glycoproteins indicated that the overexpression of these molecules was not associated with a specific pattern of phosphorylation since it was observed independently of their hyperphosphorylated or nonphosphorylated state . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Cutaneous T cell lymphomas of mycosis fungoides type usually express pan T cell antigens CD 2 , CD 5 , and CD 3 , often lack the pan T cell antigen CD 7 , and usually express the mature , peripheral helper subset phenotype , CD4+ CD 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Two to ten percent of PBMC coexpressed CR 1 and the CD 5 , CD 2 , or CD 3 antigen . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These were T lymphocyte and myeloid surface antigen ( CD 2 , CD 3 , CD 5 , CD 7 , CD 13 , CD 33 , WT 31 ) positive . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These leukemic blasts did not express both T cell lineage antigens which are detectable by monoclonal antibodies , T 6 ( CD 1 ) , T 11 ( CD 2 ) , T 3 ( CD 3 ) , T 4 ( CD 4 ) , T 1 ( CD 5 ) , Tp 40 , Leu 9 ( CD 7 ) , T 8 ( CD 8 ) , and B cell lineage antigens which are detectable by monoclonal antibodies , B 4 ( CD 19 ) , B 1 ( CD 20 ) , B 2 ( CD 21 ) and J 5 ( CD 10 ) . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Configuration of the T cell receptor ( TCR ) beta , gamma , and delta chain genes , as well as immunoglobulin ( Ig ) heavy and light chain genes , was studied in 29 cases of E rosette negative ( pre T cell ) acute lymphoblastic leukemias that lack early B cell ( CD 19 ) , myeloid ( CD 33 ) , as well as most T cell associated membrane antigens such as CD 1 , C 4 , and CD 8 , but express CD 7 , cytoplasmic CD 3 ( cCD 3 ) , and TdT strongly , as well as CD 5 and / or CD 2 heterogeneously . ^^^ Moreover , findings reported here suggest that CD 7 , as well as CD 2 and CD 5 , antigens appear on precursor cells prior to entry into the thymus and support a model for the developmental hierarchy of TCR genes during early T cell ontogeny . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Virtually all TCR gamma / delta+ thymocytes / lymphocytes expressed CD 7 , CD 2 , and CD 5 but were heterogeneous with respect to their expression of CD 1 , CD 4 , CD 8 , CD 28 , CD11b , CD 16 , and Leu 7 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Multiparameter analysis of CD 2 expression and that of CD 3 , CD 5 , JIId , and IL 2R p 55 chain showed that expression of CD 2 correlates with the maturational state of thymocytes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A combination of soluble anti CD 3 with anti CD 28 mAb but not with mAb directed at the CD 2 , CD 5 , CD 7 , CD11a / CD18 , or class 1 MHC molecules induced T cell proliferation in response to IL 4 . ^^^ Anti CD 2 and anti CD 5 mAb enhanced and anti CD 18 mAb inhibited this anti CD 3 + anti CD 28 mAb induced T cell response to IL 4 . ^^^ These results indicate that the CD 3 and CD 28 molecules play a crucial role in inducing T cell responsiveness to IL 4 and that the CD 2 , CD 5 , and CD11a / CD18 molecules influence this process . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
To investigate whether the presence or absence of tissue eosinophilia is related to the immunophenotype of the T cells , we studied 43 cases of HD ( 28 nodular sclerosing , ten mixed cellularity , and five unclassifiable ) for the relative numbers of lymphocytes positive for CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 25 , CD 38 , T 9 , TQ 1 , HLA DR , and beta F 1 , and for the number of eosinophils in tissue sections . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The leukemic cells were negative for peroxidase , but were positive for both lymphoid and myeloid cell surface markers ( CD 2 , CD 5 , CD 7 , CD 33 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The tumor cells expressed , CD 2 , CD 3 , CD 4 , CD 5 and CD 7 antigens , which corresponded to the phenotype of helper inducer T lymphocytes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Here a time dependent decrease of labelling by CD 2 ( OX 34 ) , CD 8 ( OX 8 ) , CD 4 ( ER 2 ) , and CD 5 ( OX 19 ) was observed . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
All cases were CD 3 positive and 10 were CD 2 positive ; five lacked expression of either CD 5 or CD 7 , or both markers . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In patients with both HLA identical and non identical donors , results of immunophenotypic analysis demonstrated that early graft failure was associated with peripheral lymphocytosis with T cells expressing CD 2 , CD 3 , CD 5 , CD 6 , CD 8 and Ia antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Human IEL express the same densities of the CD 2 , CD 3 , and CD 8 antigens but a lower density of the CD 5 antigen than do peripheral blood CD8+ T cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In all cases we found at least two positive antigen detected by MoP pan T ( CD 2 , CD 3 , CD 5 , CD 7 ) in one case no expression of antigen T 3 ( CD 3 ) and in two cases no antigen detected by an antibody CD 2 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The results show that the majority of surface markers considered to be expressed selectively by T lymphocytes , such as Thy 1 , CD 2 and CD 5 antigens , leukosialin ( W3 / 13 ) , or an alloantigen of peripheral T cells , are not expressed by BMM phi . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In the same subjects , we also studied the display of CD 2 , CD 3 and CD 5 on lymphocytes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Basing on the data concerning the distribution of McAb reactivity with cells from different organs and tissues , and with tumour cell lines , on experiments on the mutual blockage and comodulation of antigens , on two colour immunofluorescence and determination of the molecular weight of the detected antigens a conclusion is made that the McAb obtained react with CD 5 , CD 2 , CD 4 , CD 6 , CD 7 , CD 8 , CD 21 and HLA DR antigens , respectively . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In comparison to aged cross matched male controls , significant increases of absolute number of lymphocytes and of T and B cell subpopulations with significant reduction of the percentages of CD 3 , CD 4 , CD 2 , CD 5 , sIg , and CD 16 cells was found in haemophiliacs . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Cases that remained unclassifiable were further tested with a wider panel of T cell markers , including CD 1 , CD 2 , CD 3 and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These immature cells are TdT and do not express membrane CD 3 ( mCD 3 ) or TCR beta identified by beta F 1 , but show CD 7 and CD 45 positivity without CD 1 , CD 2 , CD 5 , CD 4 , CD 8 , CD 10 , and class 2 Ag . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
From the phenotypic point of view , these relapsed patients showed only very immature T cell differentiation antigens such as CD 2 and CD 7 ( or CD 5 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Liposomes targeted against the transferrin receptor showed greater surface binding , internalization , and growth inhibition than liposomes targeted against the T cell surface antigens , CD 2 , CD 3 , or CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The tumor cells carried the CD 3 and CD 7 T cell antigens , but were double negative for CD 4 and CD 8 and also lacked other T cell antigens ( CD 1 , CD 2 , and CD 5 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
With regard to proposed criteria for T cell lymphoma , we did not detect loss of pan T cell antigens CD 2 , CD 3 , CD 5 , or BF 1 , nor did we find populations of T cells with abnormal co expression or loss of subset antigens such as CD 4 8 or CD4+8+ . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Corresponding to plasmacytoid T cells in reactive and neoplastic lymph node conditions , plasmacytoid T cells of the skin were devoid of most T cell restricted differentiation antigens CD 2 , CD 3 , CD 5 , and CD 8 while expressing monocyte / macrophage related antigens recognized by Ki M 6 and Ki M 7 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Five isolates of Pseudomonas aeruginosa ( CD 2 , CD 3 , CD 4 , CD 5 , and CD 10 ) from a patient with cystic fibrosis were examined with regard to several genotypic and phenotypic characteristics to determine whether the patient was colonized with one or several distinct strains . ^^^ Isolates CD 2 , CD 3 , and CD 4 were obtained from a single sputum sample , and CD 5 and CD 10 were obtained 1 and 2 years later , respectively . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In addition to the CD 3 T cell receptor complex , the CD 2 , CD 4 , CD 5 , CD 7 , CD 8 and CD 28 receptors mobilize cytoplasmic calcium within minutes of binding with monoclonal antibodies and additional crosslinking occurs on the cell surface . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We have compared the requirements of the primary MLR and the responses of alloreactive , primed lymphocytes ( PL ) by inhibition studies using monoclonal antibodies ( MoAb ) directed against ( 1 ) adhesion molecules belonging to the CD 11 cluster of leucocyte antigens ( CD11a , LFA 1 ; CD11b , MAC 1 = CR 3 ; and CD11c , p 150 , 95 ) ; ( 2 ) various T cell related antigens ( CD 2 , CD 4 , CD 5 and CD 8 ) ; and ( 3 ) recombinant IL 1 beta . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Two colour immunofluorescence and flow cytometry demonstrated co expression of the antigen defined by F101 . 01 and the pan T cell antigens defined by CD 2 , CD 3 , CD 5 , and CD 7 antibodies . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A small T cell subpopulation expressing the phenotype Leu 5 ( CD 2 ) + , Leu 4 ( CD 3 ) + , Leu 1 ( CD 5 ) can be found in peripheral blood and bone marrow of normal individuals . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Most CD3+ , Leu 19+ T cells co expressed the CD 2 , CD 8 , and CD 5 differentiation antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A variety of other immobilized Mab directed at T cell surface proteins including class 1 major histocompatibility complex encoded gene products , CD 2 , CD 5 , 4F2 , and Tp 44 , did not induce proliferation even in the presence of IL 2 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Antibodies binding to a large subset of T cell differentiation antigens , including CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , CD 8 , Tp 44 , and CDw 18 , cause an increase in the cytoplasmic calcium concentration [ ( Ca2+ ] 1 ) after the antigens are crosslinked on the cell surface . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Subsequent transcription of the beta gene is coordinated with surface expression of T 1 ( CD 5 ) and T 11 ( CD 2 ) , transcription of T 3 delta mRNA , and the appearance of intracellular T 3 ( CD 3 ) protein . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The immunologic phenotype of PTC , as revealed on frozen tumor tissue sections , comprised the expression of CD 5 ( T 1 ) , CD 4 ( T 4 ) , and HLA DR , but not CD 8 ( T 8 ) and CD 2 ( T 11 ) and suggested an affiliation to the T cell system . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We used the mAb 35 . 1 , T 101 , and G3 . 7 to test for expression of CD 2 , CD 5 , and CD 7 on fresh marrow blasts from 126 T lineage ALL patients . ^^^ CD 2 , CD 5 , and CD 7 were expressed in 84 % , 93 % , and 99 % of cases , respectively . ^^^ Ricin conjugates of 35 . 1 , T 101 , and G3 . 7 mAb were used as Ag specific cytotoxic probes to test for expression of CD 2 , CD 5 , and CD 7 at the level of T lineage leukemic progenitor blasts . ^^^ Each immunotoxin was able to selectively eliminate greater than 99 % of leukemic progenitor blasts , providing unique and direct evidence that these cells co express CD 2 , CD 5 , and CD 7 . ^^^ Neither mixtures of anti CD 5 and anti CD 7 nor anti CD 2 , anti CD 5 , and anti CD 7 immunotoxins were more effective against blast progenitor cells than the individual immunotoxins alone , confirming that CD 2 , CD 5 , and CD 7 are not expressed on non overlapping progenitor cell subpopulations . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
THP 6 cells were positive for CD 7 and CD 5 antigens and terminal deoxynucleotidyl transferase , but negative for CD 2 , CD 1 , CD 4 , CD 8 , CD 10 , cytoplasmic and surface CD 3 and HLA DR antigens , suggesting a precursor T cell line . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A loss of pan T antigens ( CD 7 , CD 5 , CD 2 , CD4 / CD8 ) was observed in all but three of these CD 3 positive samples . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MoAb ) that react with the T lymphocyte markers called cluster of differentiation CD 5 and CD 2 were labeled with iodine 131 ( 131I ) and were injected intravenously in nude mice bearing solid subcutaneous xenografts derived from the human T cell leukemia line Ichikawa . ^^^ Both MoAb anti CD 5 and anti CD 2 yielded favorable mean tumor to whole body ratios of 3 . 8 and 5 . 1 , respectively . ^^^ These ratios were further increased up to 10 . 0 for MoAb anti CD 5 and 15 . 5 for MoAb anti CD 2 by using their F ( ab ' ) 2 fragments . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Detailed immunological analysis demonstrated that the vast majority of these cells expressed T cell associated antigens ( i . e . , CD 7 , CD 5 , CD 2 , CD 4 , and to a lesser extent , CD 8 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We investigated the phosphorylation of CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 28 ( Tp 44 ) , CD 43 ( sialophorin , gp 115 ) , and LFA 1 after incubation of human PBMC with the ( PKC ) activator PMA . ^^^ These proteins were chosen for their role in transmembrane signal transduction ( CD 2 , CD 3 , CD 5 , CD 28 , CD 43 ) , cell cell interaction and adhesion ( CD 2 , CD 4 , CD 8 , and LFA 1 ) , or involvement in immunodeficiency states ( CD 43 , CD 7 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We have synthesized 3 immunotoxins ( ITs ) by covalently coupling the saporin 6 hemitoxin ( SAP ) to OKT 11 , SOT 3 , and SOT1a murine monoclonal antibodies that recognize human T lymphocyte CD 2 , CD 3 , and CD 5 surface antigens , respectively . ^^^ Whereas the anti CD 2 IT , OKT 11 SAP , shows moderate cytotoxicity against T lymphocytes , the anti CD 3 IT , SOT 3 SAP , and the anti CD 5 IT , SOT1a SAP , are highly effective in eliminating the same target cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
With our system , a wide variety of antigens are detected in plastic sections without trypsinization or prolonged embedding procedures ; pan B ( CD 19 , CD 22 ) , pan T ( CD 7 , CD 5 , CD 3 , CD 2 ) , T subset ( CD 4 , CD 8 , CD 1 , CD 25 ) markers as well as surface immunoglobulin and markers for myeloid and mononuclear phagocyte cells are preserved . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We report herein an in vitro mature T cell depletion using a cocktail of three monoclonal antibodies ( CD 2 , CD 5 , and CD 7 ) and baby rabbit complement in 38 histocompatibility leucocyte antigen ( HLA ) identical BMT with no more than grade 2 acute GVHD . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Phenotypic analysis showed that the hybrids could be grouped as follows : a high frequency expressing CD 25 ( IL 2 receptor ) , human T 200 , HLA class 1 alpha and beta 2microglobulin , and reacting with the mAb H 207 and 12E7 ; an intermediate frequency expressing CD 1 and CD 2 ; and a low frequency expressing CD 3 , CD 4 , CD 5 , CD 7 , CD 8 and CD 9 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The exception ( germ line for T beta and T gamma ) was an immature CD 2 ( T 11 ) + , CD 3 ( T 3 ) , CD 7 ( 3A1 ) + , CD 1 ( T 6 ) + , CD 5 ( T 101 ) + phenotype . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In the present study , it was our intention to further the characterization of the neoplastic cells at the early stage of the T lineage , which were defined as those which bore pan T marker ( s ) ( CD 2 , CD 5 and CD 7 ) but not CD 3 antigen on the surface . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The immunological phenotype of the lymphoma resembled that of immature T cells present in the normal thymus cortex positivity for CD 1 , CD 2 , CD 4 , CD 7 , CD 38 and terminal deoxynucleotidyl transferase ; faint positivity for CD 5 and in the second specimen for CD 3 ; negativity for CD 6 and MHC class 1 antigen . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These patterns of CD3 / beta F 1 expression , along with the patterns of CD 2 , CD 4 , CD 5 , CD 7 , and CD 8 antigen expression in these neoplasms , indicate that T cell lymphomas can manifest phenotypes not apparently reflective of normal T populations and suggest the presence of abnormal gene expression in these malignancies . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Bone marrow long term cultures were studied for 8 weeks in four experiments before and after T cell depletion with a mixture of monoclonal antibodies directed against CD 2 , CD 5 and CD 7 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Most cases also showed CD 2 and CD 5 positivity with some also showing CD 3 and CD 7 expression . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunohistological analysis with a range of monoclonal antibodies showed the PTC of our case to be CD 5 ( T 1 ) + , CD 4 ( T 4 ) + , CD 3 ( T 3 ) , CD 8 ( T 8 ) , CD 2 ( T 11 ) , and CD 25 ( TAC ) , but HLA DR+ and transferrin receptor positive . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
T cells were depleted with a combination of 3 pan T cell monoclonal antibodies ( CD 2 `` D 66 ' ' ; CD 5 `` A 50 ' ' ; CD 7 `` I 21 ' ' ) with a single incubation of rabbit complement ( C ' ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These MoAb detect , respectively , the CD 5 [ gp 67 ] , CD 7 [ p 41 ] , CD 2 [ p 50 ] , and [ gp 95 , 170 ] determinants that are found in the vast majority of cases of T cell acute lymphocytic leukemia ( T ALL ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Three monoclonal antibodies to the same epitope on cytochrome P 450c , ( CD 2 , CD 3 , and CD 5 ) cross reacted strongly with cytochrome P 450d , another isozyme induced by 3 methylcholanthrene treatment of rats . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Surface marker analysis revealed the blasts to be CD 2 , CD 3 , CD 4 , CD 5 , CD7+ , CD 8 , CD 10 , CD 13 + / , CD 19 , CD 20 , CD 25 , CD33+ and human leukocyte antigen DR ( HLA DR+ ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The CD 21 antigen was expressed by one of the eight cases of neoplastic lymphoid cells expressing the CD 7 antigen as a sole pan T antigen , by three of the 20 cases of pro or early thymic stage ( CD7+ CD5+ CD 2 , CD7+ CD 5 CD2+ , or CD7+ CD5+ CD2+ , and ten of 11 cases of thymic stage ( CD3+ / CD4+ CD8+ ) , but not by one case of late thymic stage ( CD3+ CD4+ CD 8 ) T ALL / LBL cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Lineage determination of CD7+ CD 5 CD 2 and CD7+ CD5+ CD 2 lymphoblasts : studies on phenotype , genotype , and gene expression of myeloperoxidase , CD 3 epsilon , and CD 3 delta . ^^^ The gene expression of myeloperoxidase ( MPO ) , CD 3 epsilon , and CD 3 delta molecules , the gene rearrangement of T cell receptor ( TCR ) delta , gamma , and beta and immunoglobulin heavy ( IgH ) chain , and the expression of cell surface antigens were investigated in seven cases of CD7+ CD 5 CD 2 and four cases of CD7+ CD5+ CD 2 acute lymphoblastic leukemia or lymphoblastic lymphoma ( ALL / LBL ) blasts , which were negative for cytochemical myeloperoxidase ( cyMPO ) . ^^^ In conclusion , the CD7+ CD 5 CD 2 blasts included four categories : undifferentiated blasts without lineage commitment , T lineage blasts , T / myeloid lineage blasts , and cyMPO negative myeloblasts . ^^^ The expression or in vitro induction of CD 13 and / or CD 33 antigens correlated with the immaturity of these neoplastic T cells , since it was observed in all 11 CD7+ CD 5 CD 2 and CD7+ CD5+ CD 2 , and some CD7+ CD5+ CD2+ ( CD 3 CD 4 CD 8 ) cases , but not in CD 3 + / CD4+ CD8+ or CD3+ CD4+ CD 8 cases . ^^^ CD 3 epsilon mRNA , but not CD 3 delta mRNA , was detected in two CD7+ CD 5 CD 2 cases , while mRNA of neither of the two CD 3 molecules was detected in the other tested CD7+ CD 5 CD 2 cases . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD34bright thymocytes were CD 33 / dull and were negative for CD 38 , CD 2 , and CD 5 as well as for the lineage markers CD 3 , CD 4 , and CD 8 ( T cells ) , CD 19 and CD 20 ( B cells ) , CD 56 ( NK cells ) , glycophorin ( erythrocytes ) , and CD 14 ( monocytes ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In sheep at the asymptomatic stage , depending on the extent of progression of the disease , the proportions of CD 2 ( + ) , CD 4 ( + ) , CD 8 ( + ) , and gamma delta TCR ( + ) T cells that coexpressed CD 5 decreased , but CD5+ sIgM+ cells as well as CD 5 sIgM+ cells increased for a period . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Quantitative characterization of the circulating CD5+ lymphocyte population in sheep was performed using monoclonal antibodies against ovine CD 5 , ovine CD 2 , and ovine sIgM . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The tumor cells were pleomorphic medium sized cells that expressed a range of T cell specific antigens , including CD 2 , CD 3 , CD 4 , CD 5 , CD 6 , CD 7 , and beta F 1 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Expression of cell interaction molecules by immature rat thymocytes during passage through the CD4+8+ compartment : developmental regulation and induction by T cell receptor engagement of CD 2 , CD 5 , CD 28 , CD11a , CD 44 and CD 53 . ^^^ Rat thymocytes of the T cell receptorlow ( TcRlow ) CD4+8+ subset which is the target of repertoire selection are heterogeneous with respect to expression of the cell interaction ( CI ) molecules CD 2 , CD 5 , CD11a / CD18 ( LFA 1 ) , CD 28 and CD 44 . ^^^ Upon entry into the CD4+8+ compartment , they expressed relatively high levels of CD 2 and CD 44 , and moderate levels of CD 5 , CD 28 and CD11a . ^^^ CD 2 , CD 28 and CD 44 were slightly down regulated during the following 2 days , whereas CD 5 slightly increased and CD11a remained constant . ^^^ TcR stimulation using immobilized monoclonal antibodies resulted in rapid and dramatic up regulation of CD 2 , CD 5 and CD 28 and , to a lesser extent , of CD11a and CD 44 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The leukemia cells expressed CD 2 , CD 6 , CD 7 , CD13low , CD 56 , beta chain of IL 2 receptorlow ( IL 2R beta ) , and HLA DR antigens , but not other pan T ( CD 5 , CD 3 , CD 4 , and CD 8 ) ; pan B ( CD 10 , CD 19 , CD 20 , and CD 24 ) ; natural killer ( NK ) ( CD 16 , CD 57 ) ; or myeloid ( CD 33 ) antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In the absence of gp 120 , CD 4 displayed high association with CD 3 , CD 5 , CD45RC , CD 25 , CD 28 , CD 44 , and CD 53 ; weak association with CD 2 , CD 38 , CD45RB , CD62L , and CD 26 ; and no association with CD45RA , CD45RO , CD11b , CD11a , CD 54 , CD 7 , CD 48 , CD 98 , CD 59 CD55 , HLA class 1 and class 2 molecules . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The cell line with the highest level of binding was PER 423 ( Kees et al , Leukemia Res 1993 ; 17 : 51 59 which has the phenotype CD7+ , CD56bright , CD 2 , CD 4 , CD 5 , CD 8 , CD 16 , has rearranged T cell receptor beta chain genes , expresses cytoplasmic CD 3 and is strictly dependent on interleukin 2 ( IL 2 ) for proliferation . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Murine Thy 1+ , TCR 5 gamma 3 / V delta 1+ dendritic epidermal T cells ( DETC ) express CD 2 antigens , but differ from most other T cell subsets in their absence of CD 4 , CD 5 , and CD 8 antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The percentage of LNL expressing CD 2 also increased but those expressing CD 5 decreased . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
When the samples were analyzed as a group , seven antigens ( CD 2 , CD 3 , CD 5 , CD11c , CD 20 , CD 22 , and CD 34 ) demonstrated significantly different percentages of positively staining cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Analysis of several R CR pairs ( CD 2 CD58 , CD45RO CD 22 , CD 5 CD72 , CD11a CD 54 , gp 39 CD40 , and CD 28 CD80 ) demonstrated that comparable levels of expression of the Rs ( CD 2 , CD45RO , CD 5 , and CD 28 ) and of some of the CRs ( CD 58 , CD 22 , and CD 72 ) were in all cell lines ; however , CD 54 , CD 40 , and CD 80 were expressed constitutively on the HTLV 1 and HTLV 2 infected cell lines . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunohistochemical stainings showed most lymph node blasts to have T phenotype ( positivity for CD 2 , CD 3 and CD 5 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The immunological behaviour of the host was assessed through the determination of lymphoid populations ( CD 2 , CD 3 , CD 4 , CD 5 and CD 8 ) and natural killer cells were studied with monoclonal antibodies CD 3 and CD 16 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These cells have been characterized by flow cytometry and have been found to express the alpha , beta T cell receptor , co express the CD 2 , CD 5 , CD 7 and HLA DR antigens and did not express CD 14 or CD 15 antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Expression patterns of non lineage specific markers ( terminal deoxynucleotidyl transferase ( TdT ) , CD 34 , and HLA DR ) , B lineage markers ( CD 10 , CD 19 , CD 20 , and CD 22 ) , T lineage markers ( CD 1 , CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , and CD 8 ) , and cross lineage myeloid markers ( CD 14 , CD 15 , and CD 33 ) were compared at diagnosis and relapse . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Different mechanisms regulate the monoclonal antibody induced modulation of CD 2 , CD 3 , and CD 5 in human lymphocytes . ^^^ The CD 2 , CD 3 , and CD 5 antigens are down modulated from the cell surface of peripheral blood mononuclear cells after a 24 hr incubation with specific monoclonal antibodies ( mAb ) . ^^^ Here we show that active ( phorbol myristate acetate , phorbol dibutyrate acetate , and mezerein ) but not inactive ( 4 beta phorbol ) tumor promoting agents inhibit the mAb induced modulation of CD 2 and CD 5 , but not CD 3 , without concomitant changes in the surface distribution of these antigens ( such as capping ) . ^^^ The use of cytoskeleton disrupting agents shows the existence of different cytoskeletal interactions driving the mAb induced modulation of CD 2 and CD 5 with respect to CD 3 . ^^^ Treatment with cytochalasin D ( an agent that inhibits microfilament polymerization ) but not colchicine ( an agent that inhibits microtubule polymerization ) reproduced the effect of TPA on the mAb induced modulation of CD 2 , CD 3 , and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Cell suspensions from peripheral blood of previously untreated cases of CLL LLC ( n = 12 ) and typical CLL ( n = 189 ) were analyzed for immunologic evaluation of surface immunoglobulin ( SIg ) , mouse erythrocyte rosettes , CD 5 , CD 19 , CD 20 , CD 22 , and CD 2 , as well as cytochemical evaluation of tartrate resistant acid phosphatase ( TRAP ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 4 , CD 8 , CD 2 and CD 5 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In Case 1 , the lymph nodes were occupied by > 90 % lymphoblasts , which were positive for CD 2 , cytoplasmic CD 3 ( cCD 3 ) , CD 5 and CD 7 and terminal deoxynucleotidyl transferase ( TdT ) , but negative for myeloid antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Flow cytometry analysis revealed that these cells express CD 45 , CD 56 , CD 2 , CD 7 , CD11a , CD 18 , CD 69 and the intermediate affinity ( p 70 ) IL 2 receptor ( IL 2R ) but not CD 57 , CD 16 , CD 3 , CD 4 , CD 5 , CD 8 , CD45RA , CD 25 , or the high affinity p 55 IL 2R . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The K 052 cell expressed myeloid associated antigens ( CD 13 , CD 14 , and CD 33 ) , lymphoid markers ( CD 2 , CD 5 , and CD 7 ) , and HLA DR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The T CLL cells coexpressed antigens detected by MAbs CD 2 , CD 3 , CD 4 , CD 5 , Ti ( TcR alpha / beta ; WT 31 ) CD 45 and CD45RA , but did not express any other antigens including CD 1 , CD 8 , CD 29 , and TCR gamma / delta , Ti gamma A and TQ 1 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 1 lin TN thymocytes are characterized by expressing high levels of CD 2 , CD 7 , and CD 34 markers and dull levels of CD 5 , CD 10 , and CD 28 molecules . ^^^ Our data show that CD 7 does not necessarily identify T cell precursors during fetal T cell development and strongly support the hypothesis that the acquisition of early T cell markers as CD 2 , CD 28 , and CD 5 molecules on the cell surface of T cell progenitors takes place intrathymically . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The lymphoma cells expressed the thymocytic surface molecule CD 1 , pan T lymphocytic markers CD 2 , CD 5 , CD 6 , CD 7 with concurrent absence of complex CD 3 and receptors for antigen on T lymphocytes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Activities found in four lots each of horse ATG ( ATGAM , Upjohn ) , rabbit and horse ATG ( thymoglobulin and lymphoglobulin , Merieux ) , horse ALG ( Minnesota ) , and rabbit ATG ( Fresenius ) have been compared for CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD11a , CD 18 , CD 28 , CD 44 , CD 45 , and TCR alpha / beta antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
All but one CD7+ CD 5 CD 2 case were of the RA type . ^^^ While one RO type CD7+ CD 5 CD 2 and one RO type CD7+ CD 5 CD2+ cases were not in accord with this sequence , the pattern of CD 45 RA / RO antigen expression in most of T lineage neoplasms could be determined by the respective stage of differentiation . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Twenty nine of the 40 AML cases analyzed ( 73 % ) showed the existence of at least one aberrant phenotype : in 15 cases the myeloid blast cells co expressed lymphoid associated antigens ( CD 2 , CD 5 , CD 7 , and / or CD 19 ) lineage infidelity ; asynchronous antigen expression was detected in 25 patients ( CD34+CD56+ , CD34+CD11b+ , CD34+CD14+ , CD117+CD15+ , CD 33 CD13+ , CD 13 CD15+ , HLADR + CD 15 , HLADR CD14+CD11b+ CD4+ ) ; seven cases displayed antigen overexpression ( CD 13 , CD 33 , CD 15 , or CD 14 ) ; and in 13 patients leukemic cells had an abnormal FSC / SSC distribution according to their phenotype . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Antibodies to gamma delta T cell receptor , CD 2 , CD 3 , or CD11a were also inhibitory , whereas antibodies to alpha beta T cell receptor , CD 4 , CD 5 , and CD 8 had no effect . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The immunophenotypical analysis of lymphoma revealed that the tumor expressed CD 2 , CD 3 , CD 4 , CD 5 , CD 25 and HLA DR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In human T cells CD 45 is reported to associate with both cell surface and intracellular molecules including CD 2 , CD4 / CD8 , CD 5 , p56lck and p59fyn . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Thalidomide does not perturb CD 2 , CD 4 , CD 5 , CD 8 , HLA DR , or HLA A , B , C molecules in vitro on the membranes of cells with immune potential . ^^^ Thalidomide did not modify : ( a ) adhesion and / or signal transducing molecules such as CD 2 , CD 4 , CD 5 and CD 8 , or ( b ) molecules that facilitate antigen presentation such as HLA DR , HLA A , HLA B , or HLA C . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Three of four patients with available fresh frozen tissue specimens demonstrated reduced or absent expression of CD 7 ( Leu 9 ) and / or Leu 8 , while loss of the pan T cell markers CD 2 , CD 3 , and CD 5 was not observed . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Our results demonstrate that whereas expression of major histocompatibility complex ( MHC ) molecules , CD 45 , Mac 1 , LFA 1 , B cell markers , macrophage markers and some T cell markers ( as CD 2 , CD 4 and CD 8 ) did not undergo changes in culture , the level of expression of the adhesion molecules VLA 4 and ICAM 1 , and the T cell markers CD 5 , CD 25 and Thy 1 increased after 14 h incubation at 37 degrees C . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The panel of monoclonal antibodies ( MoAbs ) was selected to identify differentiation associated antigens of both the myeloid and the lymphoid lineages ( CD 13 , CD 33 , CD 14 , CD 15 , CD 7 , CD 34 , CD 10 , HLA DR , CD 19 , CD 2 , CD 5 , TdT ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The binding of Abs directed against other surface markers present on human T cells CD 2 , CD 3 , CD 5 , CD 8 , CD11A , CD 25 , CD45RO , CD45RA , CD 58 , TCR alpha , TCR gamma , and HLA DQ was not inhibited by gp 63 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Comparative two dimensional analysis of CD 2 , CD 3 , CD 4 , CD 5 , and CD 8 immunoprecipitates revealed that pp29 / 30 associates with these signaling receptor complexes but not with CD 18 , CD 27 , and CD 29 in human T lymphocytes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
For four cases of malignant lymphoma , T cell type , the pattern was again T cell phenotype with all of CD 2 , CD 5 , CD 7 and CD 4 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The binding frequencies ( % positive ) for anti CD 2 , CD 3 , CD 5 , CD 6 , CD 7 , CD 8 , CD11a , CD 14 , CD 18 , CD 19 , CD 45 , T cell receptor , and HLA DR were not significantly affected . ^^^ However , there was a partial reduction in the antigen density of CD 2 , CD 5 , CD 8 , and CD11b . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Analysis of the cell surface immunophenotype showed that all individuals express high densities of CD 2 , CD 3 , CD 5 , and TCR alpha / beta on their CD4+ CD8+ subset . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The cells expressed the alpha / beta T cell receptor and the pan T cell antigens CD 2 , CD 3 , CD 5 , and CD 7 , and were negative for both terminal deoxynucleotidyl transferase ( TdT ) and the CD 1 antigen . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In this paper , we report that cross linking of CD 28 ( but not CD 2 , CD 5 , LFA 1 , or CD 7 ) leads to an elevation of c jun mRNA , with only minimal activation of c fos expression . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Approximately 90 % of gamma / delta T cells from peripheral lymphoid organs have the same cell surface phenotype as thymus derived MHC class 1 restricted alpha / beta T cells , i . e . , they are CD 4 but express the CD 8 alpha / beta heterodimer together with CD 2 and CD 5 . ^^^ In contrast , gamma / delta T cells from the epithelium of the small intestine lack CD 2 , CD 4 , and CD 5 and express CD 8 alpha only . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
From a critical analysis of our cases and a review of the literature , we suggest that a panel of 9 monoclonal antibodies ( CD 2 , CD 5 , CD 7 , CD 10 , CD 19 , CD 20 , CD 13 , CD 33 , CD 41 ) , is sufficient for reliable , rapid and reasonably low cost typing of acute leukemia , useful for an immediate therapeutic decision . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The T cell composition of the thymus of 10 ray irradiated ( 3 . 5 Gy ) Wistar rat protected with WR 638 was analyzed by flow cytometry using monoclonal antibodies directed to the Thy 1 . 1 , CD 43 , CD 2 , CD 5 , CD 4 , CD 8 and class 1 and 2 MHC antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In T lymphocytes , CD 2 forms part of a loosely associated membrane complex which includes the T cell receptor ( TcR ) for antigen , the CD 3 subunits , CD 4 or CD 8 , CD 5 and the protein tyrosine kinases p56lck and p59fyn . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These were the antibodies against CD 2 , CD 4 , CD 5 , CD 8 , CD 14 , CD 18 , HLA DR , and the HLA ABC antigen . ^^^ Finally , the CD 2 , CD 4 , CD 5 and CD 8 antibodies reacted with leucocytes from monkey only . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
An increase in the percentage of cells expressing and / or density of surface expression of the pan T cell antigens CD 2 , CD 5 , CD 6 , MHC Class 2 and J 5 , a T cell activation antigen , also occurred . ^^^ Con A treatment led to a significant increase in the percentage of cells bearing CD 8 , CD 6 , MHC Class 2 and J 5 , but it had no effect on the percentages of cells positive for the other T cell markers CD 5 , CD 4 , or CD 2 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
None of the other cytokines tested ( IL 1 alpha , IL 6 , TNF alpha , IFN alpha , IFN gamma ) supported growth of NK 92 cells which have the following characteristics : surface marker positive for CD 2 , CD 7 , CD11a , CD 28 , CD 45 , CD 54 , CD56bright ; surface marker negative for CD 1 , CD 3 , CD 4 , CD 5 , CD 8 , CD 10 , CD 14 , CD 16 , CD 19 , CD 20 , CD 23 , CD 34 , HLA DR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens , modulated lymphocyte surface molecules CD 2 , CD 3 , CD 4 , CD 5 and CD 8 and inhibited the production of interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) and IL 6 by stimulated adherent cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These results indicate that ( a ) the mAb KH 8 , NA 6 , PD 4 and TH 8 identify the avian homologue of the mammalian CD 4 molecule , ( b ) the mAb OC 2 detects the avian CD 2 antigen , and ( c ) the mAb OC 5 recognizes the putative avian CD 5 homologue . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
AG F cell line demonstrated an unusual phenotype , lacking surface CD 2 and CD 3 , but expressing high levels of CD 4 , CD 5 , CD 7 , CD 29 , and CD45RO . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We focused on immunophenotypic differences between the two types of lesions with respect to the T cell markers CD 2 , CD 3 , CD 4 , CD 5 and CD 8 . ^^^ Three of the patients studied ( 20 % ) showed a difference in immunophenotype between plaques and tumours , with an additional loss of one of the T cell markers in the tumours ( respectively , CD 5 , CD 2 and CD 4 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Considerable proportions of the CD19+ B cells coexpressed CD 5 , CD 7 , CD 10 , CD 40 , and CD 2 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The first case expressed natural killer ( NK ) cell , some T cell ( CD 2 , CD 5 , CD 8 ) , and HLA DR antigens , but was negative for other T cell ( CD 3 , CD 4 , CD 7 ) , T cell receptor ( TCR ) , B cell , and myeloid antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The lymphoid component showed a mature T cell immunophenotype ( positive for CD 2 , CD 3 , CD 5 , CD 7 , CD 4 , CD 8 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The neoplastic cells expressed the T cell receptor ( TCR ) delta chain detected by TCR delta 1 and delta TCS 1 , CD 3 , CD 30 , CD45RO , and epithelial membrane antigen , but not the TCR beta chain detected by beta F 1 , CD1a , CD 2 , CD 4 , CD 5 , CD 7 , CD 8 , CD 25 , HLA DR , and terminal deoxynucleotidyl transferase . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The tumor had a mature , aberrant T cell immunophenotype ( CD3+ CD4+ CD7+ CD 2 CD 5 CD30+ ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Protein tyrosine kinases have been implicated in signal transduction in T lymphocytes after stimulation of many cell surface molecules , including the T cell antigen receptor , CD 4 , CD 8 , CD 2 , CD 5 , and CD 28 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
T cell numbers ( CD 2 , CD 3 , CD 5 ) were also low until 12 months but B cell numbers ( CD 19 ) became normal at 3 months . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Both the subpopulations expressed CD 2 , CD 3 , CD 5 antigens and had an alpha beta TCR , but did not express CD1a or CD 7 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
According to the results obtained , the second level of investigation assessed the positivity for intra cytoplasmic ( Cy ) Ig , CD1a , CD 2 , CD 3 , CD 4 , CD 5 , CD 8 and CD 20 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The inability of LOA to present superantigen is not due to a structural difference in MHC 2 molecules between LOA and the splenic APC or to differential expression of major accessory / adhesion molecules , including CD 2 , CD 5 , CD 4 and CD 44 , on LOA . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Five dimensional flow cytometric analysis of normal bone marrow cells was exploited to investigate the hypothesis of a developmental stage in haemopoiesis comprising CD34+ cells coexpressing CD 2 , CD 5 , CD 7 , CD 10 , CD 19 and CD 33 or any combination of these molecules . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In this study the expression of ' classically ' considered lymphoid associated antigens ( CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 10 , CD 19 , CD 20 , and CD 22 ) was explored both in peripheral blood ( PB ) and bone marrow ( BM ) mast cells ( MC ) in a case of systemic mast cell disease ( SMCD ) by means of using multiple stainings and a direct immunofluorescence technique . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Most of the infiltrated lymphocytes were positive for CD 2 , CD 3 , CD 4 and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NKL cells express CD 2 , CD 6 , CD11a , CD 26 , CD 27 , CD 29 , CD 38 , CD 43 , CD 58 , CD 81 , CD 94 , CD 95 , class 2 MHC , and the C1 . 7 . 1 antigen , but do not express detectable levels of CD 3 , CD 4 , CD 5 , CD 8 , CD 14 , CD 19 , CD 20 , CD 28 , alpha / beta or gamma / delta T cell receptors on the cell surface . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The tumor cells were negative for the CD 2 , CD 3 , CD 5 , CD 10 , CD11c , CD 25 , CD 35 , CD 38 , CD45RO , and CD 68 antigens , and tartrate resistant acid phosphatase . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Recently we reported that the human thymus contains a minute population of CD34+CD38dim cells that do not express the T cell lineage markers CD 2 and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The induction of IL 1 beta mRNA during anti CD 3 mitogenesis was significantly inhibited by anti CD 2 mAb , whereas mAb against CD11a , CD 18 , CD 69 , or CD 5 molecules had no effect . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Although they usually express a restricted number of T cell related antigens , namely , CD 2 , CD 43 , and CD45RO , other pan T or subset T lineage antigens , such as CD 3 ( membrane ) , CD 5 , CD 4 , CD 8 , and CD 7 , are frequently absent . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Acute myeloid leukemia and MPD / MBC cases expressing one or more of the following antigens , CD 2 , CD 3 , CD 5 , CD 7 , CD 19 , or CD 20 , were considered to be Ly + AML . ^^^ Of these , the T cell associated markers CD 7 , CD 2 , and CD 5 were expressed on 7 ( 44 % ) , 6 ( 38 % ) , and 4 ( 25 % ) Ly + AML cases , respectively . ^^^ These results suggest that expression of CD 2 , CD 5 , and CD 7 in otherwise straightforward AML should not be taken as evidence of lymphoid lineage commitment and does not warrant a diagnosis of AMLL . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
No differences in proportions were found with respect to the expression of CD 14 , CD 15 , CD45RA ( myeloid commitment ) , CD 2 , CD 5 , CD 7 ( T lymphoid commitment ) , CD 117 , CD 71 and CD45RO antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Phenotypically , gamma / delta thymocytes from fetal and neonatal thymus expressed CD 3 , CD 2 , and CD 5 , but only 60 80 % were CD8+ and approximately 40 50 % expressed the alpha chain ( p 55 ) of the IL 2R . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Flow cytometry was used to determine the percentage of CD4+CD7 cells and the CD4 / CD8 ratio and to detect aberrant expression of the pan T cell antigens CD 2 , CD 3 , and CD 5 . ^^^ Aberrant CD 2 , CD 3 , or CD 5 expression was observed in 66 % of patients with SS , 29 % with pre SS , 30 % with MF , but in none of the patients with a benign dermatosis . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Bronchoalveolar lavage fluid ( BALF ) and peripheral blood were obtained from each of 17 adult Arabian mares and absolute numbers and relative lymphocyte proportions were determined for total T lymphocytes , using CD 2 as a marker , CD 4 + T lymphocytes , CD 8 + T lymphocytes , CD 5 + lymphocytes , and sIgM + B lymphocytes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
For each sample phycoerythrin ( PE ) conjugated CD 2 , CD 4 , CD 5 , CD 8 , and CD 56 monoclonal antibodies were combined with Cy 5 R phycoerythrin ( TC ) conjugated CD 3 and fluorescein isothiocyanate ( FITC ) conjugated CD 7 ; CD 2 and CD 7 PE were also combined with CD 3 TC and CD 4 FITC . ^^^ Within the CD4+ T cells , the CD4+CD7 subset expressed a lower level of CD 3 compared with CD4+CD7+ and CD8+CD7+ cells , and higher CD 2 and CD 5 expression than the main CD3+CD7+ subset . ^^^ Major differences in antigen expression were also detected between CD3+ T cells and CD 3 CD56+ natural killer ( NK ) cells : NK cells exhibited higher levels of CD 7 and CD 56 and lower levels of CD 2 and CD 5 than T cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Two types of large complexes containing protein tyrosine kinases were observed : the first one contained CD 3 and the transmembrane proteins CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , CD 8 , CD11a , CD 38 , CD 43 , CD 45 , CD 71 , CD 98 and CD 99 and the other contained mainly the GPI anchored proteins CD 48 , CD 55 , CD 59 and CDw 108 as well as a fraction of CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The mononuclear cells stained positively for Pan T , CD 2 , CD 3 , CD 4 , CD 5 , CD 25 , and DNA from the cells showed HTLV 1 provirus monoclonal integration . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Frozen sections were stained with monoclonal antibodies directed against IL 7R , CD 25 , CD 30 and T antigens ( CD 3 , CD 2 , CD 5 , CD 7 , CD 4 , CD 8 ) , using the alkaline phosphatase antialkaline phosphatase technique . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A substantial proportion of these cells ( about 40 % ) co expressed CD45RA and CD 117 , while a very small number displayed markers of advanced myeloid commitment , such as CD 14 , CD 15 and CD 41 ( less than 2 % ) , or those of lymphoid differentiation : CD 2 , CD 5 , CD 7 , CD 10 and CD 19 ( less than 6 % ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These patients were unclassifiable by FAB criteria , they were CD34+ and did not express myeloid or lymphoid associated antigens ( CD 13 , CD 33 , CD 14 , CD 15 , CD 61 , CD 19 , CD 10 , CD 22 , CD 7 , CD 2 , CD 5 , CD 3 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The peripheral blood lymphocytes were analyzed using a double colored flow cytometry and adequate monoclonal antibodies to CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD11b , CD 16 , CD 19 , and HLA DR receptors . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 2 , CD 5 , CD 10 , and CD 19 were expressed in a similar fashion among the different FAB groups , whereas CD 4 expression was significantly more frequent in AML M 0 , AML M 4 , and AML M 5 ( P = . 014 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In both situations , the absence of CD 2 appeared to promote the positive selection of cells in a manner that is similar to that which occurs in the absence of CD 5 . ^^^ Consistent with this , compound homozygotes that lacked both CD 2 and CD 5 showed evidence of enhanced positive selection even in the absence of a transgenic TCR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A remarkable number of different molecules on DP thymocytes possessed `` coinducing ' ' activity , including CD 2 , CD 5 , CD 24 , CD 28 , CD49d , CD 81 , and TSA 1 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Human thymus contains a small population of B cells , a fraction of which expresses CD 2 and / or CD 5 , as revealed by FACS analysis . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Two immunologically distinct blast cell subsets expressed T markers ( CD 2 , CD 5 , CD 7 ) and common ALL markers ( TdT , CD 19 , CD 22 , CD 10 ) , respectively . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Induction of HIV 1 resistance was specific for CD 28 costimulation , in that a variety of other accessory receptors , such as CD 2 , CD 4 , CD 5 , and MHC class 1 , failed to confer the antiviral resistance . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 19 , CD 20 , CD 5 , CD 2 , CD 4 , CD 8 surface markers and amplification of the Ig heavy chain CDR 3 locus were used for immunophenotypic and genotypic analysis , respectively . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Aberrant expression of CD 2 , CD 3 , and / or CD 5 antigens was noted in 3 of 6 ( 50 % ) cases of patch / plaque stage MF , all three cases of tumor stage MF , and 5 of 8 ( 62 % ) pleomorphic CTCLs , but not in any of the 11 pseudo T cell lymphomas . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NK cells also have phenotypic and genotypic characteristics : they express the NK related antigen CD 56 , T cell markers such as CD 2 and CD 7 , but do not express CD 5 and T cell receptor ( TCR ) proteins , and their TCR locus is not rearranged . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In the current analysis , T lineage ALL patients were immunophenotypically classified as follows : CD7+ CD 2 CD 5 pro thymocyte leukemia ( pro TL ) , CD7+ ( CD 2 or CD 5 ) + CD 3 immature TL , and CD7+ CD2+ CD5+ CD3+ mature TL . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : Mononuclear cells of 17 patients with CML in BC were immunophenotyped employing a panel of 18 monoclonal antibodies : CD 5 , CD 10 , CD 14 , CD 22 , and anti HLA DR used in all patients ; CD 2 , CD 15 , CD 19 , CD 34 , and CD 41 in 13 to 16 patients ; and CD 3 , CD 7 , CD 13 , CD 20 , CD 21 , CD 33 , CD42b , and CD 61 in less than 10 patients . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotyping showed that most peripheral blood mononuclear cells were negative with B lymphoid , myeloid , and stem cell associated markers and were also negative with most T lymphoid markers ( CD 2 , CD 4 , membrane / cytoplasmic CD 3 , CD 5 and CD 8 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Subsequently we examine the expression of costimulatory and activation molecules ( CD 2 , CD 5 , CD11a , CD11b , CD 25 , CD 28 , CD 43 , CD 54 , OX 40 , RT 1A , RT 1B and RT 1D ) during distinct maturational stages in order to detect possible clues to the observed effects of CsA on thymocyte maturation and selection . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Constant detection of CD 2 , CD 3 , CD 4 , and CD 5 in fixed and paraffin embedded tissue using the peroxidase mediated deposition of biotin tyramide . ^^^ Using this optimized ImmunoMax method , we were able to detect CD 2 , CD 3 , CD 4 , and CD 5 with conventional monoclonal antibodies in formalin fixed , paraffin embedded tissue specimens of various lymphoid tissues . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The lymphoid cells were positive for mature B cell antigens and the phenotype was : CD 5 , CD 10 , CD19+ , 20+ , CD22+ , IgG+ , IgA , IgM , kappa , lambda+ , CD 1 , CD 2 , CD 3 , CD 4 , CD 7 , CD 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Cells reactive with MAb WT 1 ( CD 7 ) were present in a scattered single pattern ( < or = 20 / mm2 ) among the parenchymal cells ; cells expressing mature T cell markers ( CD 2 , CD 3 , CD 5 ) were rare . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
PBL subsets were analyzed by flow cytometry with the use of monoclonal antibodies against CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 16 , CD 20 , CD45RA , CD 56 , CD 57 and HLA DR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The LGLL cells expressed T cell markers such as CD 1 , CD 2 , CD 3 , CD 5 , CD 7 , CD 8 and CD 57 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
All glycosylphospha tidylinositol ( GPI ) anchored proteins ( CD 14 , CD16B , CD 48 , CD 59 , CD 87 and GPI anchored versions of CD 2 and CD 25 ) and protein tyrosine kinase ( PTK ) Lck but not transmembrane proteins ( CD 2 , CD 4 , CD 5 , CD 6 , CD 8 ) and PTK ZAP 70 were in part localized in buoyant , lipid rich , detergent resistant membrane GPI microdomains of the COS cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Cell surface antigens were investigated with monoclonal antibodies directed to : B lymphoid ( CD 10 , CD 19 , CD 20 , CD 21 , CD 22 ) ; T lymphoid ( CD 2 , CD 3 , CD 5 , CD 7 ) ; and myeloid ( CD 13 , CD 14 , CD 15 , CD 33 , CD 41 ) cell lineages . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Anti CD 28 monoclonal antibody ( mAb ) and mAb against CD 5 , CD 9 , CD 2 , CD 44 or CD11a all induced activation of naive T cells in the absence of APC when co immobilized with a submitogenic dose of anti CD 3 mAb . [ 3H ] Thymidine incorporation determined 2 days after co stimulation was all comparable . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We describe a CD 3 CD7 + IEL subset frequently found in control subjects ( 41 . 41+ / 21 . 8 ) , with the following features : 1 ) most of these cells are CD45R0+ CD103+ and CD 44 CD 28 CD 5 ; 2 ) a significant percentage express CD 56 ( 44 . 7 % + / 21 . 3 ) , CD 2 ( 55 . 1 % + / 16 . 2 ) , and CD 94 ( 16 . 2 % + / 7 . 3 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
CD 20 was the most commonly expressed lymphoid antigen ( 17 % ) , although often expressed in only a subpopulation of leukemic cells , followed by CD 7 ( 16 % ) , CD 19 ( 9 . 8 % ) , CD 2 ( 7 . 5 % ) , CD 3 ( 6 . 7 % ) , CD 5 ( 4 . 8 % ) , and CD 10 ( 2 . 9 % ) . ^^^ Some immunophenotypes correlated with FAB type , including increased frequency of CD 2 expression in AML M 3 ; lack of CD 4 , CD11c , CD 36 , CD 117 , and HLA DR expression in AML M 3 ; increased frequency of CD 20 and CD 36 expression and lack of CD 34 expression in AML M 5 ; increased frequency of CD 5 expression in AML M5a ; and increased frequency of CD 14 expression in AML M5b , when compared with all other AMLs ( P < . 05 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Newly confirmed mAb assignments included : two CD 2 ; one CD 4 ; two CD 5 ; one wCD 6 ; and one wCD 25 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The association with CD 7 , CD 2 , CD 5 ( without CD 3 membrane expression ) and CD 34 in T blasts was evident . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The lowest concentration eliciting 2 or more coughs ( CD 2 ) or 5 or more coughs ( CD 5 ) was recorded . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
However , these CD 8 ( + ) TCR cells did express surface markers characteristic of T cells , including Thy1 . 2 , CD 2 , and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The NK YS cells showed LGL morphology and expressed surface CD 2 , CD 5 , CD 7 , CD 25 , CD 56 , and CD 95 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The patchy infiltrate consisted equally of CD 2 , CD 3 , CD 5 , and CD 7 positive T lymphocytes as well as CD 20 and CD 22 positive B lymphocytes expressing both kappa and lambda immunoglobulin light chains . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The leukaemic cells were also positive for T cell antigens such as CD 2 , CD 3 , CD 5 , CD 7 , CD 8 and T cell receptor ( TCR ) Vbeta 8 and for activation antigens such as CD 38 and HLA DR , but were negative for CD 19 , CD 21 , CD 22 , CD 25 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
All cell lines expressed CD 2 , CD 5 and CD 25 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The vast majority of DPP 4 positive T ALL cases expressed CD 4 , CD 8 , CD 7 , CD 5 , CD 2 along with CD 71 and CD 38 antigens , but the cells were surface membrane CD 3 antigen negative . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Nonlineage expression of markers ( CD 1 , CD 2 , CD 4 , CD 5 , CD 7 , and CD 56 ) was nonspecific as to AML subtype . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Virtually all TCRgammadelta+ T ALLs expressed TdT , CD 2 , CD 3 , CD 5 , CD 6 , and CD 7 , but they were heterogeneous in their CD1 / CD4 / CD8 immunophenotype . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Recombinant soluble forms of six leukocyte antigens belonging to the Ly 6 ( CD 59 ) , scavenger receptor ( CD 5 ) , and immunoglobulin ( CD 2 , CD 48 , CD 4 , and Thy 1 ) superfamilies were expressed in the same Chinese hamster ovary cell line , thus providing an opportunity to examine the extent to which N linked oligosaccharide processing might vary in a superfamily , domain , or protein dependent manner in a given cell . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The lymphoma expressed CD 2 , CD 3 , CD 7 , CD 8 and CD 56 , and the gammadelta T cell receptor and did not express CD 5 , CD 4 and the alphabeta T cell receptor . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotypes of 33 samples from patients with acute leukemia were analyzed using a panel of these monoclonal antibodies : anti immature / stem cell ( HLA DR , CD 34 ) ; anti mature myeloid ( CD 33 , CD 15 ) ; anti T lymphoid ( CD 2 , CD 3 , CD 5 , CD 7 , CD 8 ) , and anti B lymphoid ( CD 10 , CD 19 , CD 20 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A small fraction of rat 13 day old fetal liver ( r13FL ) cells , which weakly expressed the leukocyte common antigen CD 45 , constituted a homogeneous Thy 1 ( hi ) , CD 71 ( ) , CD 44 ( + ) , MHC class I+ , CD 43 ( + ) cell subpopulation negative for CD45RC , CD 3 , TCRalphabeta , TCRgammadelta , CD 2 , CD 5 , CD 4 , CD 8 , CD 25 , CD 28 , NKR P1a and sIg . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In three patients with identified clones ( Vbeta 3 . 1 , 5 . 3 and 6 . 7 ) , double staining revealed positivity for CD 2 , CD 3 , CD 4 , CD 5 , CD45RO and CD 7 in a significant proportion ( at least 35 % ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The neoplastic cells showed a high Ki 67 proliferation index and expression of CD 3 , CD 8 , CD 7 , CD45RA , betaF 1 , and TIA 1 markers , whereas CD 2 and CD 5 were frequently lost . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The blasts were strongly positive for both CD 7 and CD 56 but negative for other T lineage associated antigens , including CD 1 , CD 2 , surface membrane CD 3 , cytoplasmic CD3c ( 2 / 2 ) , CD 4 , CD 5 and CD 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The percentages ( % ) of patients with double Ag coexpression in at least 20 % of the CD19+ or CD20+ lymphoma cells were : stem cell ( SC ) Ag : CD 10 = 58 and CD 34 = 15 ; T cell Ag : CD 2 = 38 , CD 5 = 19 and CD 7 = 19 ; myeloid ( My ) Ag : CD 13 = 19 and CD 33 = 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Her bone marrow was normocellular with an excess of blasts ( 89 . 1 % , peroxidase stain ( ) , PAS stain ( ) ) that displayed a positive immunophenotype for CD 2 , CD 4 , CD 5 , CD 7 , CD 34 , CD 38 , and CD 71 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotyping of the peripheral blood T cells revealed evidence for a clonal expansion of highly activated CD 4 ( + ) T cells with reduced CD 2 and CD 5 surface expression . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In addition , this association was enhanced following independent ligation of the CD 2 , CD 4 , or CD 28 costimulatory molecules , but not of CD 5 or CD 6 surface receptors , correlating to the induced tyrosine phosphorylation of Emt . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunoprecipitation of T cell lysates with anti CD 9 mAb followed by immunoblotting with mAb against various T cell molecules showed the association of CD 9 with CD 3 , CD 4 , CD 5 , CD 2 , CD 29 and CD 44 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Histologic sections of a cervical lymph node demonstrated a marked paracortical proliferation of occasional small and intermediate sized lymphocytes and numerous large immunoblasts , the majority of which displayed a CD 3 ( + ) , CD 43 ( + ) , CD45RO ( ) ( OPD 4 , UCHL 1 ) CD 4 ( ) , CD 8 ( ) phenotype on paraffin sections , and which had a CD 2 ( + ) , CD 3 ( + ) , CD 5 ( + ) , CD 56 ( ) , Tdelta 1 ( ) , [ CD 4 ( ) , CD 8 ( ) ] double negative profile on flow cytometric analysis . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Moreover , the former DC subpopulation clearly showed higher expression of the CD 13 myeloid associated antigen , the CD 29 and CD 58 adhesion molecules , the CD 2 , CD 5 and CD 86 costimulatory molecules , the CD 32 IgG receptor and the CD11c complement receptor . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The patient had marked splenomegaly , generalized lymphadenopathy and marked proliferation of abnormal lymphocytes in the peripheral blood with an irregular nucleus , deeply basophilic cytoplasm and a single prominent nucleolus , which were positive for CD 2 , CD 3 , CD 5 , CD 7 , CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Non CD 28 costimulatory molecules such as CD 5 , CD 9 , CD 2 , and CD 44 were present in the detergent insoluble glycolipid enriched ( DIG ) fraction / raft of the T cell surface , which is rich in TCR signaling molecules and generates a TCR signal upon recruitment of the TCR complex . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
To further characterize the cellular phenotypes we used an indirect immunoperoxidase assay to analyze sections from two atopic dermatitis lesion skin biopsies using the following as first step monoclonal antibodies ( MAB ) : anti CD 34 , CD 2 , CD 5 and CD 7 . ^^^ A strong immunoreaction was observed for the T lineage marker CD 2 and CD 5 , but a poor reaction , if any , was seen for the CD 7 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Flow cytometric analysis revealed that the expression of CD 4 and CD 8 on T cells was decreased in Donryu rats , though the expression of other T cell markers such as CD 2 , CD 3 and CD 5 was not different . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Extracellular release of free fatty acids by rat T lymphocytes is stimulus dependent and is affected by dietary lipid manipulation . [ ( 3 ) H ] Arachidonic acid labelled rat T lymphocytes released radioactivity extracellularly when stimulated by the calcium ionophore A 23187 or by monoclonal antibodies to some cell surface structures ( CD 2 , CD 5 , CD11a , CD 18 , CD 54 , T cell receptor ) but not to others ( CD49d , CD62L ) ; release was greater with the calcium ionophore . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Surface marker analysis of lymph node cells was positive for CD 2 , CD 3 , CD 4 , CD 5 , CD 56 , and HLA DR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunologic characterization of these cells revealed positivity for CD 3 , CD 5 , CD45RO , CD 56 , and T cell intracellular antigen ( TIA ) , and negativity for CD 2 , CD 3 , CD 4 , CD 8 , CD 57 , CD 34 , and terminal deoxynucleotidyl transferase ( TdT ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Cerebrospinal fluid examination revealed atypical lymphoid cells with azurophilic granules , which were positive for CD 2 , CD 8 , and CD 56 , and negative for CD 3 and CD 5 by flow cytometry . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Blast cells showed strong positive expression of CD 7 and HLA DR , and weakly expressed CD 2 , CD 5 and CD 10 , as well . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
These cells express the T cell antigens CD 2 and CD 5 on their surface , but not CD 7 , and they express CD 4 and CD 45 at numbers of molecules per cell typical for T lymphocytes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
They exhibited an early pre B immunophenotype ( TdT , CD 19 , CD 10 , CD 20 and CD 22 positive ) and stained negative for T ( CD 7 , CD 2 , CD 5 and CD 3 ) and myeloid markers ( MPO , CD 33 and CD 13 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We performed the immunophenotyping of 101 patients with B cell non Hodgkin ' s lymphoma ( B NHL ) using two colour flow cytometry ( FCM ) and found that lymphoma cells coexpressed at least one kind of T cell associated antigen ( T Ag ; CD 2 , CD 5 , CD 7 ) in 25 patients ( 24 . 8 % ) . ^^^ Among these three T Ags , CD 5 was the most frequently expressed , in 21 patients ( 20 . 8 % ) , followed by CD 7 , expressed in five patients ( 5 . 0 % ) , and CD 2 , which was expressed in two patients ( 2 . 0 % ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
To minimize the risk of misinterpretation of lymphoma cell lineage , especially in cases of extranodal , lymphoproliferative disease , we suggest the use of both CD79a and CD 20 in combination with a panel of antibodies reactive to T cells , such as betaF 1 and CD 5 , and to T cells and NK cells , such as CD 3 , CD 2 , CD 56 , and TIA 1 . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In the two cases where tissue was available for immunohistochemical study in frozen sections , neoplastic cells showed CD 56 ( Leu 19 ) + perforin+ Fas ligand ( FasL ) + CD 2 ( Leu5b ) CD 3 ( Leu 4 ) CD 4 ( Leu 3 ) CD 5 ( Leu 1 ) CD 7 ( Leu 9 ) CD 8 ( Leu 2 ) betaF 1 TCRdelta 1 phenotypes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Lymphoma cells expressed the gd T cell receptor ( TCR ) , CD 2 , CD 3 , CD 5 , CD 7 , CD 38 , CD 45 , CD 161 ( NKR P 1 ) , TIA and Ki 67 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A 72 year old Caucasian man presented with a malignant neoplasm comprised of blastoid cells without azurophilic granules in the Giemsa stain , with positivity for CD 2 , CD 4 , HLA DR , CD 45 and CD 56 , and negativity for CD 3 ( surface and cytoplasmic ) and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The main outcome measures were lymphocyte subset and activation markers determined by two and three color flow cytometry ( CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 16 , CD 19 , CD 23 , CD 25 , CD 56 , and HLA DR ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Skin biopsies were taken at the same time points , fixed , sectioned , and stained with Giemsa for histologic evaluation , or with mouse anti swine monoclonal antibodies ( CD 1 , CD 2 , CD 4 , CD 5 , CD 8 , CD 25 , CD 45 , MHCII ) and with one mouse anti human monoclonal antibody ( CD62E ) cross reacting with swine for immunohistochemical evaluation . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
BCL 6 ( + ) cortical and medullary thymocytes also expressed CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , or CD 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Expression of some leukocyte antigens ( including CD 45 ) and its isoforms ( CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , and CD 8 ) was examined in the human periapical granulation tissue samples in the present study . ^^^ Expression of CD 2 , CD 5 , CD 6 , and CD 7 antigens was also detected , implying significant roles for these antigens in the immune reaction taking place in periapical lesions . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The atypical lymphocytes were positive for CD 2 , CD 3 , CD 5 , CD 7 , CD 56 and TCR gamma delta , but negative for CD 4 , CD 8 , CD 57 , TCR alpha beta and B cell antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Most ( > 75 % ) agreed that at least one more B ( CD 20 , CD 22 , CD79a , IgM ) , T ( CD1a , CD 2 , CD 4 , CD 5 , CD 8 ) , myeloid ( CD11b , CD 15 , CD 64 , CD 117 , myeloperoxidase ) , erythroid ( CD 36 , CD 71 , glycophorin A ) , and megakaryocytic ( CD 41 , CD 61 ) reagents should be included in the essential panel . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotypic analysis revealed that blast cells were positive for myeloid antigens ( CD 13 , CD 33 ) , and natural killer ( NK ) cell antigen ( CD 56 ) , but negative for T cell antigens ( CD 2 , CD 5 , CD 7 ) , B cell antigens ( CD 19 , CD 20 ) , CD 34 , and HLA DR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Bone marrow and lymph node biopsies showed a T cell lymphoproliferative disease expressing NKRs ( CD 2 ( + ) , CD 3 ( + ) , CD 4 ( + ) , CD 5 ( + ) , CD 7 ( + ) , CD 8 ( ) , CD 56 ( ) , CD 94 ( + ) , CD158a ( + ) , CD158b ( + ) , CD 161 ( ) , p 70 ( ) , TCRalphabeta ( 1 ) , TCRgammadelta ( 2 ) , TIA 1 ( ) ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The reverse association was observed between CD 20 expression and the presence of co expression of myeloid ( CD 13 , CD 33 , CD 65 , CD 15 ) and T lymphoid determinants ( CD 2 , CD 5 , CD 7 ) on leukemia cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The most common abnormally expressed antigen was CD 3 , followed by CD 7 , CD 5 , and CD 2 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
All tested patients had CD 2 , CD 7 , CD 4 , and / or CD 8 positivity , whereas CD 5 and CD 3 were positive in 98 % and 96 % of tested patients , respectively . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
B cell markers , such as terminal deoxynucleotidyl transferase ( TdT ) , CD 10 , CD 19 , CD 20 and HLA DR were positive , and CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , kappa , lambda , cytoplasmic mu and myeloperoxidase were negative . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The flow cytometric immunophenotype of the lymphoma cells was CD 2 , CD 3 , CD 4 , CD 5 , CD8+ , CD10+ , CD19+ , CD20+ , CD 23 , kappa+ , lambda , CD25+ , and CD 56 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Flow cytometric immunophenotyping showed expression of CD 2 , CD 3 , and CD 7 with lack of expression of CD1a , CD 4 , CD 5 , CD 8 , and CD 56 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We immunophenotyped 128 patients with B cell non Hodgkin ' s lymphoma ( B NHL ) of various histological subtypes using two color flow cytometry ( FCM ) , and found that lymphoma cells obtained from 31 patients ( 24 . 2 % ) coexpressed at least one of the following T cell associated antigens ( T Ag ) ; CD 2 ( 2 . 3 % ) , CD 5 ( 18 . 0 % ) or CD 7 ( 6 . 3 % ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The tumor cells in all cases tested were positive for CD 2 , CD 3 , CD 4 , CD 5 , and CD 25 and were negative for CD 7 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Tumor cells were negative for surface CD 3 , CD 5 , and CD 20 in all cases , but some patients showed expression of CD 2 ( three out of five ) , cytoplasmic CD 3 ( two out of seven ) , CD 4 ( six out of seven ) , and CD 16 ( three out of seven ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The cell line and its source coexpressed CD 2 and CD 20 molecules , but other representative B and T cell markers such as CD 1 , CD 3 , CD 5 , CD 7 , CD 10 and CD 19 were not found . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In conditions of severe energy structural deficiency and impaired function of oxygen transport systems , CVD patients develop secondary immune deficiency presenting with depression of basic immunoregulatory subpopulations of T and B cellular immunity ( CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 16 , CD 22 ) . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The tumor was composed of primitive lymphoid cells expressing CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , and CD 10 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
By flow cytometry , we have defined three distinct patterns of cytoskeletal association ; constitutive , inductive , and mAb crosslink induced , and assigned human and bovine CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 18 , CD 19 , CD 44 , CD45RA , CD45RO , alphabeta TCR , gammadelta TCR , E selectin ligands , and L selectin surface antigens to one of these respective patterns . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Hematoxylin and eosin stained sections were examined and immunophenotyping was carried out on paraffin embedded , formalin fixed tissue using antibodies to CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 20 , CD 30 , and CD 56 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We conclude that AILT is mainly derived from CD 2 ( + ) CD 3 ( + ) CD 4 ( + ) CD 5 ( + ) CD 7 ( ) mature T helper cells with varying expression and partial loss of detectable CD 4 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : To investigate this hypothesis , bone marrow mononuclear cells ( MNC ) from 15 patients with low grade MDS , refractory anemia , and refractory anemia with ringed sideroblasts ( RA and RARS ) , and from 7 normal donors were depleted of CD 2 ( + ) , CD 5 ( + ) , and CD 7 ( + ) lymphocytes using magnetic cell sorting . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Tumor cells expressed CD 4 , CD 7 , CD 10 , CD45RB , CD 56 , CD 68 , and HLA DR and were negative for CD1a , CD 2 , sCD 3 , CD 5 , CD 13 , CD 14 , CD 20 , CD 33 , CD 34 , CD 43 , CD45RA , TIA 1 , S 100 , and TdT . cCD 3 was not detected in the immunostaining using paraffin tissue , but was faintly expressed in flow cytometry and immunostaining using a touch imprint slide . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunoprecipitation analysis showed that CD 6 coprecipitated with CD 5 , which in turn , was coprecipitated equivalently with CD 2 , CD 6 , and the T cell receptor ( TCR ) , but the fraction of CD 5 associated with CD 6 was highly phosphorylated in kinase assays , in marked contrast with the low level of phosphorylation of CD 5 associated with TCR or CD 2 . ^^^ CD 6 also associated with Lck , Fyn , and ZAP 70 , although at lower levels but additionally coprecipitated the Tec family kinase Itk , which is absent from CD 2 , CD 5 , and TCR complexes . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Moreover , these cells were CD 90 ( low ) but negative for the classical T cell markers CD 2 and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
At least 1 T cell associated antigen was expressed in each case ( CD 2 , 12 / 17 [ 71 % ] ; CD 4 , 12 / 19 [ 63 % ] ; CD 3 , 6 / 19 [ 32 % ] ; CD 7 , 6 / 19 [ 32 % ] ; CD 5 , 5 / 19 [ 26 % ] ; CD 8 , 4 / 19 [ 21 % ] ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Frozen sections of the tissues were immunohistochemically stained using monoclonal antibodies against surface markers CD 2 , CD 4 , CD 5 , CD 8 , B cell and granulocyte monocyte / macrophage and antiserum against specific granules of bovine eosinophils . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The lymphoma cells were positive for CD 2 , CD 3 , CD 5 , CD 8 , and T cell receptor ( TCR ) beta F 1 , but negative for CD 4 , CD 19 , CD 20 , CD 103 , and CD 56 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Light microscopy , immunohistochemical analysis using antibodies to CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , and CD 30 in 6 cases , and polymerase chain reaction single stranded conformational polymorphism analysis for T cell receptor gamma chain gene rearrangement in 5 cases revealed 2 cytomorphologic patterns ( large cell dominant with polymorphous inflammation , small cell lymphocyte rich with an inconspicuous large cell component [ phenotypes , CD30+ / CD3+ / CD4+ / CD7 for large atypical cells ; reactive for small lymphocytes ] ) and clonal restriction in 4 and polyclonality in 1 of the lymphocyte dominant cases . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The diagnosis of T cell prolymphocytic leukemia ( T PLL ) was confirmed by cytological and immunological assays ( TdT ( ) , CD 2 ( + ) , CD 5 ( + ) , CD3m , and CD 7 ( + ) ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We studied the expression of CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 56 , and CD 138 in 447 cases of common human neoplasms with epithelioid features . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunostaining of formalin fixed , paraffin wax embedded bone marrow specimens was performed using antibodies against CD 2 , CD 5 , CD 20 , CD 23 , and CD 25 ; kappa and lambda immunoglobulin light chains ; and MC markers chymase , tryptase , and CD 117 ( KIT ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A number of ( non chimeric ) subpopulations of bone marrow cells including CD 34 ( + ) stem cells and the CD 34 ( ) early progeny like CD 38 ( + ) , CD 2 ( + ) , CD 5 ( + ) and CD 1 ( + ) lymphoid cells as well as CD 33 ( + ) ( but CD 15 ( ) ) myeloid cells down regulated the MLR and CML responses of allogeneic PBMC stimulated with ( autologous ) donor spleen cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
In recombinase gene null pre T cells , membrane and cytosolic active PKD both induced differentiation reminiscent of beta selection : downregulation of CD 25 and upregulation of CD 2 and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
They hypothesize that the key event in T cell activation is the formation of multimolecular complexes consisting of the TCR and several other polypeptides , including CD 4 or CD 8 , CD 2 , CD 5 and the associated tyrosine kinases p 59 ( fyn ) and p 56 ( lck ) . . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The immunoprofile of the cells was concordant with that of MM cells : positive for CD 10 , CD 28 , CD 38 , CD 138 , CD 56 , CD49d , CD 44 , CD 54 and CD 58 , negative for CD 19 , CD 40 , CD 95 , CD95L , CD 34 , CD 2 and CD 5 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The prothymocytes are positive for the terminal deoxynucleotidyl transferase ( TdT ) and give rise to cortical thymocytes , which express CD 1 , CD 2 , CD 3 , CD 5 , and both CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The least mature cells ( double negative ) expressed low density CD 2 and CD 5 , high density CD 7 , CD 10 , CD 34 , and heterogeneous CD 4 and CD 8 . ^^^ The immature cells ( double positive ) expressed CD 2 , CD 5 , CD 7 , CD 4 , CD 8 , heterogeneous surface CD 3 , and intermediate density CD 45 . ^^^ The mature cells ( single positive ) expressed CD 2 , surface CD 3 , CD 5 , CD 7 , and CD 4 or CD 8 . ^^^ Of 7 double positive cases , 5 showed complete loss of surface CD 3 , CD 2 , and / or CD 5 ; 4 were CD10+ ; and 2 were CD34+ . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
METHODS : Peripheral blood lymphocyte subpopulations were analyzed by dual color flow cytometry by using monoclonal antibodies for the lymphocyte receptors CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 16 , CD 19 , CD11b , CD11c , and HLA DR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Flow cytometric immunophenotype analysis showed that over 80 % of the cells were positive for CD 2 , CD 3 , CD 4 , CD 5 and CD 7 antigens and negative for terminal deoxynucleotidyl transferase and CD1a antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Staining for CD 2 , CD 3 , CD 5 , CD 7 , CD 20 , CD 23 , CD 33 , CD 14 , CD 15 , AC 133 and KOR SA 3544 was negative . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
RESULTS : HR 8348 cell line did not express CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , TCR , CD 10 , CD11b , CD 14 , CD 16 , CD 19 , CD 22 , CD 25 , CD 28 , SmIg , CD 33 , CD 35 , CD 36 , CD41a , CD 45 , CD45RA , CD45RO , CD 56 , CD 61 , CD 64 , CD66b , CD 69 , CD 71 , CD 117 , CD 122 and P glycoprotein but expressed CD 13 , CD 15 , CD 20 , CD 38 , CD 95 and HLA DR . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotyping of her leukemic cells showed positive for CD 2 , CD 5 , CD 7 , CD 34 , CD 56 , HLA DR , and cytoplasmic CD 3 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotypic study was as follows : CD 2 + ( 97 % ) , CD 3 + ( 95 % ) , CD 5 + ( 95 % ) , CD3 / CD4 + ( 93 % ) , CD3 / CD25 + ( 84 % ) , CD 7 / CD4 + ( 89 % ) CD 2 + / HLA DR + ( 53 % ) , TCRabeta + ( 96 % ) and CD 7 ( 7 % ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
MATERIAL / METHODS : To further elucidate phenotypic differences of T cell subsets , and begin to determine what information relative antigen density contributes to immunology , we analyzed normal human peripheral blood T cells for a variety of immunophenotypic ( CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD45RA , CD45RO , TCR alpha beta ) and light scatter characteristics using 6 color flow cytometry . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Both large and small malignant cells were positive for CD43 / MT1 T cell associated antigen , perforin , granzyme B and TIA 1 , but negative for CD 2 , CD 3 , CD 5 , CD 7 , CD 4 and CD 8 antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immune system tests including white blood cell count , lymphocyte count , T and B cells subgroups ( CD 2 , CD 4 , CD 5 , CD 7 , CD 8 , CD 16 , CD 20 , CD 22 , CD 56 ) , mitotic reaction to phytohaemagglutinin in lymphocyte culture . ^^^ Significant differences in mean lymphocyte number , and CD 2 , CD 4 , CD 5 , CD 8 , CD 16 ratios between the two groups were defined ( P < 0 . 05 ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The expression of CD 2 , CD 3 , CD 5 , CD 20 , CD 21 , CD 23 , CD 43 , CD 56 , CD 79 , and bcl 2 was analyzed immunohistochemically and of lambda and kappa light chains by an in situ hybridization assay . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotype analysis showed that lymphocytes were positive for CD 2 , CD 3 , CD 5 , CD 7 , CD 8 , and TCR gammadelta antigens and negative for CD1a , CD 4 , and TCR alphabeta antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The T cells expressed CD 2 , CD 3 , CD 5 , CD 7 , and CD 8 , with partial loss of CD 4 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Comprehensive immunophenotypic analysis showed that the MCL cells expressed the typical B lymphocytic markers , were CD 5 and CD 8 positive , but did not express other T cell proteins , such as CD 2 , CD 3 , CD 4 , CD 7 , TCRalphabeta and TCRgammadelta . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Expression of the T cell antigens CD 2 , CD 3 , CD 4 , CD 5 , CD 7 and CD 8 was assessed by immunohistochemistry . ^^^ In all , 12 cases ( 5 % ) expressed at least one T cell marker in the following order : CD 2 in 11 cases , CD 4 in five , CD 3 in two , and CD 5 and CD 8 in one case each ; there were no CD 7 positive cases , and five cases ( 2 % ) expressed more than one T cell antigen . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A partial loss of CD 2 and CD 5 in the predominant CD 3 T cell lymphocytes suggested a clonal proliferation . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Cultured MC did not express CD 2 , CD 3 , CD 5 , CD 10 , CD 19 , or CD 25 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Flow cytometric analysis of the bone marrow showed positivity for CD 2 , CD 3 , CD 4 , CD 5 and CD 7 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
By contrast , HGMC did not express detectable amounts of CD 1 , CD 2 , CD 4 , CD 5 , CD 14 , CD 15 , CD 16 , CD 22 , CD 24 , CD 25 , CD 26 , CD 27 , CD 28 , CD 31 , CD 32 , CD 34 , CD 35 , CD 88 , or CD 116 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Low density of CD 4 and CD 2 , CD 4 and CD 5 , the presence of CD 7 were registered in 1 patient each . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Leukemic LGLs were predominantly positive for CD 2 , CD 5 , CD 7 , CD 8 , and CD 57 , whereas variable expression was seen for CD 16 , CD 56 , CD11b , and CD11c . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The neoplastic populations expressed CD 2 , CD 4 , CD 5 , and CD45RO in all cases , lacked expression of CD 8 and CD 56 in all cases , and showed negative or dim surface CD 3 in most cases . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
An immunophenotypical study disclosed that CD 2 , CD 3 , CD 5 , and CD 8 were positive . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
A portion of each skin specimen was stored at 80 degrees C and later examined using monoclonal antibodies against CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 15 , CD 19 , CD 20 and CD 30 . ^^^ In both disorders there were scattered CD3+ and CD45RO+ atypical lymphoid cells , but CD 2 , CD 5 , CD 15 , CD 19 , CD 20 and ALK 1 showed negative reactivity . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Cytological examination of ascitis revealed numerous atypical lymphoid cells , which were positive for CD 2 , CD 5 , CD 8 , and CD 25 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Immunophenotyping was performed to evaluate expression of CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 20 , CD 30 , and MIB 1 . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The World Health Organization ( WHO ) suggested immunophenotype for pre T ALL / LBL typically includes the expression of TdT , cCD 3 , and CD 7 , while CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , and CD 10 are variably expressed . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We correlate this arrest with up regulation of Bcl 2 , CD 2 , CD 5 , and CD 27 proteins and constitutive activation of NFAT but a severe impairment of Rag 1 , Rag 2 , and intracellular TCR beta as well as intracellular TCR gammadelta protein expression . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
T 560 is IgG2a kappa + , Ia+ , B220+ , J11d+ , Thy 1 , CD 3 , CD 4 , CD 5 , Mac 1 , Mac 2 , nonspecific esterase negative and binds bromelain treated mouse RBC but not SRBC or ORBC . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
Complement mediated cytotoxicity experiments using various McAb demonstrated that in both normal and leukaemia cultures NK like effectors react with the pan T OKT 3 McAb and with the OKT 11 McAB directed to the SRBC receptor , but not with Leu 1 1b and OKM 1 McAbs , directed against antigens expressed on peripheral blood NK cells . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The majority of cases ( 24 of 27 ) showed the Leu 2a , 3a+ , MASO36c phenotype similar to adult T cell leukemia , but seemed to be subdivided into four groups according to the presence or absence of Leu 1 antigen and the receptor for sheep erythrocytes ( SRBC ) . ^^^ Eleven cases had both Leu 1 antigen and the receptor for SRBC ( E RFC+ , Leu 1+ , 2a , 3a+ ) , but 6 cases lacked Leu 1 antigen ( E RFC+ , Leu 1 , 2a , 3a+ ) , 4 cases lacked receptors for SRBC ( E RFC , Leu 1+ , 2a , 3a+ ) , and 3 cases lacked both of these markers ( E RFC , Leu 1 , 2a , 3a+ ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The number of cells that form rosettes ( E RFC ) with sheep red blood cells ( SRBC ) in a sample of PBL treated with anti Leu 1 antibodies and subsequently passed once through GAMIg conjugated APAMB dropped from a range of 41 . 5 86 . 0 % to a range of 1 . 6 13 . 3 % . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The leukemic cells formed rosettes with sheep red blood cells ( SRBC ; E ) and expressed T cell antigen , Leu 1 , and DR antigen . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
The immunologic cell marker study showed that the cells were positive for surface IgA and HLA DR antigen ; negative for SRBC receptors , Leu 1 , Leu 2a , and Leu 3a antigens . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
We hypothesized that the differences in the responses of old mice to BrMRBC and SRBC reflects differences in the activity of CD5+ and CD 5 B cells . ^^^ To test this hypothesis we immunized young and old mice with foreign antigens reported ( and confirmed in our studies ) to stimulate CD5+ B cells [ TNP ficoll and phosphorylcholine keyhole limpet hemocyanin ( KLH ) ] or CD 5 B cells ( SRBC and TNP KLH ) . ^^^
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P06127	Pubmed	SVM Score :0.0
NA