Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The percentages of positive cells for CD 2 , a sheep erythrocyte receptor , CD 4 and CD 8 were unchanged after incubation of PBL with morphine or morphine plus Tyr MIF 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CMC were not recognized by MoAbs to lymphocyte function associated antigen 2 ( LFA 2 ; CD 2 ) , T cell receptor ( TcR ; CD 3 ) , T 4 antigen ( CD 4 ) , LFA 1 alpha chain ( CD11a ) , C3biR alpha chain ( CD11b ) , CR 4 alpha chain ( CD11c ) , LPS R related Ag ( CD 14 ) , 3 FAL / x hapten ( CD 15 ) , Fc gamma RIII ( CD 16 ) , lactosylceramid ( CDw 17 ) , the B cell antigen CD 19 , or CR 1 ( CD 35 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In 10 cutaneous cases , the lesions consisted of pleomorphic large cell lymphoma that expressed CD3epsilon ( CD 3 ) , CD 2 ( LFA 2 ) , CD 4 , CD 122 ( IL 2B receptor ) , TIA 1 , perforin , and granzyme B and displayed angiocentric / angiodestructive features . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the periplaque area , numerous CD 2 , CD 4 , and CD 8 positive T cells and cells reactive for the CD45RO phenotype of memory cells and for gamma / delta T cell receptors are located between MHC positive glial cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
RESULTS : A profile of significantly elevated T ( CD 2 , CD 3 ) and helper cells ( CD 4 ) and depressed Natural Killer cells ( CD 16 , CD 56 ) is characteristic of term Cesarean section neonates . ^^^ Significantly depressed frequency of T cells ( CD 2 , CD 3 ) and helper T cells ( CD 4 ) and elevated Natural Killer cells ( CD 16 , CD 56 ) is characteristic of vaginally delivered neonates . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the laboratory study of seropositive PSP , mononuclear pleocytosis was found in 35 . 7 % ; there was an abnormal increase of the IgG index in 66 . 6 % and an increase in CD 2 in blood and CSF , and CD 4 in blood . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The influence of Ukrain on immune parameters was evaluated by monoclonal antibodies ( MAb ) to CD 2 , CD 4 , CD 8 and CD 22 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The HT 1 cells expressed CD 1 , CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 57 , and terminal deoxynucleotidyl transferase ( TdT ) but lacked B cell associated antigens and myeloid associated antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The SMZ 1 cells , as well as the parental lymphoma cells , were of helper / inducer T cell immunophenotype ; they were positive for CD 2 , CD 3 , and CD 4 antigens , and negative for CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface phenotypic studies on nasal and cutaneous lesions demonstrated a population of T cells expressing CD 2 , CD 4 , CD 25 , CD 30 , and histocompatibility antigen DR ( HLA DR ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A panel of leukocyte differentiation antigen specific monoclonal antibodies ( MAbs ) , specific for bovine CD 2 , CD 4 or CD 8 , monocytes and granulocytes , B cells , gamma delta T cells or the IL 2 receptor ( IL 2r ) , was directly conjugated to fluorescein isothiocyanate , and a MAb specific for the BTV major core protein VP 7 was directly conjugated to phycoerythrin . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In none of these patients did the leukemic cells react with CD 1 , CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 10 , CD 19 or CD 20 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 2 and / or CD 4 and / or CD 7 ) , we examined blasts from a selected group of 56 AML cases ( 25 children , 31 adults ) coexpressing either of these antigens without cytoplasmic CD 3 expression . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
FT lines belong to the very immature T cell lineage as they exhibit rearranged TCR genes but no expression of T cell membrane antigens , including CD 2 , CD 3 , CD 4 , CD 6 , CD 7 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The data obtained in experiments of flow cytometry and immuno peroxidase staining show that a CD 2 , CD 4 , CD 8 , TcR gamma delta , CD3+ , CD45+ , FcR+ lymphoid killer cell does exist within bovine peripheral blood leucocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Leukemic cells in the peripheral blood and bone marrow were monoblasts positive for alpha naphthol butyrate esterase ( alpha NBE ) staining , CD11c and CD 36 antigens , whereas tumor cells in the pleural effusion were ATL cells positive for CD 2 , CD 4 , CD 25 , CD 29 and CD45RA antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
TLC from both panels showed similar levels of expression of TCR alpha / beta , CD 4 , CD 2 , CD 25 , and CD 29 and recognized nickel in association with class 2 HLA molecules with restriction determinants in HLA DR , HLA DP , and HLA DQ . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cell surface molecules other than CD 4 , including TCR , CD 3 , CD11a , CD 2 , CD 45 , CD 44 , and MHC class 1 , remained identical on D10H and D10L sublines as on D 10 wild type cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 2 expression correlates with proliferative capacity of alpha beta + or gamma delta + CD 4 CD8 T cells in lpr mice . ^^^ The T lymphocytes that accumulate in vast numbers in the lymphoid tissues of lpr / lpr ( lpr ) mice express a TCR alpha beta that is polyclonally rearranged , and yet is devoid of surface CD 4 or CD 8 ( CD 4 8 ) as well as CD 2 . lpr CD 2 alpha beta + CD 4 8 T cells exhibit an apparent block in signal transduction , in that when activated they produce little or no IL 2 and proliferate minimally in the absence of exogenous IL 2 . ^^^ The functional and phenotypic distinctions of lpr gamma delta T cells led us to identify an analogous minor ( 4 to 10 % ) subset of alpha beta + CD 4 8 cells in lpr thymus and lymph nodes that does express CD 2 . ^^^ Thus the capacity for IL 2 production and proliferation by a small proportion of lpr CD 4 8 T cells , either alpha beta + or gamma delta + , correlates with their expression of surface CD 2 . ^^^ This correlation is supported by the observation that the lpr liver contains actively cycling alpha beta + CD 4 8 lymphocytes that are strikingly enriched for CD 2 expression . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
On hematological examination , leukocyte count was 23 , 500 / microliters , of which 36 % abnormal lymphocytes expressing CD 2 , CD 3 , CD 4 and CD 25 as same as the lymph node cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
However , although they do not express the T cell markers Thy 1 , CD 2 , CD 3 , CD 4 and CD 5 , 20 % 30 % of dendritic cells are positive for the interleukin 2 receptor alpha chain ( CD 25 ) , and about 30 % express intermediate levels of CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Internalization of p56lck appeared to be specific of CD 2 stimulation as : 1 ) in Jurkat cells triggered with an anti CD 3 mAb , p56lck was not internalized whereas CD 3 receptors were completely endocytosed ; 2 ) when cells were stimulated via CD 4 , the kinase and CD 4 receptors remained associated with the plasma membrane . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Anti CD 2 mAb was also more potent than an anti CD 4 mAb in this model . ^^^ Investigation of the effect of anti CD 2 mAb on cellular immune functions demonstrated , in agreement with previous results , that it caused antigenic down modulation of CD 2 with relative sparing of CD 3 , CD 4 , and CD 8 cell surface expression . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Maturation of CD 4 8 alpha / beta TCR+ T cells induced by CD 2 stimulation in vivo and in vitro . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies specific to B and T cells were used to identify where the following cells were localized : IgM B cells ( cells positive to surface immunoglobulin ) , IgM , IgG and IgA containing cells ( cells positive to cytoplasmic immunoglobulin ) , and CD 2 , CD 4 and CD 8 positive cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In immunocompetent T cell clones , cell proliferation and lymphokine production in response to activating stimuli ( IL 2 , alloantigens , phorbol esters , or antibodies directed against CD 2 , CD 3 , CD 4 , CD 28 ) remained unmodified . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The activities of anti CD 3 stimulated human CD4+ PBL were compared to anti CD 3 plus anti CD 2 , anti CD 4 , or anti CD11a ( LFA 1 ) stimulated cells . [ 3H ] thymidine incorporation , lymphokine receptor expression , expansion of cell numbers , and lymphokine mRNA and protein were measured . ^^^ Although costimulation through CD 2 , CD 4 , or LFA 1 appeared equally effective for the induction of the lymphokine receptors , these additional stimuli had a different impact on lymphokine secretion . ^^^ These results indicate that specific control of lymphokine secretion and receptor induction can be another function of the CD 2 , CD 4 , and CD11a cell surface receptors . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The percentages of total B lymphocytes ( CD 19 ) , natural killer ( NK ) cells ( CD 16 ) , T lymphocytes and their subsets ( CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 ) , and IL 2R ( CD 25 ) were found to be within the range found in normal donors . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Molecular associations between the T lymphocyte antigen receptor complex and the surface antigens CD 2 , CD 4 , or CD 8 and CD 5 . ^^^ This provided a sensitive assay for molecular complexes , and associations were demonstrated between the TCR complex and the surface antigens CD 2 , CD 4 , or CD 8 and CD 5 in normal rat T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The acquisition of CD 1 molecule is selective since CD 4 , CD 2 , and HLA ABC molecules are not upregulated under the same conditions . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Reactivity with antibodies against T lineage markers ( CD 2 , CD 3 , CD 4 , CD 7 , and CD 8 ) was generally detected only on 1 2 % of the cells or less . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
T cell antigens including CD 2 , CD 4 , CD 6 , CD 8 , and CD 28 serve as coreceptors with the T cell receptor ( TCR ) / CD3 complex in control of T cell growth . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunohistochemical analysis of six cases showed no reactivity with CD 1 , CD 2 , CD 4 , CD 5 , CD 8 , and CD 10 and high reactivity with CD 19 and CD 20 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lymphocyte subsets ( CD 2 , CD 4 , CD 8 , CD 19 , HLA DR and NK ) were studied in each blood sample using a monoclonal antibody kit and a two colour fluorescence flow cytometer . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
All of these cell lines harbored HTLV 1 and showed T cell markers CD 2 , CD 3 and CD 4 , but not B cell markers . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Useful methods for characterizing AIDS related non hodgkin ' s lymphomas include immunophenotypic studies using B cell differentiation and activation antigens ( HLA DR , CD 10 , CD 19 , CD 20 , CD 21 , CD 22 , CD 23 , CD 38 ) , evaluation of expression of surface immunoglobulins ( IgS ) , activation and proliferation ( CD 25 , CD 30 , CD 71 , Ki 67 ) , and identification of T cell markers ( CD 1 , CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Leukocyte antigens investigated were CD 2 , CD 3 , CD 4 ( two antibodies ) , CD 5 , CD 8 , CD 25 , CD 30 , CD 63 antigens and HLA DR ; HIV 1 encoded antigens were gag p 24 , pol reverse transcriptase , and env gp 41 and gp 120 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In order to identify specific intracellular events linked to triggering through accessory surface receptors , mAbs against CD 2 , CD 3 , CD 4 , and CD 8 were employed to activate resting human T lymphocytes in vitro . ^^^ As in responses to CD 2 mAbs , cross linking of CD 4 and / or CD 8 to the TCR CD 3 complex but not CD 3 cross linking alone promoted pp 19 dephosphorylation . ^^^ Taken together , a common intracellular pathway appears to exist in which signals mediated through CD 2 , CD 4 , and CD 8 merge to promote monokine responsiveness and IL 2 production in human T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunohistologic study of the specimens revealed that immature or atypical cells had phenotypes of T cells , CD 2 , CD 3 , CD 4 ( Case 1 ) , CD 4 ( Case 2 ) , and CD 2 , CD 3 ( Case 3 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The cutaneous infiltrates during aGVHD consisted of CD 2 , CD 4 , CD 8 and FMC 33 positive cells both in the epithelium and in the dermis . ^^^ In rectal biopsies the differences were not so prominent because most of the pretransplant biopsies showed CD 2 , CD 4 , CD 8 and CD 57 positive lymphocytes both in the lamina propria and epithelium . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The immunological behaviour of the host was assessed through the determination of lymphoid populations ( CD 2 , CD 4 , CD 5 and CD 8 ) and cytolytic cells were studied with monoclonal antibodies CD and CD 16 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Both normal and WAS T cell lines express cell surface molecules CD 2 , CD 3 , T cell receptor alpha / beta , human histocompatibility leukocyte antigen class 1 , CD 45 and CD11a , and varying ratios of CD 4 and CD 8 , and are negative for natural killer cell and monocyte surface molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The immunophenotype of sample lymphocytes was determined by indirect immunofluorescent techniques , by listing the percentual level of CD 2 , CD 3 , CD 4 , CD 8 , CD 19 surface antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
With a combination of 15 antibodies , including CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , and CD 8 for T cell marker analysis , CD 10 , CD 19 , CD 20 , surface immunoglobulins , and cytoplasmic mu chain for B cell marker analysis , CD 13 and CD 33 for myeloid marker analysis , and HLA DR and CD 25 for other marker analysis , acute lymphoblastic leukemias of T cell type , cALL type , pre B cell type and B cell type , acute myeloid leukemias , acute unclassified leukemias and adult T cell leukemias could be clearly diagnosed by immunophenotyping of cell membrane molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
MRL lpr / lpr ( lpr ) mice develop a polyclonal accumulation of abnormal peripheral T lymphocytes , which bear surface alpha beta TCR , CD 3 , and the B 220 isoform of CD 45 , but lack CD 4 , CD 8 , and CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In conclusion , this work shows that in human T cells different CD 45 isoforms are associated to different surface molecules : LFA 1 is associated to CD45RA , CD 2 to CD45R0 and CD 4 and CD 8 presumably to CD45RC . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface markers of the leukemic cells were CD 2 ( + ) , CD 3 ( + ) , CD 5 ( + ) , CD 7 ( + ) , CD 8 ( + ) , and CD 4 ( ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface marker analysis by immunohistochemical technique revealed that neoplastic cells expressed CD 2 , CD 38 , CD 56 and HLA DR but lacked CD 3 , CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We studied the relative proliferation of the phenotypes CD 2 , CD 4 , CD 8 , CD 19 , CD 14 and CD 56 by immunofluorescence and flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Peripheral blood samples from healthy adults , patients with transplanted bone marrow , and healthy children were analyzed for the proportions of cells positive for CD 2 , CD 4 , CD 8 , CD 19 , CD 56 , CDw 65 , and KiM 8 cell membrane markers . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Using an immunoperoxidase technique , frozen liver biopsy specimens were examined with MoAbs for the presence of T helper cells ( CD 4 ) , T suppressor / cytotoxic cells ( CD 8 ) , total T cells ( CD 2 ) and B cells ( CD 22 ) before and after treatment . beta 2 microglobulin ( beta 2 MG ) expression on hepatocytes was semiquantified using a scoring system on sections from paraffin embedded biopsy specimens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The level of cells defined by monoclonal antibodies ( CD 1 , CD 2 , CD 3 , CD 4 , WT 31 , and CD 5 ) was less than 3 % . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The N terminal domain of CEA was modelled using the first domain of the recently solved NMR structure of rat CD 2 , as well as the first domain of the 10 ray crystal structure of human CD 4 and an immunoglobulin variable domain REI as templates . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Differentiation antigens evaluated included cluster of differentiation antigens 2 , 4 , and 8 ( CD 2 , CD 4 , and CD 8 , respectively ) ; B cells ; and major histocompatibility complex ( MHC ) class 2 , DQ , and DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
FACS for CD 2 , CD 3 , CD 4 , and CD 8 T , B , and NK cell surface markers demonstrated no major change in the distribution of splenic lymphoid cell populations in animals pretreated with anti TNF antibody . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The T cell line expressed CD 2 , CD 3 , CD 4 , CD45RA , CD 29 , HLA DR , CD 25 , and CD 26 antigens , but not CD 8 and CD 20 antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lack of antigens reactive with CD 2 , CD 3 , CD 5 , and WT 31 monoclonal antibody panels was one factor in bad prognosis , but the presence of CD 4 and CD 8 antigen abnormalities was much more significant . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
While all the CD4+ and CD 4 variants tested possessed comparable surface expression of TCR , CD 3 , CD 2 and LFA 1 , and responded similarly to immobilized anti TCR and anti CD 3 monoclonal antibodies , they differed dramatically in their responses to either the naturally processed HEL antigen , synthetic peptide 46 61 or staphylococcal enterotoxin superantigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Myelomonocytic cells in peripheral blood expressed both myeloid antigens ( CD11b , CD 13 , CD 14 , CD 15 , CD 33 ) and T / B lymphoid antigens ( CD 2 , CD 4 , CD 5 , CD 7 , CD 10 , PCA 1 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
FACS analysis revealed a marked downmodulation of CD 2 in vivo , a small and variable decrease in CD 8 , and essentially no change in CD 3 or CD 4 after treatment with anti CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Autonomous roles for the cytoplasmic domains of the CD 2 and CD 4 T cell surface antigens . ^^^ CD 2 and CD 4 are single chain transmembrane T cell surface molecules that are involved in signal transduction . ^^^ Chimaeric constructs from rat CD 2 and CD 4 antigens were expressed in the Jurkat human T cell line to examine the role of extracellular , transmembrane and cytoplasmic domains in mediating functions controlled by CD 2 and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Moreover , crosslinkage of TCR with the CD 2 antigen and not of either antigen with the CD 4 antigen ( on the surface of CD4+ T cells ) or the CD 8 antigen ( on the surface of CD8+ T cells ) resulted in marked proliferation . ^^^ Our demonstration that the CD 2 antigen derived signal ( s ) contribute to the expression of growth promoting genes elicited via the TCR , and that the CD 2 antigen is more efficient compared with the CD 4 or CD 8 antigen in evoking T cell proliferation , suggests that autoimmunity as well as alloimmunity might be regulated by targeting the CD 2 antigen . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The proliferative response to CD 3 ligation was modulated by the presence of antibodies to the CD 2 , CD 4 , or CD 8 accessory T cell receptors . ^^^ Crosslinking CD 3 , CD 2 , CD 4 , or CD 8 alone did not induce cytoplasmic calcium mobilization in T ALLs , but crosslinking the accessory receptors with CD3 / Ti induced calcium responses in three of the T ALLs and enhanced calcium responses in three of the T ALL cell lines , including HPB ALL , MOLT 4 , and CEM . ^^^ Crosslinking CD 4 but not CD 2 with CD3 / Ti greatly enhanced tyrosine phosphorylation of multiple substrates in comparison with crosslinking either CD 4 or CD3 / Ti separately on both normal mature T cells and the CEM T ALL cell line . ^^^ Thus , CD 4 regulates CD3 / Ti signal transduction in T ALL cells through the tyrosine phosphorylation of substrates whereas CD 2 may regulate [ Ca2+ ] 1 signal transduction through a separate mechanism . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometric analysis of Dharmendra lepromin treated cells showed that , in addition to CD 2 , CD 4 and CD 8 were modulated while the surface expression of CD 3 was not affected . ^^^ Our results indicate that certain M . leprae factor ( s ) specifically modulate ( s ) CD 2 , CD 4 , CD 8 and IL 2R but not CD 3 on T lymphocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In contrast , 7 to 50 % of mAb to CD 2 , CD 4 , CD 8 , CD11a / CD18 , CD 44 , and class 1 MHC molecules were resistant to detergent solubilization , demonstrating that a fraction of these molecules was constitutively associated with the cytoskeleton . ^^^ In addition , cross linking increased the fraction of CD 2 , CD 4 , CD 8 , CD11a / CD18 , CD 44 , and class 1 MHC molecules that was associated with the cytoskeleton . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
To investigate whether the retargeting of resting CTL can benefit from cooperative signaling between the TCR / CD3 complex and various accessory molecules , such as CD 2 , CD 4 , CD 5 , and CD 8 , we have constructed a series of trispecific F ( ab ' ) 3 derivatives . ^^^ Bispecific derivatives containing specificities for ( CD 2 ( T 11 ( 1 ) ) 10 CD 3 ) , ( CD 3 10 CD 4 ) , ( CD 3 10 CD 8 ) or two epitopes on CD 2 , ( ( T 11 ( 1 ) 10 ( T 11 ( 3 ) ) , all yielded two to three times the uptake of [ 3H ] thymidine with fresh PBMC to that seen with intact IgG from anti CD 3 ( OKT 3 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
This adhesion process has been previously shown to be mediated by the LFA 1 and CD 2 molecules and not by the TCR / CD3 complex and by CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We have investigated the role of CD 2 molecules in Ag specific T cell activation by using a mouse model system in which the function of CD 2 can be analyzed without the apparent influence of major accessory molecules , such as CD 4 or LFA 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A panel of different monoclonal antibodies ( MoAb ) was employed including anti CD 2 , CD 3 , CD 4 , CD 8 , CD11b , CD 16 , CD 56 , and CD 57 , as well as a recently described reagent ( HP 3B1 ) specific for a novel natural killer ( NK ) associated cell surface antigen ( Kp 43 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
TNF release was not abrogated by treatment of the crude LGL preparations with anti Leu M 3 , CD 4 , and CD 8 antibodies ( Ab ) plus complement ( C ) , but was abrogated by anti CD 16 and CD 2 Ab , as expected . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
No dual fluorescence was seen using C5B6 and antibodies to bovine IgM , CD 2 , CD 4 or CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
HFRS patients had lower total T cell ( CD 2 ) and T helper ( CD 4 subset ) counts . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In contrast , mAb stimulation via CD 2 and CD 4 structures does not induce phosphorylation of pp 68 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Here we examine the role of CD 4 , CD 8 , CD 2 , and CD 45 in the regulation of intracellular Ca2+ levels in mature and immature thymocytes . ^^^ Flow cytometric analysis by using Indo 1 showed that coaggregation of CD 4 , CD 8 , and CD 2 with CD3 / TCR clearly enhances a minimal signal delivered via CD3 / TCR on immature thymocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Such cells showed marked upregulation of CD 4 , CD 2 , class 1 and 2 MHC , and IL 2 receptor molecules , a finding we also observed in the case of BP cultured cells from BP / CFA sensitized rats with severe EAE . ^^^ These data suggest that BP / IFA sensitization can also induce BP reactive cells capable of becoming CD4+ blastoid T cells with marked upregulation of CD 4 , CD 2 , class 1 and 2 MHC , and IL 2 receptor molecules directly related to potent encephalitogenicity , in vivo . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The mAb used in the panel were : CD 1 , ( T 6 ) , CD 2 ( T 11 , X 11 , D 66 , clone 2 ) , CD 3 ( T3 / Leu4 ) , CD 4 , ( T4 / Leu3a ) , CD 5 ( Leu 1 , T 1 , A 50 , I73D9 ) , CD 7 ( Leu 9 , I 21 ) , CD 8 ( T8 / Leu2a ) and HNK 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Fewer than 13 % expressed CD 4 , IgM , or MHC class 2 on their surface , and 6 20 % expressed low levels of CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface phenotypical analysis of LGLs showed that these LGLs express CD 2 , Ia and NKH 1 but not express CD 3 , CD 4 , CD 8 and Leu 7 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin ( PHA ) and purified derivative of tuberculin ( PPD ) , while isoprinosine had no effect on the following immune parameters : the expression of surface markers on blood mononuclear cells including CD 2 , CD 3 , CD 4 , CD 8 , CD 14 , CD 19 , CD 20 , CD 25 , leu 8 , and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In this study , we demonstrated that antibodies reactive with a common beta 1 subunit ( CD 29 ) of the VLA family of antigens could synergize with CD 3 but not CD 2 in inducing CD 4 cell proliferation in a serum free culture system . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A second family of adhesion receptors is the immunoglobulin superfamily , members of which include CD 2 , LFA 3 and ICAM 1 , which participate in T cell adhesive interactions , and the antigen specific receptors of T and B cells , CD 4 , CD 8 and the MHC Class 1 and 2 molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Subsets of CD56+ NK cells co expressing CD 2 , CD 4 or CD 8 did not show any significant difference between PFS patients and healthy controls . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Autologous non T cell stimulation of the T cell clones resulted in a decrease in cell surface expression of CD 4 , whereas the expression of CD 2 , CD 3 , and WT 31 was unchanged . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cytochalasins enhance the proliferation of CD 4 cells through the CD 3 Ti antigen receptor complex or the CD 2 molecule through an effect on early events of activation . ^^^ Cytochalasins enhanced the proliferation of CD 4 cells induced by optimal doses of anti CD 3 antibody or suboptimal doses of anti CD 2 antibodies . ^^^ Cytochalasins , at low concentrations , enhanced the rise in intracellular Ca2+ and production of IP 3 in CD 4 cells activated by anti CD 2 or CD 3 antibodies . ^^^ These results suggest that cytochalasins enhance the proliferation of CD 4 cells by affecting early events in signal transduction after activation through the CD 3 Ti Ag receptor complex or CD 2 molecule . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Melanin also impeded the HIV 1 envelope surface glycoprotein , and T cell specific monoclonal antibody leu 3a ( CD 4 ) , but not leu 5b ( CD 2 ) , from binding to the surface of MT 2 cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometry of the abnormal lymphocytes showed that they expressed CD 2 , CD 3 , CD 11 , CD 16 , and CD 56 , but not CD 4 nor CD 8 , so they were T cell large granular lymphocytes ( T LGL ) . ^^^ Abnormal lymphocytes obtained from a lymph node expressed CD 2 , CD 16 , CD 38 , and CD 56 , but not CD 3 , CD 4 , and CD 8 , so they were natural killer ( NK ) cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The adhesion does not appear to involve members of the CD 2 , CD 3 , CD 4 , or CD 18 receptor groups . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Whereas CD 7 expression was increased 78 + / 25 % by 0 . 5 microM ionomycin , expression of CD 25 ( IL 2R alpha ) , class 2 MHC , 4F2 , transferrin receptor , CD 2 , CD 3 , CD 4 , CD 5 , and CD 8 molecules was not increased . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Further at 4 degrees C , DxS does not alter the expression of molecules recognized by Mab such as Leu3a ( CD 4 ) , Leu2a ( CD 8 ) , Leu 4 ( CD 3 ) and Leu5b ( CD 2 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MAb ) against classes 1 and 2 antigens of the major histocompatibility complex ( MHC ) and their receptors , CD 8 and CD 4 , had no effect on T cell interaction with SSc and normal cells , while MAb against lymphocyte function associated antigen type 3 ( LFA 3 ) and CD 2 both strongly inhibited lymphocyte attachment . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Antigen ( tetanus toxoid , TT ) or an antigenic peptide of TT ( residue 830 843 , P 2 ) was coupled to antibodies directed to T cell surface molecules such as CD 2 , CD 4 , CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
By means of immunohistochemical analysis , using antisera specific for perforin and monoclonal antibodies to CD 56 ( NKH 1 ) , CD 2 ( T 11 ) , CD 3 ( Leu 4 ) , CD 4 ( Leu 3a ) , and CD 8 ( OKT 8 ) , we demonstrated that perforin is present in EGs in the decidualized endometrial stroma and decidual tissue of first trimester gestational endometrium . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
HIV 1 infection of target monocytes or T cells by cell free virus was blocked completely or partially by some mAb that prevent cell cell interactions ( CD 4 , HLA DR , LFA 1 , LFA 3 ) , but not by others ( ICAM 1 , MAC 1 , gp150 . 95 , CD 2 , CD 3 , CD 14 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
There was no change in CD 2 , CD 3 , CD 4 , CD 8 , CD 16 , CD 56 and CD 57 cell marker expression . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Reactivity with the following antigens was assessed : MHC class 1 , 2 DR , DQ , and DP antigens ; leukocyte markers CD 1 , CD 2 , CD 3 , CD 4 , CD 8 , CD 14 , CD 16 , CD 25 , CD 57 ; a proliferation associated nuclear antigen ; interferon gamma and tumor necrosis factor alpha . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We have examined the functional heterogeneity of 43 monoclonal antibodies which recognised CD 1 , CD 2 , CD 4 , CD 5 , CD 6 or CD 8 . ^^^ The majority of anti CD 2 and CD 4 antibodies could inhibit an alloantigen response . ^^^ Only a few antibodies to CD 2 and CD 4 could prevent proliferation of lymphocytes to PHA or virus . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Extensive immuno cytochemical studies showed that the neoplastic cells were almost exclusively localized in the epidermis , expressed the gamma / delta variant of the T cell receptor ( CD3+ , TCR delta 1+ ) and were CD5+ , CD7+ , CD27+ , CD29+ , CD43+ , CD44+ , CD45+ , CD45RA+ , CD54+ , CD69+ , but beta F 1 , Ti gamma a , BB 3 , A 13 , CD 2 , CD 4 , CD 8 , CD11a , CD49d , CD 25 , CD 30 , and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We used immunofluorescence or immunoperoxidase techniques to study frozen sections of muscle from our patient , who had mild weakness of cervical and proximal limb muscles , and from control patients with polymyositis , inclusion body myositis , dermatomyositis , or granulomatous myopathy with monoclonal antibodies against T cell related antigens ( CD 2 , CD 3 , CD 4 , CD 8 , and gamma / delta T cell receptor ) , B cells ( CD 22 ) , major histocompatibility complex ( MHC ) and MHC related antigens ( MHC Class 1 , CD1a , CD1b , and CD1c ) , and the 65 kd heat shock protein . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , GT1b ganglioside could also decrease strongly the expression of the T cell antigens CD 3 , CD 2 , CD 4 , CD 8 and the alpha / beta T cell receptor antigenic complex whereas it did not affect HLA class 1 antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
This cell is of donor origin and expresses several T cell surface proteins including Thy 1 , CD 2 , and CD 4 but does not express CD 8 , CD 3 , NK1 . 1 , or macrophage antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Peripheral blood lymphocytes expressing CD 8 , CD 4 , and / or CD 2 were responsible for most of the binding , indicating that CD8+ T lymphocytes in the peripheral blood and in the intestinal epithelium differ in their capacity to bind VIP . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Percentages of CD 2 and CD 4 lymphocytes increased significantly , but numbers of cells in T lymphocyte subpopulations ( total , helper and cytotoxic / suppressor lymphocytes ) were not significantly altered . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunohistochemically most GC expressed SIV antigens and markers of mononuclear phagocytes ( CD 68 ) , CD 4 and also occasionally the T cell markers CD45RO , CD 43 and CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The peripheral blood lymphocytes showed the T suppressor cell phenotype ( CD 2 , CD 3 , CD 8 , and CD 4 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We found a good correlation between the two methods for CD 2 ( 4 / 4 ) , CD 7 ( 4 / 5 ) , CD 20 ( 1 / 1 ) and CD 4 ( 2 / 2 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Comitogenic effect of solid phase immobilized anti 1F7 on human CD 4 T cell activation via CD 3 and CD 2 pathways . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These cells were negative for surface Ig , a monocyte / granulocyte marker , and the T lymphocyte antigens CD 2 , CD 6 , CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Biopsies during R6 . 5 administration showed decreased T cell infiltration ( CD 2 , CD 8 , CD 4 ) compared with controls and decreased arterial endothelial inflammation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Transmembrane signaling of normal human T cells was explored with mAbs directed at TCR , CD 2 , CD 4 , CD 5 , or CD 8 antigens and highly purified CD4+ T cells and CD8+ T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The surface marker analysis showed that malignant cells were positive for CD 4 and CD 2 but negative for CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We therefore tested whether the differences in epidermotropism of these T cells could reside in the different levels of expression of T cell surface molecules such as CD 3 , CD 4 , CD 2 , and lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 4 and CD 8 T cells from SIV infected macaques have defective signaling responses after perturbation of either CD 3 or CD 2 receptors . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
MAbs specific to other adherence molecules such as ICAM 1 , CD 2 , CD 58 , CD 4 , CD 8 , CD11b and LAM 1 did not affect leukocyte adherence in this model . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Additional karyotypic abnormalities , a 12p rearrangement and the possible presence of a homogeneous staining region ( HSR ) on 19q+ are discussed both in relation to T cell ( CD 2 , CD 4 ) and monocyte ( CD 9 ) markers , and to the acquired cell growth autonomy . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
On admission , both groups demonstrated increases in the numbers of CD20+ B cells and T cells of the CD 2 , CD 4 , CD 8 , and CD 56 ( NKH 1 ) phenotypes compared with control values . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These proteins include CD 2 , CD 3 , CD 4 , the TCR , and MHC class 1 Ag . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Antibodies to HLA DR , CD 2 , CD 4 , CD 8 , and CD 25 were also demonstrated but could not be quantified . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In some clusters almost all antibodies cross reacted ( CD 2 , CD 8 ) , in others almost none cross reacted ( CD 4 , CD 5 ) and in cluster CD 6 , mAbs only reacted with buffalo but not waterbuck . ^^^ This was shown with reagents against CD 2 , CD 4 , CD 6 , CD 8 , CD 11 , WC 1 , WC 3 and Ig . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The relative molecular weight ( Mr ) of the CD 1 , CD 2 , CD 4 , CD 5 , CD 6 , CD 8 and additional molecules identified by monoclonal antibodies ( mAb ) submitted to the workshop was determined using 125I surface labelled leukocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The association of total lymphocyte , CD 4 ( T helper cell ) , CD 8 ( T suppressor cell ) , CD 2 ( total T cell ) , and CD 16 ( natural killer cell ) counts with biopsy proved colorectal polyp status was investigated in 70 patternmakers participating in one or more of four sequential screenings . ^^^ In logistic regression analyses after adjusting for age or trade years , pack years smoked , and material worked with most , a history of any type of polyp was significantly associated with total lymphocyte count ( odds ratio of 2 . 01 for a 500 cell / cc decrease , P = 0 . 03 ) , and somewhat associated with decreased CD 4 and CD 2 counts ( P values of 0 . 06 and 0 . 07 , respectively ) . ^^^ In linear regression models adjusted for age , pattern and model makers had ( regardless of polyp status ) significantly lower CD 4 , CD 8 , CD 2 , and CD 16 counts than did laboratory reference controls ( P value less than 0 . 01 for each comparison ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
They demonstrated the T cell association antigens , CD 2 and CD 4 , but no CD 3 , CD 8 , CD 1 , CD 5 , CD 7 nor T cell antigen receptor on their cell surfaces . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
ATL cells show usually positive for CD 2 , CD 3 , CD 4 , CD 25 and HLA DR , but negative for CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , they expressed CD 45 antigen and T cell antigens ( CD 2 , CD 4 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Several anthropometric and hematological parameters were determined in the patient and healthy groups : weight , height , body mass index ( BMI ) , WBC , blood lymphocyte count , lymphocyte subsets : T 11 ( CD 2 ) , B 1 ( CD 20 ) , T 4 ( CD 4 ) and T 8 ( CD 8 ) ( through flow cytometry ) . ^^^ CD 2 and CD 4 lymphocyte percentages were lower in the bulimic group , the CD 20 percentage was higher and the CD 8 subset did not change . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In contrast , the diagnosis of lymphoid leukaemias requires all information obtained by immunophenotyping by a series of monoclonal antibodies CD 3 , CD 2 , CD 4 , CD 8 , CD 1 , CD 19 , CD 20 , CD 21 and CD 10 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Our results show that , unlike IL 4 dependent IgE synthesis induced in normals , spontaneous IgE production by PBMC from HIE patients was not blocked by monoclonal antibodies to CD 2 , CD 4 , CD 3 , and MHC class 2 antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Significant reductions in total lymphocytes , T lymphocytes ( CD 2 cells ) , and T lymphocyte subsets ( CD 4 and CD 8 cells ) were most notable in the 1600 mg group . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunoperoxidase studies revealed a novel aberrant T cell phenotype characterized by lack of expression of CD 4 and CD 2 ( T 11 ) but positive staining for CD 3 ( T 3 ) and CD 7 ( 3A1 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Finally , even the major population of IEL which expressed the usual markers of the T cell lineage ( CD 3 , TcR alpha / beta , CD 2 , CD 4 or CD 8 alpha / beta ) differed from peripheral blood T lymphocytes by their peculiar expression of surface antigens associated with activation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A majority of the cells from peripheral blood coexpressed the antigens against MAbs CD 2 , CD 3 , CD 4 , CD 5 , Ti ( WT 31 ) , CD 25 , CD 38 , CD 45 , and CD 29 , but did not express the antigens against CD 1 , CD 13 , CD 14 , CD 33 , CD 36 , CD 10 , CD 19 , CD 20 , CD 21 , CD 24 , CD 41 , CD 42 , CD45RA , CD 56 , and CD 57 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Other cell membrane markers , such as CD 2 and CD 25 , remain constant throughout the course of infection ; after its initial decrease , CD 4 remains at 70 % of control values . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Antigen specific nonresponsiveness was induced by both nonmitogenic and mitogenic anti CD 3 antibodies but not by antibodies against CD 2 , CD 4 , CD 5 , CD 8 , CD 18 , or CD 28 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A particular role seems to be played by a family of molecules named lymphocyte function associated antigens ( LFA ) and by CD 2 , CD 4 and CD 8 antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Signals delivered via the accessory molecules CD 2 , CD 4 , and CD 8 have a crucial role in this phase of T cell differentiation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The surface markers of lymphoma cells were CD 2 ( + ) , CD 8 ( + ) and CD 4 ( ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The neoplastic cells lacked B cell associated antigens and lacked most T cell associated markers , with the exception of CD 2 and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
TNF did not affect the expression of LFA 1 , CD 2 , CD 4 , and CD 8 , molecules that are associated with CTL target interactions , on responder cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A small subset of CD3+ cells ( 5 to 10 % ) was also identified by these probes and further phenotypically characterized by two color flow microfluorimetry as predominantly coexpressing CD 2 , CD 4 or CD 8 , CD 57 , CD11b , and alpha / beta TCR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Leukemic cells had azurophilic large granules with basophilic cytoplasm and positive for CD 2 , OKIa 1 , NKH 1 and negative for CD 3 , CD 4 , CD 8 , CD 16 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Finally , other non organ specific lymphocyte adhesion molecules for EC may include CD 4 and CD 8 ( which bind to class 2 and class 1 MHC antigens , respectively ) , and CD 2 ( which binds to LFA 3 ) . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Four patients expressed T helper antigen ( Leu 3 , CD 4 ) , one expressed T cell antigen receptor ( Leu 4 , CD 3 ) , and one expressed E rosette antigen receptor ( Leu 5 , CD 2 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunoperoxidase showed tumor cells to be strongly reactive for Leu M 1 ( CD 15 ) , BER H 2 ( CD 30 ) , Leu 3 ( CD 4 ) , and T 11 ( CD 2 ) and weakly reactive for Leu 4 ( CD 3 ) but nonreactive for EMA , LCA , lysozyme , Leu 9 , Leu M 3 , Leu M 5 , and immunoglobulin light chains . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The leukemic cells of all these patients coexpressed la ( HLA DR ) , CD 19 , CD 20 , CD 21 , CD 24 , CD 38 , and surface immunoglobulins , whereas a negative reaction with MAbs CD 1 , CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , and Ti ( WT 31 ) , Ti gamma A , delta TCS 1 , and anti TCR gamma / delta was observed . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 7 , CD 5 , and CD 2 were the most frequently expressed T cell antigens , and CD 2 and CD 4 were more frequently observed in children than in adults . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The predominant cell population expressed CD 3 , CD 2 , CD 5 , and CD 4 , while results of testing for CD 8 were negative . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Using immunohistochemical methods , the authors studied the expression of pan T and majority T cell antigens ( CD 5 , CD 2 , CD 3 , TCR beta , CD 7 ) and T cell subset antigens ( CD 4 , CD 8 ) in cutaneous T cells in mycosis fungoides ( MF ) ( 177 biopsies from 124 patients ) and a variety of inflammatory lesions ( 45 biopsies from 45 patients ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunophenotypically , 9 of these patients expressed some T cell markers ; CD 2 in 9 , CD 4 in 9 , CD 3 in 6 , CD 8 in 4 , and UCHL 1 in 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
On PTCs , the antigenic density was high for CD 4 and CD 26 antigens and low for CD 2 ; they furthermore reacted with the mAb OKM 5 recognizing an undefined antigen associated with the myelomonocytic lineage and expressed the monocyte associated antigen CD 68 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In patients with chronic fatigue syndrome , a significant ( P less than 0 . 01 ) reduction was found in the absolute number of peripheral blood lymphocytes in the total T cell ( CD 2 ) , the helper / inducer T cell ( CD 4 ) and the suppressor / cytotoxic T cell ( CD 8 ) subsets . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The Ag independent homotypic adhesion induced by mAb L 25 was not inhibited by mAb to the lymphocyte function associated Ag 1 ( CD11a / CD18 ) , CD 2 , CD 4 , and CD 8 , or to their ligands ICAM 1 , LFA 3 , MHC class 1 , or MHC class 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Bone marrow cells were incubated with a combination of CD 2 , CD 3 , CD 4 , and CD 8 monoclonal antibodies . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Most of these long term interleukin 2 dependent cell lines exhibited a pattern characteristic of CD 4 ( + ) activated T cells with high expression of CD 2 , CD 3 and CD 4 antigens , associated with a strong density of TAC and DR molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The T cell surface antigens CD 5 and / or CD 2 and focal acid phosphatase were additional markers of this subgroup traditionally called pre T ALL , whereas thymocyte antigen CD 1 as well as CD 4 and CD 8 antigens were not expressed . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
On cryostat sections all CBCL so tested were positive for surface membrane immunoglobulins ( IgMk most often ) and B cell antigens ( CD22+ , CD37+ ) with a variable T cell reactive component identified by MoAbs against T cell antigens ( CD 2 , CD 3 , CD 4 , CD 5 , CD 8 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The reason for the restricted responsiveness of CD 4 T cells is presently unclear ; jacalin bound to all blood cells and did not significantly co cap with CD 1 , CD 2 , CD 3 , CD 4 , CD 8 and CD 38 , and jacalin response was neither enhanced nor inhibited by antibodies to these surface antigens . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
At relapse the leukemic cells expressed CD 1 , CD 2 , CD 5 , CD 7 , and CD 4 or CD 8 , antigens of the common thymocyte compartment . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Such macrophages also expressed CD 4 ( Leu 3a and 3b ) and 2H4 , which are the cell membrane determinants of suppressor inducer T lymphocyte ; CD 2 ( Leu 5b ) , which is a marker of pan T cell ; Leu M 3 , Leu M 5 and Mac 1 , which are the markers of monocyte and macrophage lineage ; leukocyte common antigen , which is a marker of bone marrow derived cell ; and alpha antichymotrypsin , which is a glycoprotein associated with macrophages . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Following this preliminary analysis , lymphocytes were exposed to the metal ions found to inhibit the E rosette reaction ( Fe3+ , Ni2+ , and Co2+ ) in order to determine which of the following surface antigens were affected : CD 2 , CD 3 , CD 4 , CD 8 , CD 1 , CD 22 , CD 10 , and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 2 , CD 3 , CD 4 , and CD 5 antigens were homogeneously expressed on all TLC in contrast to CD 6 and CD 7 antigens which were present on only a fraction of the cells in a given TLC . ^^^ In functional assays , anti CD 2 , anti DR 6 15C , and anti CD 25 MoAbs blocked the proliferative response to DT and anti CD 3 , anti CD 4 , anti D 44 MoAbs had intermediate inhibition effects . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In search for agents able to complement the signals provided by BMA 030 F ( ab ' ) 2 , several antibodies directed against CD 2 , CD 4 , CD 5 , CD 6 and CD 8 were used . ^^^ However , if BMA 030 F ( ab ' ) 2 and any other of these anti CD 2 , CD 4 , CD 5 , CD 6 or CD 8 antibodies were cross linked , then proliferation of T cells occurred . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
S 100 beta+ T cells recognized by their diffuse intracytoplasmic immunoperoxidase reaction , also expressed CD 2 , CD 3 , CD 8 antigens demonstrated by surface blue alkaline phosphatase reactivity , but not CD 4 , CD 1 , CD 25 ( interleukin 2 receptor ) , or HLA DR antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Costimulation was observed when MAb to CD 3 and class 1 MHC molecules but not CD 2 , LFA 1 or CD 4 were immobilized to separate surfaces . ^^^ The data suggest that when anti CD 3 stimulation is suboptimal , responses can be enhanced by MAb to CD 5 or CD 28 ( Tp 44 ) or by immobilized MAb to CD 4 , CD 2 , CD11a ( LFA 1 ) , or class 1 MHC encoded gene products . ^^^ Although crosslinking of CD 4 , CD 2 , or CD11a with CD 3 may be necessary for costimulation , immobilized MAb to CD 3 and class 1 MHC molecules appear to deliver independent signals that result in enhanced T 4 cell activation and proliferation . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Anti CD 4 and anti CD 2 monoclonal antibody infusions in subjects with multiple sclerosis . ^^^ Eight subjects received five daily infusions ( 0 . 2 mg / kg / day ) of either anti T 11 ( CD 2 ) or anti T 4 ( CD 4 ) murine mAb . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These data suggest that some part of the functional diversity of CD 4 cell subsets might be explained by the differences in cell activation through the CD 2 molecule . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Re distribution of DAF occurred independently of CD 2 , CD 3 , CD 4 , or CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD7+ , CD 2 , CD 3 , CD 8 , CD 4 , WT 31 cells in thorax and fetal liver , when stimulated for 10 15 d with T cell conditioned media and rIL 2 , expressed CD 2 , CD 3 , CD 4 , CD 8 , and WT 31 markers of the T cell lineage . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The different effect of alpha and gamma interferons and interleukin 2 on the expression of CD 2 , CD 3 , CD 4 and CD 8 antigens in comparison to histocompatibility antigens of human lymphocytes . ^^^ IFN gamma and IFN alpha in high doses significantly increased the expression of T 11 ( CD 2 ) differentiation antigen , but did not affect the expression of T 4 ( CD 4 ) , T 8 ( CD 8 ) , T 3 ( CD 3 ) and Leu 7 antigens ( HNK 1 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
No differences in expression of the CD 2 , CD 3 , CD 4 , Tp 103 , and CD 28 Ag between these cells and the parental cells could be demonstrated , with the exception of the expression of IL R p 55 and HLA DR Ag , which were constitutively expressed on the phase 1 cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Quantification on single cell preparations showed an average of 67 % of the lymphocytes to be CD 2 positive , 73 % to be CD 8 positive , while only 12 % of the lymphocytes expressed the CD 4 antigen . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The results show that C . aethiops T lymphocytes express surface markers which react specifically with anti human MoAbs including CD 3 , CD 4 , CD 8 , CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In this article , Barton Haynes and colleagues discuss the sequential expression of CD 7 , CD 4 , CD 8 , CD 3 , CD 2 , CD 1 , CD 45 , TCR gamma delta and TCR alpha beta , and propose a model defining the stages of T cell precursors during fetal ontogeny . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The modulatory activity of dextran sulfate with a relative molecular mass of 8 and 500 kDa and pentosan polysulfate with a relative molecular mass of 6 kDa on human T cell surface molecules CD 2 , CD 3 , CD 4 , CD 8 and HLA DR was investigated by analytical flow cytometry . ^^^ The 500 kDa dextran sulfate induces a complete disappearance of the CD 4 and a 50 % diminution of CD 2 immune reactivity on peripheral blood lymphocytes after a 4 h incubation while the low molecular mass polyanions do not . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The addition of monosialoganglioside GM 1 to serum free culture medium efficiently and specifically inhibited CD 4 antigen expression on normal T lymphocytes from peripheral blood or thymus as well as on cells from H 9 and Molt 3 lines ; other molecules such as CD 3 , CD 2 and CD 8 were not affected . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
On the other hand , the majority of thymocytes bound to DC strongly express the CD 1 , CD 4 , CD 8 and CD 2 antigens and weakly the CD 3 antigen , indicating that they represent double positive immature thymocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
T lymphocyte activation : the biology and function of CD 2 and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Very early T cell precursors in humans have been characterized as CD7+ 45+ cells which lack the T cell differentiation antigens CD 1 , CD 2 , CD 3 , CD 4 , and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
HIV positive haemophiliacs showed a decreased number of CD 4 and CD 2 lymphocytes , inversed CD4 / CD8 lymphocytes ratio , anergy to skin tests , decreased NK ( natural killer ) , cell cytoxic activity , increased IgG and increased immune complexes . ^^^ Haemophiliacs in asymptomatic stage of HIV infection showed qualitative abnormalities of T cell immunity , manifested with decreased NK cells cytotoxic activity and anergy to skin tests , while haemophiliacs in persistent generalized lymphadenopathy stage , besides qualitative , showed quantitative abnormalities of T cell immunity , manifested with decreased lymphocyte subpopulations ( CD 2 , CD 3 , CD 4 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Bone marrow and peripheral blood of 25 healthy bone marrow donors from our allogeneic bone marrow transplantation program were assessed for cell subsets bearing T 11 ( CD 2 ) , T 4 ( CD 4 ) , T 8 ( CD 8 ) , B 1 ( CD 20 ) J 5 ( CALLA , CD 10 ) , Mo 1 ( CD11b ) , MY 7 ( CD 13 ) . ^^^ The proportions of CD 2 and CD 4 T cell markers in the bone marrow correlated with those in the peripheral blood , thus further documenting a substantial bone marrow contamination with peripheral blood cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Using monoclonal antibodies against CD 2 , CD 4 , CD 8 and CD 19 antigens and an automated biotin avidin immunoperoxidase technique on whole blood samples , we evaluated the technical performance and clinical usefulness of lymphocyte subset counting by the routine hematology analyzer Technicon H * 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The surface markers of these cells were positive for E rosette , CD 2 , CD 3 , and Leu 7 but negative for CD 4 , CD 8 , CD 11 ( OKM 1 ) , CD 16 ( Leu 11 ) , and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Aliquots at 5 time intervals were evaluated using CD 3 , CD 2 , CD 4 , CD 8 , and CD 19 monoclonal antibodies . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
An extensive phenotypical analysis of total and T depleted TLC showed that both PB and BM derived TLC contained a mean of 5 % immature T lymphocytes ( ITL ) , which were negative for the CD 3 , CD 4 , and CD 8 antigens but displayed the CD 2 and CD 7 antigens . ^^^ In addition , the auto MLR of ITL was totally inhibited by anti HLA class 2 but not by anti class 1 monoclonal antibody ( MoAb ) and only partially by anti CD 4 moAb , whereas the anti CD 3 and anti CD 2 MoAbs gave no inhibition . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We show herein that the induction of human IgE synthesis by rIL 4 requires cognate interaction between the T cell receptor / CD3 complex on T cells and MHC class 2 antigens on B cells : mAbs directed against these molecules completely blocked IL 4 dependent IgE induction . mAbs against cell adhesion molecules ( CD 2 , CD 4 , LFA 1 ) also inhibited IgE synthesis induced by IL 4 , confirming that cell cell contact is necessary for IgE induction . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Also , CD 4 and CD 8 can serve as adhesion molecules by binding to monomorphic determinants expressed on class 2 and class 1 MHC antigens , respectively , on the target cells , but compared to LFA 1 and CD 2 antigens their contribution to conjugate formation is minor . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Pretreatment of lymphocytes with mAb to the accessory molecules CD 2 , CD 3 , CD 4 , CD 8 , CD11b , or CD11c did not interfere with their response to HD cells . mAb to CD11a ( LFA 1 ) , the alleged ligand of ICAM 1 , inhibited the ICAM 1 but not the HD lectin mediated lymphocyte stimulation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Examination by flow cytometry and an immunohistological method revealed that the surface phenotype of the lymphoma cells were NKH1+ , CD5+ , CD7+ , CD 1 , CD 2 , CD 4 , CD 8 and CD 16 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Crosslinking of CD 2 , CD 4 and CD 45 with Ti / CD3 to several of these antigens can augment the minimal signal induced by antigen binding to the Ti / CD3 complex . ^^^ Crosslinking of CD 4 with the Ti / CD3 complex preferentially activated the CD4+ CD45+ RA subset , while soluble antibodies to CD 2 preferentially affected the CD 45 CD45RA+ subset . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Bovine gamma delta T cells were also CD 2 , CD 4 , and mostly CD 8 , and failed to express CD 6 , a molecule possibly involved in T cell activation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The distribution and number of CD 2 ( Coulter T 11 ) + cells , CD 16 ( Leu 11b ) + cells , Leu 7+ cells , CD 8 ( OKT 8 ) + cells , CD 11 ( Leu 15 ) + cells , CD 4 ( Leu 3a + 3b ) + cells and Leu 10+ or Leu 14+ cells in the liver of patients with hepatocellular carcinoma ( HCC ) and metastatic liver cancer ( MLC ) were investigated using monoclonal antibodies and immunohistological methods . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These leukemic blasts did not express both T cell lineage antigens which are detectable by monoclonal antibodies , T 6 ( CD 1 ) , T 11 ( CD 2 ) , T 3 ( CD 3 ) , T 4 ( CD 4 ) , T 1 ( CD 5 ) , Tp 40 , Leu 9 ( CD 7 ) , T 8 ( CD 8 ) , and B cell lineage antigens which are detectable by monoclonal antibodies , B 4 ( CD 19 ) , B 1 ( CD 20 ) , B 2 ( CD 21 ) and J 5 ( CD 10 ) . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
This T cell line expressed a very unusual phenotype : CD1+ , CD 2 , CD3+ ( cytoplasmic ) , CD 4 , CD5+ , CD7+ , CD 8 , interleukin 2 receptor ( IL 2 R ) ( p 55 ) , and T cell antigen receptor ( TCAR ) alpha beta . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In two colour analysis , cells labelled were negative for keratin and HLA DR , and showed positivity for CD 1 , CD 2 , CD 3 , CD 4 , CD 7 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Virtually all TCR gamma / delta+ thymocytes / lymphocytes expressed CD 7 , CD 2 , and CD 5 but were heterogeneous with respect to their expression of CD 1 , CD 4 , CD 8 , CD 28 , CD11b , CD 16 , and Leu 7 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In either situation , suppression of CD 2 expression does not significantly alter the generation of T cells expressing CD 3 , CD 4 , CD 8 and T cell receptor 5 beta 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
T cell ontogeny after autologous bone marrow transplantation : failure to synthesize interleukin 2 ( IL 2 ) and lack of CD 2 and CD 3 mediated proliferation by both CD 4 and CD8+ cells even in the presence of exogeneous IL 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Responses were inhibited by monoclonal antibodies to CD 3 , the alpha beta chain T cell receptor , or CD 4 molecules but not to CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
To investigate whether the presence or absence of tissue eosinophilia is related to the immunophenotype of the T cells , we studied 43 cases of HD ( 28 nodular sclerosing , ten mixed cellularity , and five unclassifiable ) for the relative numbers of lymphocytes positive for CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 25 , CD 38 , T 9 , TQ 1 , HLA DR , and beta F 1 , and for the number of eosinophils in tissue sections . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
After short term culture without an addition of any differentiation stimulators , the blast cells expressed CD 2 , CD 3 , CD 4 , CD 8 , and CD 25 antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The tumor cells expressed , CD 2 , CD 3 , CD 4 , CD 5 and CD 7 antigens , which corresponded to the phenotype of helper inducer T lymphocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Here a time dependent decrease of labelling by CD 2 ( OX 34 ) , CD 8 ( OX 8 ) , CD 4 ( ER 2 ) , and CD 5 ( OX 19 ) was observed . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The number of CD57+ lymphocytes ( this being the antigen present in NK cells ) increased after alpha IFN treatment , without any changes in the remaining T lymphocyte ( CD 2 , CD 4 and CD 8 ) and NK ( CD 16 and CD11b ) subpopulations . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The biologic roles of CD 2 , CD 4 , and CD 8 in T cell activation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Blood samples were obtained at varying intervals after infusion and analyzed for differential cell counts and lymphocyte subsets ( CD 2 , CD 3 , CD 4 , CD 8 , CD 20 , and HLA DR ) by flow microfluorimetry , and also assayed for plasma cachectin / TNF , epinephrine , and cortisol . ^^^ During the period of hypercortisolemia , CD 2 , CD 3 , and CD 4 lymphocyte percentages were decreased ( p less than 0 . 01 ) while CD 20 and HLA DR lymphocyte percentages were increased ( p less than 0 . 01 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Mononuclear white cells were separated from 0 . 4 ml capillary blood , kept covered by culture medium on a Multitest slide , and incubated with monoclonal antibodies to the CD 2 , CD 4 , CD 8 , and interleukin 2 receptor antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
T cell related antigens were detected in 44 % of the cases ( CD 2 , 24 % ; CD 4 , 12 % ; CD 7 36 % ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Perivenular infiltrates contained CD 2 positive T lymphocytes , mostly belonging to the CD 4 subset , and some C3bi receptor positive monocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
HLA class 1 phenotyping was performed using T lymphocyte populations isolated by immunomagnetic beads ( IMBs ) coated with monoclonal antibodies with specificity for CD 2 , CD 4 or CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
After 15 months of proficiency testing , the multicenter cumulative average standard deviation for the percentage of positive CD 2 was 3 . 3 , CD 3 was 4 . 4 , CD 4 was 3 . 3 , CD 8 was 3 . 6 , CD8 * CD3 was 2 . 8 , CD19 / 20 was 2 . 9 , and 3 . 0 for natural killer ( NK ) cells . ^^^ The cumulative average coefficient of variation for the percentage of positive CD 2 was 3 . 9 % , CD 3 was 4 . 9 % , CD 4 was 6 . 6 % , CD 8 was 11 . 4 % , CD8 * CD3 was 9 . 4 % , CD19 / 20 was 18 . 8 % , and 26 . 5 % for NK . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Basing on the data concerning the distribution of McAb reactivity with cells from different organs and tissues , and with tumour cell lines , on experiments on the mutual blockage and comodulation of antigens , on two colour immunofluorescence and determination of the molecular weight of the detected antigens a conclusion is made that the McAb obtained react with CD 5 , CD 2 , CD 4 , CD 6 , CD 7 , CD 8 , CD 21 and HLA DR antigens , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In comparison to aged cross matched male controls , significant increases of absolute number of lymphocytes and of T and B cell subpopulations with significant reduction of the percentages of CD 3 , CD 4 , CD 2 , CD 5 , sIg , and CD 16 cells was found in haemophiliacs . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Sixty two of these cases were tested with a panel of mAb directed against the T cell markers CD 2 , CD 4 , CD 8 , B cell markers CD 20 , kappa and lambda , the common ALL antigen ( common ALLa ) and class 2 HLA antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These immature cells are TdT and do not express membrane CD 3 ( mCD 3 ) or TCR beta identified by beta F 1 , but show CD 7 and CD 45 positivity without CD 1 , CD 2 , CD 5 , CD 4 , CD 8 , CD 10 , and class 2 Ag . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Regulation of CD 4 and CD 8 surface expression on human thymocyte subpopulations by triggering through CD 2 and the CD 3 T cell receptor . ^^^ We show that the expression of CD 4 and CD 8 on thymocyte subpopulations with low CD 3 ( CD3L ) and high CD 3 ( CD3H ) is regulated by activation through the CD 2 molecule and perturbation of the CD 3 T cell receptor complex ( CD 3 Ti ) . ^^^ Treatment with anti T 11 ( 2 ) and anti T 11 ( 3 ) antibodies ( CD 2 activation pathway ) resulted in partial down regulation of CD 4 but not CD 8 surface expression on both CD3L and CD3H thymocytes . ^^^ The down regulation of surface CD 4 induced by activation via CD 2 could be inhibited by treatment of thymocytes with anti CD 3 antibodies . ^^^ These results suggest that CD 2 and CD 3 Ti triggering may regulate CD 4 and CD 8 surface expression on thymocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The predominant phenotype of T cells after six to 12 weeks in culture was CD 2 , CD 3 , and CD 4 positive . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies against CD 2 , CD 4 , CD11a , CD 18 , LFA 3 , ICAM 1 , class 1 and class 2 major histocompatibility complex ( MHC ) inhibited T cell proliferation in this response , whereas antibodies against CD 8 , CD11b , CD11c and CD 16 had no effect . ^^^ Studies examining the expression of the respective molecules upon isolated dendritic cells and T cells suggest that anti LFA 3 and anti class 2 MHC antibodies inhibit at the level of the dendritic cell , whereas anti CD 2 and anti CD 4 antibodies inhibit at the level of the T cell . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Phenotypic analysis using the monoclonal antibodies MT 910 ( CD 2 ) , MT 811 ( CD 8 ) , and MT 151 ( CD 4 ) revealed that in nine of 14 TLL cytotoxic suppressor T cells predominated ( CD8+ : 52 84 % ; CD4+ : 14 48 % ) , whereas in five of 14 TLL a preponderance of the CD4+ subpopulation was found ( CD4+ : 56 73 % ; CD8+ : 28 45 % ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Parenteral heroin abusers also had higher absolute numbers of CD 2 , CD 3 , CD 4 and CD 8 positive cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The tumor cells carried the CD 3 and CD 7 T cell antigens , but were double negative for CD 4 and CD 8 and also lacked other T cell antigens ( CD 1 , CD 2 , and CD 5 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Precursor cells were seen to express CD 2 , CD 11 , and some CD 16 markers , but not CD 3 , CD 4 , CD 8 , CD 15 , Leu M 3 , or Leu 7 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The OX 40 MAb did not detect an activation determinant of CD 2 or CD 4 molecules but recognized a distinct chain of mol . wt 50 , 000 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
T cell molecules that function to strengthen adhesion include lymphocyte function associated antigen ( LFA ) 1 , CD 2 , CD 4 , and CD 8 . ^^^ LFA 1 is a member of the integrin family of adhesion receptors and one of its ligands is intercellular adhesion molecule 1 ( ICAM 1 ) ; a ligand for CD 2 is LFA 3 ; and ligands for CD 4 and CD 8 appear to be major histocompatibility complex class 2 and class 1 molecules , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The surface phenotype of these cells was CD 2 ( + ) , CD 4 ( + ) , CD 8 ( ) , Ia ( + ) and Tac ( + ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Five isolates of Pseudomonas aeruginosa ( CD 2 , CD 3 , CD 4 , CD 5 , and CD 10 ) from a patient with cystic fibrosis were examined with regard to several genotypic and phenotypic characteristics to determine whether the patient was colonized with one or several distinct strains . ^^^ Isolates CD 2 , CD 3 , and CD 4 were obtained from a single sputum sample , and CD 5 and CD 10 were obtained 1 and 2 years later , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The relative mitogenic potency of the accessory molecules tested was CD 2 greater than CD 4 greater than CD 8 greater than 2H4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The target cells are sensitized with antibodies directed against the CD 2 , CD 3 , CD 4 and / or CD 8 cell surface antigens , captured by magnetic beads coated with sheep anti mouse IgG antibody and collected by placing the cell suspension in a magnetic field . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The following markers were examined : E rosette formation , CD 2 , CD 3 , CD 4 , CD 8 , CD 1 , CD 22 , CD 10 and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Analysis of CD 4 and CD 2 receptor function . ^^^ We have expressed the human CD 4 and CD 2 molecules in a murine hybridoma , 155 . 16 , that responds to stimulation with human HLA DR antigens by producing interleukin 2 ( IL 2 ) . ^^^ When stimulated by HLA DR expressing human cells , the CD4+ and CD2+ hybridomas produce significantly more IL 2 than the parent hybridomas , indicating that CD 4 and CD 2 are functional . ^^^ We have used this model system to analyze the role of the CD 4 and CD 2 surface receptors in T cell activation . ^^^ Different monoclonal antibodies ( mAbs ) against CD 4 and CD 2 were used to define regions of these molecules that may be important for ligand binding and function . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition to the CD 3 T cell receptor complex , the CD 2 , CD 4 , CD 5 , CD 7 , CD 8 and CD 28 receptors mobilize cytoplasmic calcium within minutes of binding with monoclonal antibodies and additional crosslinking occurs on the cell surface . ^^^ The increased activity was dependent in each case on the relevant second receptor , since unconjugated CD 2 , CD 4 , CD 6 or CD 8 MAb could block the activity of the corresponding heteroconjugate . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The cell was negative for antibodies to Leu 2 ( CD 8 ) , Leu 3 ( CD 4 ) , Leu 4 ( CD 3 ) , Leu 5 ( CD 2 ) , Leu 7 , Leu 8 , Leu 11 ( CD 16 ) , Leu M 1 ( CD 15 ) , Leu M 3 , and CALLA ( CD 10 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We tested the effect of MoAb to LFA 1 , CD 2 , CD 3 , CD 4 , CD 8 , and HLA molecules on killing mediated by IEL . ^^^ Anti CD 2 , CD 3 , CD 4 , CD 8 , and HLA class 1 molecules did not inhibit the nonspecific killing ; rather , anti CD 3 potentiated the killing of PBL , K 562 , and Daudi cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Activation of T cells through the CD 2 sheep erythrocyte binding protein , using anti T 11 ( 2 ) and T 11 ( 3 ) antibodies , also resulted in CD 4 and CD 8 phosphorylation . ^^^ Furthermore , phorbol myristate acetate treatment or activation via the CD 2 pathway induced phosphorylation of the CD 4 and CD 8 molecules of thymocytes , suggesting that these molecules may be functional in thymus . ^^^ Together , our findings indicate that CD 4 and CD 8 phosphorylation is a consequence of T cell triggering , and suggest that CD 4 and CD 8 phosphorylation may represent a molecular signaling mechanism among the CD 3 T cell receptor complex , CD 2 , CD 4 , and CD8 . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In contrast to both sibs ' normal expression of other peripheral leucocyte markers , as measured by flow cytometry ( including CD 1 , CD 2 , CD 4 , CD 8 , and CD 16 ) , only about 6 % of CD2+ polyclonal T cells expressed surface antigen specific T cell receptor ( Ti / WT31 ) , and only about 23 % weakly expressed surface CD 3 determinants . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Incubation of human T lymphocytes with saturating concentrations of combinations of certain anti CD 2 and CD 4 mAb results in reciprocal down regulation of the cell surface density expression of the respective CD molecules . ^^^ Such reciprocal down regulation occurs at 0 degrees C in the presence of sodium azide and appears selective for CD 2 and CD 4 molecules because mAb identifying various other CD T cell surface molecules ( anti Leu2a , OK CLL , W6 / 32 , beta 2 microglobulin , 4B4 ) do not modulate CD 2 or CD 4 R density , and because anti CD 2 mAb ( anti OKT 11 and D 66 clone 1 ) do not alter CD 8 R density ( anti OKT 8 , Leu2a ) and vice versa . ^^^ Down regulation of CD 2 by mAb specific to CD 4 is epitope specific but does not vary on the basis of the antibody isotype used . ^^^ The anti CD 4 mAb , Leu3a , was the strongest CD 2 down regulator examined followed by OKT4F . mAb specific to other CD 4 epitopes ( B , C , D , and E ) caused only slight down regulation of CD 2 expression whereas anti OKT 4 and OKT4A mAb had no significant regulatory effect . ^^^ Also , mAb specific to the 9 . 6 ( anti OKT 11 ) and D 66 ( anti D 66 clone 1 ) epitopes of the CD 2 molecule down regulated CD 4 density detectable with Leu3a , OKT 4 , and OKT4A anti CD 4 mAb . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We have compared the requirements of the primary MLR and the responses of alloreactive , primed lymphocytes ( PL ) by inhibition studies using monoclonal antibodies ( MoAb ) directed against ( 1 ) adhesion molecules belonging to the CD 11 cluster of leucocyte antigens ( CD11a , LFA 1 ; CD11b , MAC 1 = CR 3 ; and CD11c , p 150 , 95 ) ; ( 2 ) various T cell related antigens ( CD 2 , CD 4 , CD 5 and CD 8 ) ; and ( 3 ) recombinant IL 1 beta . ^^^ CD 2 and CD 4 reactive MoAb significantly inhibited both primary MLR ( greater than 80 % , P less than or equal to 0 . 01 ) and to a lesser extent the PLR ( 40 65 % , P less than or equal to 0 . 01 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We tested the ability of these heterodimers to direct a CD 2 + CD 3 + CD 8 + CD 4 CD 25 + transferrin receptor + MHC restricted human cytolytic T lymphocyte ( CTL ) clone to lyse a CALLA + human tumor in vitro . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Our data indicate that binding of ligand to LFA 1 results in the transduction of regulatory signal across the plasma membrane , rather like other molecules ( CD 2 , CD 4 , CD 8 ) ( refs 8 11 ) with signal modifying properties involved in the adhesion of T cells to target / stimulator cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Parallel experiments performed on the T 11 ( CD 2 ) and T 4 ( CD 4 ) / AIDS retrovirus receptor indicate that the same mechanism applies for the down regulation of those molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Functional analysis of CD 2 , CD 4 , and CD 8 in T cell activation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
DAF deficiency was intermediate in cells expressing the CD 2 , CD 3 , CD 4 , or CD 8 markers . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Similarities in sequences and cellular expression between rat CD 2 and CD 4 antigens . ^^^ Within the T lymphocyte lineage , rat CD 2 seemed to be present on all stages with the exception of approximately 50 % of the thymic CD 4 , CD 8 cells . ^^^ CD 4 antigen is also expressed on T lymphocytes and macrophages , and thus CD 2 and CD 4 appear similar in their cellular expression as well as structural characteristics . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Antibodies binding to a large subset of T cell differentiation antigens , including CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , CD 8 , Tp 44 , and CDw 18 , cause an increase in the cytoplasmic calcium concentration [ ( Ca2+ ] 1 ) after the antigens are crosslinked on the cell surface . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The immunologic phenotype of PTC , as revealed on frozen tumor tissue sections , comprised the expression of CD 5 ( T 1 ) , CD 4 ( T 4 ) , and HLA DR , but not CD 8 ( T 8 ) and CD 2 ( T 11 ) and suggested an affiliation to the T cell system . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The expression of CD 2 was compared with the expression of CD 4 and CD 8 , i . e . , T cell differentiation antigens on cytotoxic / suppressor or helper T cells , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In patients as well as controls , both LAK precursors and LAK effectors lacked antigens present on mature T lymphocytes ( CD 3 , CD 4 , or CD 8 ) but expressed antigens present on NK cells ( CD 2 , CD 16 , and NKH1A ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
THP 6 cells were positive for CD 7 and CD 5 antigens and terminal deoxynucleotidyl transferase , but negative for CD 2 , CD 1 , CD 4 , CD 8 , CD 10 , cytoplasmic and surface CD 3 and HLA DR antigens , suggesting a precursor T cell line . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Concerning the leukocyte subpopulations evaluated ( CD 2 , CD 4 , CD 8 , CD 20 , MO 2 ) , the most significant findings were a decrease of both CD4+ cells and the CD4 / CD8 ratio in MCL patients compared with the other groups . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The presence of mAbs against CD 4 and the IL 2 R also abrogated this mitogenesis , whereas an anti CD 5 mAb augmented the CD 2 induced proliferation . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
H 10 cells were T6+ ( CD1a ) , S 100+ , T4+ ( CD 4 ) and HLA DR+ ; in addition they were consistently T11+ ( CD 2 ) and were stained by antibodies directed against receptors for transferrin ( T 9 ) , C3bi ( OKM 1 / CD11b ) , IgG Fc ( Leu 11 / CD16 ) and Interleukin 2 ( IL 2R / CD25 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The T lymphocyte response to concanavalin A ( con A ) and PHA and dual marker phenotype analysis of lymphocyte ( CD 2 , CD 4 , CD4 / DR , CD 8 , CD8 / DR ) and macrophage ( M3 / DR ) subsets were determined . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We achieved 2 Log elimination of mature T cells from BM using a cocktail of monoclonal antibodies : CD 2 , CD 3 , CD 4 , CD 6 , and CD 8 followed by two successive baby rabbit C ' treatment . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Detailed immunological analysis demonstrated that the vast majority of these cells expressed T cell associated antigens ( i . e . , CD 7 , CD 5 , CD 2 , CD 4 , and to a lesser extent , CD 8 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We investigated the phosphorylation of CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 28 ( Tp 44 ) , CD 43 ( sialophorin , gp 115 ) , and LFA 1 after incubation of human PBMC with the ( PKC ) activator PMA . ^^^ These proteins were chosen for their role in transmembrane signal transduction ( CD 2 , CD 3 , CD 5 , CD 28 , CD 43 ) , cell cell interaction and adhesion ( CD 2 , CD 4 , CD 8 , and LFA 1 ) , or involvement in immunodeficiency states ( CD 43 , CD 7 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Stimulation by PDBu alone induced phosphorylation of several endogenous substrates and altered expression of phenotypic markers , downregulating expression of CD 4 and CD 3 while increasing expression of CD 2 and the interleukin 2 ( IL 2 ) receptor . ^^^ Stimulation with ionomycin alone caused an increase in intracellular Ca2+ levels but did not induce proliferation or cause major changes in the expression of phenotypic markers ( CD 2 , CD 3 , CD 4 , CD 8 , IL 2 , and transferrin receptors ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In 12 cases immunohistochemical technics were applied to determine SmIg , B cell differentiation antigens ( CD 19 , CD 20 , CD 21 , BL 14 , FmC 7 ) and T cells subsets ( CD 2 , CD 3 , CD 4 , CD 8 ) the quantification of the various T cell subsets showed that CD 3 , CD 4 , positive T cell were lower in advanced stages of CLL . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The tumor cells were positive for the Pan T cell markers CD 3 and CD 2 , but were negative for the subset markers CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
With our system , a wide variety of antigens are detected in plastic sections without trypsinization or prolonged embedding procedures ; pan B ( CD 19 , CD 22 ) , pan T ( CD 7 , CD 5 , CD 3 , CD 2 ) , T subset ( CD 4 , CD 8 , CD 1 , CD 25 ) markers as well as surface immunoglobulin and markers for myeloid and mononuclear phagocyte cells are preserved . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
With MoAb specific for CD 2 , CD 4 , CD 8 and CD 19 , reproducible absolute counts of the corresponding lymphocyte subsets were obtained which correlated closely with those obtained by an indirect quantification method . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Phenotypic analysis showed that the hybrids could be grouped as follows : a high frequency expressing CD 25 ( IL 2 receptor ) , human T 200 , HLA class 1 alpha and beta 2microglobulin , and reacting with the mAb H 207 and 12E7 ; an intermediate frequency expressing CD 1 and CD 2 ; and a low frequency expressing CD 3 , CD 4 , CD 5 , CD 7 , CD 8 and CD 9 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
To circumvent this problem , extensive purging of BM cells was achieved , using E rosetting and complement dependent cytotoxicity , with a cocktail of monoclonal antibodies ( Mabs ) : CD 6 + CD 8 + CD 4 + CD 2 and two successive rabbit Complement ( C ) treatments . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunologically all cases expressed CD 2 ( OKT 11 ) and CD 4 ( T 4 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cells in this fraction were negative for CD 3 , CD 4 , CD 1 , CD 8 , and CD 2 antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The immunological phenotype of the lymphoma resembled that of immature T cells present in the normal thymus cortex positivity for CD 1 , CD 2 , CD 4 , CD 7 , CD 38 and terminal deoxynucleotidyl transferase ; faint positivity for CD 5 and in the second specimen for CD 3 ; negativity for CD 6 and MHC class 1 antigen . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These patterns of CD3 / beta F 1 expression , along with the patterns of CD 2 , CD 4 , CD 5 , CD 7 , and CD 8 antigen expression in these neoplasms , indicate that T cell lymphomas can manifest phenotypes not apparently reflective of normal T populations and suggest the presence of abnormal gene expression in these malignancies . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies have been derived which detect the bovine equivalents of the human pan T cell marker CD 2 and the T lymphocyte subpopulation markers CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The different peripheral blood lymphocyte subsets were characterized by means of monoclonal antibodies ( indirect immunofluorescence assay ) belonging to the following classes of differentiation : OKT 11 T11 ( CD 2 ) , OKT 3 T3 ( CD 3 ) , OKT 4 T4 ( CD 4 ) , OKT 8 T8 ( CD 8 ) , OKIal I 2 ( HLA DR ) , Leu 7 ( natural killer / killer ) and by means of polyspecific antiimmunoglobulin sera ( direct immunofluorescence assay ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A number of discordances were observed with other antigens [ CD 19 ( B 4 ) , CD 20 ( B 1 ) , CD 22 ( To 15 ) , CD 1 ( T 6 ) , CD 2 ( T 11 ) , CD 4 ( T 4 ) , CD 8 ( T 8 ) , CD 3 ( T 3 ) , T 9 , T 10 ] . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunohistological analysis with a range of monoclonal antibodies showed the PTC of our case to be CD 5 ( T 1 ) + , CD 4 ( T 4 ) + , CD 3 ( T 3 ) , CD 8 ( T 8 ) , CD 2 ( T 11 ) , and CD 25 ( TAC ) , but HLA DR+ and transferrin receptor positive . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Alloreactive T cell clones primed in vivo were tested for the expression of T cell differentiation antigens CD 2 , CD 3 , CD 4 , and CD 8 . ^^^ Each of 29 different clones were found to express CD 2 and CD 3 , but were variable in their expression of CD 4 ( 7 positive clones ) and CD 8 ( 15 positive clones ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lymphocyte subpopulations including CD 2 , CD 3 , CD 4 , CD 8 , CD 19 , CD 20 , and CD 25 were also measured , rhG CSF was administered once daily as a 30 min infusion . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the present study , the expression of two NK associated antigens ( CD 56 and CD 16 ) together with six ' classically ' considered lymphoid related markers ( TDT , CD 19 , CD 10 , CD 7 , CD 2 , CD 4 ) has been analyzed by appropriate dual combinations in 265 acute myelogenous leukemia ( AML ) patients . ^^^ Among the lymphoid markers , CD 4 and CD 7 were those most frequently expressed by AML blast cells ( 58 % and 21 . 6 % , respectively ) while the incidence of positivity for the other markers was lower : CD 19 ( 7 . 8 % ) , CD 10 ( 10 . 9 % ) , CD 2 ( 11 . 4 % ) , and TDT ( 11 . 3 % ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface marker analysis revealed the blasts to be CD 2 , CD 3 , CD 4 , CD 5 , CD7+ , CD 8 , CD 10 , CD 13 + / , CD 19 , CD 20 , CD 25 , CD33+ and human leukocyte antigen DR ( HLA DR+ ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Using monoclonal antibodies authors determined the percentage of CD 2 ( + ) , CD 4 ( + ) and CD 8 ( + ) lymphocytes in the peripheral blood of 45 asthmatic children . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We describe a new , rapid , sensitive , and reproducible method for examining gene expression of several cell specific surface cluster determinants , CD 2 , CD 3 gamma , CD 4 , CD 8 beta , CD 14 , CD 19 , CD 20 , CD 23 , and CD 25 alpha , and terminal deoxynucleotidyl transferase which heretofore have been commonly detected by flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunocytochemistry showed lymphocyte populations to be predominantly CD 2 + ve CD 3 + ve T lymphocytes of the CD 4 sub set . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Most clones express Thy 1 , Pgp 1 , ICAM 1 , HSA and B 220 antigen , but are negative for LFA 1 , CD 2 , Mel 14 , Fc receptor , Mac 1 , CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The morphological evaluation was in each case combined with immunofluorescence ( to detect immunoglobulins and complement fractions ) and immunohistochemistry with a wide panel of monoclonal antibodies for T cells ( CD 2 , CD 3 , CD 4 , CD 8 , gamma delta ) , B cells ( CD 20 , CD 22 ) , macrophages ( CD 68 , MAC 387 ) NK cells ( leu 7 , CD 16 ) , activation markers ( IL 2 R , Ki 67 , transferrin R ) , MHC antigens ( HLA ABC , HLA DR ) , adhesion molecules ( ICAM 1 , VCAM 1 , ELAM 1 , PADGEM , VLA 4 , LFA 1 alpha / beta ) , and growth factors ( EGF , TGF alpha , EGF R ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Abnormalities which could contribute to this defect include low expression and rapid TCR / CD3 modulation , loss of CD 4 , CD 8 , CD 2 and Ly 6 . 2 , aberrant expression of CD 45 , and constitutive elevations of inositol phospholipid turnover , tyrosine phosphorylation , and expression of the p59fyn protein tyrosine kinase ( PTK ) and a few other protooncogenes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The expression or in vitro induction of CD 13 and / or CD 33 antigens correlated with the immaturity of these neoplastic T cells , since it was observed in all 11 CD7+ CD 5 CD 2 and CD7+ CD5+ CD 2 , and some CD7+ CD5+ CD2+ ( CD 3 CD 4 CD 8 ) cases , but not in CD 3 + / CD4+ CD8+ or CD3+ CD4+ CD 8 cases . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The IVIG treatment had no effect upon T cell populations stained with antibodies specific for CD 2 , CD 3 , CD 4 , CD 8 and on CD4+CD45RA+ , CD4+CD29+ , CD8+CD28+ , CD8+CD28 subpopulations . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD34bright thymocytes were CD 33 / dull and were negative for CD 38 , CD 2 , and CD 5 as well as for the lineage markers CD 3 , CD 4 , and CD 8 ( T cells ) , CD 19 and CD 20 ( B cells ) , CD 56 ( NK cells ) , glycophorin ( erythrocytes ) , and CD 14 ( monocytes ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In sheep at the asymptomatic stage , depending on the extent of progression of the disease , the proportions of CD 2 ( + ) , CD 4 ( + ) , CD 8 ( + ) , and gamma delta TCR ( + ) T cells that coexpressed CD 5 decreased , but CD5+ sIgM+ cells as well as CD 5 sIgM+ cells increased for a period . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cell surface analysis showed that they had the phenotype of a helper / inducer T subset that was positive for CD 2 , CD 3 , and CD 4 , but negative for CD 8 , similar to adult T cell leukemia cells induced by HTLV 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 2 , CD 3 , CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The CD 48 chimeric protein has been used both as multivalent complexes produced by cross linking with mAbs recognizing CD 4 and in a monomeric form to analyse the kinetics of the interaction between CD 48 and CD 2 [ van der Merwe et al . ( 1993 ) EMBO J . , 12 , 4945 4954 ] . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the immunohistochemical study , antibodies against 8 lymphocyte differentiation antigens , including CD 4 , CD 8 , CD 3 , CD 1 , CD 2 , CD 25 , CD 22 and T 9 as well as those against keration and S 100 protein were used . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Although two cases expressed CD 4 , no case expressed CD 2 , CD 3 , or CD 8 and no case showed clonal rearrangement of genes encoding the T cell receptor ( TCR beta , gamma , delta ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
This effect of gp 160 was not observed when the target cells consisted of PBMC depleted of either CD4+ cells ( CD 4 PBMC ) or of CD2+ cells ( CD 2 PBMC ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Costimulation of the T cell antigen receptor ( TCR / CD3 ) with either the CD 2 or CD 4 costimulatory receptors induced synergistic fakB tyrosine phosphorylation in normal human T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The tumor cells were pleomorphic medium sized cells that expressed a range of T cell specific antigens , including CD 2 , CD 3 , CD 4 , CD 5 , CD 6 , CD 7 , and beta F 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
PMT 2Y cells are positive for CD 2 , CD 3 , CD 4 , CD 25 , T cell receptor alpha beta and HLA DR , but negative for CD 1 , CD 7 , CD 8 , CD 19 and CD 20 , indicating that the clone belongs to a helper / inducer subset of T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
They commonly express some T cell markers , such as CD 2 , CD 3 , CD 4 , and CD 7 , and thus termed as CTCL ( cutaneous T cell lymphoma ) . ^^^ Here , we present a case with CD56 / N CAM positive cutaneous lymphoma , which appears lymphocytic morphology and expresses CD 4 , but does not express CD 2 , CD 3 , CD 8 , CD 14 , CD 16 , CD 57 , and CD 20 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The anti CD 2 mAb 12 15 caused CD 2 expression on purified splenic T cells to decrease from 83 . 4 to 22 . 7 % total positive cells while CD 3 , CD 4 , and CD 8 expression remained unchanged . ^^^ Anti CD 2 mAb could down modulate CD 2 on both CD 4 and CD 8 splenic lymphocyte subsets , thymocytes , and the T cell lymphoma EL 4 ; and , non T cells did not seem to participate in the process of modulation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The leukemia cells expressed CD 2 , CD 6 , CD 7 , CD13low , CD 56 , beta chain of IL 2 receptorlow ( IL 2R beta ) , and HLA DR antigens , but not other pan T ( CD 5 , CD 3 , CD 4 , and CD 8 ) ; pan B ( CD 10 , CD 19 , CD 20 , and CD 24 ) ; natural killer ( NK ) ( CD 16 , CD 57 ) ; or myeloid ( CD 33 ) antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunohistochemical analysis of tissue specimens from human pregnancy decidua basalis in contact with invasive trophoblast of chorion frondosum and decidua parietalis in contact with non invasive chorion laeve do not differ in the frequency of lymphoid cells of the following phenotypes ( CD 2 , CD 4 , CD 8 , CD 14 , CD 21 and gamma / delta TCR ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the absence of gp 120 , CD 4 displayed high association with CD 3 , CD 5 , CD45RC , CD 25 , CD 28 , CD 44 , and CD 53 ; weak association with CD 2 , CD 38 , CD45RB , CD62L , and CD 26 ; and no association with CD45RA , CD45RO , CD11b , CD11a , CD 54 , CD 7 , CD 48 , CD 98 , CD 59 CD55 , HLA class 1 and class 2 molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Frozen tissue samples were stained by a labeled avidin biotin technique using primary antibodies to LFA 1 ( CD11a ) , CD 2 , CD 4 , CD 8 , CD 20 , CD 68 , HLA DR , ICAM 1 ( CD 54 ) , and VCAM 1 . ^^^ Cells positive for LFA 1 , CD 2 , CD 4 , CD 8 , and CD 20 were increased in the tumors in the same cases . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The cell line with the highest level of binding was PER 423 ( Kees et al , Leukemia Res 1993 ; 17 : 51 59 which has the phenotype CD7+ , CD56bright , CD 2 , CD 4 , CD 5 , CD 8 , CD 16 , has rearranged T cell receptor beta chain genes , expresses cytoplasmic CD 3 and is strictly dependent on interleukin 2 ( IL 2 ) for proliferation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Murine Thy 1+ , TCR 5 gamma 3 / V delta 1+ dendritic epidermal T cells ( DETC ) express CD 2 antigens , but differ from most other T cell subsets in their absence of CD 4 , CD 5 , and CD 8 antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The leukemic blast cells expressed both myeloid antigens ( CD11b , CD 13 , CD 14 , CD 15 , CD 33 and CD 34 ) and T / B lymphoid antigens ( CD 2 , CD 4 , CD 22 and PCA 1 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Here , we demonstrate that ligation of CD 2 and CD 28 in conjunction with TCR occupancy rescue T cells that have been programmed for apoptotic death by prior CD 4 ligation to gp 120 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Alterations in the expression of cell surface receptors have been reported in HIV infected cells for CD 4 , CD 25 ( IL 2 receptor ) , CD 2 , CD 3 and CD 8 and CD 26 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
RESULTS : Several factors , including chromosomal abnormalities [ t ( 8 ; 21 ) , inv ( 16 ) ] , cell surface markers ( CD 56 , CD 2 , CD 4 , CD 7 ) , French American British ( FAB ) subtype ( M 2 , M 4 , M 5 ) , blast differentiation and maturation , patient nutritional status , age , cellular immune dysfunction , high presenting leukocyte count , and decreased blast Auer rods , have been associated with a higher incidence of EML . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Total T cells , T 4 and T 8 were measured as CD 2 , CD 4 and CD 8 respectively by flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
After isolation of lymphocytes by gradient centrifugation , flow cytometric immunophenotyping was performed using CD 2 , CD 3 , CD 4 , CD 8 , CD11 / CD18 , CD 20 , CD 44 and MHC 2 monoclonal antibodies . ^^^ Endotoxemia and surgery were both accompanied by increased serum cortisol , lymphocytopenia , and a decrease in CD 2 , CD 3 and CD 4 lymphocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
PHA activated PBL released elevated quantities of soluble CD 2 , CD 4 , and CD 8 compared with control cultures . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 2 and CD 3 expression were normal , and the proportions of CD 4 , CD 8 and CD45RO and CD45RA subsets were also unaffected by disease . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The presence of T cell markers ( CD 2 , CD 3 , CD 4 , CD 8 in our cases ) and antigens of cell activation ( CD 25 , HLA DR ) were found . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The immunological behaviour of the host was assessed through the determination of lymphoid populations ( CD 2 , CD 3 , CD 4 , CD 5 and CD 8 ) and natural killer cells were studied with monoclonal antibodies CD 3 and CD 16 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
First , we examined the regions of CD 4 involved in the association with CD 81 and CD 82 by employing chimeric proteins generated from CD 4 and CD 2 . ^^^ It was confirmed that CD 4 , but not CD 2 , was capable of binding with CD 81 and CD 82 in transfected cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Although pretransplant percentages of the standard T cell ( CD 2 , CD 3 , CD 4 , CD 8 ) and B cell ( DR and CD 19 ) markers differed from post transplant values , the changes could be explained by the immunosuppressive regimen and did not differ between PPS+ and PPS patients . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Following the graft vs host reaction , PLN lymphocytes from animals fed the MO diet had significantly lower levels of expression of LFA 1 and CD 2 compared with PLN lymphocytes from animals fed the LF diet ; furthermore , they had lower levels of expression of T cell receptor ( TcR ) , CD 4 , CD 8 , LFA 1 , and CD 2 compared with lymphocytes from animals fed some , and in the case of CD 2 each , of the other high fat diets . ^^^ Following the host vs graft reaction , PLN lymphocytes from animals fed the MO diet had significantly lower levels of expression of TcR and CD 8 compared with lymphocytes from animals fed each of the other diets ; furthermore , they had lower levels of expression of CD 4 , CD 2 , and LFA 1 compared with lymphocytes from animals fed the LF , HCO , OO , or SO diets . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Expression patterns of non lineage specific markers ( terminal deoxynucleotidyl transferase ( TdT ) , CD 34 , and HLA DR ) , B lineage markers ( CD 10 , CD 19 , CD 20 , and CD 22 ) , T lineage markers ( CD 1 , CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , and CD 8 ) , and cross lineage myeloid markers ( CD 14 , CD 15 , and CD 33 ) were compared at diagnosis and relapse . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Leukaemic cells were positive for myeloperoxidase and expressed CD 13 , CD 33 and DR ; some expressed CD 2 , CD 4 and CD 34 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of CD 6 by stimulation of CD 3 : augmentation by the CD 4 and CD 2 coreceptors . ^^^ Tyr phosphorylation was observed when the T cells were activated by crosslinking CD 3 or by cocrosslinking CD 3 with CD 2 or CD 4 , but not when the cells were stimulated by crosslinking CD 2 , CD 4 , or CD 28 alone . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We evaluated the infiltrating mononuclear cells in both epithelium and lamina propria for expression of CD 2 , CD 4 , CD 8 , CD 25 , T alpha / beta and gamma / delta receptors , CD 16 , CD 56 , CD 57 and also studied the distribution of cell adhesion molecules ( ELAM 1 , VCAM 1 , ICAM 1 , PECAM 1 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 4 , CD 8 , CD 2 and CD 5 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Indeed , using MoAbs against CD 3 , CD 4 and to a lesser extent CD 2 , proliferation of N 18 to activated N 16 cells was abrogated . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Mice homozygous for lpr and gld develop lymphadenopathy characterized by the progressive accumulation of an unusual population of CD 4 , CD 8 , CD 2 , IL 2R double negative ( DN ) T cells that express reduced levels of TCR alpha / beta , high levels of CD 45 ( B 220 ) and Ly 6C and variable levels of CD 69 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These results suggest that there is a common pathway of early PTK activation following CD 3 or CD 2 mediated stimulation in mature T cells , whether they express surface CD 4 or CD 8 , and also that the PTK may be differently regulated in different T cell populations leading to different kinetics or intensity of tyrosyl phosphorylation . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 4 , CD 8 and CD 3 were used to divide the populations into the conventional major categories , and the distribution of CD1a , CD 2 , CD 7 , CD 34 , CD 44 , class 1 MHC and class 2 MHC was then determined . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometry analysis revealed that these cells express CD 45 , CD 56 , CD 2 , CD 7 , CD11a , CD 18 , CD 69 and the intermediate affinity ( p 70 ) IL 2 receptor ( IL 2R ) but not CD 57 , CD 16 , CD 3 , CD 4 , CD 5 , CD 8 , CD45RA , CD 25 , or the high affinity p 55 IL 2R . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The T CLL cells coexpressed antigens detected by MAbs CD 2 , CD 3 , CD 4 , CD 5 , Ti ( TcR alpha / beta ; WT 31 ) CD 45 and CD45RA , but did not express any other antigens including CD 1 , CD 8 , CD 29 , and TCR gamma / delta , Ti gamma A and TQ 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Beyond day 10 , however , CD 3 counts were lower in the ATG F group , as were CD 2 counts , CD 4 counts , and the CD4 / CD8 ratio , suggesting a more prolonged immunosuppressive effect of ATG F . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cleavage of lymphocyte surface antigens CD 2 , CD 4 , and CD 8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis . ^^^ In 10 CF sputum samples 1 . 0 % , 19 . 1 % , and 15 . 7 % of all CD3+ T lymphocytes expressed CD 4 , CD 8 , and CD 2 , respectively . ^^^ Incubation of CF sputum supernatant fluids with peripheral blood T lymphocytes resulted in total reduction of CD 4 and CD 8 but not CD 2 . ^^^ Purified PMN elastase and cathepsin G cleaved CD 2 , CD 4 , and CD 8 on peripheral blood T lymphocytes at proteinase concentrations of 0 . 83 to 8 . 3 microM in a dose dependent manner . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In particular , lymphocytes expressing the T cell surface markers CD 2 , CD 3 , CD 4 , CD 7 , and CD 8 were significantly decreased . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A significant decrease in CD 2 ( pan T cells ) and CD 4 ( T helper ) lymphocyte subpopulations , but unchanged CD 8 ( T suppressor ) subset , and a reduced response in delayed cutaneous hypersensitivity tests were observed in senile underweight anorectic patients . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Activities found in four lots each of horse ATG ( ATGAM , Upjohn ) , rabbit and horse ATG ( thymoglobulin and lymphoglobulin , Merieux ) , horse ALG ( Minnesota ) , and rabbit ATG ( Fresenius ) have been compared for CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD11a , CD 18 , CD 28 , CD 44 , CD 45 , and TCR alpha / beta antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These markers consist of T cell specific antigens ( CD 2 , CD 3 , CD 4 , and CD 8 ) , activated T cell antigens ( CD 25 and CD 71 ) , major histocompatibility complex ( MHC ) antigens ( class 1 and 2 ) , and adhesion molecules ( LFA 1 and ICAM 1 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 2 , CD 4 and CD 7 , which were observed in four of 11 analysed patients ( P < 0 . 01 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunostaining showed that NK lysin was present in cells positive for CD 8 , CD 2 and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the present study , we isolated IEL from both small and large intestine of three mouse strains ( BALB / c , C3H / HeN , C57BL / 6 ) and determined the frequency of CD 2 , CD 4 , and CD 8 expression on CD3+ IEL , as well as the frequency of alpha beta and gamma delta TCR usage and 5 beta distribution . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In both groups , CD 2 , CD 3 , CD 4 , CD 8 , and CD 19 cells were measured by flow cytometry and the levels of cytokines IL 1 beta , IL 2R , ICAM 1 , IL 6 , IL 7 , and levels of cytokines IL 1 beta , IL 2R , ICAM 1 , IL 6 , IL 7 , and levels of cytokines IL 1 beta , IL 2R , ICAM 1 , IL 6 , Il 7 , and IL 10 were measured by ELISA . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the abnormal lymphocyte cells surface marker test by flow cytometry showed that they expressed CD 2 , CD 3 , CD 4 , CD 29 , CD45RA , and CD 38 , but not CD 8 , CD 16 , and CD 25 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
T cell inactivation mirrors induction of anergy , T cell receptor downregulation , and that of CD 2 , CD 4 and CD 8 cell surface molecules , as well as of apoptosis . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The neoplastic cells stained positively with anti HLA DR , CD 1 , and CD 2 antibodies and showed lack of T cell subset antigens CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Antibodies to gamma delta T cell receptor , CD 2 , CD 3 , or CD11a were also inhibitory , whereas antibodies to alpha beta T cell receptor , CD 4 , CD 5 , and CD 8 had no effect . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The immunophenotypical analysis of lymphoma revealed that the tumor expressed CD 2 , CD 3 , CD 4 , CD 5 , CD 25 and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The percentages of gated lymphocytes expressing CD 3 , CD 8 , CD 19 , and HLA DR , but not CD 2 , CD 4 , CD 16 , and CD 25 , were significantly lower in FITC stained versus PE stained preparations . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
DS 500 mediated internalisation is a slow and energy dependent process , where CD 4 but not CD 2 , 3 , 8 , 16 , 56 and HLA DR molecules are involved . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
It was found that a number of adhesion molecules , such as CD 2 , CD 4 , CD 8 , LFA 1 , CD 18 , ICAM 1 and Thy 1 , was partly involved in the nursing activity . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The cloned cells ( named BC 1 . 10 , phenotype Thy 1 . 2+ , LFA 1+ , TCR alpha beta , TCR gamma delta , Fc gamma RII , CD 2 , CD 3 epsilon , CD 4 , CD 8 and express mRNA of zeta chain ) suppressed LPS induced Ig synthesis by B lymphoblasts previously stimulated with LPS . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Results : prior to transplantation both the numbers of T lymphocyte subpopulations such as CD 2 , CD 4 , CD 8 and the concentrations of C peptide in all IDDM patients were lowered ; after transplantation the numbers of CD 2 , CD 4 were significantly elevated ( P < 0 . 01 ) , the ratio of CD4 / CD8 in control group was higher than that in TII group ( P < 0 . 01 ) , while the concentration of C peptide were greatly increased ( normal : 2 . 24 + / 0 . 34 ; before transplantation : 0 . 21 + / 0 . 01 ; 15 days after transplantation : 3 . 24 + / 1 . 2 ng / ml ) . ^^^ Half a year after transplantation TII group remained stable for the requirement of insulin , whereas the control group gradually increased the dose of insulin . ( 1 ) Islet transplantation could adjust the immunological disorder in IDDM patients , increase the numbers of T lymphocyte subset such as CD 2 , CD 4 , CD 8 while the chronic immuno rejective response occurred . ( 2 ) T 2 inhibited both the numbers and function of T lymphocyte subpopulation and normalized the ratio of CD4 / CD8 . ( 3 ) TII prolonged the survival time of grafts in IDDM patients and suppressed immunological rejection . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The CD 2 , CD 4 and CD 8 mRNA expression of T lymphocytes in patients with acromegaly and hyperprolactinemia ] . ^^^ The CD 2 , CD 4 and CD 8 mRNA expression of human peripheral blood lymphocytes ( HPBL ) from 49 female patients with acromegaly and hyperprolactinemia and 15 healthy women were studied by dot blotting assay using corresponding CD 2 , CD 4 and CD 8 antisense RNA probes . ^^^ It was found that CD 2 mRNA expression increased in women with growth hormone over expression and the ratio of CD 4 and CD 8 mRNA declined significantly in the women with prolactin over expression . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Five mAb could be distributed to the porcine CD 2 , four mAb to the CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These hybridomas express the T cell surface markers CD 2 , CD 3 , CD 4 , and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Thalidomide does not perturb CD 2 , CD 4 , CD 5 , CD 8 , HLA DR , or HLA A , B , C molecules in vitro on the membranes of cells with immune potential . ^^^ Thalidomide did not modify : ( a ) adhesion and / or signal transducing molecules such as CD 2 , CD 4 , CD 5 and CD 8 , or ( b ) molecules that facilitate antigen presentation such as HLA DR , HLA A , HLA B , or HLA C . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
This training effect was accompanied by increases in the resting level of the following lymphocyte subpopulations : CD 2 ( 1717 vs 2183 mm 3 ; p < . 01 ) , CD 4 ( 942 vs 1280 mm 3 ; p < . 01 ) , CD45RA+CD4+ ( 312 vs 595 mm 3 ; p < . 01 ) , CD 8 ( 655 vs 816 mm 3 ; p < . 05 ) , and CD 20 ( 162 vs 244 mm 3 ; p < . 01 ) cell counts . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Like CD 2 , CD 4 and CD 8 function to promote adhesion between T cells and antigen presenting cells and potentiate signaling via the T cell receptor . ^^^ The clinical and immunologic findings in this patient provide in vivo evidence that the accessory molecules CD 2 , CD 4 , and CD 8 play important roles in the regulation of normal human T cell activation . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Phenotypic changes in the resulting lymphocyte populations were assessed by flow cytometry utilizing monoclonal antibodies specific for the cell surface determinates CD 2 , CD 4 , and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Serum soluble CD 2 , CD 4 and CD 8 levels in infectious mononucleosis ] . ^^^ In the present study , we investigated whether soluble antigen levels of CD 2 , CD 4 and CD 8 in serum increase during acute IM . ^^^ Soluble CD 2 , CD 4 and CD 8 levels in serum were measured by a sandwich enzyme immunoassay . ^^^ Patients with IM had increased levels of soluble CD 2 , CD 4 and CD 8 in serum samples obtained during acute stages . ^^^ Our findings suggest that the soluble antigen levels of CD 2 , CD 4 and CD 8 , in particular CD 8 , in serum are an important immunologic parameter for determining the activation of T cells during acute IM . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Our results demonstrate that whereas expression of major histocompatibility complex ( MHC ) molecules , CD 45 , Mac 1 , LFA 1 , B cell markers , macrophage markers and some T cell markers ( as CD 2 , CD 4 and CD 8 ) did not undergo changes in culture , the level of expression of the adhesion molecules VLA 4 and ICAM 1 , and the T cell markers CD 5 , CD 25 and Thy 1 increased after 14 h incubation at 37 degrees C . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A soluble chimeric protein , comprising the extracellular portion of rat CD 48 and domains 3 and 4 of rat CD 4 ( sCD 48 CD4 ) , bound to immobilized soluble CD 2 ( sCD 2 ) with a KD of 90 microM . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Several T antigens ( Leu 5b CD 2 , Leu 9 CD 7 , Leu 3a CD 4 ) were not expressed . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 4 , CD 8 and CD 2 in T cell adhesion and signaling . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Phosphorylation of p 67 is , however , not restricted to CD 2 stimulation because it can also be induced by costimulation through CD 4 and CD 8 coreceptors when approximated to the TCR CD 3 complex , suggesting a common signaling mechanism for these accessory receptors of the Ig superfamily . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 2 , CD 4 , CD 28 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The blasts were positive for CD1a , CD 4 , CD 16 , CD 35 , HLADR , HLADQ , CD11b , CD11c , CD 14 , CD 33 , CD 34 , CD11a , CD 71 , CD 19 , CD 25 , IL 2R beta and negative for CD 2 , CD 7 , CD 8 , CD 10 , CD 22 , CD 56 , CD 57 , surface or cytoplasmic CD 3 , TCR delta and TCR beta , HTLV 1p19 and P glycoprotein . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Comparative two dimensional analysis of CD 2 , CD 3 , CD 4 , CD 5 , and CD 8 immunoprecipitates revealed that pp29 / 30 associates with these signaling receptor complexes but not with CD 18 , CD 27 , and CD 29 in human T lymphocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
New insights have been gained in several areas : the avidity regulation of beta 1 and beta 2 integrins and their role in signal transduction ; the regulation of CD 8 avidity ; the role of Lck in CD 4 coreceptor activity ; and the novel role for CD 2 adhesion in the T cell antigen response . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , picked CB CFU GM and BFU E colonies ( cultured in hu SLF , GM CSF , and Epo ) were analyzed by simultaneous genotypic ( for Y and 10 ) and immunophenotypic analysis ( monoclonal antibodies [ MAbs ] CD 13 , CD 14 , CD 2 , CD 8 , CD 4 , and glycophorin A ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cryostat sections from retrobulbar tissues of 15 GO patients and 11 controls were analyzed with a battery of monoclonal antibodies against CD 2 , CD 4 , CD 8 , CD11a , CD19 / 22 , CD 25 , CD 54 , CD 57 , CD 68 , C3b , HLA A , B , C , and HLA DR . ^^^ In contrast to controls , the retrobulbar adipose tissue showed an increase of HLA DR expression , an activation of intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) , as well as a marked infiltration of activated T cells ( especially CD 4 ) and macrophages ( CD 68 ) , whereas a positive staining for interleukin 2 receptors ( CD 25 ) , T cells ( CD 2 ) , B cells ( CD19 / 22 ) , complement factors ( C3b ) , and LFA 1 ( CD11a ) was present only in a few patients ' specimens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We have investigated several aspects of gamma delta T cells in sheep . gamma delta T cells of sheep express a unique transmembrane protein termed T 19 but lack the expression of particular cell surface molecules such as CD 2 , CD 4 and CD 8 which are typically associated with alpha beta T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The two clones ' cytotoxic activity , while inhibited by anti LFA 1 mAb , could not be abolished by mAbs to CD 3 , to class 1 and class 2 MHC molecules , and by mAbs to molecules involved in T cell function ( i . e . , CD 4 , CD 8 , CD 2 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Depletion of CD 2 , CD 3 , CD 4 , and CD 8 T cell subsets and platelet and white blood cells was similar . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
For four cases of malignant lymphoma , T cell type , the pattern was again T cell phenotype with all of CD 2 , CD 5 , CD 7 and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The subsets determined were CD 2 , CD 3 , CD 4 , CD 8 , CD 16 , CD 20 , CD 56 , CD 57 and HLA DR positive . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
P56lck A lymphocyte specific protein tyrosine kinase : activation , regulation and signal transduction . p56lck , a src family protein tyrosine kinase interacts with several T cell receptors , like : CD 4 , CD 8 , CD 2 and the beta chain of the IL 2 , thereby receptors devoid of kinase activity may transduce signals via tyr phosphorylation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The proliferation of CD 8 T cells is inhibited by mAbs reactive with CD 8 or HLA A and B molecules but not with CD 4 or HLA DR . mAb blocking studies show a role for CD 2 , LFA 3 , and CD 59 , but not for intercellular adhesion molecule 1 , intercellular adhesion molecule 2 , very late activation Ag 4 , vascular cell adhesion molecule 1 , CD 28 , or CD 28 ligand , as costimulatory molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Certain antigens which delineate clinical useful lymphocyte subsets such as CD 2 , CD 4 , CD 8 , CD 14 , CD 16 , CD 20 , and MHC class 2 are apparently well conserved since most human cell specific antibodies identified the homologous cell subset in monkeys . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
An immunohistochemical examination of the tumor tissue using a specific monoclonal antibody was positive for CD 2 and CD 4 , and negative for CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Other non B cell lineage markers such as myeloid ( CD 13 , CD 14 , CD 15 , CD 33 , CD 41 , and glycophorin A ) , T cell ( CD 2 and CD 4 ) , and natural killer associated ( CD 56 ) antigens , as well as CD 23 , CD 24 , CD 25 , CD 37 , CD 39 , CDw 40 , CD45R , CD 71 , and certain unclustered antigens ( R 1 3 , PCA 1 , PCA 2 , PC 1 , 62B1 , 8A , 8F6 , and MM 4 ) , have been noted in myelomatous PCs . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the present study we report a serial investigation of the numbers of the peripheral blood cells erythrocytes , polymorphonuclear neutrophils , total lymphocytes , T lymphocyte subpopulations ( CD 2 , CD 4 , CD 8 ) , B lymphocytes and monocytes in a group of 21 patients with haemochromatosis during the time of intensive phlebotomy treatment , i . e . , from iron overload until the onset of iron deficiency . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Approximately 90 % of gamma / delta T cells from peripheral lymphoid organs have the same cell surface phenotype as thymus derived MHC class 1 restricted alpha / beta T cells , i . e . , they are CD 4 but express the CD 8 alpha / beta heterodimer together with CD 2 and CD 5 . ^^^ In contrast , gamma / delta T cells from the epithelium of the small intestine lack CD 2 , CD 4 , and CD 5 and express CD 8 alpha only . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The immunophenotype study showed that the leukaemic cells were positive for CD 2 , CD 38 , CD 56 and anti HLA DR monoclonal antibodies and negative for other T cell ( CD 3 , CD 4 , CD 8 ) and B cell markers ( CD 19 , CD 20 and surface immunoglobulins ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
At high SEB concentrations ( 1 10 mg ) about 50 % of the anergic 5 beta 8+ T cells additionally down regulate their TcR CD 3 complex , followed by a loss of CD 2 , CD 4 , CD 8 accessory molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These delta TCS1+ cells coexpressed CD 2 , CD 3 , CD 8 and CD 56 , but were negative for TCR alpha / beta and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Percentages of the different lymphocytes subsets , including CD 2 ( T cells ) ; CD 4 ; CD 45 RA ( suppressor inducer / virgin T cells ) ; CD 4 CD29 ; CD 8 ; CD 19 ( B cells ) as well as interleukin 2 ( IL 2 ) receptor ( CD 25 ) and class 2 antigen ( HLA DR ) expression , were analyzed by flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The T cell composition of the thymus of 10 ray irradiated ( 3 . 5 Gy ) Wistar rat protected with WR 638 was analyzed by flow cytometry using monoclonal antibodies directed to the Thy 1 . 1 , CD 43 , CD 2 , CD 5 , CD 4 , CD 8 and class 1 and 2 MHC antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Synovial fluid and peripheral blood mononuclear cells were analysed for cell surface expression of CD 2 , CD 3 , CD 4 , CD 8 , CD 19 , CD 25 , CD 29 , CD45R and Ia using flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
This T cell M phi interaction involves CD 2 and CD 4 molecules and requires a signal transduced in the T cells by a protein tyrosine kinase . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Anti CD 2 mAb also prolongs allograft survival , by suppression of mature and precursor CD 4 and CD 8 T cells and NK cells , without an associated cytokine release . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Further characterization revealed that the majority of the CD 4 CD 8 and CD 4 CD8+ CD 53 blasts expressed high levels of CD 2 and no or low levels of T cell receptor ( TcR ) alpha beta . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We constructed a soluble chimeric molecule comprising the extracellular portion of rat CD 48 and domains 3 and 4 of rat CD 4 ( sCD 48 CD4 ) and used it to examine whether CD 2 is a ligand for CD 48 in rats . sCD 48 CD4 coated polystyrene Dynabeads formed rosettes on rat CD 2 transfected COS 7 cells , and this rosetting was blocked by anti CD 2 ( OX 34 ) and anti CD 48 ( OX 45 ) monoclonal antibodies . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
There was no difference in the level of expression of CD 4 , CD 2 , or LFA 1 molecules between these Th cell clones , and anti CD 4 , CD 2 , LFA 1 or ICAM 1 mAb did not differentially affect Ag induced proliferation among the clones . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Concerning T cell marker expression , they were negative for T cell receptor ( TcR ) and OX 40 , but they expressed CD 2 , CD 4 and CD 8 , and interestingly , 50 % of DC were CD5+ , 50 % expressed the alpha chain of interleukin 2 receptor ( IL 2R ) , and 80 % were positive for the T cell activation antigen recognized by the mAb OX 48 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In T lymphocytes , CD 2 forms part of a loosely associated membrane complex which includes the T cell receptor ( TcR ) for antigen , the CD 3 subunits , CD 4 or CD 8 , CD 5 and the protein tyrosine kinases p56lck and p59fyn . ^^^ Using in vitro kinase assays with immune complexes precipitated from cell lysates , we demonstrate that CD 2 can associate with p56lck and p59fyn in a rat thymoma line that does not express CD 4 or CD 8 , and in a TcR negative Jurkat cell line . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These were the antibodies against CD 2 , CD 4 , CD 5 , CD 8 , CD 14 , CD 18 , HLA DR , and the HLA ABC antigen . ^^^ Finally , the CD 2 , CD 4 , CD 5 and CD 8 antibodies reacted with leucocytes from monkey only . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Con A treatment led to a significant increase in the percentage of cells bearing CD 8 , CD 6 , MHC Class 2 and J 5 , but it had no effect on the percentages of cells positive for the other T cell markers CD 5 , CD 4 , or CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the present work , iron ( FeC6H5O7 ) and zinc ( ZnCl 2 ) were tested in comparison to nickel ( NiCl 2 ) and cobalt ( CoCl 2 ) for their effect on six different surface molecules known to be involved in recognition and activation processes , namely CD 4 , CD 2 , CD 3 , CD 8 , HLA ABC , and HLA DR . ^^^ Iron was seen to down modulate expression of the CD 4 and the CD 2 molecules on the surface of T lymphocytes , as indicated by a decrease in the mean fluorescence intensity measured by FACS analysis . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The p180+ T cells have a distribution in lymphoid tissues that is distinct from that of T cells that express the CD 2 , CD 4 or CD 8 molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
No alterations in other cell phenotypes tested ( CD 4 , CD 8 , CD 2 , CD 6 , B cells , monocytes or MHC class 2 ) were observed , nor were there changes in lymphokine activated killer ( LAK ) , natural killer ( NK ) cell activity , or oxygen radical formation ( assessed by reduction of nitroblue tetrazolium ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Crosslinking CD 28 causes a shift in the relative mobility of p56lck from 56 to 60 kD similar to that seen after crosslinking of CD 2 and CD 4 , cell surface receptors known to be associate with and activate p56lck . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
None of the other cytokines tested ( IL 1 alpha , IL 6 , TNF alpha , IFN alpha , IFN gamma ) supported growth of NK 92 cells which have the following characteristics : surface marker positive for CD 2 , CD 7 , CD11a , CD 28 , CD 45 , CD 54 , CD56bright ; surface marker negative for CD 1 , CD 3 , CD 4 , CD 5 , CD 8 , CD 10 , CD 14 , CD 16 , CD 19 , CD 20 , CD 23 , CD 34 , HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Most of the neoplastic cells from five cattle with EBL appeared to be divided into four types , CD 2 , CD 4 , CD 8 , WC 1 , B2+ or B 2 , IgM+ or IgM , MHC II+ and strong TAA+ . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens , modulated lymphocyte surface molecules CD 2 , CD 3 , CD 4 , CD 5 and CD 8 and inhibited the production of interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) and IL 6 by stimulated adherent cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The unresponsiveness of lpr CD 4 8 T cells correlates closely with their absence of CD 2 expression . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
With peripheral blood derived T cells as a model , flow cytometric analysis revealed strongly reduced expression of distinct CD molecules for each enzyme , notably CD 2 , CD 4 , CD 8 and CD 44 for DNase , and CD 4 , CD 14 , CD 16 , and CD 56 for collagenase . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Examination of a muscle member of the immunoglobulin superfamily , telokin , shows that its structure is closely related to those of the variable domains found in antibodies , CD 2 , CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Tumor cell markers were examined and showed the following phenotypes : all patients were CD 2 , CD 3 , and CD 7 positive but CD 19 and CD 20 negative ; three patients were CD 4 positive and CD 8 negative ; the other two patients were CD 4 negative and CD 8 positive . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Resting T lymphocytes that have recognized antigen bound to a major histocompatibility complex molecule with the T cell receptor require costimulatory signals through accessory receptors , including CD 2 , CD 4 , CD 8 , and CD 28 , for their clonal growth and expression of their functional repertoires . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The number of total , CD 2 , CD 4 T lymphocytes , B and NK cells correlated positively with LH and negatively with FSH serum levels ( P < 0 . 05 and P < 0 . 002 , respectively ) . ^^^ PRL positively influenced CD 2 , CD 4 and B lymphocyte numbers ( P < 0 . 001 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , PBMCs from these patients were phenotyped after in vitro MoAb stimulation with antibodies against CD 2 , CD 3 , CD 4 , CD 8 , CD 16 , CD 20 , CD 25 ( interleukin 2 receptor [ IL 2R ] ) , CD45RA , and UCHL 1 , and the production of interleukin 2 ( IL 2 ) was evaluated by the CTLL 2 bioassay . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The cellular measures were the absolute numbers of CD 2 , CD 3 , CD 22 , CD 25 , CD 4 , CD 8 and CD4 / CD8 T cell ratio and serologic measures were the levels of cellular products ie interleukin 2 ( IL 2 ) and soluble interleukin 2 receptors ( SIL 2 R ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Patients with Sheehan ' s syndrome had higher T lymphocytes ( CD 2 ) , including helper ( CD 4 ) and suppressor ( CD 8 ) cell subpopulations and B lymphocytes ( CD 19 ) when compared with normal menstruating women . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These results indicate that ( a ) the mAb KH 8 , NA 6 , PD 4 and TH 8 identify the avian homologue of the mammalian CD 4 molecule , ( b ) the mAb OC 2 detects the avian CD 2 antigen , and ( c ) the mAb OC 5 recognizes the putative avian CD 5 homologue . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
At the permissive temperature , MegT cells exhibit the characteristics of early 2N and 4N megakaryocytes which include the presence of specific gene products such as PF 4 , glycoprotein IIb , acetylcholinesterase , and CD 45 as well as the absence of molecular markers of other cell lineages such as the macrophage marker Mac 1 , the T helper cell marker CD 4 , the mast cell marker IgE , the T cell marker CD 2 or the erythroid cell marker alpha globin . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
AG F cell line demonstrated an unusual phenotype , lacking surface CD 2 and CD 3 , but expressing high levels of CD 4 , CD 5 , CD 7 , CD 29 , and CD45RO . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The cell lines were shown to be CD 2 , CD 4 , CD 8 , and slg , a phenotype consistent with a null cell population described in swine . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Total lymphocytes , pan T ( CD 2 ) , helper T ( CD 4 ) , suppressor T ( CD 8 ) , pan B ( CD 20 ) , and DR expressing lymphocytes were quantitated by monoclonal antibodies and flow cytometric analysis . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Macaques infected with SIVmne had an initial sharp decrease in CD 2 , CD 20 , CD 4 , CD 8 , and CD4CD29 lymphocyte subsets , whereas the CD 4 : CD 8 ratio increased . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We focused on immunophenotypic differences between the two types of lesions with respect to the T cell markers CD 2 , CD 3 , CD 4 , CD 5 and CD 8 . ^^^ Three of the patients studied ( 20 % ) showed a difference in immunophenotype between plaques and tumours , with an additional loss of one of the T cell markers in the tumours ( respectively , CD 5 , CD 2 and CD 4 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Frozen sections were stained by an immunoperoxidase technique using antibodies to the T cell associated antigens CD 2 , CD 7 , CD 4 , CD 8 , and T cell receptors alpha beta and gamma delta . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the submucosa , pan T cell marker CD 2 was detected more often than CD 19 ( B cell ) , and more CD 8 ( T suppressor / cytotoxic ) cells than CD 4 ( T helper / inducer ) cells were found . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Conversely , focal mononuclear infiltration of the myocardium was associated with significantly elevated CD4 / CD8 ratios ( 2 . 1 + / 0 . 6 vs . 1 . 3 + / 0 . 2 , P < 0 . 05 ) , higher total numbers and percentages of endomyocardial lymphocytes expressing the pan T markers CD 2 and CD 3 , more CD45RO / UCHL1 positive cells and more CD 4 positive T helper cells , compared with non reactive cases the lymphocytes of which were scattered throughout the myocardium . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface marker analysis showed that the abnormal lymphoid cells in the peripheral blood were positive for CD 2 and CD 4 but negative for CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cell surface expression of T lymphocyte antigens , CD 2 , CD 4 , and CD 8 , and cell surface IgM on B lymphocytes was also evaluated . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Suramin also decreased the expression of T cell surface molecules such as CD 2 , CD 25 and CD 4 in preactivated PBMC and had pronounced effects on cytokine production . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Subpopulations of synovial and inflammatory cells were identified with MoAbs against cell surface glycoproteins present on B lymphocytes ( CD 45 ) , T lymphocytes ( CD 2 , CD 4 , CD 8 ) , macrophages ( CD 14 ) and endothelial cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Twenty runs were performed in which the following T and B lymphocyte and natural killer surface markers were analyzed : CD 2 , CD 3 , 13 , CD 4 , CD 29 , CD45RA , CD 8 , CD 56 , and CD 19 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Using monoclonal antibodies in immunohistochemistry , the distribution of the cells with the following surface antigens was studied in samples of proximal and distal small intestine of five 6 month old pigs : CD 2 , CD 4 ( helper / inducer T cells ) , CD 8 ( suppressor / cytotoxic T cells ) , accessory cell marker ( monocyte / granulocyte ) , MHC Class 2 ( DRw ) , and interleukin 2 ( IL 2 ) receptor . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The first case expressed natural killer ( NK ) cell , some T cell ( CD 2 , CD 5 , CD 8 ) , and HLA DR antigens , but was negative for other T cell ( CD 3 , CD 4 , CD 7 ) , T cell receptor ( TCR ) , B cell , and myeloid antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Transbronchial biopsy specimens , which revealed findings consistent with non Hodgkin ' s lymphoma , were positive for surface markers of CD 2 , CD 4 , and CD 8 and negative for those of CD 19 and CD 20 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The lymphoid component showed a mature T cell immunophenotype ( positive for CD 2 , CD 3 , CD 5 , CD 7 , CD 4 , CD 8 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The gate for lymphocytes was located by cell size ( forward scatter ) , cytoplasmic complexity ( side scatter ) and by expression of the markers CD 2 , CD 4 , CD 8 and CD 19 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The relative and absolute numbers of total lymphocytes , CD 2 , CD 4 , and CD 19 cells ; absolute numbers of CD 3 and CD 8 cells ; and CD4 / CD8 ratios were high at birth , decreased during early childhood , and closely approximated adult reference values after age 3 years . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The neoplastic cells expressed the T cell receptor ( TCR ) delta chain detected by TCR delta 1 and delta TCS 1 , CD 3 , CD 30 , CD45RO , and epithelial membrane antigen , but not the TCR beta chain detected by beta F 1 , CD1a , CD 2 , CD 4 , CD 5 , CD 7 , CD 8 , CD 25 , HLA DR , and terminal deoxynucleotidyl transferase . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Most of the clones proven to be gamma / delta 1+ clones had the CD2+ CD3+ CD 4 ( ) + CD 8 ( ) + TCR delta 1+ beta F 1 alpha F 1 and delta TCS 1 phenotype , but few clones displayed CD 2 or delta TCS 1+ phenotype . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Several groups have reported a physical interaction between distinct isoforms of CD 45 and CD 2 , CD 4 , and the TCR CD 3 complex . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The surface phenotype showed that both the original leukemic cells and the WHN 2 cells had a common phenotype of ATL , i . e . , positive for CD 2 , CD 4 , human leukocyte antigen DR ( HLA DR ) and CD 25 , but negative for CD 8 , a characteristic of helper / inducer T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lymphocyte subsets CD 2 and CD 4 in bulimic patients were lower than in controls , whereas CD 8 remained unmodified , leading to a lower CD 4 : CD 8 in bulimic patients . ^^^ The decreases in CD 2 and CD 4 numbers might be linked to an impaired cell mediated immune function , as evaluated by the response to skin tests . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Protein tyrosine kinases have been implicated in signal transduction in T lymphocytes after stimulation of many cell surface molecules , including the T cell antigen receptor , CD 4 , CD 8 , CD 2 , CD 5 , and CD 28 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We have studied the expression of several leukocyte surface markers ( CD 2 , CD 3 , CD 4 , CD 8 , CD 7 , CD 26 , CD 25 , CD 14 , CD 18 , kCD 20 , CD 43 , CD 45 , CD45R , CD 71 and HLA class 1 and 2 ) and we find no differences in their expression between PPL . 1 and its parental Jurkat cell line . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD2+ , CD3+ , and CD8+ lymphocyte subsets were selectively reduced by the leucyl leucine methyl ester treatment ( CD 2 : 84 . 2 67 . 5 % ; CD 3 : 76 . 1 62 . 3 % ; and CD 8 : 8 . 0 3 . 4 % ) , but there was no significant reduction in the CD4+ and CD19+ subsets ( CD 4 : 68 . 2 64 . 7 % ; and CD 19 : 22 . 6 33 . 2 % ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The percentage and absolute numbers of circulating CD 2 and CD 4 cells decreased during relapse , while CD 8 and CD 20 cell counts were not significantly altered . ^^^ The numbers of circulating CD 2 and CD 4 cells fall during relapse and increase as inflammatory activity subsides during corticosteroid therapy . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Sixteen of the resulting T lymphocyte cell lines ( from the S 19 and S19+IL 2 groups ) were tested through indirect immunofluorescence for expression of cell surface markers CD 2 , CD 4 , CD 6 , CD 8 , major histocompatibility complex ( MHC ) Class 2 molecules and a marker expressed on a subset of helper T lymphocytes ( Th ) as well as sIgM , CD 1 and a MHC Class II+ monocyte / macrophage marker . ^^^ However , two cell lines contained significant populations ( > 80 % ) of CD 2 , CD 4 , CD 6 , CD 8 cells that were both responsive to exogenous rBoIL 2 and were capable of exhibiting antigen induced LP responses . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
According to the results obtained , the second level of investigation assessed the positivity for intra cytoplasmic ( Cy ) Ig , CD1a , CD 2 , CD 3 , CD 4 , CD 5 , CD 8 and CD 20 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cell surface marker studies for CD 2 ( total T cells ) , CD 4 ( helper T cells ) , CD 8 ( suppressor T cells ) , CD 25 ( activated T cells ) , CD 20 ( total B cells ) , CD 14 ( monocytes ) , and HLA DR positive cell populations were measured . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
One additional case , with a peculiar phenotype ( CD 3 , CD 2 , CD 4 , CD8+ , CD 57 ) and a germline configuration of the TcR beta and gamma chain genes , expressed only the CD 8 alpha chain . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The inability of LOA to present superantigen is not due to a structural difference in MHC 2 molecules between LOA and the splenic APC or to differential expression of major accessory / adhesion molecules , including CD 2 , CD 5 , CD 4 and CD 44 , on LOA . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Duodenal cryosections of 4 week old HTSP piglets ( n = 10 ) and ETSP piglets ( n = 8 ) were analysed for IgA , IgM , IgG 1 and IgG 2 positive cells , CD 2 , CD 4 , CD 8 , WC 1 T cell positive antigens using immunohistochemical peroxidase reactions . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In this study the expression of ' classically ' considered lymphoid associated antigens ( CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 10 , CD 19 , CD 20 , and CD 22 ) was explored both in peripheral blood ( PB ) and bone marrow ( BM ) mast cells ( MC ) in a case of systemic mast cell disease ( SMCD ) by means of using multiple stainings and a direct immunofluorescence technique . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The effects of dexamethasone on this and other subsets ( CD 3 , CD 2 , CD 4 , CD 8 ) of peripheral blood T lymphocytes were determined by flow cytometric analysis . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
There was a statistically significant decrease for each of the T cell phenotypes studied ( CD 2 , CD 3 , CD 4 , CD 8 , CD 16 , CD 19 , CD 20 , CD 56 , CD 57 ) between patients and controls ( P < 0 . 0001 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometry showed that they were T cell lines expressing CD 2 , CD 3 , CD 4 , CD 8 and CD 25 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monovalent chimeric proteins containing the two IgSF domains of rat CD 48 or CD 2 and domains 3 and 4 of rat CD 4 ( CD4d3+4 ) were anchored to fluorescent covaspheres via a CD 4 monoclonal antibody ( mAb ) with the CD 48 or CD 2 domains available for ligand binding . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In contrast , the WC1+ , CD 2 , CD 4 , CD 8 , gamma delta T cell receptor ( TCR ) + T cells in bovine peripheral blood mononuclear cells ( PBMC ) were all CD45RO+ . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Most of the infiltrated lymphocytes were positive for CD 2 , CD 3 , CD 4 and CD 5 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
During treatment with OKT 3 , T cells bearing the usual array of surface molecules ( CD 2 , CD 4 , CD 8 ) reappear in the peripheral blood circulation but these cells are devoid of the OKT 3 target molecule , CD 3 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NKL cells express CD 2 , CD 6 , CD11a , CD 26 , CD 27 , CD 29 , CD 38 , CD 43 , CD 58 , CD 81 , CD 94 , CD 95 , class 2 MHC , and the C1 . 7 . 1 antigen , but do not express detectable levels of CD 3 , CD 4 , CD 5 , CD 8 , CD 14 , CD 19 , CD 20 , CD 28 , alpha / beta or gamma / delta T cell receptors on the cell surface . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Modulation of CD 2 and CD 3 expression was similar on mixed splenic T lymphocytes and isolated CD 4 and CD 8 subsets . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Most TDC were LFA 1 ( CD11a ) + , CD18+ , ICAM 1 ( CD 54 ) + and CD 53 ( OX 44 ) + , but only certain subsets expressed CD11b and thymocyte markers Thy 1 , CD 2 , CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The composition of inflammatory infiltrates present in perilesional skin was analyzed by antibodies to T cells ( CD 2 , CD 3 , CD 4 , and CD 8 ) , Langerhans cells ( CD1a ) , and macrophages ( CD 36 and CD 68 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We took advantage of the monoclonal antibody ( mAb ) 191B8 that was obtained by immunizing mice with cultured human thymocytes characterized by an immature surface phenotype [ CD 2 CD 3 CD 4 CD 8 stem cell factor receptor ( SCFR ) + ] and expressing cytoplasmic CD 3 epsilon chain . ^^^ Following culture of the CD34+ or CD 34 fractions of CD 2 CD 3 CD 4 CD 8 purified immature thymocytes with recombinant interleukin 2 ( rIL 2 ) , the 191B8 defined antigen was expressed on virtually all cells even when 191B8+ cells were removed from the starting population . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A putative FAK related phosphoprotein ( fakB ) was identified that is responsive to intracellular signals induced through ligation of antigen receptors on both T and B lymphocytes , and whose induced tyrosine phosphorylation is augmented by TCR costimulation through the adhesion / costimulatory receptors CD 2 and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The lymphocyte subsets affected were CD 2 , CD 3 , and CD 4 . ^^^ When the cardiac patients were compared to the normal newborns , again differences in lymphocyte subsets CD 2 , CD 3 , and CD 4 were seen . ^^^ When comparing nonsurvivors with survivors , the mean percentages of the CD 2 , CD 3 , and CD 4 T lymphocyte markers , as well as the mean lymphocyte , B cell ( CD 20 ) , and natural killer cell ( CD 16 ) percentages were all lower in the nonsurvivors . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunohistochemical , ultrastructural , morphological and morphometric techniques as well as monoclonal antibodies to F 8 R : Ag endotheliocytes , CD 2 and CD 3 T lymphocytes , CD 1 and CD 10 T lymphoblasts , CD 4 T helpers , CD 8 and CD 30 T killers and activated lymphocytes were used to study blood microcirculation relationship to cellular immunity in lymph nodes regional to malignant tumor . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The lymphocytes showed variable positivity for T cell markers ( CD 2 , CD 4 , CD 8 and CD 56 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the two patients that were tested , the GPI anchored surface molecules CD 55 and CD 59 were also absent on the CD 52 cells , although expression of other cell surface transmembrane , proteins ( CD 3 , CD 4 and CD 2 ) was unaffected . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Infiltrating mononuclear cells expressed CD11a ( 68 % ) , CD 18 ( 73 % ) , CD11b ( 13 % ) , CD11c ( 21 % ) , CD 58 ( 13 % ) , CD 4 ( 44 % ) , CD 8 ( 17 % ) , CD62L ( L selectin ) ( 18 % ) , CD49d ( 38 % ) , CD49e ( 15 % ) , CD 2 ( 56 % ) , and CD 44 ( 77 % ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Activated T lymphocytes , expressing surface IL 2 receptor , HLA DR , DR alpha 1 , DP , DQ , and CD 2 > CD 8 > CD 4 antigens , were seen throughout the dermis and occasionally infiltrating the suprabasal layer of the epidermis in all biopsies . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The surface phenotype of lymphocytes was positive for CD 2 , CD 4 , CD 25 , CD 29 suggesting helper inducer T cell . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A total of 387 HD cases were tested for differences among LMP 1 positive and negative cases with respect to age , sex , histotype and immunophenotypic parameters ( CD 2 , CD 3 , CD 4 , CD 15 , CD 19 , CD 20 , CD 21 , CD 22 , CD 23 , CD 25 , CD 30 , CD 43 , CD45RA , CD45R0 , CD 70 , HLA DR , T cell receptor beta chain , and p 53 expression ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Although they usually express a restricted number of T cell related antigens , namely , CD 2 , CD 43 , and CD45RO , other pan T or subset T lineage antigens , such as CD 3 ( membrane ) , CD 5 , CD 4 , CD 8 , and CD 7 , are frequently absent . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
They had lower numbers of CD 4 , CD 8 , CD 2 , CD 3 , and B cells in the peripheral blood but no differences in spleen lymphocytes . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Of 26 cases of CD117+ AML , CD 4 was expressed in 15 ( 58 % ) cases , CD 7 in 7 ( 27 % ) cases , and CD 2 in 2 ( 8 % ) cases . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The majority of PCL T cells exhibited markers of the thymus dependent lineage ( CD 2 , CD 3 , TcR alpha beta , CD 8 alpha beta or CD 4 ) and surface antigens associated with memory and activation ( CD45RO , CD11a , CD 18 , CD49d , HLA DR ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A large population of YAP cells reacted with the CD 4 , CD11b , CD 25 and CD 33 surface markers , but not with CD 2 , CD 3 , CD 8 or CD 19 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface marker analysis of the lymphocyte populations showed increases in CD 2 , CD 3 , CD 4 , and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Bronchoalveolar lavage fluid ( BALF ) and peripheral blood were obtained from each of 17 adult Arabian mares and absolute numbers and relative lymphocyte proportions were determined for total T lymphocytes , using CD 2 as a marker , CD 4 + T lymphocytes , CD 8 + T lymphocytes , CD 5 + lymphocytes , and sIgM + B lymphocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies ( mAbs ) to surface markers of bovine lymphocytes MHC 1 , MHC 2 , B cells , T cells ( CD 2 , CD 4 , CD 8 and gamma / delta ) and interleukin 2 ( IL 2 ) receptor were tested in the goat by flow cytometry and using immunohistochemical methods . ^^^ The percentage of positive cells obtained by flow cytometry and its compartmentalisation in different tissue sections showed that the mAbs against MHC 1 , MHC 2 , CD 2 , CD 4 , CD 8 , gamma / delta and IL 2 receptor recognised lymphocyte subpopulations similar to those present in the bovine . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
For each sample phycoerythrin ( PE ) conjugated CD 2 , CD 4 , CD 5 , CD 8 , and CD 56 monoclonal antibodies were combined with Cy 5 R phycoerythrin ( TC ) conjugated CD 3 and fluorescein isothiocyanate ( FITC ) conjugated CD 7 ; CD 2 and CD 7 PE were also combined with CD 3 TC and CD 4 FITC . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
When HIV seropositive hemophiliacs ' enriched CD34+ SC were cocultured with allogeneic CTEFs , acquisition of the T cell phenotypic markers CD 7 , CD 2 , CD 3 , CD 4 , CD 8 and T cell receptor for antigen ( TCR ) alpha beta was observed from cells harvested from the culture media peaking at approximately 28 days . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Specimens were analysed histologically and by indirect immunoperoxidase method using anti monoclonal antibodies to CD 2 , CD 4 , CD 8 , CD 25 , CD45RO , RFDR 1 , RFD 1 and RFD 7 by two ' blind ' observers . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface marker analysis revealed LGLs were positive for CD 2 CD16 , and CD 56 and negative for CD 3 , CD 4 , CD 8 , and CD 20 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lymphocyte subsets were characterized according to the following cluster of differentiation ( CD ) numbers : CD 2 , CD 4 , CD 8 and CD 19 and quantified according to both their absolute number and as a percentage of total lymphocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The mean percentage and absolute numbers for the cell surface markers identified with the human mAbs CD 2 ( FITC , Ortho , Paritan , NJ ) , CD 4 ( PE , B D , Mountain View , CA ) , and CD 8 ( PE , B D ) when these were combined with a series of PE or FITC labelled human mAbs were similar across all combinations tested . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
On PHA activated , Fas sensitive T cell blasts , anti Fas mAb rapidly triggered downmodulation of a variety of antigens , including CD 2 , CD 4 , CD 8 , CD 7 , CD 44 , LFA1alpha , LFA1beta , and CD62L , but not CD 3 , CD 25 , or CD 26 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Treatment of whole blood from 7 normal donors showed no significant difference in percentage of cells positive for CD 2 , CD 3 , CD 4 , CD 8 , CD 16 , or CD 19 between fixed and unfixed samples when cells were stained before fixation , and no difference in CD 3 , CD 4 , CD 8 , CD 16 , or CD 19 percentages when cells were stained following fixation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In vitro exposure of human peripheral blood mononuclear cells ( PBMNC ) with unconjugated bilirubin at pathological levels ( 6 to 12 mg / dl ) did not alter the subsets of CD 3 , CD 4 , CD 8 , CD 14 , CD 19 and CD 56 positive populations , or expression of costimulatory surface molecules CD 2 , CD 3 , CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Dendritic cells induced proliferative responses in allogeneic CD4+ and CD8+ cells sorted from blood but did not induce responses in purified allogeneic WC1+ , gamma / delta T cells , which are CD 2 , CD 4 , CD 8 and are the major gamma delta T cell population in cattle blood , even when interleukin 2 ( IL 2 ) was added to cultures . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A number of T cell surface transmembrane molecules such as CD 2 , CD 4 , CD 8 , lymphocyte functional antigen ( LFA ) 1 and CD 45 are known to interact functionally with the T cell receptor ( TCR ) complex during T cell activation . ^^^ Two types of large complexes containing protein tyrosine kinases were observed : the first one contained CD 3 and the transmembrane proteins CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , CD 8 , CD11a , CD 38 , CD 43 , CD 45 , CD 71 , CD 98 and CD 99 and the other contained mainly the GPI anchored proteins CD 48 , CD 55 , CD 59 and CDw 108 as well as a fraction of CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The mononuclear cells stained positively for Pan T , CD 2 , CD 3 , CD 4 , CD 5 , CD 25 , and DNA from the cells showed HTLV 1 provirus monoclonal integration . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Frozen sections were stained with monoclonal antibodies directed against IL 7R , CD 25 , CD 30 and T antigens ( CD 3 , CD 2 , CD 5 , CD 7 , CD 4 , CD 8 ) , using the alkaline phosphatase antialkaline phosphatase technique . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Percentages of the different lymphocytes subsets , including CD 2 ( T cells ) , CD 4 , CD 45 RA ( suppressor inducer / virgin T cells ) , CD 4 , CD 29 , CD 8 , CD 19 ( B cells ) , as well as interleukin 2 ( IL 2 ) receptor ( CD 25 ) and class 2 antigen ( human leukocyte antigen HLA DR ) expression , were analyzed by flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In H 2b CD 4 knock out mice expressing human CD 2 under the control of the mouse CD 4 promoter , mature DO TCR+ cells did not express human CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We have used this method to generate functional sFv to human CD 2 , CD 3 , CD 4 , CD 8 , CD 28 , CD 40 , CD 45 and to murine CD 3 and gp 39 , from hybridomas producing murine , rat , or hamster antibodies . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Assessment of CD 2 , CD 4 , CD 8 and gamma delta cell distribution among mononuclear cells obtained from the blood and lymphoid tissues of fetal calves , 0 150 day old calves and adult cows was the focus of this investigation . ^^^ In blood , CD 2 ( + ) were significantly higher at 1 , 30 and 90 days of age , CD 4 ( + ) and CD 8 cells demonstrated a peak in the fetuses that dropped below adult levels from 1 to 120 days of age , and gamma delta ( + ) cells were highest at birth and decreased to adult levels by 150 days of age . ^^^ An interesting pattern was seen in a longitudinal study of T cell subsets that showed 7 8 day cyclical changes in CD 2 and CD 4 marked cells in adult peripheral blood . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The peripheral blood lymphocytes were analyzed using a double colored flow cytometry and adequate monoclonal antibodies to CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD11b , CD 16 , CD 19 , and HLA DR receptors . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
It was found that LP patients had T cell immunodeficiency indicated by a reduction in the number of CD 2 DR+ , CD 2 , CD 3 , CD 4 lymphocytes and suppression of nonspecific defense as shown by decreased C 3 component of complement , number of NK cells , lymphocyte enzyme activity . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
METHODS : Urethral lymphocytes were extracted from first void urine ( FVU ) of patients with non gonococcal urethritis and gonorrhoea using magnetic beads coated with antibody against either the pan T cell marker CD 2 or to CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Chimeric proteins in which the CD 2 transmembrane and / or cytoplasmic domains were deleted or exchanged with analogous regions of CD 4 , CD 28 or CD 58 retained association with high levels of murine CD 45 phosphatase activity , suggesting that the CD 2 extracellular domain largely controls interaction with CD 45 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Peripheral blood lymphocyte subpopulations were analysed by double coloured flow cytometry using monoclonal antibodies for the receptors CD 2 , CD 3 , CD 4 , CD 8 , CD 19 , CD 29 , CD45RA+ , 34 , 29dK , CD 56 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 2 , CD 5 , CD 10 , and CD 19 were expressed in a similar fashion among the different FAB groups , whereas CD 4 expression was significantly more frequent in AML M 0 , AML M 4 , and AML M 5 ( P = . 014 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Assays for the specific surface antigens CD 45 , CD 2 , CD 4 , CD 8 , CD 1 , MHC class 2 , and N 1 were employed to develop immunophenotypic profiles within the gated lymphocyte clusters from each TIL and PBL suspension . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
However , the percentage of PBMC expressing delta IK 17 tended to increase as the stage of the disease advanced . delta IK 17 seems to be the only antigen among the other cellular markers tested ( CD 2 , CD 4 , CD 8 , HLA DR ) with a statistically significant correlation between a low percentage of positive cells and the early stages of malignancy and between a high expression and advanced disease . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
General conformity was found concerning age dependent changes in the major subsets ( CD 4 , CD 8 , CD 2 , CD 20 ) and the adhesion molecules CD11a and CD 29 on peripheral blood lymphocytes in children and young marmosets ( Callithrix jacchus ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lymphocytes were analyzed for expression of CD 2 , CD 3 , CD 4 , CD 8 , CD 25 , gamma delta TCR , and CD 20 by two or three color flow cytometric analysis . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
While displaying normal development of CD 2 , CD 3 , CD 4 , and CD 8 expression , CD 25 deficient cortical thymocytes do not express CD 1 , and furthermore they fail to normally down regulate levels of the anti apoptotic protein bcl 2 . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Heterogenous results were observed concerning different antigens : CD 2 , CD 4 , CD 8 , CD 16 , CD 94 , CD 122 , TiA 1 , perforin , and granzyme B . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometry analysis of the phenotypic distribution of MNC revealed age related differences in the expression of CD 3 , CD 4 , CD 8 , CD 14 , CD 19 , CD45RA , CD45R0 , CD 2 , LFA 1 , ICAM 1 and LFA 3 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
There was no change in other lymphocyte adhesion molecules expression ( ICAM 1 , LFA 3 or CD 2 ) at day 4 , although LFA 3 and CD 2 expression was moderately decreased at day 28 and day 90 respectively ; nor was there any change in the distribution of lymphocyte subsets ( CD 4 , CD 8 , and CD45RA , CD45RO ) , although a small decrease in CD45RO circulatory T cells was noted at day 28 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
RESULTS : Treatment of human PBL with BF d 12 decreases the percentage of CD 4 and TCR positive cells , as compared to non stimulated cells , but has no significant effect on CD 2 , CD 3 , and CD 8 positive cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Whole blood samples were labelled with the nuclear dye LDS 751 and with antibodies to HLA DR or belonging to CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , CD 10 , CD 13 , CD 14 , CD 19 , CD 20 , CD 29 , CD 33 , CD 45 , CD45RA , CD 56 , and CD62L ( TQ 1 ) that were directly conjugated to either phycoerythrin ( PE ) and / or fluorescein isothiocyanate ( FITC ) . ^^^ The binding of eight antibodies , CD 19 FITC , CD 2 PE , CD 3 PE , CD 4 PE , CD 19 PE , CD 29 PE , CD45RA PE , and CD 56 PE , to the surface of lymphocytes was reduced , resulting in significant changes ( P < 0 . 05 ) in the percentages of cells that stained positively and / or their mean molecules of equivalent fluorochrome ( MEF ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The levels of expression of the CD 2 , CD 3 , CD 4 and CD 28 antigens were similar ; however , CD 45 and CD45RA antigen expression were slightly lower in cord cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Induction of HIV 1 resistance was specific for CD 28 costimulation , in that a variety of other accessory receptors , such as CD 2 , CD 4 , CD 5 , and MHC class 1 , failed to confer the antiviral resistance . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 19 , CD 20 , CD 5 , CD 2 , CD 4 , CD 8 surface markers and amplification of the Ig heavy chain CDR 3 locus were used for immunophenotypic and genotypic analysis , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cytometric analysis showed Oxo M treatment did not up regulate expression of cell surface molecules such as CD 3 , CD 2 , CD 4 , CD 8 , and IL 2 receptors . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The transformed T cells expressed CD 2 , CD 3 , and either CD 4 or CD 8 surface molecules and more generally displayed the phenotype of naive T cells with a complete and clonal rearrangement of the T cell receptor . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The mRNA expression of CD 2 , CD 4 and CD 8 in peripheral blood lymphocytes from the patients with acute lymphoblastic leukemia and non Hodgkin ' s lymphoma ] . ^^^ The paper for the first time reports the detection of the levels of CD 2 , CD 4 and CD 8 mRNA expression in peripheral blood lymphocytes from 9 cases with T acute lymphoblastic leukemia ( ALL ) and 10 cases with T non Hodgkin ' s lymphoma ( NHL ) by using RNA dot blotting technique . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We measured blood cellularity ( white blood cells and total lymphocytes ) , the total number and percentage of lymphocyte subsets ( CD 2 , CD 3 , CD 4 , CD 8 , and CD 19 ) , natural killer ( NK ) cell activity , cytokines ( interleukin 1 beta , interleukin 2 , interleukin 6 , granulocyte macrophage colony stimulating factor , tumor necrosis factor alpha , and interferon gamma ) , and soluble interleukin 2 receptors . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The main immunophenotypes were as follow : CD7+ , CD34+ , HLA DR+ , CD38+ , CD13+ , CD33+ , CDw65+ , CD 2 , CD 3 , CD 4 , CD 8 , CD19+ , CD 20 , CD11b . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Serum was used for PRRS virus isolation and antibody detection and stabilized blood for total leucocyte counts , differential counts and characterization of lymphocyte subpopulations by flow cytometry analysis using monoclonal antibodies specific for porcine CD 2 , CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The patient reacted to colour film developers ( CD 1 , CD 2 , CD 3 , and CD 4 ) , but not to other p phenylenediamine derivatives tested . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunophenotyping showed that most peripheral blood mononuclear cells were negative with B lymphoid , myeloid , and stem cell associated markers and were also negative with most T lymphoid markers ( CD 2 , CD 4 , membrane / cytoplasmic CD 3 , CD 5 and CD 8 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The values of CD 2 , CD 4 , CD 8 , B and NK cells in these different lymphoid compartments did not differ between the control group and the experimental group . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
ConA activated cells were cultured with BHV 1 and stained with monoclonal antibodies specific for virus envelope glycoproteins ( gB , gC and gD ) and lymphocyte surface proteins ( CD 2 , CD 4 and CD 8 ) and a molecule associated with gamma / delta cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The lymphoma cells were positive for CD 2 , CD 3 , CD 4 , and CD 56 , and negative for CD 8 , CD 16 , CD 20 , and CD 57 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MCAB ) against antigens CD 1 , CD 2 , CD 3 , CD 4 , CD 8 , CD 10 , CD 19 , CD 20 , CD 30 , CD 45 , CD 56 , BLA 36 were used for differentiating lymphoid cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Frozen sections were immunostained using primary antibodies to CD 2 , CD 20 , CD 4 , CD 8 , intercellular adhesion molecule ( ICAM 1 ) , vascular cell adhesion molecule ( VCAM ) 1 , HLA DR , lymphocyte function associated antigen ( LFA ) 1 , and TGF beta . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the present study the response of purified CD4+ and CD8+ T lymphocytes to stimulation with anti TCR monoclonal antibody ( the first signal ) in combination with anti CD 4 or anti CD 8 , anti CD 2 and anti CD 28 MoAbs ( the costimulatory signals ) was investigated . ^^^ Both CD4+ and CD8+ T cells from the patients showed significantly reduced IL 2 release following stimulation via TCR and costimulation via CD 4 or CD 8 and CD 2 , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The antibody panel included the nonlymphoid markers CD 13 , CD 33 , CD 14 , and CD 4 in combination with CD 2 , as well as a broad panel of lymphoid and nonlineage specific markers . ^^^ When leukemic cells were positive for CD 4 ( CD 2 ) and either CD 13 or CD 33 , specificity and positive predictive value ( PPV ) for ANLL rose to 96 % and 98 % , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Constant detection of CD 2 , CD 3 , CD 4 , and CD 5 in fixed and paraffin embedded tissue using the peroxidase mediated deposition of biotin tyramide . ^^^ Using this optimized ImmunoMax method , we were able to detect CD 2 , CD 3 , CD 4 , and CD 5 with conventional monoclonal antibodies in formalin fixed , paraffin embedded tissue specimens of various lymphoid tissues . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The lymphoid cells were positive for mature B cell antigens and the phenotype was : CD 5 , CD 10 , CD19+ , 20+ , CD22+ , IgG+ , IgA , IgM , kappa , lambda+ , CD 1 , CD 2 , CD 3 , CD 4 , CD 7 , CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Using locus specific probes for CD 2 , CD 4 , CD8alpha , CD 19 , CD 45 , and lambda 5 genes , we show that transcriptionally inactive but not transcriptionally active genes associate with Ikaros heterochromatin foci . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunophenotypic analysis of abnormal lymphocytes demonstrated CD 2 ( + ) , CD 3 ( + / ) , CD 4 ( ) , and CD 8 ( ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
PBL subsets were analyzed by flow cytometry with the use of monoclonal antibodies against CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 16 , CD 20 , CD45RA , CD 56 , CD 57 and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Results were expressed as the percentage of positive stained cells expressing CD 2 , CD 4 , CD 8 , WC 1 ( gamma delta ) , IgM and class 2 major histocompatibility complex ( MHC 2 ) molecules , as determined by flow cytometry . ^^^ Mean fluorescence intensity ( MFI ) values were also examined across the periparturient period for CD 2 , CD 4 , CD 8 and gamma delta T cell subsets . ^^^ CD 2 , CD 4 , and CD 8 subsets decreased significantly at wk 3 and returned to initial subset proportions by wk 16 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Tissue sections were stained for the T cell markers CD 2 , CD 3 gamma delta , CD 4 and CD 8 , for the B cell markers IgM , IgA and IgG , for a macrophage marker , and for PRV antigen . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
When human peritoneal cells were analyzed using flow cytometry , the cell population showed reactivity for CD 2 , CD 4 , CD 8 , CD 20 , CD 14 and HLA DR antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In contrast , HRMCs were not recognized by mAbs to CD 2 , CD 3 , CD 4 , CD11b , CD 14 , CD 15 , CD 16 , CDw 17 , CD 19 , or CD 23 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
All obtained clones expressed CD 2 and CD 8 and were negative for CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Using an anti CD 2 antibody , CD 2 was down modulated in vivo on mouse T lymphocytes without affecting the levels of surface CD 3 , TCR alphabeta , CD 4 or CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
One population expresses the previously described 215 , 000 MW WC 1 antigen and is negative for the cell surface differentiation antigens CD 2 , CD 4 , and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Mononuclear cell suspensions prepared from the samples of 39 human thymuses were analysed for the total number of cells per gram of thymus tissue , percentage of single marker positive CD 2 , CD 4 and CD 8 cells , percentages of double positive CD4CD8 and CD2CD8 cells , double negative CD4CD8 cells , absolute numbers of these cells per gram of tissue , and extent of the in vitro proliferation upon stimulation with concanavalin A ( Con A ) , phytohaemagglutinin ( PHA ) and pokeweed mitogen ( PWM ) mitogens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
All glycosylphospha tidylinositol ( GPI ) anchored proteins ( CD 14 , CD16B , CD 48 , CD 59 , CD 87 and GPI anchored versions of CD 2 and CD 25 ) and protein tyrosine kinase ( PTK ) Lck but not transmembrane proteins ( CD 2 , CD 4 , CD 5 , CD 6 , CD 8 ) and PTK ZAP 70 were in part localized in buoyant , lipid rich , detergent resistant membrane GPI microdomains of the COS cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Specimens were processed for histopathological analysis and stained by the immunoperoxidase technique , using the following monoclonal antibodies : CD 2 , CD 3 , CD 4 , CD 8 , anti T cell receptor ( TcR ) gamma / delta , RFD 1 and RFD 7 ( two different macrophage markers ) , Ki67+ ( proliferating ) cells , antihuman leucocyte antigen ( HLA ) DR , and anticollagen 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These cells expressed class 1 and class 2 MHC , CD1a , CD 2 , CD 4 , CD11c , CD 40 , CD 45 , CD 80 , CD 83 , and CD 86 and were potent stimulators of allogeneic T cell activation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Resting immune [ WBC and differential cell counts lymphocyte phenotyping ( CD 2 , CD 4 , CD 8 , CD 16 , CD 20 , and CD 56 ) , and NK activity ] and endocrine ( cortisol , prolactin , growth hormone , and DHEA SO 4 ) parameters were measured in 10 male , Vietnam combat veterans diagnosed with long term post traumatic stress disorder ( PTSD ) and 9 control Vietnam combat veterans without a PTSD diagnosis but with a comparable history of alcohol abuse . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , the population experienced a significant fall in total lymphocytes and CD 4 , CD 3 , and CD 2 lymphocytes , as well as a rise in NK cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We have found that patients with mental anorexia or bulimia present a significant decrease of leucocytes , lymphocytes , CD 2 and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
There was no statistically significant difference in the observed values of CD 2 ( total T lymphocytes ) , CD 4 ( helper / inducer T cells ) , CD 8 ( suppressor / cytotoxic T cells ) , CD4 / CD8 ratio , CD 16 ( natural killer cells ) , HLA DR ( B cells and activated T cells ) , TcR delta 1 ( epitope of the constant domain of delta chain of T cell receptor 1 ) , cortisol , melatonin , TRH , TSH , FT 4 ' ' GH , IGF 1 , IL 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Ratios of CD 4 to CD 8 cells were not altered but the ratio of CD 2 to CD 19 cells was lower in all phases except AN 6 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Some immunophenotypes correlated with FAB type , including increased frequency of CD 2 expression in AML M 3 ; lack of CD 4 , CD11c , CD 36 , CD 117 , and HLA DR expression in AML M 3 ; increased frequency of CD 20 and CD 36 expression and lack of CD 34 expression in AML M 5 ; increased frequency of CD 5 expression in AML M5a ; and increased frequency of CD 14 expression in AML M5b , when compared with all other AMLs ( P < . 05 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These 57 mAb were further analyzed using flow cytometry on whole blood lymphocytes , splenocytes , Peyer ' s patch lymphocytes , in vitro cell lines , broncho alveolar lavage cells , Con A and PHA blasts , fetal cell populations , and by 2 color flow cytometry against mAb to porcine CD 2 , CD 4 , and CD 8 . ^^^ Newly confirmed mAb assignments included : two CD 2 ; one CD 4 ; two CD 5 ; one wCD 6 ; and one wCD 25 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
K 562 cells incubated with activated T cells acquired CD 2 but not the CD 4 and CD 8 antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
No changes in CD 2 , CD 4 , CD 8 , CD 20 , CD 29 , and CD45R cell numbers in lymph node of infected animals were seen when compared to control animals . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In neonates we have observed the increase in the absolute number of CD1a and CD 7 positive lymphocytes as well as CD 2 , CD 3 , CD 4 , CD 8 , CD 16 , CD 19 and CD 20 positive , while number of CD 57 positive cells was significantly decreased . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Serial frozen sections of grafts and controls were stained by immunoperoxidase for rat MAC 1 , class 2 MHC , CD 2 , CD 4 , CD 8 , B cells , VLA 4 , LFA 1 , L selectin , ICAM 1 , and VCAM 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Eight monoclonal antibodies ( specific for CD 3 , CD 2 , CD 4 , CD 8 , WC 1 , cell surface IgM , cell surface IgG and MHC class 2 molecules ) and an avidin / biotin complex method on frozen sections were used . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
MTX resistance of Jurkat T cells in vitro was accompanied by significantly ( P < 0 . 05 ) decreased expression of CD 2 , CD 3 , CD 4 , CD 28 , and CD 69 , IL 2 production , and MTX uptake assessed by cell association or disassociation of 3 [ H ] MTX or fluoresceinated MTX ( FMTX ) , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
MAbs against CD 3 , CD 2 , or HLA DR had no effect on the GM 1 induced down modulation of CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Subpopulations of blood lymphocytes ( CD 2 , CD 4 , CD 8 , WC 1 and IgM mu chain ) were evaluated in clinically manifested bovine papillomatosis . ^^^ Significantly lower numbers of CD 2 ( 44 . 7 % ) , CD 4 ( 22 . 8 % ) and a lower ratio of CD4 / CD8 ( 1 . 5 ) were found in animals with tumours compared to a group of cattle free of papillomas ( 62 . 3 % , 34 % , and 2 . 3 , respectively ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The monoclonal antibody panel included RT 1 ( a ) ( ACI , MHC 1 ) combined with CD 2 , CD 4 , CD 8 , CD 16 , and CD 25 or RT 1 ( a , c ) ( bone marrow chimeras ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , there was aberrant expression of CD 2 and no expression of CD 14 or CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The distribution of CD 2 , CD 4 , CD 8 , gamma / delta T lymphocytes , B cells and IgG lambda light chain ( lambda IgG ) containing cells were analysed in the inflammatory infiltrate associated to hepatic lesions and gallbladder ( HL ) , and in hepatic lymph nodes ( HLN ) of goats primarily and secondarily infected with Fasciola hepatica . ^^^ In the HL , CD 2 and CD 8 T cells were more numerous ( p=0 . 01 ) in secondarily rather than in primarily infected goats , whereas CD 4 T lymphocytes were less numerous than CD 8 and showed no significant change in both groups . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A unique conformational domain , member of the immunoglobulin superfamily , recognises differently its partners for an antigen antibody reaction or for a cell adhesion process involving immunological determinants such as CD 2 or CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The biopsy specimen showed angiocentric infiltrates of small to medium sized cells positive for CD 4 , CD 45 , and CD 56 but negative for CD 2 , surface and cytoplasmic CD 3 , CD 8 , CD 20 , and CD 57 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the stepwise forward multivariate logistic regression models , after adjustment for CD 4 T cell counts , depending on whether it was analyzed continuously or after dichotomization ( 20th percentile ) , both T cell reactivity to CD 2 plus CD 28 antibodies or to CD 3 antibodies were the most predictive markers of DTHA ( odds ratio , 0 . 80 ; 95 % confidence interval , 0 . 67 0 . 94 ; and odds ratio , 2 . 97 ; 95 % confidence interval , 1 . 1 8 . 3 , respectively ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In order to evaluate immune response during pollen exposition cellular populations CD 2 , CD 4 , CD 8 , CD 19 , CD 22 , CD 23 , CD 28 , CD 29 , CD45RA , CD45RO have been studied before , during and after pollen season by flux cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Because these T cell functions have been implicated in graft versus host disease ( GVHD ) pathogenesis , we have analyzed the effects of the CD 2 : CD 48 pathway on GVHD mediated by CD 4 ( + ) and CD 8 ( + ) T cells infused into sublethally irradiated recipients . ^^^ CD 4 ( + ) T cell mediated , and to a lesser extent , CD 8 ( + ) T cell mediated GVHD was inhibited by CD 2 + 48 monoclonal antibody ( MoAb ) infusion . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies ( mAbs ) against bovine leukocyte antigens specific for T cells ( CD 2 , CD 4 , CD 8 and gammadelta receptor ) and B cells ( surface IgM ) were used in samples from one week and one , three and seven month old goats to study the evolution of lymphocyte subsets by flow cytometry in peripheral blood and the lymphoid organs : thymus , jejunal ( JPP ) and ileal ( IPP ) Peyer ' s patches , spleen and mesenteric lymph nodes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Absolute blood levels of the following lymphocyte subsets were measured before induction of a standardized general anesthetic ( baseline ) and the morning after surgery : CD 2 , CD 3 , CD 4 , CD 8 , CD 20 , CD 56 , and the CD 4 : CD 8 ratio . ^^^ Significant decreases in lymphocyte subsets CD 2 , CD 3 , and CD 4 were found in both groups ; CD 56 was significantly decreased only in the placebo group . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A clear circadian rhythm was validated for cortisol serum levels , for CD 8 , CD 8 dim , CD 16 and delta TcS 1 with acrophase in the morning , and for CD 2 , CD 4 , CD / CD8 ratio , HLA DR , CD 20 and CD 25 with acrophase at night . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Our results show a significant increase in NK cells from 0 . 20+ / 0 . 12 to 0 . 27+ / 0 . 28 ( P=0 . 001 ) , without a significant change in CD 2 , CD 19 , CD 4 , CD 8 population , and CD4 / CD8 ratio . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunophenotyping was performed assaying the following cell surface antigens : CD 2 , CD 4 , CD 8 , CD 14 , CD 20 , CD 26 , CD 29 , CD45R , CD 56 , and PMN . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the present study we report that the expression of both CD 4 and CD 2 antigen is down regulated during the acute phase of infection . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The vast majority of DPP 4 positive T ALL cases expressed CD 4 , CD 8 , CD 7 , CD 5 , CD 2 along with CD 71 and CD 38 antigens , but the cells were surface membrane CD 3 antigen negative . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In students , who were reactors to psychological stress ( criterion based on changes in the Perceived Stress Scale , PSS ) , but not in stress non reactors , a significant increase in the number of neutrophils , monocytes , CD 8 ( + ) , CD 2 ( + ) CD 26 ( + ) , and CD 2 ( + ) HLA DR+ T cells and CD 19 ( + ) B cells , and significant reductions in the CD 4 ( + ) / CD8 ( + ) T cell ratio were observed in the stress condition . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The peripheral blood leukocytes were studied by 2 color flow cytometric analysis using anti human CD 2 , CD 3 , CD 4 , CD 8 , CD11b , CD11c , CD 16 , CD 19 , HLA DR , and CD3+HLA DR+ monoclonal antibodies . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Nonlineage expression of markers ( CD 1 , CD 2 , CD 4 , CD 5 , CD 7 , and CD 56 ) was nonspecific as to AML subtype . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The leukemic cells had a unique immunophenotype : it was positive for T cell antigens ( CD1a , CD 2 , cytoplasmic CD 3 , CD 4 ) , myeloid antigens ( CD 13 and CD 33 ) , NK cell antigen ( CD 56 ) , CD 19 and CD 30 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
RESULTS : Laparoscopy was found to cause significantly less reduction in the number of cells expressing T lymphocyte phenotypic surface markers ( CD 2 , CD 3 , CD 8 , CD 4 : CD 8 ratio ) , activation markers ( CD 71 and HLA DR ) , and NK cell subsets ( CD11b , CD 16 , CD 56 and CD 57 ) , when compared with the minilaparotomy technique . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Expression of CD 2 , CD 4 and CD 8 lymphocyte differentiation antigens was consistently lower and more heterogeneous on bronchoalveolar lymphocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Recombinant soluble forms of six leukocyte antigens belonging to the Ly 6 ( CD 59 ) , scavenger receptor ( CD 5 ) , and immunoglobulin ( CD 2 , CD 48 , CD 4 , and Thy 1 ) superfamilies were expressed in the same Chinese hamster ovary cell line , thus providing an opportunity to examine the extent to which N linked oligosaccharide processing might vary in a superfamily , domain , or protein dependent manner in a given cell . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The lymphoma expressed CD 2 , CD 3 , CD 7 , CD 8 and CD 56 , and the gammadelta T cell receptor and did not express CD 5 , CD 4 and the alphabeta T cell receptor . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
T lymphocytes ( CD 2 ( + ) or CD 4 ( + ) ) from BHV 1 immune cattle were stimulated in the presence of APC previously incubated with live or inactivated wild type BHV 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These lymphocytes were found to be positive to immunophenotyping for CD 2 ( Leu5b ) , CD 3 epsilon ( DAKO ) , CD 4 ( Leu3a ) , and CD 56 ( Leu 19 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Development of thymocytes can be staged according to the levels of expression of the cell surface markers CD 4 , CD 8 , CD 44 , CD 25 and CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A small fraction of rat 13 day old fetal liver ( r13FL ) cells , which weakly expressed the leukocyte common antigen CD 45 , constituted a homogeneous Thy 1 ( hi ) , CD 71 ( ) , CD 44 ( + ) , MHC class I+ , CD 43 ( + ) cell subpopulation negative for CD45RC , CD 3 , TCRalphabeta , TCRgammadelta , CD 2 , CD 5 , CD 4 , CD 8 , CD 25 , CD 28 , NKR P1a and sIg . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The rat pups were separated from their mothers 22 days after birth . 78 young rats were divided into two main groups : controls ( C 1 , C 2 , C 4 ) and cadmium groups ( Cd 1 , Cd 2 , Cd 4 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 4 positive or CD 8 positive clones of the CD 2 positive clones were 12 and 5 clones , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The CD 4 positive or CD 8 positive hybridomas of the CD 2 positive were approximately 35 % and 15 % , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Then expression of CD 2 , CD 3 , CD 4 , CD 8 , and CD 56 antigens was studied by cytofluorimetric assay using propidium iodide ( PI ) staining and annexin procedure , and by gel electrophoresis of low molecular weight DNA . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In three patients with identified clones ( Vbeta 3 . 1 , 5 . 3 and 6 . 7 ) , double staining revealed positivity for CD 2 , CD 3 , CD 4 , CD 5 , CD45RO and CD 7 in a significant proportion ( at least 35 % ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We have proposed that molecules at the T cell / antigen presenting cell ( APC ) interface segregate according to size , with small `` accessory ' ' molecules ( e . g . , CD 2 , CD 4 , CD 8 , CD 28 , and CD 154 ) contributing to the formation of a close contact zone , within which the TCR engages peptide MHC , and from which large molecules are excluded ( Davis , S . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The tumoral cells expressed CD 2 , CD 3 , CD 4 and 75 p . 100 were positive for CD 30 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The blasts were strongly positive for both CD 7 and CD 56 but negative for other T lineage associated antigens , including CD 1 , CD 2 , surface membrane CD 3 , cytoplasmic CD3c ( 2 / 2 ) , CD 4 , CD 5 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
They expressed intermediate density CD 45 , as is characteristic of blasts ; in addition , the cells were positive for HLA DR , CD 2 , CD 4 , and the NK associated antigen CD 56 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
No significant differences among the groups were found in the values of CD 2 ( total T cells ) , CD 4 ( T helper / inducer subset ) , CD8dim ( T cytotoxic subset ) , CD4 / CD8 ratio , HLA DR ( B cells and activated T cells ) , CD 20 ( total B cells ) and CD 25 ( T activated lymphocytes with expression of the alpha chain of interleukin 2 receptor ) . ^^^ Nyctohemeral variations of CD 2 in control subjects and in 1 2 stage cancer patients and of CD 4 and CD 20 in 3 4 stage cancer patients presented circadian rhythmicity . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometric analysis demonstrates that mPEG modification dramatically decreases antibody recognition of multiple molecules involved in essential cell : cell interactions , including both T cell molecules ( CD 2 , CD 3 , CD 4 , CD 8 , CD 28 , CD11a , CD62L ) and antigen presenting cell ( APC ) molecules ( CD 80 , CD 58 , CD62L ) likely preventing the initial adhesion and costimulatory events necessary for immune recognition and response . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The location of these CD 2 ( + ) T lymphocytes in the germinal center suggested that they were CD 4 ( + ) T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
RESULTS : Ovalbumin exposure induced significant BHR , with increases in eosinophils , lymphocytes , and neutrophils in bronchoalveolar lavage fluid and an increase in eosinophils , CD 2 ( + ) and CD 8 ( + ) , but not CD 4 ( + ) T cells , in the airway submucosa . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Her bone marrow was normocellular with an excess of blasts ( 89 . 1 % , peroxidase stain ( ) , PAS stain ( ) ) that displayed a positive immunophenotype for CD 2 , CD 4 , CD 5 , CD 7 , CD 34 , CD 38 , and CD 71 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In this study we investigated B cells ( surface IgG : sIgG , sIgM and sIgA ) and T cells ( CD 2 , CD 4 , CD 8 , 8 / 1 , MAC 320 ) in the peripheral blood ( pBL ) , thymus , spleen , tonsil , mesenteric and inguinal lymph nodes ( mLN , iLN ) , jejunal and ileal Peyer ' s patches ( jejPP , ilPP ) in Gttingen minipigs . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunophenotyping of the peripheral blood T cells revealed evidence for a clonal expansion of highly activated CD 4 ( + ) T cells with reduced CD 2 and CD 5 surface expression . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , this association was enhanced following independent ligation of the CD 2 , CD 4 , or CD 28 costimulatory molecules , but not of CD 5 or CD 6 surface receptors , correlating to the induced tyrosine phosphorylation of Emt . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We have identified a rare ( approximately 0 . 05 0 . 1 % ) population of cells ( Thy 1 ( hi ) CD 16 ( + ) CD 44 ( hi ) CD 2 ( ) TCRalphabeta ( ) B 220 ( ) M ac 1 ( ) NK 1 . 1 ( ) ) in the adult mouse bone marrow that generates CD 4 ( + ) and CD 8 ( + ) TCRalphabeta ( + ) T cells after tissue culture for 48 hr in the presence of Ly 5 congenic marrow cells . ^^^ The essential stages in the maturation of the progenitors were determined ; the stages included an early transition from CD 2 ( ) CD 16 ( + ) CD 44 ( hi ) TCRalphabeta ( ) to CD 2 ( + ) CD 16 ( int / ) CD 44 ( int / ) TCRalphabeta ( ) cells , and a later transition to CD 4 ( + ) CD 8 ( + ) TCRalphabeta ( + ) double positive T cells that rapidly generate the CD 4 ( + ) and CD 8 ( + ) single positive T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunoprecipitation of T cell lysates with anti CD 9 mAb followed by immunoblotting with mAb against various T cell molecules showed the association of CD 9 with CD 3 , CD 4 , CD 5 , CD 2 , CD 29 and CD 44 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Histologic sections of a cervical lymph node demonstrated a marked paracortical proliferation of occasional small and intermediate sized lymphocytes and numerous large immunoblasts , the majority of which displayed a CD 3 ( + ) , CD 43 ( + ) , CD45RO ( ) ( OPD 4 , UCHL 1 ) CD 4 ( ) , CD 8 ( ) phenotype on paraffin sections , and which had a CD 2 ( + ) , CD 3 ( + ) , CD 5 ( + ) , CD 56 ( ) , Tdelta 1 ( ) , [ CD 4 ( ) , CD 8 ( ) ] double negative profile on flow cytometric analysis . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
All expressed CD 2 , CD 4 , CD 58 , CD 69 and CD 80 and therefore resembled activated T cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The patient had marked splenomegaly , generalized lymphadenopathy and marked proliferation of abnormal lymphocytes in the peripheral blood with an irregular nucleus , deeply basophilic cytoplasm and a single prominent nucleolus , which were positive for CD 2 , CD 3 , CD 5 , CD 7 , CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Supplemental retinyl palmitate , but not beta carotene , was associated with a reduction in the percentage of blood mononuclear leukocytes expressing CD 2 , CD 4 , and CD 8 T cell antigens and interleukin 2 receptors . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Analysis of the tissue samples confirmed a lower number of CD 2 cells ( two tailed P = . 002 in epidermis , . 005 in dermis ) , CD 3 cells ( two tailed P = . 001 in epidermis and in dermis ) , CD 4 cells ( two tailed P = . 002 in epidermis , . 011 in dermis ) , and CD 8 cells ( two tailed P = . 002 in epidermis , . 051 in dermis ) in subjects than in controls . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
There was no significant difference between elderly group and controls in CD 2 , CD 3 , CD 4 , CD 8 , CD 19 , CD 25 and HLA DR antigen distribution . ^^^ In apparent correlation with reduced lymphocyte responsiveness , CD 2 , CD 3 , CD 4 and CD 8 molecular densities , to different extents , were found relevantly ( about 1 to 3 fold ) lower in all aging groups than in controls . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
On day 21 of infection in specific pathogen free piglets approximately 60 % of the SLAC consisted of CD 2 ( + ) CD 8 ( + ) CD 4 ( ) gammadeltaTCR ( ) cells , which were partly CD 8 ( + ) CD 6 ( + ) and partly CD 8 ( + ) CD 6 ( ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometric analysis revealed that the expression of CD 4 and CD 8 on T cells was decreased in Donryu rats , though the expression of other T cell markers such as CD 2 , CD 3 and CD 5 was not different . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Activation of T cells requires co stimulation of the TCR and accessory receptors like CD 2 , CD 4 , CD 8 , CD11a or CD 28 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface marker analysis of lymph node cells was positive for CD 2 , CD 3 , CD 4 , CD 5 , CD 56 , and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunologic characterization of these cells revealed positivity for CD 3 , CD 5 , CD45RO , CD 56 , and T cell intracellular antigen ( TIA ) , and negativity for CD 2 , CD 3 , CD 4 , CD 8 , CD 57 , CD 34 , and terminal deoxynucleotidyl transferase ( TdT ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cofilin is dephosphorylated on phosphoserine residues following co stimulation via accessory receptors such as CD 2 , CD 4 , CD 8 or CD 28 , but not in response to TCR engagement alone . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The authors investigated the capacity of restoration of differentiation antigens CD 2 , CD 4 , CD 8 and CD45RA . ^^^ CONCLUSION : From the results ensues that during physiological ageing the ability of spontaneous restoration of antigens CD 2 and CD45RA declines but not of antigens CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometry analyses showed that the mAb recognized a subset of T lymphocytes of which the majority expressed no CD 2 , CD 4 and CD 8 whilst the minority bore CD 2 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Normalization of cell numbers displaying CD 2 , CD 3 and CD 19 was delayed until 52 , 52 and 24 weeks respectively , while CD 4 counts persisted subnormal even at 72 weeks . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Unexpectedly , several of the NK related molecules , together with certain other molecules including CD 2 , CD 3 , CD 4 , CD 32 , and CD 44 , were often expressed in a mosaic manner , even on freshly derived clones , indicating frequent switching in expression . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We constructed a set of retroviral expression vectors containing an IRES followed by a quantitative selectable marker such as green fluorescent protein ( GFP ) or truncated cell surface proteins CD 2 or CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : The proportion of CD 2 , CD 4 and CD 8 receptor positive lymphocytes , expressed as a mean ( and standard deviation ) percentage of the total lymphocyte population , measured at 7 , 15 and 30 days and 6 months after transplantation . ^^^ RESULTS : At 7 days after transplantation , CD 2 lymphocytes averaged 55 % ( 18 % ) , 16 % ( 15 % ) and 14 % ( 11 % ) in groups 1 , 2 and 3 respectively ( p < 0 . 05 ) , CD 4 averaged 36 % ( 11 % ) , 9 % ( 12 % ) and 7 % ( 8 % ) in groups 1 , 2 and 3 ( p < 0 . 05 ) , and CD 8 averaged 14 % ( 6 % ) , 4 % ( 3 % ) and 4 % ( 3 % ) in groups 1 , 2 and 3 ( p < 0 . 05 ) . ^^^ At 30 days after transplantation the percentages of CD 2 , CD 4 and CD 8 lymphocytes were similar among the groups . ^^^ CONCLUSIONS : A short course of RATG causes severe , transitory depletion of CD 2 , CD 4 and CD 8 lymphocyte subpopulations . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These cells express the T cell antigens CD 2 and CD 5 on their surface , but not CD 7 , and they express CD 4 and CD 45 at numbers of molecules per cell typical for T lymphocytes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Although displaying normal development of CD 2 , CD 3 , CD 4 , and CD 8 expression , CD 25 deficient cortical thymocytes do not express CD 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The percentage and absolute numbers of lymphocyte populations , T cells ( CD 2 ( + ) , CD 3 ( + ) ) , B cells ( CD 19 ( + ) ) , NK cells ( CD 56 ( + ) CD 3 ( ) and CD 16 ( + ) CD 3 ( ) ) and T cell subpopulations ( CD 4 ( + ) , CD 8 ( + ) , CD 4 ( + ) CD45RA ( + ) , CD 4 ( + ) CD45RO ( + ) , CD 4 ( + ) DR ( + ) , CD 8 ( + ) CD45RO ( + ) , CD 8 ( + ) DR ( + ) ) , were monitored with flow cytometry during the first year after APSCT . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The absolute number and relative proportion of lymphocytes bearing CD 2 , CD 3 , CD 4 , CD 8 , CD 16 , CD 19 , HLA DR , kappa and lambda antigens were compared with the levels of IL 1beta , IL 6 and PGE 2 in the pseudosynovial membrane as well as with a semiquantitative estimate of metal and polyethylene particles , necrosis and chronic inflammation and the total concentration of metals within the periprosthetic tissues . ^^^ There was a significant increase in the relative proportion of CD 2 positive T cells and CD 16 positive natural killer cells in the peripheral blood at revision arthroplasty compared with primary arthroplasty and an increased proportion of CD 8 positive T cells and a decreased ratio of CD 4 to CD 8 ( helper inducer / suppressor cytotoxic cells ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , the number of total leukocytes , total lymphocytes and lymphocyte subsets CD 2 , CD 3 , CD 4 , CD 8 , CD 19 and CD 56 were counted . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the two cases where tissue was available for immunohistochemical study in frozen sections , neoplastic cells showed CD 56 ( Leu 19 ) + perforin+ Fas ligand ( FasL ) + CD 2 ( Leu5b ) CD 3 ( Leu 4 ) CD 4 ( Leu 3 ) CD 5 ( Leu 1 ) CD 7 ( Leu 9 ) CD 8 ( Leu 2 ) betaF 1 TCRdelta 1 phenotypes . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
To determine whether the regulation of IFN gammaR 2 expression , and therefore IFN gamma responsiveness , is important for the differentiation of naive CD 4 ( + ) T cells into Th 1 cells or for Th 1 effector function , we generated mice in which transgenic ( TG ) expression of IFN gammaR 2 is controlled by the CD 2 promoter and enhancer . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
METHODS : Cell subsets present in whole blood samples were labeled with a combination of anti human monoclonal antibodies to CD 2 , CD 20 , CD 4 , CD 8 , and CD 14 coupled to FITC or PE and analyzed by flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Peripheral blood lymphocytes were highly pleomorphic and presented CD 2 , CD 4 , CD 25 , CD 38 membrane surface antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Because CD produced almost complete protection , we prepared four E . coli expressed , MBP fused chimeras containing overlapping fragments of the CD region ( i . e . , CD 1 , CD 2 , CD 3 , and CD 4 ) whose lengths ranged from 61 to 67 amino acid residues . ^^^ Following i . n . immunization , CD 1 , CD 2 , and CD 4 induced significant ( P < / = 0 . 004 ) protection ( 88 , 84 , and 92 % reduction , respectively ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Leucocyte number and viability were essentially unchanged from freshly obtained blood , but the expression of cell surface lymphocyte activation antigens ( CD 3 , CD 4 , CD 28 , CD 2 , CD 45 ) decreased rapidly within the first 24 h and continued to fall to less than 20 % of original levels by d 9 of storage at 4 degrees C . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A 72 year old Caucasian man presented with a malignant neoplasm comprised of blastoid cells without azurophilic granules in the Giemsa stain , with positivity for CD 2 , CD 4 , HLA DR , CD 45 and CD 56 , and negativity for CD 3 ( surface and cytoplasmic ) and CD 5 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The main outcome measures were lymphocyte subset and activation markers determined by two and three color flow cytometry ( CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 16 , CD 19 , CD 23 , CD 25 , CD 56 , and HLA DR ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Skin biopsies were taken at the same time points , fixed , sectioned , and stained with Giemsa for histologic evaluation , or with mouse anti swine monoclonal antibodies ( CD 1 , CD 2 , CD 4 , CD 5 , CD 8 , CD 25 , CD 45 , MHCII ) and with one mouse anti human monoclonal antibody ( CD62E ) cross reacting with swine for immunohistochemical evaluation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cell surface markers ( CD 3 , CD 4 , CD 8 ) and adhesion molecules ( CD 18 , CD 54 , CD 2 ) were analyzed using specific monoclonal antibodies ( MoAbs ) and flow cytometry on the PBMC , freshly isolated and treated for 72 hours with medium alone , PHA , r alpha 2b IFN and their combination . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
BCL 6 ( + ) cortical and medullary thymocytes also expressed CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , or CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In N15tg RAG 2 ( / ) CD 2 ( / ) mice , thymic dysfunction is evident by 6 wk with a pre TCR block in the CD 4 ( ) CD 8 ( ) double negative thymocytes at the CD 25 ( + ) CD 44 ( ) stage . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Expression of some leukocyte antigens ( including CD 45 ) and its isoforms ( CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , and CD 8 ) was examined in the human periapical granulation tissue samples in the present study . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immature double positive ( DP ) thymocytes mature into CD 4 ( + ) CD 8 ( ) cells in response to coengagement of TCR with any of a variety of cell surface `` coinducer ' ' receptors , including CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The atypical lymphocytes were positive for CD 2 , CD 3 , CD 5 , CD 7 , CD 56 and TCR gamma delta , but negative for CD 4 , CD 8 , CD 57 , TCR alpha beta and B cell antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Remaining T cells in peripheral lymphoid organs were coated by antibodies and had down modulated surface expression of CD 2 , CD 3 , CD 4 , and CD 8 molecules , whereas their responsiveness in mixed leukocyte reaction was impaired . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
There was near unanimity that additional markers ( selected from CD 22 , FMC 7 , CD11c , CD 103 , CD 38 , CD 25 , CD79b and heavy chains for B cell disorders , and CD 4 , CD 7 , CD 8 , CD 2 , CD 56 , CD 16 , TCRa / b , and TCRg / d for T cell disorders ) would be needed to fully characterize CLD , although not every marker would be useful in all cases . ^^^ Most ( > 75 % ) agreed that at least one more B ( CD 20 , CD 22 , CD79a , IgM ) , T ( CD1a , CD 2 , CD 4 , CD 5 , CD 8 ) , myeloid ( CD11b , CD 15 , CD 64 , CD 117 , myeloperoxidase ) , erythroid ( CD 36 , CD 71 , glycophorin A ) , and megakaryocytic ( CD 41 , CD 61 ) reagents should be included in the essential panel . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
METHODS : T helper cells , alphabeta T cells , or gammadelta T cells were depleted using previously described monoclonal antibodies directed at the CD 4 molecule ( OX 38 ) , the CD 2 molecule ( OX 34 , both depleting CD4+ T cells ) , the alphabeta T cell receptor ( R 73 ) , and the gammadelta T cell receptor ( V 65 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
DC stained directly in whole blood were heterogeneous with regard to their expression of CD 2 and CD 4 molecules , and did not express CD 80 and CD 83 molecules . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A rare form of putative natural killer ( NK ) cell lymphoma called blastic NK cell lymphoma appears to be clinicopathologically distinctive in showing a homogenous lymphoblast , variable expression of CD 2 , CD 4 , CD 56 and TdT , negative for surface CD 3 , T cell receptor antigen , CD 16 , CD 34 and lack of association with Epstein Barr virus ( EBV ) . ^^^ In addition , the cells were positive for HLA DR , CD 2 , CD 4 , CD 56 and TdT , and negative for EBV transcripts . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lymphocytes subsets , including CD 4 T cells , CD 8 T cells , CD4 / CD8 Ratio , CD 2 ( + ) T cells , CD 3 ( + ) T cells , and CD 19 ( + ) B cells , were measured in these patients , as well as variables that might suggest transfusion induced immunomodulation , such as duration of antibiotic use , duration of hospital stay , and total hospital charges . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The analytical method included the evaluation of T cell subpopulations ( using AcMc CD 2 , CD 4 , CD 8 ) and activated T cells ( AcMc HLA DR and CD 25 ) from CSF and peripheral blood by immunocytochemical techniques on a fixed cell slide as described by Bernd . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Surface CD 2 , CD 4 , CD 8 markers and IL 2 and TNF alpha cytokines in amyotrophic lateral sclerosis ] . ^^^ In the paper CD 2 , CD 4 and CD 8 markers on mononuclear cells as well as levels of TNF alpha and IL 2 in sera from 15 patients with ALS were evaluated . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
T cell antigen CD 2 , CD 4 , and CD 7 was seen in four , four , and two cases , respectively , and CD4+ and CD7+ cases commonly expressed CD 13 and / or CD 33 ( CD13 / CD33 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The cell surface markers CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , CD 19 , and CD 45 were studied for the lymphocyte sub population analysis . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The two lines retained phenotypic profiles indicative of a myeloid origin but coexpressed some lymphoid antigens ( CD 2 , CD 4 , CD 8 ) , although not CD 3 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Bone marrow and lymph node biopsies showed a T cell lymphoproliferative disease expressing NKRs ( CD 2 ( + ) , CD 3 ( + ) , CD 4 ( + ) , CD 5 ( + ) , CD 7 ( + ) , CD 8 ( ) , CD 56 ( ) , CD 94 ( + ) , CD158a ( + ) , CD158b ( + ) , CD 161 ( ) , p 70 ( ) , TCRalphabeta ( 1 ) , TCRgammadelta ( 2 ) , TIA 1 ( ) ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The bone marrow was filled with atypical lymphoid cells , and a skin biopsy showed diffuse dermal infiltration of neoplastic cells , which were positive for CD 2 , CD 8 , CD 56 , TIA 1 , Granzyme B and EBER ( ISH ) , but negative for CD 3 , CD 4 , CD 16 and CD 57 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition to CD 2 , PSTPIP associated with CD 4 , CD 8 , CD 54 , and CD62L . ^^^ CD 2 and CD 4 ligation reciprocally regulated their association with PSTPIP . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Corrigendum to `` The sow endometrium at different stages of the oestrous cycle : studies on the distribution of CD 2 , CD 4 , CD 8 and MHC class 2 expressing ' ' cells . [ Anim . ^^^ The aim of this study was to investigate the distribution of CD 2 ( + ) , CD 4 ( + ) , CD 8 ( + ) lymphocyte subpopulations and MHC class 2 expressing cells in the sow endometrium throughout the oestrous cycle . ^^^ In conclusion , the present study showed a variation in the distribution of T lymphocyte subpopulations ( CD 2 ( + ) , CD 4 ( + ) and CD 8 ( + ) ) and MHC class 2 expressing cells in the sow endometrium during different stages of the oestrous cycle . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
ATL cells were CD 2 , CD 3 , CD 4 , CD 25 positive and CD 8 negative . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We describe a 54 year old man with CD 2 , CD 7 , and CD 56 positive but CD 3 , CD 4 , and CD 8 negative aggressive NK cell lymphoma / leukemia . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Allergen exposure of sensitized rats induced bronchial hyperresponsiveness ( BHR ) , accumulation of inflammatory cells in bronchoalveolar lavage ( BAL ) fluid , and also an increase in eosinophils and CD 2 ( + ) , CD 4 ( + ) and CD 8 ( + ) T cells in the airways together with mRNA expression for IL 2 , IL 4 , IL 5 , IL 10 , and IFN gamma . 3 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
All tested patients had CD 2 , CD 7 , CD 4 , and / or CD 8 positivity , whereas CD 5 and CD 3 were positive in 98 % and 96 % of tested patients , respectively . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunophenotypic analysis revealed positivity for CD 2 , CD 4 , CD 56 , and HLA DR , and negativity for CD 3 , CD 13 , CD 16 , CD 33 , CD 34 , and T cell receptor ( TCR ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
To facilitate a detailed investigation of cetacean lymphoid organs , 13 canine , six bovine , one equine , one human and four killer whale specific monoclonal antibodies ( mAbs ) directed against cell surface antigens of the haematopoietic system ( including CD 2 , CD 4 , CD 8 , CD45R , MHC class 2 , granulocyte , thrombocyte , pan T cell and B cell antigen ) , as well as a mAb and a polyclonal antibody ( pAb ) directed against the peptide of the human CD 3 complex , were tested for immunohistochemical cross reactivity on frozen or formalin fixed , paraffin wax embedded lymphatic tissues of harbour porpoises . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 2 facilitates differentiation of CD 4 Th cells without affecting Th1 / Th2 polarization . ^^^ The role of CD 2 in murine CD 4 helper T cell differentiation and polarization was examined using TCR Cyt 5CC7 1 transgenic recombination activating gene 2 / H 2 ( a ) mice on CD2+ / + or CD 2 / backgrounds . ^^^ In the absence of CD 2 , thymic development was abnormal as judged by reduction in the steady state number of total , double positive , and CD 4 single positive ( SP ) thymocytes , as well as a defect in their restorative dynamics after peptide induced negative selection in vivo . ^^^ In addition , in CD 2 / animals , lymph node CD 4 SP T cells manifest a 10 to 100 fold attenuated activation response to cytochrome c ( CytC ) agonist peptides as judged by induction of CD 25 and CD 69 cell surface expression or [ ( 3 ) H ] TdR incorporation ; differences in the magnitude of responsiveness and requisite molar peptide concentrations were even greater for altered peptide ligands . ^^^ In vivo administration of CytC peptide to CD 2 / animals yielded an impaired CD 4 SP T cell effector / memory phenotype compared with similarly treated CD2+ / + mice . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
B cell markers , such as terminal deoxynucleotidyl transferase ( TdT ) , CD 10 , CD 19 , CD 20 and HLA DR were positive , and CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , kappa , lambda , cytoplasmic mu and myeloperoxidase were negative . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The flow cytometric immunophenotype of the lymphoma cells was CD 2 , CD 3 , CD 4 , CD 5 , CD8+ , CD10+ , CD19+ , CD20+ , CD 23 , kappa+ , lambda , CD25+ , and CD 56 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Medial synovium was immunostained using antibodies to anti type 2 collagen , CD 68 , CD 2 , CD 4 , CD 8 , CD 15 , CD 19 , CD 25 , HLA DR , CD1a and LN 5 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometric immunophenotyping showed expression of CD 2 , CD 3 , and CD 7 with lack of expression of CD1a , CD 4 , CD 5 , CD 8 , and CD 56 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
PTEN expression was up regulated on RNA and protein level in freshly isolated human CD 4 ( + ) T cells following stimulation with CD 28 or CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The tumor cells in all cases tested were positive for CD 2 , CD 3 , CD 4 , CD 5 , and CD 25 and were negative for CD 7 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The malignant lymphocytes showed a natural killer like gammadelta T cell phenotype ( CD 2 ( + ) , CD 3 ( + ) , CD 7 ( + ) , TCR gammadelta ( + ) , CD 56 ( + ) , TIA 1 ( + ) , CD 4 ( ) , CD 8 ( ) , and TCR alphabeta ( ) ) and infiltrated the sinusoids of liver and the red pulp of the spleen . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
MATERIAL / METHODS : 140 EMBs from dilated cardiomyopathy ( DCM ) patients and 14 autopsy heart samples ( controls ) were immunostained for T lymphocytes ( CD 2 , CD 3 , CD 4 , CD 8 ) , beta ( 2 ) integrin+ infiltrates ( CD 18 , LFA 1 , Mac 1 ) and CAMs ( immunoglobulin superfamily : ICAM 1 , HLA class 1 , HLA DR , VCAM 1 , CD 58 ; selectins : CD62E and CD62P ; and the beta ( 1 ) integrin chain CD 29 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Tumor cells were negative for surface CD 3 , CD 5 , and CD 20 in all cases , but some patients showed expression of CD 2 ( three out of five ) , cytoplasmic CD 3 ( two out of seven ) , CD 4 ( six out of seven ) , and CD 16 ( three out of seven ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Aberrant expression of T cell markers ( CD 2 , CD 3 , CD 4 ) was noted in five cases . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Studies in gnotobiotic piglets have revealed that the appearance of CD 4 ( + ) CD 8 ( + ) T cells and CD 2 ( ) B cells is absolutely dependent on the contact of immune system with live viruses and bacteria , respectively . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Parameters of cellular and humoral immunity ( differential blood count , T cell markers CD 2 , CD 3 , CD 4 , and CD 8 , B cell markers CD 19 and CD 20 , monocyte markers CD 13 and CD 14 , NK ( natural killer ) cell marker CD 16 , activation markers CD 25 , CD 26 , CD 69 , and HLA DR , and cytokines IL 1 receptor antagonist ( IL 1RA ) , IL 2 , soluble IL 2 receptor ( sIL 2R ) , IL 6 , IL 10 , and TGFbeta ) were measured in venous blood . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lymphocyte counts / high power field ; CD 2 , CD 3 , CD 4 , and CD 8 ( independent of IgG class / subclass response and left ventricular dysfunction ) were significantly higher in patients positive for IFN gamma ( 25 % ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In conditions of severe energy structural deficiency and impaired function of oxygen transport systems , CVD patients develop secondary immune deficiency presenting with depression of basic immunoregulatory subpopulations of T and B cellular immunity ( CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 16 , CD 22 ) . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
His tumor showed extensive coagulative necrosis with angioinvasion by large lymphoma cells expressing CD 2 , CD 8 , CD 16 , CD 43 , CD 45 , CD45RO , CD 56 , T cell intracellular antigen 1 , and granzyme B , but not CD 3 , CD 4 , CD 20 , CD 57 , CD 68 , and betaF 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The tumor was composed of primitive lymphoid cells expressing CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , and CD 10 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
By flow cytometry , we have defined three distinct patterns of cytoskeletal association ; constitutive , inductive , and mAb crosslink induced , and assigned human and bovine CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 18 , CD 19 , CD 44 , CD45RA , CD45RO , alphabeta TCR , gammadelta TCR , E selectin ligands , and L selectin surface antigens to one of these respective patterns . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Hematoxylin and eosin stained sections were examined and immunophenotyping was carried out on paraffin embedded , formalin fixed tissue using antibodies to CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 20 , CD 30 , and CD 56 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The numbers of T lymphocytes and T cell subsets ( CD 2 ( + ) , CD 3 ( + ) , CD 4 ( + ) , CD 8 ( + ) ) , activated T cells ( CD 26 ( + ) ) , B cells ( CD 19 ( + ) ) , granulocytes ( CD 15 ( + ) ) and natural killer cells ( CD16 / 56 ) were monitored by flow cytometry in 79 kidney transplant recipients , 35 of whom had cytomegalovirus infection . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Furthermore , enforced expression of Runx 2 in transgenic mice under the CD 2 promoter was found to affect T cell development at a stage coincident with beta selection , resulting in an expansion of double negative CD 4 and CD 8 immature single positive cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The sow endometrium at different stages of the oestrous cycle : studies on the distribution of CD 2 , CD 4 , CD 8 and MHC class 2 expressing cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The effect of Fasciola hepatica excretory secretory products ( FhESPs ) on mitogen induced proliferation of sheep peripheral blood mononuclear cells ( PBMCs ) and PBMC subsets ( CD 2 ( + ) , CD 4 ( + ) , CD 8 ( + ) , gammadeltaTCR ( + ) or CD 21 ( + ) cells ) were studied . ^^^ T lymphocyte subsets ( CD 2 ( + ) , CD 4 ( + ) or CD 8 ( + ) cells ) proliferation was decreased by FhESPs at 5 microg per well . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The immunophenotype showed the expression of CD 4 , CD 56 , CD 68 , CD 33 , CD 7 , CD 2 , CD45RA , and CD 38 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Using an immunoperoxidase technique , cryostat sections were stained using antibodies to T cell markers CD 2 , CD 3 , CD 4 and CD 8 ; cutaneous leucocyte associated antigen ; NK cell markers CD 16 , CD 56 , CD 57 , CD 94 and CD158a ; and the NK T cell marker CD 161 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Neutralization of endogenous BMP 2 and BMP 4 by treatment with the antagonist Noggin promotes and accelerates thymocyte differentiation , increasing the expression of CD 2 and the proportion of CD 44 ( ) CD 25 ( ) DN cells and CD 4 ( + ) CD 8 ( + ) double positive cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
To gain a profound insight into the underlying mechanisms , we phenotypically characterized pan leukocytes ( CD 18 ) , naive T lymphocytes ( CD 3 , CD 2 , CD 4 , CD 8 ) , activated lymphocytes ( LFA 1 , LFA 3 , VLA 4 , ICAM 1 , CD 69 , CD45R0 ) , macrophages ( Mac 1 , 27E10 ) , B lymphocytes ( CD 19 ) and NK cells ( CD 57 ) in DCM and control hearts . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We conclude that AILT is mainly derived from CD 2 ( + ) CD 3 ( + ) CD 4 ( + ) CD 5 ( + ) CD 7 ( ) mature T helper cells with varying expression and partial loss of detectable CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunocytochemical analysis showed a significant increase of CD 2 , CD 4 CD 8 , CD 25 and HLA DR positive cells with rejection . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Tumor cells expressed CD 4 , CD 7 , CD 10 , CD45RB , CD 56 , CD 68 , and HLA DR and were negative for CD1a , CD 2 , sCD 3 , CD 5 , CD 13 , CD 14 , CD 20 , CD 33 , CD 34 , CD 43 , CD45RA , TIA 1 , S 100 , and TdT . cCD 3 was not detected in the immunostaining using paraffin tissue , but was faintly expressed in flow cytometry and immunostaining using a touch imprint slide . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Significantly increased percentages of CD 2 ( + ) and CD 8 ( + ) T lymphocytes were also found in peripheral blood of these animals at this time , while the percentages of CD 4 ( + ) and MHC class 2 lymphocytes were significantly reduced . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
At least 1 T cell associated antigen was expressed in each case ( CD 2 , 12 / 17 [ 71 % ] ; CD 4 , 12 / 19 [ 63 % ] ; CD 3 , 6 / 19 [ 32 % ] ; CD 7 , 6 / 19 [ 32 % ] ; CD 5 , 5 / 19 [ 26 % ] ; CD 8 , 4 / 19 [ 21 % ] ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Influence of pre ovulatory insemination and early pregnancy on the distribution of CD 2 , CD 4 , CD 8 and MHC class 2 expressing cells in the sow endometrium . ^^^ The aim was to investigate the distribution of CD 2 ( + ) , CD 4 ( + ) and CD 8 ( + ) lymphocyte subpopulations and MHC class 2 expressing cells in the sow endometrium following pre ovulatory insemination and during early pregnancy . ^^^ In the SL and GL , the largest numbers of CD 2 ( + ) , CD 4 ( + ) and CD 8 ( + ) cells were found in group 5 . ^^^ In conclusion , the immunomodulation illustrated by the distribution of CD 2 ( + ) , CD 4 ( + ) , CD 8 ( + ) and MHC class 2 expressing cells at the attachment sites on day 19 , i . e . the low numbers in the surface epithelium and the high numbers in the subepithelial layer , shows that the porcine trophoblast may influence the endometrium to develop the conditions required for embryonic attachment and survival in pigs . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Considerable progress has been made in characterizing four key sets of interactions controlling antigen responsiveness in T cells , involving the following : the T cell antigen receptor , its coreceptors CD 4 and CD 8 , the costimulatory receptors CD 28 and CTLA 4 , and the accessory molecule CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Frozen sections of the tissues were immunohistochemically stained using monoclonal antibodies against surface markers CD 2 , CD 4 , CD 5 , CD 8 , B cell and granulocyte monocyte / macrophage and antiserum against specific granules of bovine eosinophils . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
These have included interactions involving the T cell antigen receptor ( TCR ) itself , its coreceptors CD 4 and CD 8 , the accessory molecule CD 2 , and the costimulatory receptors CD 28 and CTLA 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies specific for human T lymphocytes and subpopulations : CD 2 , CD 3 , CD 4 , CD 8 , CD 19 and activation markers : CD 25 , CD45RA , CD45RO , CD 54 AND HLA ( ) DR were used and detected using a two colour fluorescence analysis with an automated flow cytometer . ^^^ The total number of T lymphocytes : CD 2 , CD 3 , CD 4 , CD 8 and CD 19 were significantly decreased in PIH particularly PE ( P < 0 . 05 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Antibodies recognizing macrophages ( CD 68 ) , natural killer cells ( CD 56 ) , T cells ( CD 2 ) , helper T cells ( CD 4 ) , suppressor / cytotoxic T cells ( CD 8 ) , and neutrophils ( lactoferrin ) were applied in a labelled streptavidin biotin method by using a DAKO TechMate staining robot . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
At diagnosis , five year nonsurvivors showed increased patient age and higher concentration of cells in the analyzed specimen , as well as increased levels of % CD 2 , CD 4 , CD 13 , CD 36 , and CD 45 positive AML blasts . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The lymphoma cells were positive for CD 2 , CD 3 , CD 5 , CD 8 , and T cell receptor ( TCR ) beta F 1 , but negative for CD 4 , CD 19 , CD 20 , CD 103 , and CD 56 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Examination of the patient ' s pleural effusion revealed large abnormal lymphocytes , which were CD 2 ( + ) , CD 7 ( + ) , CD 30 ( + ) , CD 56 ( + ) , CD 3 ( ) , and CD 4 ( ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Light microscopy , immunohistochemical analysis using antibodies to CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , and CD 30 in 6 cases , and polymerase chain reaction single stranded conformational polymorphism analysis for T cell receptor gamma chain gene rearrangement in 5 cases revealed 2 cytomorphologic patterns ( large cell dominant with polymorphous inflammation , small cell lymphocyte rich with an inconspicuous large cell component [ phenotypes , CD30+ / CD3+ / CD4+ / CD7 for large atypical cells ; reactive for small lymphocytes ] ) and clonal restriction in 4 and polyclonality in 1 of the lymphocyte dominant cases . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies to porcine CD 1 , CD 2 , CD 4 , CD 8 , CD 45 and IgM were used for immunohistochemical staining . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Parameters of cellular and humoral immunity ( differential blood count , T cell markers CD 2 , CD 3 , CD 4 , and CD 8 , B cell markers CD 19 and CD 20 , monocyte markers CD 13 and CD 14 , NK cell marker CD 16 , activation markers CD 25 , CD 26 , CD 69 and HLA DR , and cytokines IL 1 receptor antagonist ( IL 1RA ) , IL 2 , soluble IL 2 receptor ( sIL 2R ) , IL 6 , IL 10 , and TGFbeta ) were measured in peripheral venous blood . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Furthermore , the numbers of CD 2 ( + ) , CD 4 ( + ) CD 8 ( + ) and SLA classII ( + ) cells , respectively , in peripheral blood , together with the levels of CD 2 ( + ) and CD 3 ( + ) cells in BALF were increased in the infected piglets infected in utero compared to the uninfected controls . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In contrast to CCR 9 ( ) , CCR 9 ( + ) CD 4 ( + ) peripheral blood T cells proliferate to anti CD 3 or anti CD 2 stimulation and produce high levels of IFN gamma and IL 10 . ^^^ Moreover , memory CCR 9 ( + ) CD 4 ( + ) lymphocytes respond to CD 2 stimulation with proliferation and IFN gamma / IL 10 production , whereas memory CCR 9 ( ) CD 4 ( + ) cells were unresponsive . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Changes in leukocyte subpopulations in the blood of the calves were detected both with routine haematological methods and by FCM using specific monoclonal antibodies directed against CD 14 , CD 45 , CD 2 , CD 4 , CD 8 and WC 4 ( a specific surface marker for bovine B lymphocytes ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We studied the expression of CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 56 , and CD 138 in 447 cases of common human neoplasms with epithelioid features . ^^^ CD 2 , CD 3 , CD 4 , and CD 8 antigens were detected in none of 447 cases of nonhematopoietic tumors . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Monoclonal CD 4 ( + ) T LGLshowed expression of TCRalphabeta , variable levels of CD 8 ( CD 8 ( / +dim ) ) and a homogeneous typical cytotoxic ( granzyme B ( + ) , CD 56 ( + ) , CD 57 ( + ) , CD11b ( + / ) ) and activated / memory T cell ( CD 2 ( +bright ) , CD 7 ( / +dim ) , CD11a ( +bright ) , CD 28 ( ) , CD62L ( ) HLA DR ( + ) ) immunophenotype . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunohistochemical detection of SWC 3 , CD 2 , CD 3 , CD 4 and CD 8 antigens in paraformaldehyde fixed and paraffin embedded porcine lymphoid tissue . ^^^ Combining this method with different antigen retrieval techniques enabled us to detect CD 2 , CD 3 , CD 4 , CD 8 and SWC 3 antigen expressing cells in porcine lymphoid tissue . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The most frequent phenotypic aberrations consisted in decreased expression of CD3 / TCRalphabeta ( 94 % ) , CD 4 ( 94 % ) , CD 7 ( 100 % ) and / or CD 2 ( 83 % ) . ^^^ INTERPRETATION AND CONCLUSIONS : The presence of CD28+ / CD5+ / NKa / CD4+ T cells expressing abnormally low levels of CD 3 , TCRalphabeta , CD 4 , CD 7 and / or CD 2 would support the diagnosis of SS in patients with erythroderma . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Influence of post ovulatory insemination on sperm distribution , pregnancy and the infiltration by cells of the immune system , and the distribution of CD 2 , CD 4 , CD 8 and MHC class 2 expressing cells in the sow endometrium . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Liver biopsies were immunostained using monoclonal antibodies to C 3 , C5b 9 , IgG , IgM , CD 2 , CD 4 , CD 8 , CD 68 , CD 20 , Bric 216 , CD 31 , and fibrin , and polyclonal antibody to C 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We studied a group of 42 patients with SSc and a group of 28 matched normal controls by flow cytometry using the lymphocyte cell surface markers CD 2 , CD 3 , CD 4 , CD 8 , CD 19 , CD 25 , CD45RA , CD 56 , CD 71 , HLA DR , TCR alpha / beta , and TCR gamma / delta . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Of the two main candidates , i . e . , CD 48 and CD 58 , the cDNA of the most likely ligand poCD 58 was cloned from CD 48 negative endothelial cells costimulating human CD 4 ( + ) T cells through the CD 2 pathway . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In vitro , Tyloxapol blocked the binding of endotoxin to murine macrophages and CHO cells expressing CD 14 , activation of macrophages , and also some antigen antibody immune reactions ( mediated by CD 2 , CD 4 , CD 22 , HLA DR ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometry was performed for T , B , and NK cell count using CD 2 , CD 3 , CD 4 , CD 8 ( T cells ) , CD 19 , CD 20 ( B cells ) , and a combination of CD 3 CD16 and CD 56 monoclonal antibodies ( NK cells ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The MET 1 cells are activated T cells that express CD 2 , CD 3 , CD 4 , CD 25 , CD 122 , and CD 52 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The immunoprofile of the cells was positive for CD 45 , HLA DR , CD 30 and negative for EMA , CD 34 , CD 38 , CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , CD 10 , CD 15 , CD 19 and CD 20 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The expression of HLA class 1 ( A , B , C ) and class 2 ( DR , DQ , DP ) , CD 2 , CD 3 , CD 4 , CD 8 , and interleukin ( IL ) 2 receptor ( IL 2R ) on lymphocytes was assessed using a panel of monoclonal antibodies . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
After cell count and differentiation of second morning urine samples with New Sternheimer and Papanicolaou stains , immunocytochemistry was performed using antibodies against the following antigens : CD 2 , CD 4 , CD 8 , CD 25 , CD 71 ( transferrin receptor ) , HLA DR and cytokeratin ( Lu 5 ) . ^^^ Immunocytochemical analysis showed a significant increase in CD 2 , CD 4 , CD 8 , CD 25 , CD 71 , and HLA DR positive epithelial cells and in the ratio HLA DR / cytokeratin positive epithelial cells in rejection . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In this study , we performed three color flow cytometric analysis for activation associated cell surface molecules ( CD 2 , CD11a , CD45RA like and major histocompatibility complex antigen class 2 ( MHC 2 ) ) and light scatters ( cellular size and complexity ) to examine whether phenotypic changes also occurred in CD 4 ( + ) PBLs in addition to CD 8 ( + ) PBLs , of five FIV infected cats and one uninfected cat . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Quantification of T lymphocyte subsets was assessed by indirect immunofluorescence staining after incubation with monoclonal antibodies specific for CD 2 , CD 3 , CD 4 and CD 8 cell markers by flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
They hypothesize that the key event in T cell activation is the formation of multimolecular complexes consisting of the TCR and several other polypeptides , including CD 4 or CD 8 , CD 2 , CD 5 and the associated tyrosine kinases p 59 ( fyn ) and p 56 ( lck ) . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Tissue was harvested 2 d ( d 2 ) or 4 d ( d 4 ) after injection , resulting in four experimental groups : Cd 2 ( n = 6 ) , Cd 4 ( n = 4 ) , Id 2 ( n = 6 ) , and Id 4 ( n = 7 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The prothymocytes are positive for the terminal deoxynucleotidyl transferase ( TdT ) and give rise to cortical thymocytes , which express CD 1 , CD 2 , CD 3 , CD 5 , and both CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The least mature cells ( double negative ) expressed low density CD 2 and CD 5 , high density CD 7 , CD 10 , CD 34 , and heterogeneous CD 4 and CD 8 . ^^^ The immature cells ( double positive ) expressed CD 2 , CD 5 , CD 7 , CD 4 , CD 8 , heterogeneous surface CD 3 , and intermediate density CD 45 . ^^^ The mature cells ( single positive ) expressed CD 2 , surface CD 3 , CD 5 , CD 7 , and CD 4 or CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
METHODS : Peripheral blood lymphocyte subpopulations were analyzed by dual color flow cytometry by using monoclonal antibodies for the lymphocyte receptors CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 16 , CD 19 , CD11b , CD11c , and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Biopsies were taken before treatment and after four weeks of treatment , and markers for epidermal proliferation ( Ki 67 ) and epidermal differentiation ( keratin 10 ) were studied using a quantitative image analysis , and T cell subsets in epidermis and dermis ( CD 4 , CD 8 , CD 25 , CD45RO , CD45RA , CD 94 , CD 161 , and CD 2 ) were studied using immunohistochemical scoring . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometric immunophenotype analysis showed that over 80 % of the cells were positive for CD 2 , CD 3 , CD 4 , CD 5 and CD 7 antigens and negative for terminal deoxynucleotidyl transferase and CD1a antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
We digitally captured 10 G banded lymphocyte metaphases per individual and measured in microns the largest diameter ( d ) of the metaphase and six intercentromeric distances : ( 1 ) der A < > der B ( problem distance 1 , pd 1 ) , ( 2 ) der A < > B ( pd 2 ) , ( 3 ) der B < > A ( pd 3 ) , ( 4 ) A < > B ( control distance 1 , cd 1 ) , ( 5 ) the smaller distance between C and D ( cd 2 ) and ( 6 ) the largest distance between C and D ( cd 3 ) ; in addition , the average between C and D ( cd 4 ) was calculated . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
RESULTS : HR 8348 cell line did not express CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , TCR , CD 10 , CD11b , CD 14 , CD 16 , CD 19 , CD 22 , CD 25 , CD 28 , SmIg , CD 33 , CD 35 , CD 36 , CD41a , CD 45 , CD45RA , CD45RO , CD 56 , CD 61 , CD 64 , CD66b , CD 69 , CD 71 , CD 117 , CD 122 and P glycoprotein but expressed CD 13 , CD 15 , CD 20 , CD 38 , CD 95 and HLA DR . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lymphocyte blastogenesis in response to ConA and the percentages of lymphocytes positive for CD 2 , CD 4 , CD 8 , CD49d and CD 18 as well as the intensity of CD49d expression did not differ between the treatment and control groups . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
OBJECTIVES : In the present study we investigated the number of T cell subsets ( CD 4 , CD 8 , CD45RO , CD45RA , CD 2 , CD 25 ) , cells expressing NK receptors ( CD 94 and CD 161 ) , the proliferation marker Ki 67 and the keratinization marker keratin ( K 10 ) across the margin of the spreading psoriatic plaque : distant uninvolved skin , the outer margin ( immediately outside the clinical edge ) , the inner margin ( immediately inside the clinical edge ) and the central area . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A panel of immunohistochemical stains , which included CD 2 , CD 3 , CD 4 , CD 8 , CD 56 , T cell intracellular Antigen 1 and granzyme B , and in situ hybridization for Epstein Barr virus encoded RNA ( EBER ) were performed . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The Gateway recombination sequences ( attR ) flanking the ccdB and chloramphenicol resistance genes were incorporated at the 5 ' of the IRES of pMX IRES GFP , CD 2 , or CD 4 vectors . ^^^ We constructed Gateway bicistronic vectors coding for the erythropoietin receptor ( EpoR ) and GFP , CD 4 , or CD 2 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The following markers were investigated in skin biopsies taken from the aforementioned patients by quantitative immunohistochemistry : CD 2 , CD 4 , CD 8 , CD 25 , CD 161 , CD 94 , CD45RO , CD45RA , HLA DR , Keratin 10 , Ki 67 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
As in the CD 2 case , the proposed configuration of the CD 4 dimer is found as a pair of neighboring monomers in the crystallographic unit cell . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
MATERIAL / METHODS : To further elucidate phenotypic differences of T cell subsets , and begin to determine what information relative antigen density contributes to immunology , we analyzed normal human peripheral blood T cells for a variety of immunophenotypic ( CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD45RA , CD45RO , TCR alpha beta ) and light scatter characteristics using 6 color flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Both large and small malignant cells were positive for CD43 / MT1 T cell associated antigen , perforin , granzyme B and TIA 1 , but negative for CD 2 , CD 3 , CD 5 , CD 7 , CD 4 and CD 8 antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
However , they showed unequivocal expression of both CD 30 and CD 15 , and no aberrant antigen expression to suggest ALCL ( BSAP+ , EMA , LCA , CD 43 , CD 2 , CD 3 , CD 4 , CD45RO , ALK , granzymeB ) , with negative TCR gene rearrangement and no expression of EBV . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
At 18 days after plasmid administration , GHRH treated animals had increased numbers of CD 2 ( + ) alphabeta T cells ( P < 0 . 004 ) , CD 25 ( + ) CD 4 ( + ) cells ( P < 0 . 0007 ) , and CD 4 ( + ) CD45R ( + ) cells ( P < 0 . 016 ) compared to controls . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Microglial cells from brain were isolated and assessed through E rosette formation , SEM and FACS for CD 2 , MHC class 2 , CD 25 , and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In the present study , we addressed the role of c Maf in asthma by studying transgenic ( Tg ) mice overexpressing c Maf in CD 4 ( + ) T cells under the control of the CD 2 promoter . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immune system tests including white blood cell count , lymphocyte count , T and B cells subgroups ( CD 2 , CD 4 , CD 5 , CD 7 , CD 8 , CD 16 , CD 20 , CD 22 , CD 56 ) , mitotic reaction to phytohaemagglutinin in lymphocyte culture . ^^^ Significant differences in mean lymphocyte number , and CD 2 , CD 4 , CD 5 , CD 8 , CD 16 ratios between the two groups were defined ( P < 0 . 05 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
RESULTS : known to adversely affect wound healing were elevated in diabetic patients ( CD 2 p < 0 . 001 ; CD 3 p=0 . 016 , CD 4 p=0 . 22 , CD 25 p < 0 . 001 ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
AnTMSA 2 is a CD 4 T lymphocyte expressing high levels of MHC class 2 molecules , CD 58 and CD 2 , which are important for proliferation and growth . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Single stainings showed that cells positive for the CD 2 and CD 8 antigen were almost as numerous in pneumonic lesions as CD 3 positive cells whereas cells expressing the CD 4 antigen were rare . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Here , we describe a new recurrent chromosomal inversion of chromosome 7 , inv ( 7 ) ( p15q34 ) , in a subset of patients with T cell acute lymphoblastic leukemia characterized by CD 2 negative and CD 4 positive , CD 8 negative blasts . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunophenotype analysis showed that lymphocytes were positive for CD 2 , CD 3 , CD 5 , CD 7 , CD 8 , and TCR gammadelta antigens and negative for CD1a , CD 4 , and TCR alphabeta antigens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Binding of Porphyromonas gingivalis gingipains to human CD 4 ( + ) T cells preferentially down regulates surface CD 2 and CD 4 with little affect on co stimulatory molecule expression . ^^^ Binding of anti CD 2 and anti CD 4 monoclonal antibodies ( mAbs ) was reduced after challenge of T cells with gingipains , but restored to 50 and 100 % , respectively , of control levels , after 48h of incubation in medium depleted of gingipains . ^^^ Cumulatively , these results indicate that activated gingipains attach to T cells and preferentially cleave CD 2 and CD 4 molecules , with potential to impair T cell responses at periodontal sites . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The T cells expressed CD 2 , CD 3 , CD 5 , CD 7 , and CD 8 , with partial loss of CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
RESULTS : In both groups , total lymphocyte and T lymphocyte subset ( CD 4 , CD 8 , CD 2 , CD 3 ) counts decreased significantly during the first month after transplantation , increasing slowly between the first month and the third year posttransplantation . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The overall main chain structure resembles an immunoglobulin variable ( 5 ) domain fold , very similar to that seen previously for domain 1 of CD 2 and CD 4 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Several galectin 1 receptors are discussed such as CD 45 , CD 7 , CD 43 , CD 2 , CD 3 , CD 4 , CD 107 , CEA , actin , extracellular matrix proteins such as laminin and fibronectin , glycosaminoglycans , integrins , a beta lactosamine glycolipid , GM 1 ganglioside , polypeptide HBGp 82 , glycoprotein 90 K / MAC 2BP , CA 125 cancer antigen , and pre B cell receptor . . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Lymphocyte subsets were assessed by indirect immunofluorescence staining after incubation with monoclonal antibodies specific for CD 2 , CD 19 , CD 4 , CD 8 cells markers by flow cytometry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The tumor cells expressed focal immunocytochemical reactivity to CD 45 and CD 68 , but were negative for CD 2 , CD 3 , CD 4 , CD 8 , CD 20 , CD 30 , CD45RO , epithelial membrane antigen ( EMA ) , cytokeratin , and HMB 45 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Comprehensive immunophenotypic analysis showed that the MCL cells expressed the typical B lymphocytic markers , were CD 5 and CD 8 positive , but did not express other T cell proteins , such as CD 2 , CD 3 , CD 4 , CD 7 , TCRalphabeta and TCRgammadelta . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
XAFS spectra were also simulated using the coordinates from 10 ray crystallographic data for [ Cd ( SPh ) 4 ] 2 , CdS , [ Cd 2 ( mu SPh ) 2 ( SPh ) 4 ] 2 , and [ Cd 4 ( mu SPh ) 6 ( SPh ) 4 ] 2 . ^^^ The simulated XAFS data that were calculated using the FEFF 8 program closely resemble the experimental data reported for [ Cd ( SPh ) 4 ] 2 , CdS , [ Cd 2 ( mu SPh ) 2 ( SPh ) 4 ] 2 , [ Cd 4 ( mu SPh ) 6 ( SPh ) 4 ] 2 , rabbit liver metallothionein cadmium alpha domain ( Cd 4 alpha MT ) , and cadmium rabbit liver betaalpha metallothionein ( Cd 7 betaalpha MT ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In this report , we describe 12 subpopulations of porcine gammadelta thymocytes based on their expression of CD 1 , CD 2 , CD 4 , CD 8 isoforms and CD45RC . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
After in vivo infection , the CD 2 ( + ) subpopulation , which represents a relatively later stage of T cell progenitors , was selectively reduced and development of thymocytes from CD 3 ( ) CD 4 ( ) CD 8 ( ) cells to CD 4 ( + ) CD 8 ( + ) cells was impaired . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Expression of the T cell antigens CD 2 , CD 3 , CD 4 , CD 5 , CD 7 and CD 8 was assessed by immunohistochemistry . ^^^ In all , 12 cases ( 5 % ) expressed at least one T cell marker in the following order : CD 2 in 11 cases , CD 4 in five , CD 3 in two , and CD 5 and CD 8 in one case each ; there were no CD 7 positive cases , and five cases ( 2 % ) expressed more than one T cell antigen . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The relative proportions of immune cells were CD 2 52 . 2 % , CD 3 41 . 1 % , CD 4 23 . 4 % , CD 8 16 . 8 % , CD 19 8 . 0 % , CD 57 7 . 7 % and active T cells 14 . 6 % . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Flow cytometric analysis of the bone marrow showed positivity for CD 2 , CD 3 , CD 4 , CD 5 and CD 7 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
By contrast , HGMC did not express detectable amounts of CD 1 , CD 2 , CD 4 , CD 5 , CD 14 , CD 15 , CD 16 , CD 22 , CD 24 , CD 25 , CD 26 , CD 27 , CD 28 , CD 31 , CD 32 , CD 34 , CD 35 , CD 88 , or CD 116 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The virus induced the production of TNF alpha , IL 10 and IL 12 p 70 while inhibited IFN alpha secretion , increased the percentage of CD 2 ( + ) cells while decreased that of CD 4 ( + ) or CD 45 RA ( + ) cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Low density of CD 4 and CD 2 , CD 4 and CD 5 , the presence of CD 7 were registered in 1 patient each . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The color developers CD 2 , CD 3 and CD 4 and the black and white developer TSS are well known contact allergens that affect those who work in photographic processing . ^^^ The clinical morphology of the lesions was eczematous , and the patch tests showed contact sensitization to CD 2 , CD 3 , CD 4 and TSS . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The neoplastic populations expressed CD 2 , CD 4 , CD 5 , and CD45RO in all cases , lacked expression of CD 8 and CD 56 in all cases , and showed negative or dim surface CD 3 in most cases . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The numbers of cells expressing CD 2 , CD 4 , CD 8 , and CD 172 ( the 74 22 15 ( SWC 3 ) antibody is now known to be specific for CD 172 ) , MHC class 2 , and CD 25 were quantified using immunohistochemistry . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
An extensive series of Mab ( CD 2 , CD 3 , CD 4 , CD 8 , CD11b , CD 13 , CD 14 , CD 16 , CD 19 , CD 22 , CD 33 , CD 34 , CD 41 , CD42b , CD 45 , CD 56 , CD 61 , CD 64 , CD235a and HLA DR ) were tested singly or in FITC / PE combinations . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A portion of each skin specimen was stored at 80 degrees C and later examined using monoclonal antibodies against CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 15 , CD 19 , CD 20 and CD 30 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immunophenotyping was performed to evaluate expression of CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD 20 , CD 30 , and MIB 1 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Thus , the proportions of lymphocytes with the following phenotypes : CD 3 ( + ) , CD 2 ( + ) , CD 7 ( + ) , CD 4 ( + ) , CD62L ( + ) , CD 4 ( + ) CD62L ( + ) and CD 4 ( + ) CD 69 ( ) were significantly reduced in the study group compared with the control group , but significantly higher proportions were seen of lymphocytes expressing CD8alpha ( + ) CD8beta ( ) and TCRgammadelta ( + ) CD8alpha ( + ) CD8beta ( ) . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
The World Health Organization ( WHO ) suggested immunophenotype for pre T ALL / LBL typically includes the expression of TdT , cCD 3 , and CD 7 , while CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , and CD 10 are variably expressed . ^^^ Of the 18 cases evaluated for CD 2 , CD 3 , CD 4 , CD 8 , and dual expression of CD 4 and CD 8 , CD 2 was expressed in 14 ( 77 . 8 % ) , while CD 3 was expressed in 7 ( 38 . 9 % ) cases . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
When mouse spleen cells were exposed in vitro to both SRBC and monoclonal anti CD 4 , there was 55 % reduction of the anti SRBC response . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
One CD 4 bearing TH 2 cell failed to lyse efficiently either nucleated target cells or anucleated SRBC coated with anti CD 3 mAb . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Cell depletion studies revealed that L3T4 ( CD 4 ) + T cells , but not Lyt 2 ( CD 8 ) + T cells , are required in the rhuIL 11 stimulated augmentation of SRBC specific antibody responses . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
T 560 is IgG2a kappa + , Ia+ , B220+ , J11d+ , Thy 1 , CD 3 , CD 4 , CD 5 , Mac 1 , Mac 2 , nonspecific esterase negative and binds bromelain treated mouse RBC but not SRBC or ORBC . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
When spleen cells from partially CD 4 depleted mice were challenged in vitro with SRBC , they mounted a direct PFC response that was more than four times the observed PFC response of mice that received either saline or rat IgG . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
This was manifested by impairment of the allogeneic and the antibody responses in vitro to SRBC and in decreased numbers of T cells including their subsets CD 4 and CD 8 . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
When these three subsets of alpha beta TCR+ IEL from C3H / HeN mice ( H 2k ) orally immunized with SRBC were cultured with splenic B cells , adherent cells , and SRBC , both CD4+ , CD 8 and DP T cell fractions supported IgM , IgG 1 , and IgA anti SRBC responses , whereas the CD 4 , CD8+ T cell subset did not exhibit helper function . ^^^ Furthermore , when these CD 4 bearing T cells from mice orally immunized with SRBC were co cultured with B cells and adherent cells in the presence of unrelated Ag ( e . g . , horse RBC ) , SRBC specific B cell responses were not induced . ^^^ In the case of CD 4 , CD8+ T cells , approximately equal and low numbers of type 2 cytokine producing cells were noted in both SRBC stimulated and unstimulated cultures . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , anti CD 4 did not reduce T dependent antibody responses in mice previously primed against the Ag cholera toxin or SRBC . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
CD 4 and CD 8 depleted chickens , established by the combination of thymectomy and injection of T cell subset specific monoclonal antibodies , were immunized with sheep red blood cells ( SRBC ) . ^^^ Titers of anti SRBC antibody produced in CD 4 depleted chickens were lower than those in control chickens , while no difference in the antibody production was observed between CD 8 depleted and control chickens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Using a monoclonal antibody to CD 4 we have shown that occupation of CD 4 on T cells induces a strong dose dependent inhibition of in vitro IgM plaque forming cell ( PFC ) response of spleen cells to the T dependent antigen ( Ag ) , sheep red blood cells ( SRBC ) , in Mishell Dutton cultures . ^^^ The anti CD 4 antibody prevented the interaction of preactivated fixed SRBC specific T helper cells with B cells , suggesting that CD 4 had a role in contact mediated interactions between T cells and B cells . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
A significantly higher induction of the chemokine receptor CXCR 4 was observed on CD4+ lymphocytes isolated by sheep red blood cell ( SRBC ) rosetting and CD 4 MicroBeads as compared with positively selected CD4+ cells where the antibody / bead complex was immediately detached . ^^^ Furthermore , CD4+ cells isolated by SRBC rosetting and CD 4 MicroBeads formed aggregates upon in vitro culture . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
In addition , SCE inoculated chickens with the initial infection showed a significant increase in antibody responses against SRBC and BA and also improvement in decreased relative proportions of Bu 1a ( + ) and CD 4 ( ) cells in cecal tonsil lymphocytes of E . tenella challenged chickens . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
Immune organ weights , circulating granulocytes vs . agranulocytes , CD 4 and CD 8 positive T cells , cutaneous basophil hypersensitivity , and antibody titers to SRBC and breeder vaccinations were measured in progeny . ^^^
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P06729 and P01730	Pubmed	SVM Score :0.0
NA