| Here , we report that Cdk 1 phosphorylates Thr 59 and Thr 388 on inner centromere protein ( INCENP ) , which regulates the localization and kinase activity of Aurora B from prophase to metaphase . ^^^ We propose that INCENP phosphorylation by Cdk 1 is necessary for the recruitment of Plk 1 to the kinetochore , and that the complex formation of Plk 1 and Aurora B on INCENP may play crucial roles in the regulation of chromosomal dynamics . . ^^^ |