| Interacting proteins: Q9H8V3 and P06493 |
Pubmed |
SVM Score :0.0 |
| The timing of ect 2 expression matched that of proliferating cell nuclear antigen ( PCNA ) and partially overlapped cell division cycle 2 ( Cdc 2 ) expression . ^^^ |
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| Interacting proteins: Q9H8V3 and P06493 |
Pubmed |
SVM Score :0.0 |
| We propose that Cdk 1 inactivation is sufficient to activate a signaling pathway leading to cytokinesis , which emanates from mitotic spindles and is regulated by ECT 2 , MgcRacGAP , and RhoA . ^^^ Inhibition of cyclin dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT 2 and MgcRacGAP dependent manner . ^^^ |
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| Interacting proteins: Q9H8V3 and P06493 |
Pubmed |
SVM Score :0.0 |
| In G2 / M phase , ECT 2 was phosphorylated at T 341 most likely by Cyclin B / Cyclin dependent kinase 1 ( Cdk 1 ) , and then dephosphorylated before cytokinesis . ^^^ |
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| Interacting proteins: Q9H8V3 and P06493 |
Pubmed |
SVM Score :0.0 |
| Here we show that two mitotic kinases , Cdk 1 and polo like kinase 1 ( Plk 1 ) , phosphorylate ECT 2 in vitro . ^^^ We identified an in vitro Cdk 1 phosphorylation site ( T 412 ) in ECT 2 , which comprises a consensus phosphospecific binding module for the Plk 1 polo box domain ( PBD ) . ^^^ These results suggest that ECT 2 is regulated by Cdk 1 and Plk 1 in concert . . ^^^ |
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| Interacting proteins: Q9H8V3 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9H8V3 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
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