| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Human E2F 1 was found to transactivate the quail cdc 2 promoter very efficiently in avian and human cells . ^^^ |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| These included c fos , c jun , Id 1 , Id 2 , E2F 1 , and cdc 2 . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| In addition , the steady state levels of cyclin dependent kinases CDK 1 and CDK 2 and of transcription factor E2F 1 were diminished . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| In addition to the S phase genes , we also find that several genes believed to play regulatory roles in cell cycle progression , such as the cdc 2 , cyclin A , and B myb genes , are also induced by E2F1 . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Expression of Rb , E2F1 , cdc 2 , and D , and B cyclins in developing spinal cord . ^^^ The spatial and temporal distribution of transcripts for the tumor suppressor gene Rb , transcription factor E2F1 , cdc 2 kinase , cyclins D 1 , D 2 , B 1 and B 2 during neurogenesis of the spinal cord was determined by in situ hybridization . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| The expression of proliferation associated genes , cdc 2 and E2F 1 and squamous specific genes transglutaminase type 1 and cornifin were examined in senescing human epidermal keratinocytes . ^^^ This was accompanied by downregulation of cdc 2 and E2F 1 mRNA ' s . ^^^ E2F 1 , cdc 2 and cornifin were similarly altered in senescing human mammary epithelial cells . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| This induction is characterized by a > or = 95 % decrease in the mRNA level of two growth regulatory genes , cdc 2 and E2F 1 , and a 7 15 fold increase in the expression of two squamous cell specific genes , transglutaminase type 1 and cornifin . ^^^ In contrast to the decrease in cdc 2 and E2F 1 expression , the increase in transglutaminase type 1 and cornifin mRNAs by IFN gamma occurs after a lagtime of more than 12 h . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| This growth arrest was accompanied by a down regulation of cdc 2 , E2F 1 , and p 53 mRNA levels and was associated with expression of the squamous specific marker genes , transglutaminase type 1 and cornifin . ^^^ |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Band shift analysis of bacterially produced E2F 1 showed that this protein bound to the promoters of human DNA polymerase alpha , cyclin D 1 , and c myb but not to the cdc 2 gene promoter . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| The signalling pathways controlling growth and differentiation in epithelial cells appears to be different to those regulating immune functions in non epithelial cells and appear to impact on key cell cycle regulatory genes such as cdk 1 and E2F1 . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| The elevation of these complexes in arrested 5 mos transformed cells may be the cause of the transcriptional activation of the E2F regulated genes cdc 2 , DHFR , cyclin A , and E2F1 seen in serum starved 5 mos transformed cells . ^^^ |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis of BIP with cyclins / CDKs and E2F antisera indicated association with cdc 2 , cdk 2 , cdk 4 , cyclin B , cyclin D , cyclin A and E2F 4 but not with cdk 3 , cdk 5 , cdk 6 , E2F 1 , E2F 2 , E2F 3 , E2F 5 and cyclin E . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , a recently developed quantitative reverse transcriptase polymerase chain reaction method was used to assess simultaneously expression of 15 genes mechanistically associated with cell cycle control ( c myc , E2F 1 , p 21 , rb , PCNA , cyclin D 2 , cyclin D 3 , cyclin E , cdc 2 , CDK 2 , CDK 4 , mad , max p 21 , max p 22 , and p 53 ) in normal cell cultures from five individuals and in nine different malignant BEC lines . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Expression of the cell cycle specific proteins pRb , Rb2 / p130 , p 107 , cyclin A , cdc 2 , and E2F 1 was decreased after DeltaRaf 1 : ER activation in DMS 53 cells . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Binding of free E2F 1 to the cdc 2 promoter did not occur in hormone treated VSMC , which may account for the defective induction of cdc 2 . ^^^ |
|
| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| We have been able to identify a number of genes , including B myb , cyclin A , cdc 2 , cdc 6 , and DHFR , whose expression is dependent on the presence of E2F3 but not E2F1 . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| We show here that methylation of E2F elements derived from the dihydrofolate reductase , E2F1 , and cdc 2 promoters prevents the binding of all E2F family members tested ( E2F1 through E2F5 ) . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Blocking E2F activity by transfecting proliferating keratinocytes with dominant negative E2F 1 constructs inhibited the expression of cdc 2 and E2F 1 , but did not induce differentiation . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| E2F1 mediated neuronal apoptosis did not require activation of gene transcription because : ( 1 ) ectopic expression of E2F1 or its mutants lacking the transactivation domain induced neuronal apoptosis , whereas an E2F1 mutant lacking the DNA binding domain did not ; ( 2 ) under all of these conditions , known E2F1 target genes including cyclin A , cdc 2 and p 19 ( ARF ) were not induced ; and ( 3 ) DA evoked neuronal apoptosis was associated with up regulated E2F1 , but not transcription of its target genes . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Ang 2 failed to induce E2F 1 expression , or its binding to the cdc 2 promoter , even under HG conditions . ^^^ HG greatly augmented the cdc 2 inducibility of fetal calf serum ( FCS ) , through the increase in E2F 1 activity . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| CGP74514A treatment ( 5 microM ; 18 hr ) resulted in increased p 21 ( CIP 1 ) expression , p 27 ( KIP 1 ) degradation , diminished E2F1 expression , and dephosphorylation of p 34 ( CDC 2 ) . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| The transcription factor E2F1 that is expressed in granule neurons was found in DNA binding assays to bind to the EBE of the cdc 2 gene . ^^^ In chromatin immunoprecipitation analysis , endogenous E2F1 forms a complex with the promoter of the endogenous cdc 2 gene in granule neurons , indicating that endogenous E2F1 is poised to activate transcription of the endogenous cdc 2 gene in neurons . ^^^ In other experiments , we found that the expression of E2F1 in granule neurons induces Cdc 2 expression and promotes neuronal apoptosis via the activation of Cdc 2 . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Expression levels of TFDP 1 and E2F1 correlated with those of seven transcriptional targets ( TYMS , DHFR , PCNA , RRM 1 , CCNE 1 , CDC 2 , and MYBL 2 ) that play important roles in the G1 / S transition , and down regulation of TFDP 1 inhibited growth of Hep3B cells . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| We show by gene expression profiling that activation of the GLI 2 oncogene in human keratinocytes activates the transcription of a number of genes involved in cell cycle progression such as E2F1 , CCND 1 , CDC 2 and CDC45L , while it represses genes associated with epidermal differentiation . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Overexpression of SMAD 7 inhibited the activity of the proliferation specific promoters for the keratin 14 and cdc 2 genes and reduced the expression of the mRNA for the proliferation specific genes cdc 2 and E2F1 . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| We find that E2F1 , E2F2 , and E2F3 bind to the positive acting E2F site in the cdc 2 promoter , whereas E2F4 binds to the negative acting site . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Downstream in CDKI CDK cyclin cascade , consistent with its inhibitory effect on CDK kinase activity , IP 6 treatment of cells increased hypophosphorylated levels of retinoblastoma ( Rb ) with a decrease in Rb phosphorylation at serine 780 , 807 , and 811 sites , and caused a moderate to strong decrease in the levels of transcription factors E2F1 , E2F4 , and E2F5 . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| Overexpression of both viral proteins induces cellular proliferation , retinoblastoma ( pRb ) phosphorylation , and accumulation of products of genes that are negatively regulated by pRb , such as p 16 ( INK4a ) , CDC 2 , E2F 1 , and cyclin A . ^^^ |
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| Interacting proteins: Q01094 and P06493 |
Pubmed |
SVM Score :0.0 |
| E2F 1 overexpression in U2OS cells increases cyclin B 1 levels and cdc 2 kinase activity and sensitizes cells to antimitotic agents . ^^^ Therefore , we investigated the effect of E2F 1 overexpression on proteins regulating the G 2 M transition and M phase , in particular cyclin B 1 and cdc 2 kinase . ^^^ Cyclin B 1 mRNA and protein levels increased within 24 hours of E2F1 induction together with an increase in associated cdc 2 kinase activity . ^^^ |
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