| Interacting proteins: Q00597 and P06493 |
Pubmed |
SVM Score :0.0 |
| The Fanconi anemia polypeptide , FAC , binds to the cyclin dependent kinase , cdc 2 . ^^^ In addition , the FAC protein coimmunoprecipitated with the cyclin dependent kinase , cdc 2 . ^^^ We next tested various mutant forms of the FAC polypeptide for binding to cdc 2 . ^^^ A patient derived mutant FAC polypeptide , containing a point mutation at L554P , failed to bind to cdc 2 . ^^^ Moreover , binding of FAC to cdc 2 was mediated by the carboxyl terminal 50 amino acids of FAC in a region of the protein required for FAC function . ^^^ |
|
| Interacting proteins: Q00597 and P06493 |
Pubmed |
SVM Score :0.0 |
| Mass spectroscopy detected previously reported FA binding proteins , including FANCA , FANCC , FANCG , cdc 2 , and GRP 94 , thus validating the approach . ^^^ |
|
| Interacting proteins: Q00597 and P06493 |
Pubmed |
SVM Score :0.0 |
| Reasoning that a potential kinase might be cdc 2 , which was previously reported to bind to FANCC , we showed that cdc 2 chiefly phosphorylated a 14 kDa fragment of the C terminal half of FANCG . ^^^ |
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| Interacting proteins: Q00597 and P06493 |
Pubmed |
SVM Score :0.0 |
| The increased rate of mitotic entry seen in Fancc / mouse embryo fibroblasts correlated with decreased inhibitory phosphorylation of cdc 2 kinase on tyrosine 15 . ^^^ |
|
| Interacting proteins: Q00597 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
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