| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Activation of a Plasmodium falciparum cdc 2 related kinase by heterologous p 25 and cyclin H . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Together these data suggest that the Crk 1 Mcs2 complex is a CAK that interacts genetically with Cdc 2 in fission yeast . . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| The Mcs 6 CDK together with its cognate cyclin Mcs 2 represents the CDK activating kinase ( CAK ) of fission yeast Cdc 2 . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| We report here that two polypeptides of the purified mammalian TFIIH are the MO15 / Cdk7 kinase and cyclin H subunits of the Cdk activating kinase Cak , previously identified as a positive regulator of Cdc 2 and Cdk 2 . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| The human Cdk activating protein kinase ( Cak 1 ) is itself a Cdc 2 related cyclin dependent protein kinase that associates with cyclin H . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Expression of cyclin H protein , detected by western blotting of hippocampal tissue , was increased after global ischemia , but expression of cyclins B 1 and D 1 and other related cell cycle genes ( Cdk 7 and Cdc 2 ) was not increased . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Moreover , cDNA array analysis showed that PC SPES caused up regulation of p 21 ( WAF1 / CIP1 ) and decreased expression of cyclin B , Nedd 8 , cdc 2 , skp 1 , PCNA , MAD2L1 , cyclin H , CKS 2 , E2F , Rbx 1 , MCM 2 , MCM 5 , Mpp 2 , Cullin Cul4A , Cks1p9 and McM 7 , which are involved in cell cycle progression . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Effects of phosphorylation by CAK on cyclin binding by CDC 2 and CDK 2 . ^^^ One complex ( CDC 2 cyclin A ) forms with high affinity only after CAK mediated phosphorylation of CDC 2 at the activating threonine residue . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| This step is catalyzed by a cdk activating kinase ( CAK ) functionally analogous to the enzyme which phosphorylates cdc 2 and cdk 2 at Thr 161 / 160 . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| The CAK holoenzyme activates complexes of CDK 2 and CDC 2 with various cyclins and also phosphorylates CDK 2 , but not CDC 2 , in the absence of cyclin . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| CDK activation is dependent on cyclin binding and phosphorylation of a conserved threonine ( T 161 in Cdc 2 ) mediated by the CDK activating kinase CAK . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| The catalytic domain of ( HS ) Cak 1 , defined by conserved kinase Subdomains 1 through 11 , exhibits considerable homology with ( HS ) Cdc 2 , suggesting that this kinase cascade involves closely related enzymes . ^^^ Immunological studies with anti Cak antibodies confirm the presence of specific immunoreactivity in highly purified preparations of the human Cdc 2 activating kinase . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| To determine if the Cdk2 / cyclin A complex could be activated further by phosphorylation of T 160 , complexes were treated with Cdc 2 activating kinase ( CAK ) , purified approximately 12 , 000 fold from Xenopus eggs . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Differential expression of a CAK ( cdc 2 activating kinase ) like protein kinase , cyclins and cdc 2 genes from rice during the cell cycle and in response to gibberellin . ^^^ The R 2 gene from rice has 55 % sequence identity to the cdc 2 activating kinase ( CAK ) family of protein kinases which have been shown to phosphorylate and thereby activate cdc 2 protein kinases in animals and yeast . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Cdc 2 cyclin complexes isolated from the arrested cells could be activated in vitro by recombinant CAK , whereas complexes from wild type cells or either of the single mutants were refractory to activation . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Cyclin dependent kinase 7 ( CDK 7 ) is the catalytic subunit of the metazoan CDK activating kinase ( CAK ) , which activates CDKs , such as CDC 2 and CDK 2 , through phosphorylation of a conserved threonine residue in the T loop . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Mcs 6 , human Cdk 7 and budding yeast Cak 1 were all active as Caks for Cdc 2 when expressed in fission yeast . ^^^ Biochemical experiments supported these genetic results : budding yeast Cak 1 could bind and phosphorylate Cdc 2 from fission yeast lysates , whereas fission yeast Csk 1 could not . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Finally , neither cell cycle arrest nor CAK failure is recapitulated by a second mutation in mcs 6 13 that prevents Mcs 6 activation by Csk 1 , indicating that Csk 1 activates Cdc 2 directly in vivo . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| The fission yeast Mcs 6 Mcs2 Pmh 1 complex , homologous to metazoan Cdk 7 cyclin H Mat 1 , has dual functions in cell division and transcription : as a partially redundant cyclin dependent kinase ( CDK ) activating kinase ( CAK ) that phosphorylates the major cell cycle CDK , Cdc 2 , on Thr 167 ; and as the RNA polymerase ( Pol ) 2 carboxyl terminal domain ( CTD ) kinase associated with transcription factor ( TF ) IIH . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| The Cyclin dependent kinase ( CDK ) Activating Kinase ( CAK ) is responsible for the activating phosphorylation of CDK 1 , CDK 2 , CDK 4 and CDK 6 and regulation of the cell cycle . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| We report here the characterization of PNQALRE ( also known as CCRK or p 42 ) , a member of the mammalian CDK family most similar to the cell cycle effectors Cdk 1 and Cdk 2 and to the CAK , Cdk 7 . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| The addition of PfMAT 1 stimulated RNA polymerase 2 CTD phosphorylation and had no effect on the inability of Pfmrk to phosphorylate PfPK 5 , a putative CDK 1 homolog , which suggests that Pfmrk may be a CTD kinase rather than a CAK . ^^^ |
|
| Interacting proteins: P51946 and P06493 |
Pubmed |
SVM Score :0.0 |
| Cell lines with gain on proximal 5q , where CCNB 1 and CCNH reside , showed an increased growth rate , suggesting that cyclins activating cdc 2 , the dominant G2 / M phase kinase , may play a role in glioma tumorigenes . . ^^^ |
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