| Interacting proteins: P33552 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P33552 and P06493 |
Pubmed |
SVM Score :0.0 |
| We observed that binding of human CksHs 2 to p 34 ( cdc 2 ) was stimulated by cyclin B . ^^^ |
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| Interacting proteins: P33552 and P06493 |
Pubmed |
SVM Score :0.0 |
| Moreover , cDNA array analysis showed that PC SPES caused up regulation of p 21 ( WAF1 / CIP1 ) and decreased expression of cyclin B , Nedd 8 , cdc 2 , skp 1 , PCNA , MAD2L1 , cyclin H , CKS 2 , E2F , Rbx 1 , MCM 2 , MCM 5 , Mpp 2 , Cullin Cul4A , Cks1p9 and McM 7 , which are involved in cell cycle progression . ^^^ |
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| Interacting proteins: P33552 and P06493 |
Pubmed |
SVM Score :0.0 |
| The pathway analysis of expression data showed that the SPP 1 , VEGF , CDC 2 and CKS 2 genes were coordinately differentially regulated between cancer and normal . ^^^ |
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| Interacting proteins: P33552 and P06493 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND . p 13 ( suc 1 ) from fission yeast is a member of the CDC 28 kinase specific ( CKS ) class of cell cycle control proteins , that includes CKS 1 from budding yeast and the human homologues CksHs 1 and CksHs 2 . p 13 ( suc 1 ) participates in the regulation of p 34 ( cdc 2 ) , a cyclin dependent kinase controlling the G 1 S and the G 2 M transitions of the cell cycle . ^^^ |
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| Interacting proteins: P33552 and P06493 |
Pubmed |
SVM Score :0.0 |
| For analyzing relationships of CKS with cell proliferation and / or with differentiation , we investigated the expression of ckshs 1 and ckshs 2 in normal and malignant human lymphoid cells . ckshs 1 and ckshs 2 expression appeared to be related to cell proliferation : ( 1 ) mRNAs increased with stimulation of normal peripheral blood lymphocytes , and from the G 1 to the SG2M phase in elutriated cells ; ( 2 ) P 9 proteins were also induced by lymphocyte stimulation and were localized in nucleus where phosphorylated forms of CDK 1 were also found ; ( 3 ) in vitro , the phosphorylated forms of CDK 1 and CDK 2 were preferentially linked to CKS . ^^^ |
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